La Catalogna diversa: lo storico della società, oggi

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Human germline manipulation: technical limits and future perspectives

Although many technical difficulties still remain, it appears probable that germline manipulation in humans will be implemented in the near future. The aim of this brief paper is to summarise what can be technically done at present and to indicate the possible applications of the new emerging technologies in this field. In particular we discuss the technical limits to the generation of transgenic and mutant humans and evaluate the problems which may arise in each of these procedures

I tempi della storia

No abstrac

Generation of an ultrastable 578 nm laser for Yb lattice clock

In this paper we described the development and the characterization of a 578 nm laser source to be the clock laser for an Ytterbium Lattice Optical clock. Two independent laser sources have been realized and the characterization of the stability with a beat note technique is presente

Single injection dual phase CBCT technique ameliorates results of trans-arterial chemoembolization for hepatocellular cancer

Cone-beam CT (CBCT) application to the field of trans-arterial chemoembolization has been recently the focus of several researches. This imaging modality is performed with a rotation of the C-arm around the patient, without needs of patient repositioning. Datasets are immediately processed, obtaining volumetric CT-like images with the possibility of post-processing and reconstruction of images. Dual phase CBCT recently introduced in clinical practice consists in a first arterial acquisition followed by a delayed acquisition corresponding to a venous phase. The introduction of this feature has overcome the limit of single-phase acquisitions, allowing lesions characterization. Moreover these recent advantages have several intra-procedural implications. Detailed technical and acquisition parameters will be widely exposed in this review with particular attention to: catheter positioning, acquisition delay, injection parameters, patient positioning and contrast dilution. Comparison with standard of practice second line imaging [multidetector computer tomography (MDCT) and MDCT/arteriography] demonstrate the capability of detecting occult nodules providing some clinical implications thus potentially identifying a sub set of patients with aggressive disease behaviour. Other intra-procedural advantages of dual phase CBCT usage consist in a better tumor feeder visualization, reduction of proper DSA and fluoroscopic time, suggestion the presence of an extrahepatic parasitic feeder thus resulting in a more accurate treatment. Finally, the volumetrical intraprocedural evaluation of accumulation of embolic agent has proved to be correlate with treatment response if compared with MRI

Les usages de la biographie

Es posible sugerir que hubo épocas -no tan lejanas- en las que era posible relacionar un acontecimiento histórico en forma abstracta de cualquier destino individual. Estamos viviendo una fase intermedia, la biografía está en el centro de las preocupaciones de los historiadores, pero se reconocen claramente sus ambigüedades.Traducido por Guillermo Bonzato Revisión técnica de Alejandro SimonoffFacultad de Periodismo y Comunicación Socia

Los usos de la biografía

Un individuo posee límites claros, un número restringido de relaciones significativas... la biografía se abre a todo tipo de problemas, dentro de fronteras bien definidas.An individual has clear boundaries, a restricted number of significant relationships... the biography is open to all kinds of problems, within well-defined boundaries