212 research outputs found
Classificacion del Cancer Laringeo de Acuerdo a su Localizacion y Extension Anatomo-Clinica
La literatura sobre el cĂąncer larĂngeo es muy vasta y ha sido acumulada en um perĂodo relativamente reciente. AfecciĂłn conocida vagamente en la antigĂŒedad, es reciĂ©n en el ano 1760 que Morgagni (18) refiere en su carta anatĂŽmica No. 28 dos observaciones de Valsalva con descripciones autĂłpsicas bien precisas, acompanadas de Ias historias clinicas correspondientes. Se trataba en realidad de casos de cĂąncer laringofaringeo
UV to NIR photon conversion in Nd-doped rutile and anatase titanium dioxide films for silicon solar cell application
Undoped and Nd-doped titanium dioxide anatase and rutile films have been grown by pulsed-laser deposition at 700 °C under 0.1 mbar O2. By selecting adequate substrates, TiO2 films doped with 1, 2 or 5 at.% Nd were grown and constituted with polycrystalline rutile, highly oriented (2 0 0) rutile film, or oriented (0 0 4) anatase. An UV to NIR photon conversion is evidenced in the films. Indeed, intense and well-resolved emission lines from Nd3+ have been observed upon excitation above the TiO2 bandgap at room temperature. The sensitised emission of Nd3+ is found to be much efficient in rutile than in anatase structure. Low temperature photoluminescence measurements lead to fine resolved peaks corresponding to the Nd3+ 4f transitions with different spectral characteristic according to the host matrix used. Photoluminescence dependence temperature evidences that the light emission from Nd3+ in anatase-based films is probably influenced by the presence of self-trapped excitons or by orbital interaction. Mechanisms of sensitisation host to Nd3+ are proposed for both matrixes. Finally, the Nd dopant concentration and the microstructure of TiO2 rutile films are found to affect the photoluminescence emission intensity. Rutile film (2 0 0) oriented is the most adapted host matrix to sensitise 1 at.% Nd3+ ions for an emission around 1064 nm making such Nd-doped layers interesting for photon conversion by down shifting process
UV to NIR photon conversion in Nd-doped rutile and anatase titanium dioxide films for silicon solar cell application
Undoped and Nd-doped titanium dioxide anatase and rutile films have been grown by pulsed-laser deposition at 700 °C under 0.1 mbar O2. By selecting adequate substrates, TiO2 films doped with 1, 2 or 5 at.% Nd were grown and constituted with polycrystalline rutile, highly oriented (2 0 0) rutile film, or oriented (0 0 4) anatase. An UV to NIR photon conversion is evidenced in the films. Indeed, intense and well-resolved emission lines from Nd3+ have been observed upon excitation above the TiO2 bandgap at room temperature. The sensitised emission of Nd3+ is found to be much efficient in rutile than in anatase structure. Low temperature photoluminescence measurements lead to fine resolved peaks corresponding to the Nd3+ 4f transitions with different spectral characteristic according to the host matrix used. Photoluminescence dependence temperature evidences that the light emission from Nd3+ in anatase-based films is probably influenced by the presence of self-trapped excitons or by orbital interaction. Mechanisms of sensitisation host to Nd3+ are proposed for both matrixes. Finally, the Nd dopant concentration and the microstructure of TiO2 rutile films are found to affect the photoluminescence emission intensity. Rutile film (2 0 0) oriented is the most adapted host matrix to sensitise 1 at.% Nd3+ ions for an emission around 1064 nm making such Nd-doped layers interesting for photon conversion by down shifting process
Acclimation to short-term low temperatures in two Eucalyptus globulus clones with contrasting drought resistance
We tested the hypothesis that Eucalyptus
globulus Labill. genotypes that are more resistant to dry
environments might also exhibit higher cold tolerances
than drought-sensitive plants. The effect of low temperatures
was evaluated in acclimated and unacclimated
ramets of a drought-resistant clone (CN5) and a
drought-sensitive clone (ST51) of E. globulus. We
studied the plantsâ response via leaf gas exchanges, leaf
water and osmotic potentials, concentrations of soluble
sugars, several antioxidant enzymes and leaf electrolyte
leakage. Progressively lowering air temperatures (from
24/16 to 10/ 2 C, day/night) led to acclimation of both
clones. Acclimated ramets exhibited higher photosynthetic
rates, stomatal conductances and lower membrane
relative injuries when compared to unacclimated ramets.
