Epidemiological information in sheep health management

We use epidemiology whenever we consider the management of sheep health. To measure a disease, we need a precise and unique case definition and we often use diagnostic tests to assist in defining a disease. Diagnostic tests are not always accurate. Thus, it is necessary to consider the decisions that will be taken, based on the result of testing, in order to decide the most useful approach to interpret a test based on its test sensitivity and specificity and the prevalence of the disease in a flock. This is particularly important when decisions on culling or selection of sheep to attain, e.g. freedom from disease, are made on the basis of test results. Infectious diseases spread within and between flocks in a variety of ways; brought-in sheep are the most likely source for introduction of a new pathogen or strain of a pathogen. When a pathogen enters a naïve flock, it spreads through susceptible sheep and persists in the flock, whilst there are susceptible sheep that can be infected. Pathogens use a variety of techniques to persist, including changes in the pathogen itself, alterations in infected hosts enabling them to remain infectious for prolonged periods or to be re-infected, persistence in other host species or in the environment. We need to consider these strategies to decide whether elimination or control of a particular pathogen is more likely to be effective. Whatever the flock control strategy, treatment of diseased individuals is essential for their welfare and can also protect the rest of the flock, if treatment reduces the infectious period. Decisions on management of disease are based on our knowledge of the flock and its management and the evidence base for various control strategies. There are now formal techniques for evaluating the evidence base that can assist in evaluating evidence. One area where we need to evaluate evidence is on cause. It is not possible to prove anything, but we can use the weight of evidence to evaluate likely cause. There are nine aspects of association with which we can evaluate a piece of evidence; these are: strength, consistency, specificity, temporality, dose–response, plausibility, coherence, experiment and analogy

Chains of N=2, D=4 heterotic/type II duals

We report on a search for $N=2$ heterotic strings that are dual candidates of type II compactifications on Calabi-Yau threefolds described as $K3$ fibrations. We find many new heterotic duals by using standard orbifold techniques. The associated type II compactifications fall into chains in which the proposed duals are heterotic compactifications related one another by a sequential Higgs mechanism. This breaking in the heterotic side typically involves the sequence $SU(4)\rightarrow SU(3)\rightarrow$ $SU(2)\rightarrow 0$, while in the type II side the weights of the complex hypersurfaces and the structure of the $K3$ quotient singularities also follow specific patterns.Comment: Latex, 21 pages, 2 table

Superheavy Dark Matter with Discrete Gauge Symmetries

We show that there are discrete gauge symmetries protect naturally heavy X particles from decaying into the ordinary light particles in the supersymmetric standard model. This makes the proposal very attractive that the superheavy X particles constitute a part of the dark matter in the present universe. It is more interesting that there are a class of discrete gauge symmetries which naturally accommodate a long-lived unstable X particle. We find that in some discrete Z_{10} models, for example, a superheavy X particle has lifetime \tau_X \simeq 10^{11}-10^{26} years for its mass M_X \simeq 10^{13}-10^{14} GeV. This long lifetime is guaranteed by the absence of lower dimensional operators (of light particles) couple to the X. We briefly discuss a possible explanation for the recently observed ultra-high-energy cosmic ray events by the decay of this unstable X particle.Comment: 9 pages, Late

Instanton effects in N=1 brane models and the Kahler metric of twisted matter

We consider locally consistent systems of magnetized D9 branes on an orbifolded six-torus which support N=1 gauge theories. In such realizations, the matter multiplets arise from "twisted" strings connecting different stacks of branes. The introduction of Euclidean 5 branes (E5) wrapped on the six-dimensional compact space leads to instanton effects. For instance, if the system is engineered so as to yield SQCD, a single E5 brane may account for the ADS/TVY superpotential. We discuss the subtle interplay that exists between the annuli diagrams with an E5 boundary and the holomorphicity properties of the effective low-energy action of the N=1 theory. The consistency of this picture allows to obtain information on the Kahler metric of the chiral matter multiplets arising from twisted strings.Comment: 33 pages, 4 figures. V2: improved discussion, clarifyng comments and references added. Version to be published in JHE

Associations between sole ulcer, white line disease and digital dermatitis and the milk yield of 1824 dairy cows on 30 dairy cow farms in England and Wales from February 2003–November 2004

