89 research outputs found
Maximising the value of transmitted data from PSATs tracking marine fish: a case study on Atlantic bluefin tuna
This is the final version. Available from BMC via the DOI in this record. Availability of data and materials:
The data sets generated and analysed during the current study are not
publicly available due to funder restrictions but may be available from the
corresponding author on reasonable request.Background: The use of biologging tags to answer questions in animal movement ecology has increased in recent decades. Pop-up satellite archival tags (PSATs) are often used for migratory studies on large fish taxa. For PSATs, movements are normally reconstructed from variable amounts of transmitted data (unless tags are recovered, and full data archives accessed) by coupling geolocation methods with a state-space modelling (SSM) approach. Between 2018 and 2019, we deployed Wildlife Computers PSATs (MiniPATs) from which data recovery varied considerably. This led us to examine the effect of PSAT data volume on SSM performance (i.e., variation in reconstructed locations and their uncertainty). We did this by comparing movements reconstructed using partial ( 1000 km); (ii) for fish that travelled long distances, mean distance of locations from corresponding complete data set locations were inversely correlated with the volume of data received; (iii) if only 5% of data was used for geolocation, reconstructed locations for long-distance fish differed by 2213 ± 647 km from the locations derived from complete data sets; and, (iv) track reconstructions omitted migrations into the Mediterranean Sea if less than 30% of data was used for geolocation. Conclusions: For Wildlife Computers MiniPATs in our specific application, movements reconstructed with as little as 30% of the total geolocation data results in plausible outputs from the GPE3. Below this data volume, however, significant differences of more than 2000 km can occur. Whilst for a single species and manufacturer, this highlights the importance of careful study planning and the value of conducting study-specific sensitivity analysis prior to inclusion of modelled locations in research outputs. Based on our findings, we suggest general steps and refinements to maximise the value of light geolocation data from PSATs deployed on aquatic animals and highlight the importance of conducting data sensitivity analyses.European Maritime and Fisheries FundDepartment for Environment, Food and Rural Affairs (UK
Intermittent control models of human standing: similarities and differences
Two architectures of intermittent control are compared and contrasted in the context of the single inverted pendulum model often used for describing standing in humans. The architectures are similar insofar as they use periods of open-loop control punctuated by switching events when crossing a switching surface to keep the system state trajectories close to trajectories leading to equilibrium. The architectures differ in two significant ways. Firstly, in one case, the open-loop control trajectory is generated by a system-matched hold, and in the other case, the open-loop control signal is zero. Secondly, prediction is used in one case but not the other. The former difference is examined in this paper. The zero control alternative leads to periodic oscillations associated with limit cycles; whereas the system-matched control alternative gives trajectories (including homoclinic orbits) which contain the equilibrium point and do not have oscillatory behaviour. Despite this difference in behaviour, it is further shown that behaviour can appear similar when either the system is perturbed by additive noise or the system-matched trajectory generation is perturbed. The purpose of the research is to come to a common approach for understanding the theoretical properties of the two alternatives with the twin aims of choosing which provides the best explanation of current experimental data (which may not, by itself, distinguish beween the two alternatives) and suggesting future experiments to distinguish between the two alternatives
Evidence of increased occurrence of Atlantic bluefin tuna in territorial waters of the United Kingdom and Ireland
This is the final version. Available on open access from Oxford University Press via the DOI in this recordData availability:
