The four dimensional site-diluted Ising model: a finite-size scaling study

Using finite-size scaling techniques, we study the critical properties of the site-diluted Ising model in four dimensions. We carry out a high statistics Monte Carlo simulation for several values of the dilution. The results support the perturbative scenario: there is only the Ising fixed point with large logarithmic scaling corrections. We obtain, using the Perturbative Renormalization Group, functional forms for the scaling of several observables that are in agreement with the numerical data.Comment: 30 pages, 8 postscript figure

Finite size effects on measures of critical exponents in d=3 O(N) models

We study the critical properties of three-dimensional O(N) models, for N=2,3,4. Parameterizing the leading corrections-to-scaling for the $\eta$ exponent, we obtain a reliable infinite volume extrapolation, incompatible with previous Monte Carlo values, but in agreement with $\epsilon$-expansions. We also measure the critical exponent related with the tensorial magnetization as well as the $\nu$ exponents and critical couplings.Comment: 12 pages, 2 postscript figure

Theory and Satellite Experiment for Critical Exponent alpha of lambda-Transition in Superfluid Helium

On the basis recent seven-loop perturbation expansion for nu^{-1} = 3/(2 - alpha) we perform a careful reinvestigation of the critical exponent alpha governing the power behavior |T_c-T|^{- alpha} of the specific heat of superfluid helium near the phase transition. With the help of variational strong-coupling theory. we find alpha = - 0.01126 +- 0.0010, in very good agreement with the space shuttle experimental value alpha = - 0.01056 +- 0.00038.Comment: Final version to be printed in Phys. Lett. A. Author Information under http://www.physik.fu-berlin.de/~kleinert/institution.html . Latest update of paper also at http://www.physik.fu-berlin.de/~kleinert/28

Critical properties of the Antiferromagnetic \RP2$ model in three dimensions

We study the behavior of the antiferromagnetic RP$^2$ model in $d=3$. The vacuum structure is analyzed in the critical and low temperature regions, paying special attention to the spontaneous symmetry breaking pattern. Near the critical point we observe a full breakdown of the O(3) symmetry of the action. Several methods for computing critical exponents are compared. We conclude that the most solid determination is obtained using a measure of the correlation length. Corrections-to-scaling are parameterized, yielding a very accurate determination of the critical coupling and a 5\% error measure of the related exponent. This is used to estimate the systematic errors due to finite-size effects.Comment: 31 pages, 10 postscript figure

O(N) models within the local potential approximation

Using Wegner-Houghton equation, within the Local Potential Approximation, we study critical properties of O(N) vector models. Fixed Points, together with their critical exponents and eigenoperators, are obtained for a large set of values of N, including N=0 and N\to\infty. Polchinski equation is also treated. The peculiarities of the large N limit, where a line of Fixed Points at d=2+2/n is present, are studied in detail. A derivation of the equation is presented together with its projection to zero modes.Comment: 27 pages, LaTeX with psfig, 7 PostScript figures. One reference corrected and one added with respect to the journal versio

Random Fixed Point of Three-Dimensional Random-Bond Ising Models

The fixed-point structure of three-dimensional bond-disordered Ising models is investigated using the numerical domain-wall renormalization-group method. It is found that, in the +/-J Ising model, there exists a non-trivial fixed point along the phase boundary between the paramagnetic and ferromagnetic phases. The fixed-point Hamiltonian of the +/-J model numerically coincides with that of the unfrustrated random Ising models, strongly suggesting that both belong to the same universality class. Another fixed point corresponding to the multicritical point is also found in the +/-J model. Critical properties associated with the fixed point are qualitatively consistent with theoretical predictions.Comment: 4 pages, 5 figures, to be published in Journal of the Physical Society of Japa

