Can Standing Long Jump Distance be Predicted from Standing Vertical Jump Distance?

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Large increase in bloodstream infections with carbapenem-resistant Acinetobacter species during the first 2 years of the COVID-19 pandemic, EU/EEA, 2020 and 2021

EARS-Net Study Group (Portugal: Manuela Caniça).EARS-Net Study Group participants: Reinhild Strauss, Karl Mertens, Stefana Sabtcheva, Arjana Tambic Andrasevic, Panagiota Maikanti, Helena Žemličková, Henrik Hasman, Marina Ivanova, Kati Räisänen, Sylvie Maugat, Ines Noll, Kassiani Mellou, Ákos Tóth, Kristján Orri Helgason, Stephen Murchan, Giulia Errico, Ieva Voita, Esther Walser-Domjan, Jolanta Miciulevičienė, Monique Perrin, Elizabeth Anne Scicluna, Sjoukje Hs Woudt, Ørjan Samuelsen, Dorota Żabicka, Manuela Caniça, Gabriel Adrian Popescu, Eva Schréterová, Helena Ribič, Maria Belén Aracil García, Hanna Billström.Bloodstream infections (BSIs) with Acinetobacter species commonly have poor outcomes, especially in intensive care unit (ICU) patients [1]. Acinetobacter spp. is intrinsically resistant to many antimicrobials, and additional acquired resistance further complicates the treatment of serious infections in already vulnerable patient groups. Recent data from the European Antimicrobial Resistance Surveillance Network (EARS-Net) show a large and statistically significant increase in reports of Acinetobacter spp. BSIs in the European Union (EU) and European Economic Area (EEA) during the period from 2017 to 2021 [2]. Most of this increase occurred in 2020 and 2021, the first years of the coronavirus disease (COVID-19) pandemic. Here we further explore this trend in a subset of data from laboratories that continuously reported data during that period.info:eu-repo/semantics/publishedVersio

Interim report on public perceptions of marine CDR

This deliverable synthesizes the results on public perceptions of marine CDR methods from the first two years of OceanNETs. The purpose is to inform the other work packages in OceanNETs and stakeholders about our results in a timely and brief manner about the ways members of the public view marine CDR specifically but also in the broader context of net-zero targets and climate policy. The deliverable summarises results of two studies: (1) focus groups held in Germany and Norway that covered ocean fertilization, ocean alkalinity enhancement, artificial upwelling and blue carbon management and (2) a deliberative survey in Norway that covered ocean alkalinity enhancement, macroalgae farming with BECCS or biomass sinking and land-based BECCS and enhanced weathering as terrestrial approaches for comparison. Participants in both studies emphasise the importance of reducing emissions and changing consumptions patterns. They hardly discuss the need to remove CO2 from the atmosphere to reach the Paris climate goal and the concept of negative emissions seems difficult for them to engage with. Among the methods, participants prefer ecosystem-based approaches like mangrove or seagrass restoration over other methods like alkalinity enhancement or ocean fertilization. Participants are concerned about the actual feasibility of deployment at a relevant removal scale and for a longer period. Connected to this are concerns about the controllability of the deployment and the methods’ impact, like difficulties to control negative environmental effects from biomass sinking at the seafloor. They also question the buildup of additional infrastructure or additional interventions into nature on top of already existing human interference. The opportunity to deliberate the methods increases participants’ certainty about their assessment but only slightly changes the direction of the assessment

Improved performance of the LHCb Outer Tracker in LHC Run 2

The LHCb Outer Tracker is a gaseous detector covering an area of $5\times 6 m^2$ with 12 double layers of straw tubes. The performance of the detector is presented based on data of the LHC Run 2 running period from 2015 and 2016. Occupancies and operational experience for data collected in $p p$, pPb and PbPb collisions are described. An updated study of the ageing effects is presented showing no signs of gain deterioration or other radiation damage effects. In addition several improvements with respect to LHC Run 1 data taking are introduced. A novel real-time calibration of the time-alignment of the detector and the alignment of the single monolayers composing detector modules are presented, improving the drift-time and position resolution of the detector by 20\%. Finally, a potential use of the improved resolution for the timing of charged tracks is described, showing the possibility to identify low-momentum hadrons with their time-of-flight.Comment: 29 pages, 20 figures, minor changes to match the published versio

Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology

Multitarget design offers access to bioactive small molecules with potentially superior efficacy and safety. Particularly multifactorial chronic inflammatory diseases demand multiple pharmacological interventions for stable treatment. By minor structural changes, we have developed a close analogue of the cysteinyl-leukotriene receptor antagonist zafirlukast that simultaneously inhibits soluble epoxide hydrolase and activates peroxisome proliferator-activated receptor \u3b3. The triple modulator exhibits robust anti-inflammatory activity in vivo and highlights the therapeutic potential of designed multitarget agents