Fast Detection Of Paracetamol On A Gold Nanoparticle-chitosan Substrate By Sers

A fast method for detecting pharmaceutical drugs, such as paracetamol, by surface-enhanced Raman spectroscopy (SERS) using a gold nanoparticle substrate was studied. Gold nanoparticles were synthesized using chitosan (AuNP-chitosan) as a reductant and capping agent and subsequently deposited on glass slides as a thin film. The SERS performance of AuNP-chitosan films was evaluated using methylene blue (MB, 10-6 mol L-1) as a SERS probe molecule. The method is based on drop-drying an analyte solution (paracetamol, 10-3 mol L-1) onto a substrate surface and subsequently analyzing by Raman spectroscopy. The spectra were obtained in 10 seconds with two accumulations and exhibit a high signal-to-noise ratio. This preliminary study supports the AuNP-chitosan substrate as a SERS sensor, for a convenient analytical method for detection of paracetamol and other pharmaceutical drug molecules. © the Partner Organisations 2014.61135643568Halling-Sorensen, B., Nielsen, N., Lansky, P.F., Ingersley, F., Hansen, L., Lutzhoft, H.C., Jorgensen, S.E., (1998) Chemosphere, 36, p. 357Daughton, C.G., Ternes, T.A., (1999) Environ. Health Perspect., 107, p. 907Klimova, K., Leitner, J., (2012) Thermochim. Acta, 550, p. 59Parojcic, J., Karljikovic-Rajic, K., Duric, Z., Jovanovic, M., Ibric, S., (2003) Biopharm. Drug Dispos., 24, p. 309Holm, J.V., Rugge, K., Bjerg, P.L., Christensen, T.H., (1995) Environ. Sci. Technol., 29, p. 1415Ternes, T.A., (1998) Water Res., 32, p. 3245Reddersen, K., Heberer, T., Dunnbier, U., (2002) Chemosphere, 49, p. 539Zwiener, C., Glauner, T., Frimmel, F.H., (2000) High Resolut. Chromatogr., 23, p. 474Buser, H.R., Poiger, T., Muller, M.D., (1999) Environ. Sci. Technol., 33, p. 2529Chen, L.-X., Li, D.-W., Qu, L.-L., Li, Y.-T., Long, Y.-T., (2013) Anal. Methods, 5, p. 6579Péron, O., Rinnert, E., Toury, T., Chapelle, M.L., Compere, C., (2011) Analyst, 136, p. 1018Alvarez-Puebla, R.A., Liz-Marzan, L.M., (2012) Angew. Chem., Int. Ed., 51, p. 11214Fleischmann, M., Hendra, P.J., McQuillan, A.J., (1974) Chem. Phys. Lett., 26, p. 63Le Ru, E.C., Etchegoin, P.G., (2009) Principles of Surface-enhanced Raman Spectroscopy, , Elsevier, AmsterdamAroca, R., (2006) Surface-enhanced Vibrational Spectroscopy, , John Wiley & Sons, Southern GateZhang, Y., Liu, S., Wang, L., Qin, X., Tian, J., Lu, W., Chang, G., Sun, X., (2012) RSC Adv., 2, p. 538Moula, G., Aroca, R.F., (2011) Anal. Chem., 83, p. 284Yu, W.W., White, I.M., (2012) Analyst, 137, p. 1168Zhai, W.L., Li, D.W., Qu, L.L., Fossey, J.S., Long, Y.T., (2012) Nanoscale, 4, p. 37Alsawafta, M., Badilescu, S., Packirisamy, M., Truong, V.V., (2011) React. Kinet., Mech. Catal., 104, p. 437Esumi, K., Takei, N., Yoshimura, T., (2003) Colloids Surf., B, 32, p. 117Potara, M., Maniu, D., Astilean, S., (2009) Nanotechnology, 20, p. 315602Santos, E.B., Sigoli, F.A., Mazali, I.O., (2013) Vib. Spectrosc., 68, p. 246Wang, Y.Q., Liang, W.S., Geng, C.Y., (2009) Nanoscale Res. Lett., 4, p. 684Vieira, E.F.S., Cestari, A.R., Santos, E.B., Dias, F.S., (2005) J. Colloid Interface Sci., 289, p. 42Cheng, Y.-C., Yu, C.-C., Lo, T.-Y., Liu, Y.-C., (2012) Mater. Res. Bull., 47, p. 1107Nhung, T.T., Bu, Y., Lee, S.-W., (2013) J. Cryst. Growth, 373, p. 132Xiao, G.N., Man, S.Q., (2007) Chem. Phys. Lett., 447, p. 305Ruan, C.M., Wang, W., Gu, B.H., (2007) J. Raman Spectrosc., 38, p. 568Peng, Y., Niu, Z., Huang, W., Chen, S., Li, Z., (2005) J. Phys. Chem. B, 109, p. 10880Elbagerma, M.A., Azimi, G., Edwards, H.G.M., Alajtal, A.I., Scowen, I.J., (2010) Spectrochim. Acta, Part A, 75, p. 1403Chazallon, B., Celik, Y., Focsa, C., Guinet, Y., (2006) Vib. Spectrosc., 42, p. 206Nanubolu, J.B., Burley, J.C., (2012) Mol. Pharmaceutics, 9, p. 154

Grain and seed protein functionality

Editado por Jiménez-López, José Carlos (CSIC

Transitions of cardio-metabolic risk factors in the Americas between 1980 and 2014

Describing the prevalence and trends of cardiometabolic risk factors that are associated with non-communicable diseases (NCDs) is crucial for monitoring progress, planning prevention, and providing evidence to support policy efforts. We aimed to analyse the transition in body-mass index (BMI), obesity, blood pressure, raised blood pressure, and diabetes in the Americas, between 1980 and 2014