Where applicable available data sources are linked in text. Where not specifically referred to in-text, data are subject to inter-organization data-sharing agreements and/or GDPR restrictions. Consequently, data requests will be processed on a case-by-case basis by the authors.Atlantic bluefin tuna (ABT, Thunnus thynnus; Linneaus, 1758) is an ecologically important apex-predator with high commercial value. They were once common off the coast of the United Kingdom (UK), before disappearing in the 1960s. In regions lacking commercial fisheries for ABT, such as the UK and Ireland, spatial data can be scarce. In these cases, sightings and bycatch databases can offset information shortfalls. Here, we document the reappearance of ABT into territorial waters of the UK from 2014 onwards, and increased occurrence off Ireland. We analyse a novel, multi-source dataset comprising occurrence data (2008–2019; 989 sightings and 114 tonnes of bycatch) compiled from a range of sources (scientific surveys, ecotours and fisheries). We show an increasing trend in effort-corrected ABT occurrence in (i) the pelagic ecosystem survey in the western English Channel and Celtic Sea (PELTIC), (ii) an ecotour operator, and (iii) the Irish albacore fishery in on-shelf and off-shelf waters. Sightings of ABT by the PELTIC correlated with modelled abundance estimates of ABT and the Atlantic multidecadal oscillation. These data demonstrate that sightings of ABT have increased off the UK and Ireland since 2014, following the same increasing trend (2010 onwards) as the eastern ABT population.University of ExeterEuropean Maritime and Fisheries FundDepartment for Environment, Food and Rural Affairs (DEFRA)NOAA Bluefin Tuna Research ProgramTag-A-Giant Fund (TAG
Viscosity and Diffusion: Crowding and Salt Effects in Protein Solutions
We report on a joint experimental-theoretical study of collective diffusion
in, and static shear viscosity of solutions of bovine serum albumin (BSA)
proteins, focusing on the dependence on protein and salt concentration. Data
obtained from dynamic light scattering and rheometric measurements are compared
to theoretical calculations based on an analytically treatable spheroid model
of BSA with isotropic screened Coulomb plus hard-sphere interactions. The only
input to the dynamics calculations is the static structure factor obtained from
a consistent theoretical fit to a concentration series of small-angle X-ray
scattering (SAXS) data. This fit is based on an integral equation scheme that
combines high accuracy with low computational cost. All experimentally probed
dynamic and static properties are reproduced theoretically with an at least
semi-quantitative accuracy. For lower protein concentration and low salinity,
both theory and experiment show a maximum in the reduced viscosity, caused by
the electrostatic repulsion of proteins. The validity range of a generalized
Stokes-Einstein (GSE) relation connecting viscosity, collective diffusion
coefficient, and osmotic compressibility, proposed by Kholodenko and Douglas
[PRE 51, 1081 (1995)] is examined. Significant violation of the GSE relation is
found, both in experimental data and in theoretical models, in semi-dilute
systems at physiological salinity, and under low-salt conditions for arbitrary
protein concentrations
Cardiac myosin binding protein C phosphorylation in cardiac disease
Perturbations in sarcomeric function may in part underlie systolic and diastolic dysfunction of the failing heart. Sarcomeric dysfunction has been ascribed to changes in phosphorylation status of sarcomeric proteins caused by an altered balance between intracellular kinases and phosphatases during the development of cardiac disease. In the present review we discuss changes in phosphorylation of the thick filament protein myosin binding protein C (cMyBP-C) reported in failing myocardium, with emphasis on phosphorylation changes observed in familial hypertrophic cardiomyopathy caused by mutations in MYBPC3. Moreover, we will discuss assays which allow to distinguish between functional consequences of mutant sarcomeric proteins and (mal)adaptive changes in sarcomeric protein phosphorylation
One year symptom severity and health-related quality of life changes among Black African patients undergoing uterine fibroid embolisation.
