Ovarian Borderline Tumor and Fertility-Sparing Surgery

Ovarian borderline tumors (OBTs) are frequently diagnosed in women of reproductive age. There is no consensus about their management, and it sometimes represents a dilemma aboutwhat should be done: fertility sparing surgery or a hysterectomy with salpingo-oophorectomy? Case: A 32-year-old nulligravida, diagnosed with a right ovarian borderline tumor is presented. She underwent pelvic washings, right salpingo-oophorectomy, appendectomy, and omental and peritoneal biopsies (laparotomic approach). Macroscopically, the left ovary was normal and subsequent exploration for staging was also normal, including the lymph nodes. Intraoperatively, frozen section examination was unclear, suggesting an OBT. Results: The final histopathologic diagnosis was ovarian borderline tumor, stage IIC (International Federation of Gynecology and Obstetrics [FIGO] staging). The patient expressed a desire to preserve her fertility. Thirty-six months postsurgery, she became pregnant spontaneously and delivered a healthy newborn at term. Conclusions: Conservative surgery can be performed in young patients treated for an OBT, provided they are closely followed up and that this surgery is performed after careful consideration and informed consent. It is, however, controversial with respect to performing hysterectomy and salpingo-oopherectomy upon the patient’s completion of childbearing

Carbon dots from tryptophan doped glucose for peroxynitrite sensing

Tryptophan doped carbon dots (Trp-CD) were microwave synthesized. The optimum conditions of synthesizing of the Trp-CD were established by response surface multivariate optimization methodologies and were the following: 2.5 g of glucose and 300 mg of tryptophan diluted in 15 mL of water exposed for 5 min to a microwave radiation of 700 W. Trp-CD have an average size of 20 nm, were fluorescent with a quantum yield of 12.4% and the presence of peroxynitrite anion (ONOO−) provokes quenching of the fluorescence. The evaluated analytical methodology for ONOO− detection shows a linear response range from 5 to 25 μM with a limit of detection of 1.5 μM and quantification of 4.9 μM. The capability of the ONOO− quantification was evaluated in standard solutions and in fortified serum samples

Interspecies communication in holobionts by non-coding RNA exchange

PTDC-MED-GEN-29389-2017Complex organisms are associations of different cells that coexist and collaborate creating a living consortium, the holobiont. The relationships between the holobiont members are essential for proper homeostasis of the organisms, and they are founded on the establishment of complex inter-connections between all the cells. Non-coding RNAs are regulatory molecules that can also act as communication signals between cells, being involved in either homeostasis or dysbiosis of the holobionts. Eukaryotic and prokaryotic cells can transmit signals via non-coding RNAs while using specific extracellular conveyors that travel to the target cell and can be translated into a regulatory response by dedicated molecular machinery. Within holobionts, non-coding RNA regulatory signaling is involved in symbiotic and pathogenic relationships among the cells. This review analyzes current knowledge regarding the role of non-coding RNAs in cell-to-cell communication, with a special focus on the signaling between cells in multi-organism consortia.publishersversionpublishe

imAGES: intervention program to prevent ageism in children

The work presented in this training manual was developed within the framework of the SIforAGE – Social Innovation for Active and Healthy Ageing, which aims to strengthen cooperation among the stakeholders working on active and healthy ageing. The ultimate goal is to bring together scientists, end-users, civil society, public administrations and companies in the promotion of research and innovative products for longer and healthier lives. The first phase of this work involved the creation and testing of the intergenerational program against ageism (prejudice and discrimination on the basis of age). It was developed with close cooperation between two partners of the SIforAGE project, i.e. a team of the Centre for Social Research and Intervention at the University Institute of Lisbon (ISCTE-IUL) and a team from Santa Casa da Misericórdia de Lisboa (SCML). The ultimate goal is that this team be joined by several other SIforAGE partners to apply the program within their national contexts, thus allowing its dissemination in different countries in Europe as well as in Brazil

Morfoanatomia foliar em mudas de Schinus terebinthifolius sob diferentes níveis de saturação hídrica.

