1,408 research outputs found
PARENCHYMAL CELLS FROM ADULT RAT LIVER IN NONPROLIFERATING MONOLAYER CULTURE : II. Ultrastructural Studies
Hepatic parenchymal cells from adult rats, established in vitro as a monolayer, have been evaluated by electron microscopy. Within 24 h after the initial seeding, the incubated cells were polygonal and in close apposition with three to six neighboring cells. The ultrastructure of the monolayer cells was examined at this time and after 3 and 10 days of incubation. With the exception of a few enlarged mitochondria, organelles in both the 1- and 3-day monolayer cells were indistinguishable quantitatively and morphologically from those found in the intact liver. After 10 days of incubation, however, the rough-surfaced endoplasmic reticulum (RER) had become dilated and vesiculated. In all cells studied, portions of RER were found in a close spatial relationship to mitochondria. From its frequency, this association appeared to be more than fortuitous, and the organelle complex may represent a functional unit necessary for new membrane formation, as suggested previously. The Golgi complexes of 1- and 3-day cells contained very low density lipoprotein-sized particles, which suggests that the monolayer cells synthesize lipoproteins. These electron microscope observations demonstrate that adult hepatic parenchymal cells in monolayer retain for several days the subcellular structural elements characteristic of normally functioning hepatocytes
Spins, Electromagnetic Moments, and Isomers of 107-129Cd
The neutron-rich isotopes of cadmium up to the N=82 shell closure have been
investigated by high-resolution laser spectroscopy. Deep-UV excitation at 214.5
nm and radioactive-beam bunching provided the required experimental
sensitivity. Long-lived isomers are observed in 127Cd and 129Cd for the first
time. One essential feature of the spherical shell model is unambiguously
confirmed by a linear increase of the 11/2- quadrupole moments. Remarkably,
this mechanism is found to act well beyond the h11/2 shell
Ground-State Electromagnetic Moments of Calcium Isotopes
High-resolution bunched-beam collinear laser spectroscopy was used to measure
the optical hyperfine spectra of the Ca isotopes. The ground state
magnetic moments of Ca and quadrupole moments of Ca were
measured for the first time, and the Ca ground state spin was
determined in a model-independent way. Our results provide a critical test of
modern nuclear theories based on shell-model calculations using
phenomenological as well as microscopic interactions. The results for the
neutron-rich isotopes are in excellent agreement with predictions using
interactions derived from chiral effective field theory including three-nucleon
forces, while lighter isotopes illustrate the presence of particle-hole
excitations of the Ca core in their ground state.Comment: Accepted as a Rapid Communication in Physical Review
A review of implant provision for hypodontia patients within a Scottish referral centre
Background: Implant treatment to replace congenitally missing teeth often involves multidisciplinary input in a secondary care environment. High quality patient care requires an in-depth knowledge of treatment requirements.
Aim: This service review aimed to determine treatment needs, efficiency of service and outcomes achieved in hypodontia patients. It also aimed to determine any specific difficulties encountered in service provision, and suggest methods to overcome these.
Methods: Hypodontia patients in the Unit of Periodontics of the Scottish referral centre under consideration, who had implant placement and fixed restoration, or review completed over a 31 month period, were included. A standardised data collection form was developed and completed with reference to the patient's clinical record. Information was collected with regard to: the indication for implant treatment and its extent; the need for, complexity and duration of orthodontic treatment; the need for bone grafting and the techniques employed and indicators of implant success.
Conclusion: Implant survival and success rates were high for those patients reviewed. Incidence of biological complications compared very favourably with the literature
Magnetothermal instability in laser plasmas including hydrodynamic effects
The impact of both density gradients and hydrodynamics on the evolution of the field compressing magnetothermal instability is considered [J. J. Bissell et al., Phys. Rev. Lett. 105, 175001 (2010)]. Hydrodynamic motion is found to have a limited effect on overall growth-rates; however, density gradients are shown to introduce an additional source term corresponding to a generalised description of the field generating thermal instability [D. Tidman and R. Shanny, Phys. Fluids 17, 1207 (1974)]. The field compressing and field generating source terms are contrasted, and the former is found to represent either the primary or sole instability mechanism for a range of conditions, especially those with Hall parameter v > 101. The generalised theory is compared to numerical simulation in the context of a recent nano-second gas-jet experiment [D. H. Froula et al., Phys. Rev. Lett. 98, 135001 (2007)] and shown to be in good agreement: exhibiting peak growth-rates and wavelengths of order 10 ns1 and 50 lm, respectively. The instability’s relevance to other experimental conditions, including those in inertial confinement fusion (I.C.F.) hohlraums, is also discussed
Nuclear spins, magnetic moments and quadrupole moments of Cu isotopes from N = 28 to N = 46: probes for core polarization effects
Measurements of the ground-state nuclear spins, magnetic and quadrupole
moments of the copper isotopes from 61Cu up to 75Cu are reported. The
experiments were performed at the ISOLDE facility, using the technique of
collinear laser spectroscopy. The trend in the magnetic moments between the
N=28 and N=50 shell closures is reasonably reproduced by large-scale
shell-model calculations starting from a 56Ni core. The quadrupole moments
reveal a strong polarization of the underlying Ni core when the neutron shell
is opened, which is however strongly reduced at N=40 due to the parity change
between the and orbits. No enhanced core polarization is seen beyond
N=40. Deviations between measured and calculated moments are attributed to the
softness of the 56Ni core and weakening of the Z=28 and N=28 shell gaps.Comment: 13 pagers, 19 figures, accepted by Physical Review
Calling time on asthma deaths in tropical regions—how much longer must people wait for essential medicines?
Every day around 1150 people die worldwide because of asthma, and most of these deaths are avoidable.1 As a comparison, malaria—which is seen as a much bigger problem and increased prevention measures have resulted in decreasing death rates—kills about 1175 people per day.2 Most asthma deaths occur in children and adults living in tropical regions, where effective asthma management might be either non-existent or inaccessible.3 However, with correct diagnosis and treatment many deaths from asthma could be prevented
Decay-assisted collinear resonance ionization spectroscopy: Application to neutron-deficient francium
This paper reports on the hyperfine-structure and radioactive-decay studies
of the neutron-deficient francium isotopes Fr performed with the
Collinear Resonance Ionization Spectroscopy (CRIS) experiment at the ISOLDE
facility, CERN. The high resolution innate to collinear laser spectroscopy is
combined with the high efficiency of ion detection to provide a
highly-sensitive technique to probe the hyperfine structure of exotic isotopes.
The technique of decay-assisted laser spectroscopy is presented, whereby the
isomeric ion beam is deflected to a decay spectroscopy station for alpha-decay
tagging of the hyperfine components. Here, we present the first
hyperfine-structure measurements of the neutron-deficient francium isotopes
Fr, in addition to the identification of the low-lying states of
Fr performed at the CRIS experiment.Comment: Accepted for publication with Physical Review
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