Conformal compactification and cycle-preserving symmetries of spacetimes

The cycle-preserving symmetries for the nine two-dimensional real spaces of constant curvature are collectively obtained within a Cayley-Klein framework. This approach affords a unified and global study of the conformal structure of the three classical Riemannian spaces as well as of the six relativistic and non-relativistic spacetimes (Minkowskian, de Sitter, anti-de Sitter, both Newton-Hooke and Galilean), and gives rise to general expressions holding simultaneously for all of them. Their metric structure and cycles (lines with constant geodesic curvature that include geodesics and circles) are explicitly characterized. The corresponding cyclic (Mobius-like) Lie groups together with the differential realizations of their algebras are then deduced; this derivation is new and much simpler than the usual ones and applies to any homogeneous space in the Cayley-Klein family, whether flat or curved and with any signature. Laplace and wave-type differential equations with conformal algebra symmetry are constructed. Furthermore, the conformal groups are realized as matrix groups acting as globally defined linear transformations in a four-dimensional "conformal ambient space", which in turn leads to an explicit description of the "conformal completion" or compactification of the nine spaces.Comment: 43 pages, LaTe

Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma.

PurposeTumors with low frequencies of checkpoint positive tumor-infiltrating lymphocytes (cpTIL) have a low likelihood of response to PD-1 blockade. We conducted a prospective multicenter phase II trial of intratumoral plasmid IL-12 (tavokinogene telseplasmid; "tavo") electroporation combined with pembrolizumab in patients with advanced melanoma with low frequencies of checkpoint positive cytotoxic lymphocytes (cpCTL).Patients and methodsTavo was administered intratumorally days 1, 5, and 8 every 6 weeks while pembrolizumab (200 mg, i.v.) was administered every 3 weeks. The primary endpoint was objective response rate (ORR) by RECIST, secondary endpoints included duration of response, overall survival and progression-free survival. Toxicity was evaluated by the CTCAE v4. Extensive correlative analysis was done.ResultsThe combination of tavo and pembrolizumab was well tolerated with adverse events similar to those previously reported with pembrolizumab alone. Patients had a 41% ORR (n = 22, RECIST 1.1) with 36% complete responses. Correlative analysis showed that the combination enhanced immune infiltration and sustained the IL-12/IFNγ feed-forward cycle, driving intratumoral cross-presenting dendritic cell subsets with increased TILs, emerging T cell receptor clones and, ultimately, systemic cellular immune responses.ConclusionsThe combination of tavo and pembrolizumab was associated with a higher than expected response rate in this poorly immunogenic population. No new or unexpected toxicities were observed. Correlative analysis showed T cell infiltration with enhanced immunity paralleling the clinical activity in low cpCTL tumors

Galilean Conformal and Superconformal Symmetries

Firstly we discuss briefly three different algebras named as nonrelativistic (NR) conformal: Schroedinger, Galilean conformal and infinite algebra of local NR conformal isometries. Further we shall consider in some detail Galilean conformal algebra (GCA) obtained in the limit c equal to infinity from relativistic conformal algebra O(d+1,2) (d - number of space dimensions). Two different contraction limits providing GCA and some recently considered realizations will be briefly discussed. Finally by considering NR contraction of D=4 superconformal algebra the Galilei conformal superalgebra (GCSA) is obtained, in the formulation using complex Weyl supercharges.Comment: 16 pages, LateX; talk presented at XIV International Conference "Symmetry Methods in Physics", Tsakhkadzor, Armenia, August 16-22, 201

Manual Operativo Plataforma Espacio Honduras

La plataforma ESPACIO HONDURAS fue construida por la organización colombiana Cultivando Futuro, con el apoyo de los expertos del Centro Internacional de Agricultura Tropical – CIAT. Es una herramienta que resulta de un proceso de organizar datos provenientes de fuentes oficiales y secundarias, para ensamblar un conjunto de variables que permiten observar y analizar realidad climática y socioeconómica de los territorios del corredor seco, mediante esta herramienta digital. En este sentido, la plataforma ofrece una representación de los datos, de manera sencilla y a la medida del público receptor de la información; y contribuye a formular una hoja de ruta factible, para aprovechar oportunidades o tomar acciones concretas sobre posibles riesgos climáticos. La representación de los datos está organizada en perfiles municipales que genera la plataforma, en el momento en que el usuario selecciona un municipio en el menú que se encuentra disponible en la pagina de inicio