As características morfológicas e anatômicas foliares de espécies vegetais são importantes indicadores de sua ecologia e de seus hábitats. Objetivou-se caracterizar a plasticidade fenotípica de Schinus terebinthifolius Raddi em diferentes condições de saturação hídrica. As mudas foram produzidas em tubetes plásticos, permanecendo em estufa por quatro meses, sendo irrigadas normalmente. Em seguida foram submetidas aos tratamentos: T1- testemunha, T2- alagamento parcial e T3- alagamento total. Após três semanas sob alagamento, foram realizadas descrições anatômicas foliares comparativas e avaliadas as características morfológicas área foliar, área específica foliar, espessura foliar, teor de água e densidade estomática. Durante 10 semanas foram observadas as modificações fenotípicas adaptativas. Foi observado aumento da espessura da base do caule, clorose e abscisão foliar, surgimento de lenticelas e raízes adventícias. Após três semanas de alagamento, não foram verificadas grandes modificações na morfologia das folhas, principalmente para a AF e AEF. Em T3, o teor de água foi maior e a espessura foliar menor. Não houve diferença entre os tratamentos para DE. Quanto aos aspectos anatômicos, observou-se uma redução na espessura do mesofilo e das nervuras, assim como a produção de compostos fenólicos por alguns tipos celulares. Os espaços intercelulares são progressivamente mais amplos nas plantas submetidas ao alagament

Artificial reefs: from ecological processes to fishing enhancement tools

info:eu-repo/semantics/publishedVersio

ACTH-dependent Cushing's syndrome: a revision of 43 cases

AIM: To evaluate the characteristics and outcomes of the patients diagnosed as ACTH-dependent Cushing syndrome, registered in the department. MATERIAL AND METHODS: We reviewed the files of forty-three patients followed from 1974 to 2002. RESULTS: A progressive rise in the number of patients diagnosed was found, being 80% females. Clinical suspicion was based mostly on the typical fat distribution; hirsutism and amenorrhoea were important in women. The more reliable diagnostic tests were: 11 pm cortisol, day curve of ACTH and cortisol, and dexamethasone suppression tests. The ACTH response to CRH during inferior petrosal sinus sampling permitted the diagnosis of ectopic source. In thirty-seven patients a pituitary adenoma was diagnosed. The three patients diagnosed before 1985 went for bilateral adrenalectomy (Nelson's syndrome in two); the others were submitted to transsphenoidal pituitary adenomectomy, obtaining remission in twenty six at the first operation and in two others at the second. Three patients had a recidive. Of the six patients with persistent disease (all treated with metyrapone or ketoconazole), three were submitted to radiotherapy, two to bilateral adrenalectomy, and one was waiting for surgery. Four patients had a bronchial carcinoid, successfully removed in three. One patient was lost to follow-up and another was still being evaluated. CONCLUSIONS: We found a positive evolution in the capacity to diagnose and treat these patients. Neurosurgical ability to achieve remission was 80% in the operated cases. More effective technical methods and drugs, as well as a multidisciplinary and dedicated medical team, lead to long lasting remissions in most of the patients

Efeito das condições de cura no comportamento da resistência à compressão em resíduos de cerâmica ativados por álcali

