Virtual implementation of professional practices: presentation and evaluation of a proposal

El presente trabajo describe una estrategia de prácticas profesionales virtuales simuladas, desarrolladas en el marco del Aislamiento Social, Preventivo y Obligatorio (ASPO), como implementación de la asignatura Proyecto Final, correspondiente a la Tecnicatura Universitaria en Soporte Informático de la Universidad Nacional del Noroeste de Buenos Aires. Dicha estrategia, comprende la simulación de una organización que emplea como pasantes a los alumnos de la carrera; la asignación, seguimiento y control de tareas implementadas en modalidad virtual; detalla las herramientas TIC empleadas en el proceso y las consideraciones que justifican su elección; describe cómo se acredita el espacio curricular; y, por último, se presentan los resultados alcanzados que demostraron ser muy positivos.This paper describes a strategy of simulated virtual professional practices, developed within the framework of the Aislamiento Social, Preventivo y Obligatorio (ASPO), as an implementation of the Proyecto Final subject, corresponding to the Tecnicatura Universitaria en Soporte Informático of the Universidad Nacional del Noroeste de Buenos Aires. The strategy includes the simulation of an organization that employs the career students as interns; also, the assignment, monitoring, and control of tasks implemented virtually; details the ICT tools used in the process and the considerations that justify their choice; describes how the curricular space is accredited; and, finally, the results achieved are presented, which proved to be very positives.Facultad de Informátic

The meiotic phosphatase GSP-2/PP1 promotes germline immortality and small RNA-mediated genome silencing

Germ cell immortality, or transgenerational maintenance of the germ line, could be promoted by mechanisms that could occur in either mitotic or meiotic germ cells. Here we report for the first time that the GSP-2 PP1/Glc7 phosphatase promotes germ cell immortality. Small RNAinduced genome silencing is known to promote germ cell immortality, and we identified a separation-of-function allele of C. elegans gsp-2 that is compromised for germ cell immortality and is also defective for small RNA-induced genome silencing and meiotic but not mitotic chromosome segregation. Previous work has shown that GSP-2 is recruited to meiotic chromosomes by LAB-1, which also promoted germ cell immortality. At the generation of sterility, gsp-2 and lab-1 mutant adults displayed germline degeneration, univalents, histone methylation and histone phosphorylation defects in oocytes, phenotypes that mirror those observed in sterile small RNA-mediated genome silencing mutants. Our data suggest that a meiosisspecific function of GSP-2 ties small RNA-mediated silencing of the epigenome to germ cell immortality. We also show that transgenerational epigenomic silencing at hemizygous genetic elements requires the GSP-2 phosphatase, suggesting a functional link to small RNAs. Given that LAB-1 localizes to the interface between homologous chromosomes during pachytene, we hypothesize that small localized discontinuities at this interface could promote genomic silencing in a manner that depends on small RNAs and the GSP-2 phosphatase

Sharing vocabularies: towards horizontal alignment of values-driven business functions

This paper highlights the emergence of different ‘vocabularies’ that describe various values-driven business functions within large organisations and argues for improved horizontal alignment between them. We investigate two established functions that have long-standing organisational histories: Ethics and Compliance (E&C) and Corporate Social Responsibility (CSR). By drawing upon research on organisational alignment, we explain both the need for and the potential benefit of greater alignment between these values-driven functions. We then examine the structural and socio-cultural dimensions of organisational systems through which E&C and CSR horizontal alignment can be coordinated to improve synergies, address tensions, and generate insight to inform future research and practice in the field of Business and Society. The paper concludes with research questions that can inform future scholarly research and a practical model to guide organizations’ efforts towards inter-functional, horizontal alignment of values-driven organizational practice

Clinical delineation, sex differences, and genotype-phenotype correlation in pathogenic KDM6A variants causing X-linked Kabuki syndrome type 2.

PURPOSE: The variant spectrum and the phenotype of X-linked Kabuki syndrome type 2 (KS2) are poorly understood. METHODS: Genetic and clinical details of new and published individuals with pathogenic KDM6A variants were compiled and analyzed. RESULTS: Sixty-one distinct pathogenic KDM6A variants (50 truncating, 11 missense) from 80 patients (34 males, 46 females) were identified. Missense variants clustered in the TRP 2, 3, 7 and Jmj-C domains. Truncating variants were significantly more likely to be de novo. Thirteen individuals had maternally inherited variants and one had a paternally inherited variant. Neonatal feeding difficulties, hypoglycemia, postnatal growth retardation, poor weight gain, motor delay, intellectual disability (ID), microcephaly, congenital heart anomalies, palate defects, renal malformations, strabismus, hearing loss, recurrent infections, hyperinsulinism, seizures, joint hypermobility, and gastroesophageal reflux were frequent clinical findings. Facial features of over a third of patients were not typical for KS. Males were significantly more likely to be born prematurely, have shorter stature, and severe developmental delay/ID. CONCLUSION: We expand the KDM6A variant spectrum and delineate the KS2 phenotype. We demonstrate that the variability of the KS2 phenotypic depends on sex and the variant type. We also highlight the overlaps and differences between the phenotypes of KS2 and KS1

Dalla coppia coniugale alla coppia genitoriale: uno studio longitudinale

Introduzione. Con la nascita di un figlio la relazione coniugale si intreccia con quella genitoriale acquisendo una nuova forma e una maggiore complessità. Dalle ricerche si evince che durante questa fase di transizione ogni individuo si trova ad affrontare profondi cambiamenti e adattamenti, personali e di coppia, che influenzano la relazione coniugale (Velotti et al, 2011). Obiettivo della ricerca longitudinale è indagare l’andamento delle variabili individuali, relazionali e contestuali che caratterizzano questa fase. Metodo. Hanno partecipato 13 coppie primipare. La ricerca ha previsto tre step: T1 (7° mese gravidanza), T2 (3° mese post-partum), T3 (12°/18° mese post-partum). A entrambi i genitori sono stati somministrati: T1) scheda socio-anagrafica, AAI (Main et al, 2002; modelli di attaccamento infantile), CES-D (Radloff, 1977; sintomatologia depressiva), ECR-R (Brennan et al, 2000; attaccamento romantico), DAS (Spanier, 2001; adattamento diadico), MSPSS (Zimet et al, 1988; sostegno sociale percepito); T2) CES-D, ECR-R, DAS, MSPSS; T3) CES-D, ECR-R, DAS, MSPSS e la SSP (Ainsworth et al, 1978), ancora in corso, per la valutazione dell’attaccamento del bambino verso ciascun genitore. Risultati. Si evidenzia una prevalenza di attaccamento sicuro all’AAI (madri 77,8%; padri 72,2%); tra T1 e T3 si registra un lieve aumento del livello di sintomatologia depressiva e dell’evitamento nella relazione di coppia, una diminuzione dell’adattamento diadico e della percezione del supporto sociale. Conclusioni. I risultati sembrano confermare come le variabili indagate siano soggette ad una serie di cambiamenti che rispecchiano la criticità di questa fase. La valutazione dell’attaccamento del bambino permetterà di indagare l’influenza di tale processo sulla costruzione del suo senso di sicurezza. La complessità dei dati verrà discussa alla luce dei costrutti teorici di riferimento sottolineandone le implicazioni cliniche e di ricerca