BACKGROUND: The main aim in the treatment of symptomatic fibroids by various modalities including uterine fibroid embolisation (UFE) is to alleviate symptoms and ultimately improve the quality of life. The efficacy of this modality of treatment in Black African women with significant fibroid burden and large uterine volumes is not clear. The main objective of the study was to examine potential changes in symptom severity among Black African patients 1 year following UFE for symptomatic uterine fibroids in a resource-constrained setting, rated using a validated questionnaire (UFS-QOL). Secondary outcomes examined were changes in quality of life and potential associations with age, parity, uterine volume and fibroid number prior to UFE. Additional interventions after UFE were also recorded. METHODS: A prospective before and after study of Black African patients undergoing UFE was undertaken. Participants underwent pelvic MR imaging prior to UFE and completed the UFS-QOL, a validated condition-specific questionnaire at baseline and at 1 year. Ninety five participants were recruited and data from 80 completing 1 year of follow up were available for analysis of changes in the symptom severity scores. RESULTS: The mean reduction in symptom severity score was 29.6 [95% CI 23.6 to 35.6, P < 0.001] and the mean improvement in HRQOL score was 35.7 [95% CI 28.4 to 42.9, P < 0.001]. A greater number of fibroids identified prior to UFE was associated with a more substantial improvement in symptom severity score (rs = 0.28, n = 80, P = 0.013) and participants of higher parity reported a greater improvement in HRQOL score (r = 0.336, P = 0.002). Major and minor surgical interventions were needed in 5 (6.3%) and 10 (12.5%) participants respectively. CONCLUSIONS: UFE is associated with clinically useful and statistically significant symptom relief in Black African patients. Symptom improvement following UFE is not compromised by a large fibroid burden and the rate of subsequent intervention is within an acceptable range. UFE is a safe alternative and efforts are needed to widen access to this non-surgical treatment modality
Put My Skills to Use? Understanding the Joint Effect of Job Security and Skill Utilization on Job Satisfaction Between Skilled Migrants and Australian Born Workers in Australia
The topic of skilled migrants has gained importance in the past decade as they are increasingly becoming one of the main drivers for labor supply in developed countries like Australia. Although there is research on skilled migrants, most have been studied from the perspectives of (un)employment, wage and over-education. Some evidence suggests that skilled migrants are often less satisfied with their job compared to their local counterparts, yet little is known about why these differences exist. Using a nationally representative sample of Australian workers, we examine how two important job characteristics, job security and skill utilization, exert their differential interaction effect on job satisfaction for skilled migrants and Australian born workers. We found a differential moderation effect between job security and skill utilization for skilled migrants and Australian born workers. For skilled migrants, high job security did not lead to positive reaction (i.e., job satisfaction), as this effect was dependent on their skill utilization; while such moderation effect was not present for Australian born workers. This study highlights the need to take a more fine-tuned approach by understanding target sample groups (e.g., skilled migrants) when study the relationship between key job characteristics and job satisfaction. Furthermore, it highlights the importance for organizations to revisit their human resource management strategies and policies to recognize the needs for enhancing skill utilization for skilled migrants
Correction:How the COVID-19 pandemic highlights the necessity of animal research (vol 30, pg R1014, 2020)
(Current Biology 30, R1014–R1018; September 21, 2020) As a result of an author oversight in the originally published version of this article, a number of errors were introduced in the author list and affiliations. First, the middle initials were omitted from the names of several authors. Second, the surname of Dr. van Dam was mistakenly written as “Dam.” Third, the first name of author Bernhard Englitz was misspelled as “Bernard” and the surname of author B.J.A. Pollux was misspelled as “Pullox.” Finally, Dr. Keijer's first name was abbreviated rather than written in full. These errors, as well as various errors in the author affiliations, have now been corrected online
Neural Circuits Underlying Rodent Sociality: A Comparative Approach
All mammals begin life in social groups, but for some species, social relationships persist and develop throughout the course of an individual’s life. Research in multiple rodent species provides evidence of relatively conserved circuitry underlying social behaviors and processes such as social recognition and memory, social reward, and social approach/avoidance. Species exhibiting different complex social behaviors and social systems (such as social monogamy or familiarity preferences) can be characterized in part by when and how they display specific social behaviors. Prairie and meadow voles are closely related species that exhibit similarly selective peer preferences but different mating systems, aiding direct comparison of the mechanisms underlying affiliative behavior. This chapter draws on research in voles as well as other rodents to explore the mechanisms involved in individual social behavior processes, as well as specific complex social patterns. Contrasts between vole species exemplify how the laboratory study of diverse species improves our understanding of the mechanisms underlying social behavior. We identify several additional rodent species whose interesting social structures and available ecological and behavioral field data make them good candidates for study. New techniques and integration across laboratory and field settings will provide exciting opportunities for future mechanistic work in non-model species
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