Inlet spillage drag tests and numerical flow-field analysis at subsonic and transonic speeds of a 1/8-scale, two-dimensional, external-compression, variable-geometry, supersonic inlet configuration

Accurate spillage drag and pressure data are presented for a realistic supersonic inlet configuration. Results are compared with predictions from a finite-differencing, inviscid analysis computer procedure. The analytical technique shows good promise for the evaluation of inlet drag, but necessary refinements were identified. A detailed description of the analytical procedure is contained in the Appendix

Descendants of the Jurassic turiasaurs from Iberia found refuge in the Early Cretaceous of western USA

A new, largely complete eusauropod dinosaur with cranial and postcranial elements from two skeletons, Mierasaurus bobyoungi gen. nov., sp. nov. from the lower Yellow Cat Member (Early Cretaceous) of Utah (USA), is the first recognized member of Turiasauria from North America. Moreover, according to our phylogenetic results, Moabosaurus utahensis from the lower Yellow Cat Member of Utah (USA) is also a member of this clade. This group of non-neosauropod eusauropods, which now includes five genera (Losillasaurus, Turiasaurus, Mierasaurus, Moabosaurus and Zby), was previously known only from the Jurassic of Europe. These recent discoveries in Utah suggest that turiasaurs as a lineage survived the Jurassic-Cretaceous extinction boundary and expanded their known range, at least, into western North America. The revised spatiotemporal distribution of turiasaurs is consistent with the presence of a land connection between North America and Europe sometime during the late Tithonian to Valanginian (c.147-133 Ma). Mierasaurus and Moabosaurus are the only non-neosauropod eusauropods known from North America, despite being younger than the classic neosauropods of the Morrison Formation (c.150 Ma)

Cell transformation assays for prediction of carcinogenic potential: State of the science and future research needs

Copyright @ 2011 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.Cell transformation assays (CTAs) have long been proposed as in vitro methods for the identification of potential chemical carcinogens. Despite showing good correlation with rodent bioassay data, concerns over the subjective nature of using morphological criteria for identifying transformed cells and a lack of understanding of the mechanistic basis of the assays has limited their acceptance for regulatory purposes. However, recent drivers to find alternative carcinogenicity assessment methodologies, such as the Seventh Amendment to the EU Cosmetics Directive, have fuelled renewed interest in CTAs. Research is currently ongoing to improve the objectivity of the assays, reveal the underlying molecular changes leading to transformation and explore the use of novel cell types. The UK NC3Rs held an international workshop in November 2010 to review the current state of the art in this field and provide directions for future research. This paper outlines the key points highlighted at this meeting

First comparison of French and Australian OsHV-1 µvars by bath exposure

Economically devastating mortality events of farmed and wild shellfish due to infectious disease have been reported globally. Currently, one of the most significant disease threats to Pacific oyster Crassostrea gigas culture is the ostreid herpesvirus 1 (OsHV-1), in particular the emerging OsHV-1 microvariant genotypes. OsHV-1 microvariants (OsHV-1 μvars) are spreading globally, and concern is high among growers in areas unaffected by OsHV-1. No study to date has compared the relative virulence among variants. We provide the first challenge study comparing survival of naïve juvenile Pacific oysters exposed to OsHV-1 μvars from Australia (AUS μvar) and France (FRA μvar). Oysters challenged with OsHV-1 μvars had low survival (2.5% exposed toAUS μvar and 10% to FRA μvar), and high viral copy number as compared to control oysters(100% survival and no virus detected). As our study was conducted in a quarantine facility located~320 km from the ocean, we also compared the virulence of OsHV-1 μvars using artificial seawater made from either facility tap water (3782 μmol kg−1seawater total alkalinity) or purchased distilled water (2003 μmol kg−1). Although no differences in survival or viral copy number were detected in oysters exposed to seawater made using tap or distilled water, more OsHV-1 was detected in tanks containing the lower-alkalinity seawater, indicating that water quality may be important for virus transmission, as it may influence the duration of viral viability outside of the hos

Aged-senescent cells contribute to impaired heart regeneration

Aging leads to increased cellular senescence and is associated with decreased potency of tissue-specific stem/progenitor cells. Here, we have done an extensive analysis of cardiac progenitor cells (CPCs) isolated from human subjects with cardiovascular disease, aged 32-86 years. In aged subjects (>70 years old), over half of CPCs are senescent (p16INK4A , SA-β-gal, DNA damage γH2AX, telomere length, senescence-associated secretory phenotype [SASP]), unable to replicate, differentiate, regenerate or restore cardiac function following transplantation into the infarcted heart. SASP factors secreted by senescent CPCs renders otherwise healthy CPCs to senescence. Elimination of senescent CPCs using senolytics abrogates the SASP and its debilitative effect in vitro. Global elimination of senescent cells in aged mice (INK-ATTAC or wild-type mice treated with D + Q senolytics) in vivo activates resident CPCs and increased the number of small Ki67-, EdU-positive cardiomyocytes. Therapeutic approaches that eliminate senescent cells may alleviate cardiac deterioration with aging and restore the regenerative capacity of the heart

ChemCam Science Objectives for the Mars Science Laboratory (MSL) Rover

ChemCam consists of two remote sensing instruments. One, a Laser-Induced Breakdown Spectroscopy (LIBS) instrument provides rapid elemental composition data on rocks and soils within 13 m of the rover. By using laser pulses, it can remove dust or profile through weathering layers remotely. The other instrument, the Remote Micro-Imager (RMI), provides the highest resolution images between 2 m and infinity. At approximately 80 Rad field of view, its resolution exceeds that of MER Pancam by at least a factor of four. The ChemCam instruments are described in a companion paper by Maurice et al. Here we present the science objectives for the ChemCam instrument package

Transplanting cells from old but not young donors causes physical dysfunction in older recipients.