The milk yields of 1824 cows were used to investigate the effect of lesion-specific causes of lameness, based on farmer treatment and diagnosis of lame cows, on milk yield. A three level hierarchical model of repeated test day yields within cows within herds was used to investigate the impact of lesion-specific causes of lameness (sole ulcer, white line disease, digital dermatitis and other causes) on milk yield before and after treatment compared with unaffected cows. Cattle which developed sole ulcer (SU) and white line disease (WLD) were higher yielding cattle before they were diagnosed. Their milk production fell to below that of the mean of unaffected cows before diagnosis and remained low after diagnosis. In cattle which developed digital dermatitis (DD) there was no significant difference in milk yield before treatment and a slightly raised milk yield immediately after treatment. The estimated milk loss attributable to SU and WLD was approximately 570kg and 370kg respectively. These results highlight that specific types of lameness vary by herds and within herds they are associated with higher yielding cattle. Consequently lesion-specific lameness reduction programmes targeting the cow and farm specific causes of lameness might be more effective than generic recommendations. They also highlight the importance of milk loss when estimating the economic impact of SU and WLD on the farms profitability

Footrot and interdigital dermatitis in sheep: Farmer satisfaction with current management, their ideal management and sources used to adopt new strategies

The aims of this research were to identify management practices that sheep farmers currently use to treat and prevent footrot in sheep and whether they consider that these are successful management tools and to find out how sheep farmers would ideally like to manage footrot in their flock. Over 90% of lameness in sheep in the UK is caused by Dichelobacter nodosus, which presents clinically as interdigital dermatitis (ID) alone or with separation of hoof horn (FR). A questionnaire was sent to 265 farmers to investigate their current management and their satisfaction with current management of the spectrum of clinical presentations of footrot. Farmers were also asked their ideal management of footrot and their interest in, and sources of information for, change. Approximately 160 farmers responded. Farmers satisfied with current management reported a prevalence of lameness ≤5%. These farmers caught and treated lame sheep within 3 days of first seeing them lame, and treated sheep with FR and ID with parenteral antibacterials. Farmers dissatisfied with their management reported a prevalence of lameness >5%. These farmers practised routine foot trimming, footbathing and vaccination against footrot. Whilst 89% of farmers said they were satisfied with their management of FR over 34% were interested in changing management. Farmers identified veterinarians as the most influential source for new information. Farmers reported that ideally they would control FR by culling/isolating lame sheep, sourcing replacements from non-lame parents, trimming feet less, using antibacterial treatments less and using vaccination more. Footbathing was a commonly used management that was linked with dissatisfaction and that also was listed highly as an ideal management. Consequently, some of the ideal managements are in agreement with our understanding of disease control (culling and isolation, sourcing healthy replacements) but others are in contrast with our current knowledge of management and farmers self-reporting of satisfaction of management of footrot (less use of antibacterial treatment, more footbathing and vaccination). One explanation for this is the theory of cognitive dissonance where belief follows behaviour, i.e. farmers report that they believe an ideal which is what they are currently doing, even if the management is sub-optimal

A cross sectional study of the prevalence and associated risks for bursitis in 6250 weaner, grower and finisher pigs from 103 British pig farms

A cross-sectional study of 93 farms in England was carried out to estimate the prevalence and associated risk factors for bursitis. A total of 6250 pigs aged 6–22 weeks were examined for presence and severity of bursitis. Details of pen construction, pen quality and farm management were recorded including floor type, presence of bedding, condition of the floor and floor materials. The prevalence of bursitis was 41.2% and increased with each week of age (OR 1.1). Two-level logistic regression models were developed with the outcome as the proportion of pigs affected with bursitis in a pen. Pigs kept on soil floors with straw bedding were used as the reference level. In comparison with these soil floors, bursitis increased on concrete floors where the bedding was deep throughout (OR 4.6), deep in part (OR 3.7), and sparse throughout (OR 9.0), part slatted floors (OR 8.0), and fully slatted floors (OR 18.8). Slip or skid marks in the dunging area (OR 1.5), pigs observed slipping during the examination of the pen (OR 1.3) and wet floors (OR 3.6) were also associated with an increased risk of bursitis. The results indicate that bursitis is a common condition of growing pigs and that the associated risk factors for bursitis were a lack of bedding in the lying area, presence of voids and pen conditions which increased the likelihood of injury

