Polymorphous low-grade adenocarcinoma of the parotid gland : case report and review of the literature

Polymorphous low-grade adenocarcinoma (PLGA) is difficult to diagnose both clinically and histologically due to its indolent presentation, and because of its morphological diversity that includes several microscopic patterns. The aggressive biologic behavior seen in minor salivary glands as compared to major glands is apparently associated histologically to a predominance of the papillary pattern in the former. Biologic behavior of PLGA in the major salivary glands is uncertain, as some cases have developed recurrences and metastases independently of the presence of a papillary pattern. A case of PLGA originated de novo in parotid gland is presented a 60 year-old male, treatment was surgically excised through superficial parotidectomy and to postoperative radiotherapy (46 Gy). Forty-eight months later the patient is alive with no signs of recurrence, as well as a review of the literature, with particular emphasis in its differential diagnosis and biological behavior

Management of wet age-related macular degeneration in Spain: challenges for treat and extend implementation in routine clinical practice

Age-related macular degeneration; Ophthalmology services; Anti-VEGFDegeneración macular relacionada con la edad; Servicios de oftalmología; Anti-VEGFDegeneració macular relacionada amb l’edat; Serveis d’oftalmologia; Anti-VEGFPurpose. To ascertain wet AMD (wAMD) management patterns in Spain. Methods. A two-round Delphi study conducted through a questionnaire-based survey designed from literature review and validated by an independent Steering Committee. Results. Forty-nine retina specialists experienced in wAMD participated by answering the two-round study questionnaire. Retina specialists are the main responsible for wAMD diagnosis and monitoring, including visits and associated procedures, with a median time per visit of 15 minutes. Standard treatment strategies are based on anti-VEGF administration, including standard loading dose administration followed by maintenance with aflibercept or ranibizumab (81% of patients). Although treat and extend (T&E) dosing strategy is considered as optimal for wAMD management (78% of the panelists), the main routine healthcare limitations (i.e., visits overload, reduced staff, short visit time, coordination issues, lack of facilities) conduct to self-defined “flexible” strategies, based on T&E and pro-re-nata (PRN) protocols. Conclusion. Proactive treatment patterns (T&E) are the preferred ones by the retina specialists in Spain. However, their proper implementation is difficult due to healthcare resource limitations, as well as organisation and logistic issues. The use of anti-VEGF agents with longer duration of action could facilitate the use of strict T&E approaches according to routine clinical practices

Structural and magnetic characterization of oleic acid and oleylamine-capped gold nanoparticles

In this work the study of oleic acid and oleylamine-capped gold nanoparticles is presented. The structural characterization of the sample shows 6.7 nm gold nanoparticles with a narrow size distribution. The experimental optical absorption spectrum has a maximum at 2.35 eV. The calculated optical absorption spectrum is shifted and narrower than the experimental one, indicating that the oleic acid and oleylamine do not merely passivate the metallic nanoparticles but modify its electronic structure. These gold nanoparticles show in addition a kind of magnetic order similar to other organic passivated gold nanoparticles as thiol-capped gold nanoparticles. Although the magnetic interactions seem to be weaker than in thiol-capped ones, the magnetic behavior looks similar to that, i.e., an invariant temperature dependence of the magnetization from 5 to 300 K and a noticeable coercive field. We analyze the influence of the organic layer bonding the nanoparticles on the magnetic behavior. © 2006 American Institute of Physics.Financial support from the Spanish MCyT under Project No. MAT2002–04246-c05–05 and CAM under Project No. S-0505/MAT/0194 are acknowledged.Peer Reviewe

El gasto económico en centros de fitness low-cost: Diferencias según fidelidad y características del cliente

Thegrowth in thenumber of fitness centers and theirclients, thestudysoughtto examine and understandthebehavior of consumers of these sport organizations. Therefore, theobjective of thisstudywastoanalyzefordifferences in economicexpendituresbasedoncustomerloyalty and customerprofile in low-cost fitness centers. Thesamplewascomposed of 8462 clients of which50.9% (n=4303) werewomen and 49.1% (n=4159) men. A descriptiveanalysiswasconductedwiththevariancetoaddresstheobjective of thestudy. Theprincipleresultsindicatesignificantdifferences in regardstotheeconomicexpendituresaccordingtogender, age, longevitywiththeorganization and behaviorintentions as measuredwith Net Promoter Score. Thesefindings are of importantrelevanceoffering a detailedunderstanding of clients and variables whichshould be appropriatelymanagedtoincreasetheclients' expenditure.Debido al incremento en el número de instalaciones y clientes, los centros de fitness están siendo examinados para comprender el comportamiento del consumidor que asiste a estas organizaciones deportivas. Por ello, el objetivo de esta investigación fue analizar si existían diferencias de gasto económico en base al perfil y a la fidelidad de clientes en centros de fitness low-cost. La muestra se compuso de 8462 clientes de los que el 50.9% (n=4303) fueron mujeresy el 49.1% (n=4159) hombres. Se realizaron análisis descriptivos y de la varianza para dar respuesta al objetivo. Los principales resultados indican que existen diferencias significativas en cuanto al gasto económico según el género, la edad, la permanencia en la organización y las intenciones de comportamiento medidas con el Net Promoter Score. Estos hallazgos son de especial relevancia ya que favorecen el conocimiento detallado de los clientes, y de cuáles son las variables que se deberían gestionar adecuadamente para aumentar el gasto

