The Application of Think Pair Share to Enhance Vocabulary Mastery

The study's goal was to see if using think-pair-share to enhance students’ vocabulary mastery was beneficial. The pre-experimental approach was used in this study. MA YMPI Rappang's population was in its second year. The total number of pupils in the population was 65 (XI IPA=19, XI IPS 1= 24, XI IPS 2 = 22), and one class was chosen as a sample using cluster random sampling. This class had a total of 24 students (XI IPS 1). The vocabulary test was the tool employed in this study. The findings of this research revealed that the pre-test received a mean score of 25.91, while the post-test received a mean score of 60.00. This revealed that the pre-test and post-test scores differed significantly. The t-test value (15.112) was higher than the t-table value (2.069). This signifies that HO was turned down and H1 was chosen. The study found that teaching vocabulary utilizing the think-pair-share method helps improve students' vocabulary knowledge among MA YMPI Rappang second-year students

New strategies of ovarian stimulation based on the concept of ovarian follicular waves: From conventional to random and double stimulation

The theory of a multicyclic development of follicles during the menstrual cycle prompted new approaches to ovarian stimulation, such as starting gonadotrophins for ovarian stimulation at any time during the menstrual cycle or using double stimulation during it, with stimulation in both the follicular and luteal phases. Because of the asynchrony between endometrial receptivity and embryo development with a ‘non-conventional start’ stimulation, all the oocytes/embryos are generally cryopreserved and transferred subsequently. This deferred transfer policy is currently possible given the advances in vitrification techniques, with success rates comparable to those following transfer with ‘fresh’ embryos. New stimulation approaches, together with advanced cryopreservation techniques, allow for a total ‘disarticulation’ between the time of the menstrual cycle, ovarian stimulation start and embryo transfer. This new approach to ovarian stimulation is particularly useful for women seeking fertility preservation, especially where a shortened time to starting cancer treatment is desirable. Also, poor responders could benefit from the new stimulation protocols by continuing ovarian stimulation after the first oocyte retrieval, thereby obtaining more oocytes or embryos compared with the conventional approach

Coincidence and common fixed point theorems for Suzuki type hybrid contractions and applications

Coincidence and common fixed point theorems for a class of Suzuki hybrid contractions involving two pairs of single-valued and multivalued maps in a metric space are obtained. In addition, the existence of a common solution for a certain class of functional equations arising in a dynamic programming is also discussed.The authors thank the referees for their deep understanding, appreciation, and suggestions to improve upon the original typescript. They are also thankful to the Spanish Government for its support of this research through Grant DPI2012-30651, and to the Basque Government for its support of this research trough Grants IT378-10 and SAIOTEK S-PE12UN015. Further, they acknowledge the financial support by the University of Basque Country through Grant UFI 2011/0

SIW Cavity-Backed Antenna Array Based on Double Slots for mmWave Communications

This paper presents a cavity-backed antenna array in substrate integrated waveguide (SIW) technology in the millimeter-wave frequency band. The proposed antenna design uses double slots as radiating elements instead of conventional single slots. The double slots allow better control in the design of the operating frequency bands of the cavity-backed antenna. The performance of the cavity-backed antennas with single and double slots is compared to assess the enhanced behavior of the double slots. As a proof of concept, a 2 × 2 array of cavity-backed antennas is designed, manufactured, and measured. Each cavity-backed antenna contains 2 × 2 double slots; thus, a 4 × 4 antenna array is considered. The experimental operating frequency band of the proposed antenna array ranges from 35.4 to 37 GHz. There is a good agreement between the simulated and measured results. The measured gain is around 17 dBi in the whole operating frequency band with a 75% total antenna efficiency.Spanish Program of Research, Development and Innovation under Project TIN2016-75097-P, Project RTI2018-102002-A-I00, and Project EQC2018- 004988-PJunta de Andalucía under Project B-TIC-402-UGR18, and Project P18.RT.4830FPU18/0196

