La Participación Laboral de las Mujeres no Jefes de Hogar en Colombia y el Efecto del Servicio Doméstico

La oferta laboral de las mujeres no jefes de hogar está principalmente asociada a la decisión de participar en el mercado laboral. El caso específico de las mujeres es un tema muy importante en el campo de la economía laboral sobre todo porque su participación en las últimas décadas se ha incrementado de manera importante y este comportamiento no solo se ha dado en el caso colombiano, sino también en las economías más desarrolladas. Un factor importante para las economías en vía de desarrollo, y que se puede asociar al aumento de la participación de las mujeres no jefes de hogar es la existencia del servicio doméstico en el hogar, ya que en economías como la colombiana la tendencia de este tipo de servicio es abundante y no es costoso si se compara con otras economías. Este trabajo se centra en un modelo de participación laboral para el caso específico de las mujeres no jefe de hogar, desde 1984: I hasta 2002: II, con base en la ENH y la ECH del DANE. Los resultados de los ejercicios econométricos muestran que los principales determinantes de efecto positivo son la educación, la edad, la tasa de desempleo y existencia de servicio doméstico en el hogar; los principales determinantes de efecto negativo son la riqueza y la existencia de niños en edades menores. Según el modelo la TGP cae ante disminuciones en la tasa de desempleo y cambios en los programas educativos.

Проблемы медицинского обслуживания моряков в Украине

Стаття присвячена деяким проблемам медичного обслуговування моряків в Україні, в тому числі питанням професійних оглядів, які визначають придатність моряка по стану здоров‘я до роботи на суднах. Розглядаються проекти пропозицій до наказу, який готується і який буде регламентувати медичні огляди моряків.The article is devoted some problems of medical service of seafarers in Ukraine, in particular to the questions of professional examinations, determining the fitness of seafarer to be fit for work on ships. The projects of appendixes are examined to the preparing order, to regulating physical examinations of seafarers

Numerical and functional defects of blood dendritic cells in early- and late-stage breast cancer

The generation of antitumour immunity depends on the nature of dendritic cell (DC)–tumour interactions. These have been studied mostly by using in vitro-derived DC which may not reflect the natural biology of DC in vivo. In breast cancer, only one report has compared blood DC at different stages and no longitudinal evaluation has been performed. Here we conducted three cross-sectional and one one-year longitudinal assessments of blood DC in patients with early (stage I/II, n=137) and advanced (stage IV, n=36) disease compared to healthy controls (n=66). Patients with advanced disease exhibit markedly reduced blood DC counts at diagnosis. Patients with early disease show minimally reduced counts at diagnosis but a prolonged period (1 year) of marked DC suppression after tumour resection. While differing in frequency, DC from both patients with early and advanced disease exhibit reduced expression of CD86 and HLA-DR and decreased immunostimulatory capacities. Finally, by comparing a range of clinically available maturation stimuli, we demonstrate that conditioning with soluble CD40L induces the highest level of maturation and improved T-cell priming. We conclude that although circulating DC are compromised by loco-regional and systemic breast cancer, they respond vigorously to ex vivo conditioning, thus enhancing their immunostimulatory capacity and potential for immunotherapy

Validity and reliability assessment of the Brazilian version of the Faces Pain Scale-Revised

Abstract The Faces Pain Scale-Revised (FPS-R) is among the most commonly used measures of pain intensity in clinical and research settings. Little evidence exists about the Brazilian version of this scale. The purpose of the present study was to examine the validity and reliability of the Brazilian version of the FPS-R. The sample comprised 214 children, 6 to 10 years of age. In the first phase of the study, the children ranked the faces of the FPS-R according to pain intensity, and the faces were presented in all possible pair combinations (content validity). All six faces were correctly ranked by 47% of the younger children (6 to 7 years old) and 52% of the older children (8 to 10 years old). With regard to paired combinations, all of the pairs were correctly placed by 63% of the younger children and 67% of the older children. In the second phase, the children rated recalled experiences of pain using both the Brazilian version of the FPS-R and Coloured Analogue Scale (CAS; convergent validity). The children were retested 4 weeks later (test-retest reliability). The degree of agreement between the FPS-R and CAS was moderate, with a Kendall's tau-b (τ) of .49 (p < .01). The test-retest reliability coefficient was τ = .52 (p < .01). This study provides evidence of the validity and reliability of the FPS-R as a pain intensity measurement for use in Brazilian samples