Adipose-derived mesenchymal stem cell (ADSC)-based regenerative therapies have shown potential for use in many chronic diseases. Aging diminishes stem cell regenerative potential, yet it is unknown whether stem cells from aged donors cause adverse effects in recipients. ADSCs can be obtained using minimally invasive approaches and possess low immunogenicity. Nevertheless, we found that transplanting ADSCs from old donors, but not those from young donors, induces physical dysfunction in older recipient mice. Using single-cell transcriptomic analysis, we identified a naturally occurring senescent cell-like population in ADSCs primarily from old donors that resembles in vitro-generated senescent cells with regard to a number of key pathways. Our study reveals a previously unrecognized health concern due to ADSCs from old donors and lays the foundation for a new avenue of research to devise interventions to reduce harmful effects of ADSCs from old donors

Wax: A benign hydrogen-storage material that rapidly releases H2-rich gases through microwave-assisted catalytic decomposition

Hydrogen is often described as the fuel of the future, especially for application in hydrogen powered fuel-cell vehicles (HFCV’s). However, its widespread implementation in this role has been thwarted by the lack of a lightweight, safe, on-board hydrogen storage material. Here we show that benign, readily-available hydrocarbon wax is capable of rapidly releasing large amounts of hydrogen through microwave-assisted catalytic decomposition. This discovery offers a new material and system for safe and efficient hydrogen storage and could facilitate its application in a HFCV. Importantly, hydrogen storage materials made of wax can be manufactured through completely sustainable processes utilizing biomass or other renewable feedstocks

Estudo de caso : avaliação do impacto no desempenho e satisfação da força de trabalho com a reestruturação organizacional do departamento de gestão integrada (DGI) - UFRGS

A administração pública no Brasil é um tema bastante estudado e criticado por diversos autores, pois ainda está imersa em dúvidas acerca das melhores governanças, práticas de gestão e estruturas organizacionais que impactem positivamente o desempenho e, consequentemente, promova o crescimento e vigor dessas instituições. O setor da administração pública em nosso país é constantemente criticado pela disfunção da burocracia pertinente ao sistema, bem como a dificuldade de acompanhar as mudanças que são vivenciadas pelo setor privado, por exemplo. No presente trabalho, é realizado um estudo de caso no Departamento de Gestão Integrada (DGI) da PROPLAN – UFRGS (Universidade Federal do Rio Grande do Sul), que passou por mudanças na sua atuação e função como departamento perante a instituição. As modificações que foram propostas ao departamento podem ser divididas em dois campos. O primeiro em relação à orientação e função do departamento como um todo, que também influenciou uma mudança de mesmo teor em suas divisões internas. O segundo campo, pelo qual as modificações passaram, é o da força de trabalho, ou seja, pessoas. Em outras palavras, uma realocação de funções que promovesse um melhor aproveitamento das competências dos membros foi promovida. O presente estudo traça um paralelo entre o período anterior as modificações em contraste com o período após as modificações, verificando, junto ao departamento, questões ligadas ao desempenho e satisfação das pessoas que trabalham nesse espaço. Com os resultados, foi possível concluir que houve um aumento na satisfação geral dos membros, bem como aspectos relativos ao desempenho foram impactados positivamente pelas mudanças promovidas no DGI.Public administration in Brazil is a theme widely studied and criticized by authors in this area, because it stills immerged in doubts concerning the best managing practices, governance and organizational structures that impact positively the performance and, as a result, generate growth in this kind of institutions. The public administration sector in Brazil is constantly criticized by its burocracy disfunction related to the system it is involved, as well as a strong effort to be up to date with the changes that happen in the private sector of the economy. In this study, its presented a case study in the “Departamento de Gestão Integrada - (DGI)” which can be understood as the department responsible for the strategy deployment in the institution, that has been under several changes in its function an operation towards the university (Universidade Federal do Rio Grande do Sul – UFRGS). The changes on the department can be split in two, in order to be easily understood. The first is related to the orientation and function of the entire department, that influenced changes in its intern divisions. The second point in which the changes went through is people functions in the department. In other words, shifts in personal roles in the department aiming a better exploitation of each ones capacities and competences was implemented. This case study draws a parallel between the period before the changes and after them, verifying issues linked to the department’s overall performance and personal satisfaction with the role each person has in the organization. Analyzing the results, it was possible to conclude an increase in people satisfaction and aspects related to the department’s performance

Community-Based Field Experiences in Teacher Education: Possibilities for a pedagogical third space

This is the author's final draft. The published version may be found at: http://dx.doi.org/10.1080/10476210.2011.641528The present article discusses the importance of community-based field experiences as a feature of teacher education programs. Through a qualitative case study, prospective teachers’ work with homeless youth in an after-school initiative is presented. Framing community-based field experiences in teacher education through “third space” theory, the article discusses the value that such experiences have for prospective teachers’ learning. The goals of the article align with the commitment to preparing a future teaching force for the diverse educational settings that they will encounter in the twenty-first century