The industrial sector is responsible for the generation of a large amount of solid waste, of which some is partially recycled, but the majority is deposited in landfills or landfills causing various negative impacts on the environment. Alkaline cements are attracting growing interest for their potential to allow the industry to operate within the constraints imposed on CO2 emissions. The objective of this research was to know the effect of different curing conditions on the compressive strength behavior of alkaline activated ceramic residues. As a result, it was determined that an alkali-activated matrix is significantly influenced when cured at a temperature of 70 ° C, reaching, at 90 days of age, a compressive strength of up to 39.3 MPa in contrast to 27.08 MPa. when curing was carried out in environmental conditions of 20 ° C (± 0.5 ° C) and 60% (± 5%) of relative humidity (RH). This work was complemented with a microstructural analysis that included Scanning Electron Microscopy (SEM) and X-ray Energy Dispersion Analyzer (EDX).El sector industrial es responsable de la generación de una gran cantidad de residuos sólidos, de los cuales algunos son parcialmente reciclados, pero la mayoría son depositados en vertederos o rellenos sanitarios provocando diversos impactos negativos en el medio ambiente. Los cementos alcalinos están atrayendo un interés creciente por su potencial para permitir que la industria opere dentro de las limitaciones impuestas a las emisiones de CO2. La presente investigación tuvo como objetivo conocer el efecto de diferentes condiciones de curado sobre el comportamiento de resistencia a compresión de los residuos cerámicos activados alcalinamente. Como resultado se determinó que una matriz álcali-activada es significativamente influenciada cuando se cura con una temperatura de 70°C alcanzando, a los 90 días de edad, una resistencia a la compresión de hasta 39,3 MPa en contraste con 27,08 MPa cuando el curado se realizó en condiciones ambientales de 20°C (± 0,5 ° C) y 60% (± 5%) de humedad relativa (RH). Este trabajo se complementó con un análisis microestructural que incluyó Microscopía electrónica de barrido (SEM) y Analizador de dispersión de energía de rayos X (EDX).O setor industrial é responsável pela geração de grande quantidade de resíduos sólidos, alguns deles parcialmente reciclados, mas a maior parte é depositada em aterros ou aterros sanitários causando diversos impactos negativos ao meio ambiente. Os cimentos alcalinos estão atraindo cada vez mais interesse por seu potencial de permitir que a indústria opere dentro das restrições impostas às emissões de CO2. O objetivo desta pesquisa foi conhecer o efeito de diferentes condições de cura no comportamento da resistência à compressão de resíduos cerâmicos alcalinos ativados. Como resultado, determinou-se que uma matriz alcalina ativada é significativamente influenciada quando curada a uma temperatura de 70 ° C, atingindo, aos 90 dias de idade, uma resistência à compressão de até 39,3 MPa em contraste com 27,08 MPa. quando a cura foi realizada em condições ambientais de 20 ° C (± 0,5 ° C) e 60% (± 5%) de umidade relativa (UR). Este trabalho foi complementado com uma análise microestrutural que incluiu Microscopia Eletrônica de Varredura (MEV) e Analisador de Dispersão de Energia de Raios-X (EDX)

Plantas invasoras de várzea no estado de São Paulo

Due to competition for water, light and nutrients the weeds are serious problems for certain kind of crops. They are responsible for the reduction in production. The survey and the recognition of different weeds and the their biological study permit a more efficient and economical way of control. The botanical material was collected in lowland crops during three different periods of the year. The purpose was to collect as many different species of weeds as possible. The phenology, the mode of reproduction, the frequency and cycle of weed species are important factors for the rational and effective control. Although the greatest amount of weed species collected belong to the Compositae and Gramineae, the most economically important species belong to the following families: Cyperaceae, Lythraceae, Onagraceae, Polygonaceae, Pontederiaceae and Portulacaceae.As plantas invasoras que ocorrem em uma determinada cultura, constituem sério problema, tendo em vista a concorrência em água, luz e nutrientes que promove com a planta cultivada, determinando uma sensível queda da produtividade da lavoura. O levantamento e reconhecimento dessas plantas, além do estudo biológico, permitem um controle mais eficiente e económico. A coleta do material botânico foi realizada através de visitas em áreas de várzeas cultivadas e em três épocas distintas do ano, com a finalidade de se levantar o maior número possível de espécies invasoras. A fenologia, o modo ou modos de reprodução, frequência e ciclo são elementos indispensáveis para um controle racional e efetivo. Apesar do maior número de espécies pertencerem as famílias Compositae e Gramineae, as espécies de maior importância econômica estão abrigadas também nas famílias Cyperaceae, Lythraceae, Onagraceae, Polygonaceae, Pontederiaceae e Portulacaceae.859