Moreover, low temperatures led to significant increases
of soluble sugars and antioxidant enzymes activity
(glutathione reductase, ascorbate peroxidase and superoxide
dismutases) of both clones in comparison to plants
grown at control temperature (24/16 C). On the other
hand, none of the clones, either acclimated or not,
exhibited signs of photoinhibition under low temperatures
and moderate light. The main differences in the
responses to low temperatures between the two clones
resulted mainly from differences in carbon metabolism,
including a higher accumulation of soluble sugars in the
drought-resistant clone CN5 as well as a higher capacity
for osmotic regulation, as compared to the droughtsensitive
clone ST51. Although membrane injury data
suggested that both clones had the same inherent
freezing tolerance before and after cold acclimation,
the results also support the hypothesis that the droughtresistant
clone had a greater cold tolerance at intermediate
levels of acclimation than the drought-sensitive
clone. A higher capacity to acclimate in a short period
can allow a clone to maintain an undamaged leaf surface
area along sudden frost events, increasing growt
The XMM-Newton Wide-Field Survey in the COSMOS field (XMM-COSMOS): demography and multiwavelength properties of obscured and unobscured luminous AGN
We report the final optical identifications of the medium-depth (~60 ksec),
contiguous (2 deg^2) XMM-Newton survey of the COSMOS field. XMM-Newton has
detected ~800 X-ray sources down to limiting fluxes of ~5x10^{-16},
~3x10^{-15}, and ~7x10^{-15} erg/cm2/s in the 0.5-2 keV, 2-10 keV and 5-10 keV
bands, respectively. The work is complemented by an extensive collection of
multi-wavelength data from 24 micron to UV, available from the COSMOS survey,
for each of the X-ray sources, including spectroscopic redshifts for ~50% of
the sample, and high-quality photometric redshifts for the rest. The XMM and
multiwavelength flux limits are well matched: 1760 (98%) of the X-ray sources
have optical counterparts, 1711 (~95%) have IRAC counterparts, and 1394 (~78%)
have MIPS 24micron detections. Thanks to the redshift completeness (almost
100%) we were able to constrain the high-luminosity tail of the X-ray
luminosity function confirming that the peak of the number density of
logL_X>44.5 AGN is at z~2. Spectroscopically-identified obscured and unobscured
AGN, as well as normal and starforming galaxies, present well-defined optical
and infrared properties. We devised a robust method to identify a sample of
~150 high redshift (z>1), obscured AGN candidates for which optical
spectroscopy is not available. We were able to determine that the fraction of
the obscured AGN population at the highest (L_X>10^{44} erg s^{-1}) X-ray
luminosity is ~15-30% when selection effects are taken into account, providing
an important observational constraint for X-ray background synthesis. We
studied in detail the optical spectrum and the overall spectral energy
distribution of a prototypical Type 2 QSO, caught in a stage transitioning from
being starburst dominated to AGN dominated, which was possible to isolate only
thanks to the combination of X-ray and infrared observations.Comment: ApJ, in press. 59 pages, 14 figures, 2 Tables. A few typos corrected
and a reference added. Table 2 is also available at
http://www.mpe.mpg.de/XMMCosmos/xmm53_release ; a version of the paper in ApJ
format (27 pages) is available at
http://www.mpe.mpg.de/XMMCosmos/xmm53_release/brusa_xmmcosmos_optid.pd
Precision photometric redshift calibration for galaxy-galaxy weak lensing
Accurate photometric redshifts are among the key requirements for precision weak lensing measurements. Both the large size of the Sloan Digital Sky Survey (SDSS) and the existence of large spectroscopic redshift samples that are flux-limited beyond its depth have made it the optimal data source for developing methods to properly calibrate photometric redshifts for lensing. Here, we focus on galaxy-galaxy lensing in a survey with spectroscopic lens redshifts, as in the SDSS. We develop statistics that quantify the effect of source redshift errors on the lensing calibration and on the weighting scheme, and show how they can be used in the presence of redshift failure and sampling variance. We then demonstrate their use with 2838 source galaxies with