15 research outputs found
1.19 Questionable suitability of OECD 237 protocol in risk assessment scheme?
Persistent xenobiotics are potentially hazardous for the bee larvae despite that they are not directly exposed in contrary to adult foraging bees. The crucial phase of larval development is the first six days after hatching when young larva grows exponentially and during this phase larvae are potentially exposed to xenobiotics via diet. That is why the life cycle of honeybee is still a great challenge for scientists. OECD reflected “this need” and adopted the OECD 237 protocol (Honey bee (Apis mellifera) larval toxicity test, single exposure) on 26th July 2013. The protocol addresses the requirements formulated by the United States, Canada, and Europe to test the toxicity of chemicals compounds on larvae fed with spiked food under laboratory conditions in a tier1 strategy.Persistent xenobiotics are potentially hazardous for the bee larvae despite that they are not directly exposed in contrary to adult foraging bees. The crucial phase of larval development is the first six days after hatching when young larva grows exponentially and during this phase larvae are potentially exposed to xenobiotics via diet. That is why the life cycle of honeybee is still a great challenge for scientists. OECD reflected “this need” and adopted the OECD 237 protocol (Honey bee (Apis mellifera) larval toxicity test, single exposure) on 26th July 2013. The protocol addresses the requirements formulated by the United States, Canada, and Europe to test the toxicity of chemicals compounds on larvae fed with spiked food under laboratory conditions in a tier1 strategy
Transcription of the AAC1 Gene Encoding an Isoform of Mitochondrial ADP/ATP Carrier in Saccharomyces cerevisiae is Regulated by Oxygen in a Heme-Independent Manner
Expression of the AAC2 Gene Encoding the Major Mitochondrial ADP/ATP Carrier in Saccharomyces cerevisiae is Controlled at the Transcriptional Level by Oxygen, Heme and HAP2 Factor
Positive and negative elements involved in the differential regulation by heme and oxygen of the HEM13 gene (coproporphyrinogen oxidase) in Saccharomyces cerevisiae
Triplicate genes for mitochondrial ADP/ATP carriers in the aerobic yeast Yarrowia lipolytica are regulated differentially in the absence of oxygen
BJcuL, a lectin purified from Bothrops jararacussu venom, induces apoptosis in human gastric carcinoma cells accompanied by inhibition of cell adhesion and actin cytoskeleton disassembly
Data-mining bioinformatics: connecting adenylate transport and metabolic responses to stress
Adenine nucleotides are essential in countless processes within the cellular metabolism. In plants, ATP is mainly produced in chloroplasts and mitochondria through photophosphorylation and oxidative phosphorylation, respectively. Thus, efficient adenylate transport systems are required for intracellular energy partitioning between the cell organelles. Adenylate carriers present in different subcellular compartments have been previously identified and biochemically characterized in plants. Here, by using data-mining bioinformatics tools, we propose how, and to what extent, these carriers integrate energy metabolism within a plant cell under different environmental conditions. We demonstrate that the expression pattern of the corresponding genes is variable under different environmental conditions, suggesting that specific adenylate carriers have distinct and nonredundant functions in plants