Unitarity Bounds for Gauged Axionic Interactions and the Green-Schwarz Mechanism

We analyze the effective actions of anomalous models in which a four-dimensional version of the Green-Schwarz mechanism is invoked for the cancellation of the anomalies, and we compare it with those models in which gauge invariance is restored by the presence of a Wess-Zumino term. Some issues concerning an apparent violation of unitarity of the mechanism, which requires Dolgov-Zakharov poles, are carefully examined, using a class of amplitudes studied in the past by Bouchiat-Iliopoulos-Meyer (BIM), and elaborating on previous studies. In the Wess-Zumino case we determine explicitly the unitarity bound using a realistic model of intersecting branes (the Madrid model) by studying the corresponding BIM amplitudes. This is shown to depend significantly on the St\"uckelberg mass and on the coupling of the extra anomalous gauge bosons and allows one to identify Standard-Model-like regions (which are anomaly-free) from regions where the growth of certain amplitudes is dominated by the anomaly, separated by an inflection point which could be studied at the LHC. The bound can even be around 5-10 TeV's for a $Z'$ mass around 1 TeV and varies sensitively with the anomalous coupling. The results for the WZ case are quite general and apply to all the models in which an axion-like interaction is introduced as a generalization of the Peccei-Quinn mechanism, with a gauged axion.Comment: 50 pages, 28 figure

A within farm clinical trial to compare two treatments (parenteral antibacterials and hoof trimming) for sheep lame with footrot

From observational studies, farmers who use parenteral antibacterials to promptly treat all sheep with footrot (FR) or interdigital dermatitis (ID) have a prevalence of lameness of <2% compared with a prevalence of 9% lameness reported by farmers who treat lame sheep by trimming affected feet. We tested the hypothesis that prompt treatment of sheep lame with naturally developing FR or ID with parenteral and topical antibacterials reduces the prevalence and incidence of lameness with these conditions compared with less frequent treatment with trimming of hoof horn and applying topical antibacterials. A further hypothesis was that reduction of ID and FR would improve productivity. A lowland sheep flock with 700 ewes was used to test these hypotheses in an 18-month within farm clinical trial with four groups of ewes: two intervention and two control. The duration and severity of lameness was used to categorise sheep into three weighted scores of lameness (WLS): never lame (WLS0), mildly lame/lame for <6 days (WLS1) and severely or chronically lame (WLS2). The intervention reduced the prevalence of lameness due to FR and ID in ewes and lambs and the incidence of lameness in ewes. The WLS was also significantly lower in sheep in the intervention groups. Ewes with a higher WLS were subsequently significantly more likely to have a body condition score <2.5 and to have lame lambs. Significantly more ewes lambed and successfully reared more lambs that were ready for slaughter at a younger age in the intervention versus control groups. There was an increase in the gross margin of £630/100 ewes mated in the intervention group, including the cost of treatment of £150/100 ewes mated. We conclude that prompt parenteral and topical antibacterial treatment of sheep lame with ID and FR reduced the prevalence and incidence of these infectious conditions and led to improved health, welfare and productivity

A cohort study of the associations between udder conformation, milk somatic cell count, and lamb weight in suckler ewes

A cohort study of 67 suckler ewes from 1 farm was carried out from January to May 2010 to investigate associations between udder conformation, udder half milk somatic cell count (SCC), and lamb weight. Ewes and lambs were observed at lambing. Ewe health and teat condition and lamb health and weight were recorded on 4 to 5 further occasions at 14-d intervals. At each observation, a milk sample was collected from each udder half for somatic cell counting. Two weeks after lambing, ewe udder conformation and teat placement were scored. Low lamb weight was associated with ewe SCC >400,000 cells/mL (−0.73kg), a new teat lesion 14 d previously (−0.91kg), suboptimal teat position (−1.38kg), rearing in a multiple litter (−1.45kg), presence of diarrhea at the examination (−1.19kg), and rearing by a 9-yr-old ewe compared with a 6-yr-old ewe (−2.36kg). High lamb weight was associated with increasing lamb age (0.21kg/d), increasing birth weight (1.65kg/kg at birth), and increasing number of days the ewe was given supplementary feed before lambing (0.06kg/d). High udder half SCC was associated with pendulous udders (9.6% increase in SCC/cm of drop) and greater total cross-sectional area of the teats (7.2% increase of SCC/cm2). Low SCC were associated with a heavier mean litter weight (6.7% decrease in SCC/kg). Linear, quadratic, and cubic terms for days in lactation were also significant. We conclude that poor udder and teat conformation are associated with high levels of intramammary infection, as indicated by increased SCC and that both physical attributes of the udder and SCC are linked to lamb growth, suggesting that selection of suckler ewes with better udder and teat conformation would reduce intramammary infection and increase lamb growth rate