IRX-2, a Novel Immunotherapeutic, Enhances Functions of Human Dendritic Cells

Background: In a recent phase II clinical trial for HNSCC patients, IRX-2, a cell-derived biologic, promoted T-cell infiltration into the tumor and prolonged overall survival. Mechanisms responsible for these IRX-2-mediated effects are unknown. We hypothesized that IRX-2 enhanced tumor antigen-(TA)-specific immunity by up-regulating functions of dendritic cells (DC). Methodology/Principal Findings: Monocyte-derived DC obtained from 18 HNSCC patients and 12 healthy donors were matured using IRX-2 or a mix of TNF-α, IL-1β and IL-6 ("conv. mix"). Multicolor flow cytometry was used to study the DC phenotype and antigen processing machinery (APM) component expression. ELISPOT and cytotoxicity assays were used to evaluate tumor-reactive cytotoxic T lymphocytes (CTL). IL-12p70 and IL-10 production by DC was measured by Luminex® and DC migration toward CCL21 was tested in transwell migration assays. IRX-2-matured DC functions were compared with those of conv. mix-matured DC. IRX-2-matured DC expressed higher levels (p<0.05) of CD11c, CD40, CCR7 as well as LMP2, TAP1, TAP2 and tapasin than conv. mix-matured DC. IRX-2-matured DC migrated significantly better towards CCL21, produced more IL-12p70 and had a higher IL12p70/IL-10 ratio than conv. mix-matured DC (p<0.05 for all). IRX-2-matured DC carried a higher density of tumor antigen-derived peptides, and CTL primed with these DC mediated higher cytotoxicity against tumor targets (p<0.05) compared to the conv. mix-matured DC. Conclusion: Excellent ability of IRX-2 to induce ex vivo DC maturation in HNSCC patients explains, in part, its clinical benefits and emphasizes its utility in ex vivo maturation of DC generated for therapy. © 2013 Schilling et al

It\u27s Time to Listen: There is Much to be Learned from the Sounds of Tropical Ecosystems

Knowledge that can be gained from acoustic data collection in tropical ecosystems is low‐hanging fruit. There is every reason to record and with every day, there are fewer excuses not to do it. In recent years, the cost of acoustic recorders has decreased substantially (some can be purchased for under US$50, e.g., Hill et al. 2018) and the technology needed to store and analyze acoustic data is continuously improving (e.g., Corrada Bravo et al. 2017, Xie et al. 2017). Soundscape recordings provide a permanent record of a site at a given time and contain a wealth of invaluable and irreplaceable information. Although challenges remain, failure to collect acoustic data now in tropical ecosystems would represent a failure to future generations of tropical researchers and the citizens that benefit from ecological research. In this commentary, we (1) argue for the need to increase acoustic monitoring in tropical systems; (2) describe the types of research questions and conservation issues that can be addressed with passive acoustic monitoring (PAM) using both short‐ and long‐term data in terrestrial and freshwater habitats; and (3) present an initial plan for establishing a global repository of tropical recordings

Consumer perceptions of co-branding alliances: Organizational dissimilarity signals and brand fit

This study explores how consumers evaluate co-branding alliances between dissimilar partner firms. Customers are well aware that different firms are behind a co-branded product and observe the partner firms’ characteristics. Drawing on signaling theory, we assert that consumers use organizational characteristics as signals in their assessment of brand fit and for their purchasing decisions. Some organizational signals are beyond the control of the co-branding partners or at least they cannot alter them on short notice. We use a quasi-experimental design and test how co-branding partner dissimilarity affects brand fit perception. The results show that co-branding partner dissimilarity in terms of firm size, industry scope, and country-of-origin image negatively affects brand fit perception. Firm age dissimilarity does not exert significant influence. Because brand fit generally fosters a benevolent consumer attitude towards a co-branding alliance, the findings suggest that high partner dissimilarity may reduce overall co-branding alliance performance

CD40 signaling predicts response to preoperative trastuzumab and concomitant paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide in HER-2-overexpressing breast cancer