spectroscopy from DEEP2 and zCOSMOS, evaluating several public photometric redshift algorithms, in two cases including a full p(z) for each object, and find lensing calibration biases as low as <1 per cent (due to fortuitous cancellation of two types of bias) or as high as 20 per cent for methods in active use (despite the small mean photoz bias of these algorithms). Our work demonstrates that lensing-specific statistics must be used to reliably calibrate the lensing signal, due to asymmetric effects of (frequently non-Gaussian) photoz errors. We also demonstrate that large-scale structure (LSS) can strongly impact the photoz calibration and its error estimation, due to a correlation between the LSS and the photoz errors, and argue that at least two independent degree-scale spectroscopic samples are needed to suppress its effects. Given the size of our spectroscopic sample, we can reduce the galaxy-galaxy lensing calibration error well below current SDSS statistical error
Precision photometric redshift calibration for galaxyâgalaxy weak lensing
Accurate photometric redshifts are among the key requirements for precision weak lensing measurements. Both the large size of the Sloan Digital Sky Survey (SDSS) and the existence of large spectroscopic redshift samples that are flux-limited beyond its depth have made it the optimal data source for developing methods to properly calibrate photometric redshifts for lensing. Here, we focus on galaxyâgalaxy lensing in a survey with spectroscopic lens redshifts, as in the SDSS. We develop statistics that quantify the effect of source redshift errors on the lensing calibration and on the weighting scheme, and show how they can be used in the presence of redshift failure and sampling variance. We then demonstrate their use with 2838 source galaxies with spectroscopy from DEEP2 and zCOSMOS, evaluating several public photometric redshift algorithms, in two cases including a full p(z) for each object, and find lensing calibration biases as low as <1 per cent (due to fortuitous cancellation of two types of bias) or as high as 20 per cent for methods in active use (despite the small mean photoz bias of these algorithms). Our work demonstrates that lensing-specific statistics must be used to reliably calibrate the lensing signal, due to asymmetric effects of (frequently non-Gaussian) photoz errors. We also demonstrate that large-scale structure (LSS) can strongly impact the photoz calibration and its error estimation, due to a correlation between the LSS and the photoz errors, and argue that at least two independent degree-scale spectroscopic samples are needed to suppress its effects. Given the size of our spectroscopic sample, we can reduce the galaxyâgalaxy lensing calibration error well below current SDSS statistical errors
Usefulness of Routine Fractional Flow Reserve for Clinical Management of Coronary Artery Disease in Patients With Diabetes
Importance: Approximately one-third of patients considered for coronary revascularization have diabetes, which is a major determinant of clinical outcomes, often influencing the choice of the revascularization strategy. The usefulness of fractional flow reserve (FFR) to guide treatment in this population is understudied and has been questioned.
Objective: To evaluate the usefulness and rate of major adverse cardiovascular events (MACE) of integrating FFR in management decisions for patients with diabetes who undergo coronary angiography.
Design, setting, and participants: This cross-sectional study used data from the PRIME-FFR study derived from the merger of the POST-IT study (Portuguese Study on the Evaluation of FFR-Guided Treatment of Coronary Disease [March 2012-November 2013]) and R3F study (French Study of FFR Integrated Multicenter Registries Implementation of FFR in Routine Practice [October 2008-June 2010]), 2 prospective multicenter registries that shared a common design. A population of all-comers for whom angiography disclosed ambiguous lesions was analyzed for rates, patterns, and outcomes associated with management reclassification, including revascularization deferral, in patients with vs without diabetes. Data analysis was performed from June to August 2018.
Main outcomes and measures: Death from any cause, myocardial infarction, or unplanned revascularization (MACE) at 1 year.