The Effect of Transposable Element Insertions on Gene Expression Evolution in Rodents

Background:Many genomes contain a substantial number of transposable elements (TEs), a few of which are known to be involved in regulating gene expression. However, recent observations suggest that TEs may have played a very important role in the evolution of gene expression because many conserved non-genic sequences, some of which are know to be involved in gene regulation, resemble TEs. Results:Here we investigate whether new TE insertions affect gene expression profiles by testing whether gene expression divergence between mouse and rat is correlated to the numbers of new transposable elements inserted near genes. We show that expression divergence is significantly correlated to the number of new LTR and SINE elements, but not to the numbers of LINEs. We also show that expression divergence is not significantly correlated to the numbers of ancestral TEs in most cases, which suggests that the correlations between expression divergence and the numbers of new TEs are causal in nature. We quantify the effect and estimate that TE insertion has accounted for ~20% (95% confidence interval: 12% to 26%) of all expression profile divergence in rodents. Conclusions:We conclude that TE insertions may have had a major impact on the evolution of gene expression levels in rodents

Nutrition, diet and immunosenescence

Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease. This complex process affects both the innate and adaptive immune systems with a progressive decline in most immune cell populations and defects in activation resulting in loss of function. Although host genetics and environmental factors, such as stress, exercise and diet can impact on the onset or course of immunosenescence, the mechanisms involved are largely unknown. This review focusses on identifying the most significant aspects of immunosenescence and on the evidence that nutritional intervention might delay this process, and consequently improve the quality of life of the elderly

Two Earth-sized planets orbiting Kepler-20

Since the discovery of the first extrasolar giant planets around Sun-like stars, evolving observational capabilities have brought us closer to the detection of true Earth analogues. The size of an exoplanet can be determined when it periodically passes in front of (transits) its parent star, causing a decrease in starlight proportional to its radius. The smallest exoplanet hitherto discovered has a radius 1.42 times that of the Earth's radius (R Earth), and hence has 2.9 times its volume. Here we report the discovery of two planets, one Earth-sized (1.03R Earth) and the other smaller than the Earth (0.87R Earth), orbiting the star Kepler-20, which is already known to host three other, larger, transiting planets. The gravitational pull of the new planets on the parent star is too small to measure with current instrumentation. We apply a statistical method to show that the likelihood of the planetary interpretation of the transit signals is more than three orders of magnitude larger than that of the alternative hypothesis that the signals result from an eclipsing binary star. Theoretical considerations imply that these planets are rocky, with a composition of iron and silicate. The outer planet could have developed a thick water vapour atmosphere.Comment: Letter to Nature; Received 8 November; accepted 13 December 2011; Published online 20 December 201

The Association between Patient Characteristics and the Efficacy and Safety of Selinexor in Diffuse Large B-Cell Lymphoma in the SADAL Study.

Selinexor, an oral selective inhibitor of nuclear export, was evaluated in the Phase 2b SADAL study in patients with diffuse large B-cell lymphoma (DLBCL) who previously received two to five prior systemic regimens. In post hoc analyses, we analyzed several categories of patient characteristics (age, renal function, DLBCL subtype, absolute lymphocyte count, transplant status, number of prior lines of therapy, refractory status, Ann Arbor disease stage, and lactate dehydrogenase) at baseline, i.e., during screening procedures, to determine their potential contributions to the efficacy (overall response rate [ORR], duration of response [DOR], overall survival [OS]) and tolerability of selinexor. Across most categories of characteristics, no significant difference was observed in ORR or DOR. OS was significantly longer for patients ULN. The most common adverse events (AEs) across the characteristics were thrombocytopenia and nausea, and similar rates of grade 3 AEs and serious AEs were observed. With its oral administration, novel mechanism of action, and consistency in responses in heavily pretreated patients, selinexor may help to address an important unmet clinical need in the treatment of DLBCL