Introduction We performed gene expression analysis to identify molecular predictors of resistance to preoperative concomitant trastuzumab and paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide (T/FEC). Methods Pretreatment fine-needle aspiration specimens from 45 patients with HER-2-overexpressing stage II to IIIA breast cancer were subjected to transcriptional profiling and examined for differential expression of various genes and gene sets. The primary endpoint for tumor response was pathologic complete response (pCR). Correlations between pCR and gene expression were sought. Results The overall pCR rate was 64%. Age, nuclear grade, tumor size, nodal status, quantitative expression of estrogen and HER-2 receptor mRNA, and HER-2 gene copy number showed no correlation with pCR. Results of gene set enrichment analysis suggested that the lower expression of genes involved with CD40 signaling is associated with a greater risk of residual cancer after the preoperative chemotherapy that includes trastuzumab. Conclusion CD40 signaling may play a role in determining response to trastuzumab-plus-T/FEC therapy in patients with HER-2-overexpressing breast cancer.PubMedWoSScopu

Enfermedades causantes de abortos en cabras.

Se determinaron los títulos de anticuerpos de las siguientes enfermedades causantes de abortos en cabras de la sabana de Bogotá: brucelosis (asumiendo una reacción cruzada con Brucella melitensis), clamidiosis, letospirosis y toxoplasmosis. Un total de 200 muestras fueron analizadas, tomadas en 21 apriscos con una población de 1.033 animales. Para el primer caso, se encontró el 3.5 por ciento de reactores a Brucella abortus por medio de la prueba lenta en tubo (título 1:200), corroborando esta reactividad por medio de la prueba de mercaptoetanol (1:50) y fijación de complemento (1:64). Para determinar anticuerpos fijadores de complemento para Chlamydia psittachi, se comprobó que el uno por ciento fueron reactores con un rango de confianza del 95 por ciento y prueba diagnóstica específica para Chlamydia. En la leptospirosis se halló una prevalencia instantánea del 4 por ciento que representa los animales reactores. Unicamente 2 animales presentaron títulos de 1:100 y 1:400 para Leptospira icterohaemorrhagie. Las pruebas para toxoplasmosis mostraron que el 25 por ciento de los animales analizados fueron reactores a Toxoplasma gondi

Oocyte–Targeted Deletion Reveals That Hsp90b1 Is Needed for the Completion of First Mitosis in Mouse Zygotes

Hsp90b1 is an endoplasmic reticulum (ER) chaperone (also named Grp94, ERp99, gp96,Targ2, Tra-1, Tra1, Hspc4) (MGI:98817) contributing with Hspa5 (also named Grp78, BIP) (MGI:95835) to protein folding in ER compartment. Besides its high protein expression in mouse oocytes, little is known about Hsp90b1 during the transition from oocyte-to-embryo. Because the constitutive knockout of Hsp90b1 is responsible for peri-implantation embryonic lethality, it was not yet known whether Hsp90b1 is a functionally important maternal factor.To circumvent embryonic lethality, we established an oocyte-specific conditional knockout line taking advantage of the more recently created floxed Hsp90b1 line (Hsp90b1(flox), MGI:3700023) in combination with the transgenic mouse line expressing the cre recombinase under the control of zona pellucida 3 (ZP3) promoter (Zp3-cre, MGI:2176187). Altered expression of Hsp90b1 in growing oocytes provoked a limited, albeit significant reduction of the zona pellucida thickness but no obvious anomalies in follicular growth, meiotic maturation or fertilization. Interestingly, mutant zygotes obtained from oocytes lacking Hsp90b1 were unable to reach the 2-cell stage. They exhibited either a G2/M block or, more frequently an abnormal mitotic spindle leading to developmental arrest. Despite the fact that Hspa5 displayed a similar profile of expression as Hsp90b1, we found that HSPA5 and HSP90B1 did not fully colocalize in zygotes suggesting distinct function for the two chaperones. Consequently, even if HSPA5 was overexpressed in Hsp90b1 mutant embryos, it did not compensate for HSP90B1 deficiency. Finally, further characterization of ER compartment and cytoskeleton revealed a defective organization of the cytoplasmic region surrounding the mutant zygotic spindle.Our findings demonstrate that the maternal contribution of Hsp90b1 is critical for the development of murine zygotes. All together our data indicate that Hsp90b1 is involved in unique and specific aspects of the first mitosis, which brings together the maternal and paternal genomes on a single spindle