Results: Among 1983 patients (1503 [77%] male; mean [SD] age, 65 [10] years), 701 had diabetes, and FFR was performed for 1.4 lesions per patient (58.2% of lesions in the left anterior descending artery; mean [SD] stenosis, 56% [11%]; mean [SD] FFR, 0.81 [0.01]). Reclassification by FFR was high and similar in patients with and without diabetes (41.2% vs 37.5%, P = .13), but reclassification from medical treatment to revascularization was more frequent in the former (142 of 342 [41.5%] vs 230 of 730 [31.5%], P = .001). There was no statistical difference between the 1-year rates of MACE in reclassified (9.7%) and nonreclassified patients (12.0%) (P = .37). Among patients with diabetes, FFR-based deferral identified patients with a lower risk of MACE at 12 months (25 of 296 [8.4%]) compared with those undergoing revascularization (47 of 257 [13.1%]) (P = .04), and the rate was of the same magnitude of the observed rate among deferred patients without diabetes (7.9%, P = .87). Status of insulin treatment had no association with outcomes. Patients (6.6% of the population) in whom FFR was disregarded had the highest MACE rates regardless of diabetes status.
Conclusions and relevance: Routine integration of FFR for the management of coronary artery disease in patients with diabetes may be associated with a high rate of treatment reclassification. Management strategies guided by FFR, including revascularization deferral, may be useful for patients with diabetes.info:eu-repo/semantics/publishedVersio
Simple Shared Motifs (SSM) in conserved region of promoters: a new approach to identify co-regulation patterns
<p>Abstract</p> <p>Background</p> <p>Regulation of gene expression plays a pivotal role in cellular functions. However, understanding the dynamics of transcription remains a challenging task. A host of computational approaches have been developed to identify regulatory motifs, mainly based on the recognition of DNA sequences for transcription factor binding sites. Recent integration of additional data from genomic analyses or phylogenetic footprinting has significantly improved these methods.</p> <p>Results</p> <p>Here, we propose a different approach based on the compilation of Simple Shared Motifs (SSM), groups of sequences defined by their length and similarity and present in conserved sequences of gene promoters. We developed an original algorithm to search and count SSM in pairs of genes. An exceptional number of SSM is considered as a common regulatory pattern. The SSM approach is applied to a sample set of genes and validated using functional gene-set enrichment analyses. We demonstrate that the SSM approach selects genes that are over-represented in specific biological categories (Ontology and Pathways) and are enriched in co-expressed genes. Finally we show that genes co-expressed in the same tissue or involved in the same biological pathway have increased SSM values.</p> <p>Conclusions</p> <p>Using unbiased clustering of genes, Simple Shared Motifs analysis constitutes an original contribution to provide a clearer definition of expression networks.</p
The close environment of 24 micron galaxies at 0.6<z<1.0 in the COSMOS field
We investigate the close environment of 203 Spitzer 24 micron-selected
sources at 0.6<z<1.0 using zCOSMOS-bright redshifts and spectra of I<22.5 AB
mag galaxies, over 1.5 sq. deg. of the COSMOS field. We quantify the degree of
passivity of the LIRG and ULIRG environments by analysing the fraction of close
neighbours with Dn(4000)>1.4. We find that LIRGs at 0.6<z<0.8 live in more
passive environments than those of other optical galaxies that have the same
stellar mass distribution. Instead, ULIRGs inhabit more active regions (e.g.
LIRGs and ULIRGs at 0.6<z<0.8 have, respectively, (42.0 +/- 4.9)% and (24.5 +/-
5.9)% of neighbours with Dn (4000)>1.4 within 1 Mpc and +/- 500 km/s). The
contrast between the activities of the close environments of LIRGs and ULIRGs
appears especially enhanced in the COSMOS field density peak at z~0.67, because
LIRGs on this peak have a larger fraction of passive neighbours, while ULIRGs
have as active close environments as those outside the large-scale structure.
The differential environmental activity is related to the differences in the
distributions of stellar mass ratios between LIRGs/ULIRGs and their close
neighbours, as well as in the general local density fields. At 0.8<z<1.0,
instead, we find no differences in the environment densities of ULIRGs and
other similarly massive galaxies, in spite of the differential activities. We
discuss a possible scenario to explain these findings.Comment: ApJ, in press. 9 pages, including 5 figure
- âŠ