Metabolismo hepático y renal de los cuerpos cetónicos. Características de las principales enzimas implicadas

Ketone bodies, B-hydroxybutyrate and acetoacetate, constitute an excellent alternating energetic combustible to glucose by the most of the cells from the peripheric tissues mainly the brain. The most important aim of this work has been to deep in fue knowledge of ketone body metabolism, analyzing the main ernzymes implied. Also, this paper studies, in a comparative form, the metabolic behaviour of these compounds in both liver and kidney tissues.Los cuerpos cetónicos, B-hidroxibutirato y acetoacetato constituyen un excelente combustible alternativo a la glucosa para el metabolismo energético de la mayoría de las células de los tejidos periféricos, y fundamentalmente del cerebro. El principal objetivo de este trabajo ha sido profundizar en el conocimiento del metabolismo de los cuerpos cetónicos, caracterizando los principales enzimas implicados. AsÍmismo se trata de forma comparada el comportamiento metabólico de estos compuestos en hígado (principal productor de cuerpos cetónicos) y riñón

GA design of small thin-wire antennas: comparison with Sierpinski-type prefractal antennas

A new set of genetically generated electrically small thin-wire antennas with a better performance than that of several families of Sierpinsky prefractal monopoles of the same electrical size at resonance is presentedPeer Reviewe

Anestesia local y Sedación para Intubación con Fibrobroncoscopio de paciente con Vía Aérea Difícil

Presentamos el caso clínico de un varón de 60 años con vía aérea difícil que debía realizarse una tiroidectomía total por el diagnóstico de bocio multinodular tóxico y que, un mes antes, había tenido un intento fallido de intubación con fibrobroncoscopio

Dietary supplemental plant oils reduce methanogenesis from anaerobic microbial fermentation in the rumen

Ruminants contribute to the emissions of greenhouse gases, in particular methane, due to the microbial anaerobic fermentation of feed in the rumen. The rumen simulation technique was used to investigate the effects of the addition of different supplemental plant oils to a high concentrate diet on ruminal fermentation and microbial community composition. The control (CTR) diet was a high-concentrate total mixed ration with no supplemental oil. The other experimental diets were supplemented with olive (OLV), sunflower (SFL) or linseed (LNS) oils at 6%. Rumen digesta was used to inoculate the fermenters, and four fermentation units were used per treatment. Fermentation end-products, extent of feed degradation and composition of the microbial community (qPCR) in digesta were determined. Compared with the CTR diet, the addition of plant oils had no significant (P > 0.05) effect on ruminal pH, substrate degradation, total volatile fatty acids or microbial protein synthesis. Gas production from the fermentation of starch or cellulose were decreased by oil supplementation. Methane production was reduced by 21–28% (P < 0.001), propionate production was increased (P < 0.01), and butyrate and ammonia outputs and the acetate to propionate ratio were decreased (P < 0.001) with oil-supplemented diets. Addition of 6% OLV and LNS reduced (P < 0.05) copy numbers of total bacteria relative to the control. In conclusion, the supplementation of ruminant diets with plant oils, in particular from sunflower or linseed, causes some favorable effects on the fermentation processes. The addition of vegetable oils to ruminant mixed rations will reduce methane production increasing the formation of propionic acid without affecting the digestion of feed in the rumen. Adding vegetable fats to ruminant diets seems to be a suitable approach to decrease methane emissions, a relevant cleaner effect that may contribute to alleviate the environmental impact of ruminant production

Prognostic Factors in Patients with Rocky Mountain Spotted Fever

Background: Rocky Mountain Spotted Fever (RMSF) is a disease with a high mortality rate, caused by Rickettsia rickettsii, a bacteria transmitted to humans by infected ticks. In 2008 there was a Rocky Mountain Spotted Fever (RMSF) outbreak in the city of Mexicali, México, resulting in an increased mortality rate amongst the area population. Methods: Case-series study of patients admitted to the General Hospital of Mexicali between 2014 and 2019 with a confirmed diagnosis of RMSF. Mortality was compared dividing the population on those ?20 and younger than ?21 years of age. Results: A total of 129 patients’ records during a 5-year period whose diagnosis was RMSF confirmed with PCR were included. Mortality was compared among patients admitted who were younger than ?20 years of age with that among patients who were older than ?20 years of age (61 versus 68 respectively), the latter being higher with an OR 4.2 (p&lt;0.0001). Conclusion: RMSF in hospitalized patients has a high mortality rate in spite of early treatment in all age groups, without showing any predominance in gender. However, patients older than 20 years of age had a higher mortality rate than those younger than 20 years, without any predominance in gender