687 research outputs found
The periodic repolarization dynamics index identifies changes in ventricular repolarization oscillations associated with music-induced emotions
The effect of music on cardiovascular dynamics may be useful in a variety of clinical settings. The aim of this study was to assess whether listening to music characterized by different emotional valence affected ventricular periodic repolarization dynamics (PRD), a recently-proposed non-invasive index of sympathetic ventricular modulation. The 12 lead ECG was recorded in 71 healthy volunteers exposed to six 90 s excerpts of pleasant music and unpleasant acoustic stimuli as well as six 90 s intervals of silence. A 20 s interval was allowed between excerpts during which the participants were asked to evaluate the previous excerpt. A simulation study was carried out to assess the capability of the algorithm of tracking fast small changes in PRD. The simulation study shows that the algorithm implemented in this study has a time-frequency resolution sufficient to capture the fast dynamics observed in this study. PRD were higher during listening to both pleasant and unpleasant music than during silence. There was a (weak) trend for the PRD to be higher during listening to pleasant than unpleasant music that may indicate the existence of a (weak) interaction between the valence of music-induced emotions and sympathetic ventricular response. The PRD significantly increased during the 20 s interval in between conditions, possibly reflecting a sympathetic response to the evaluation task and/or to the expectation of the following excerpt
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Abnormal neural responses to harmonic syntactic structures in congenital amusia
Harmonic syntactic structures are organized hierarchically through local and long-distance dependencies. The present study investigated whether the processing of harmonic syntactic structures is impaired in congenital amusia, a neurodevelopmental disorder of pitch perception. Harmonic sequences containing two phrases were used as stimuli, in which the first phrase ended with a half cadence and the second with an authentic cadence. In Experiment 1, we manipulated the ending chord in the authentic cadence to be either syntactically regular or irregular. Sixteen amusics and 16 controls judged the expectedness of these chords while their EEG waveforms were recorded. In comparison to the regular endings, irregular endings elicited an ERAN, an N5 and a late positive component in controls but not in amusics, indicating that amusics were impaired in perceiving harmonic syntactic structures induced by local dependencies. In Experiment 2, we manipulated the half cadence of the harmonic sequences to examine the processing of harmonic syntactic structures induced by long-distance dependencies. An ERAN-like response and an N5 were elicited in controls but not in amusics, suggesting that amusics were impaired in processing long-distance syntactic dependencies. Furthermore, for controls, the neural processing of local and long-distance syntactic dependencies was correlated in the late (as indexed by the N5) but not in the early stage. These findings indicate that amusics are impaired in the detection of syntactic violations and subsequent harmonic integration. The implications of these findings in terms of hierarchical music-syntactic processing are discussed
Explicit action perception shares resources with music syntax: A controlled behavioral study
Given evidence that neural resources monitoring language syntax also underlie the perception of music syntax (Koelsch, 2005) and recently a proposed âsyntaxâ in sequential action (Fazio et al., 2009), a previous EEG study investigated whether neural resources may be shared between implicit perception of music and action (Sammler et al., 2010). Results yielded a syntactic-like ERP pattern elicited by the errors in sequential action, but no interaction of resources across the music and action domains. The present follow-up study sought behavioral signs of resource-overlap when perception is instead explicit. Five chords accompanied five reach-to-grasp images in a 2x2 factorial interference paradigm (target: regular/irregular cadence paired with correct/incorrect grasp). Results indeed revealed an interaction of resources which monitored the action and music sequences, manifested in task accuracy. A control experiment with accompanying pure tones instead of chords (standard/deviant final tone) did not, however, show the same interaction. Crucially, the null-result control study speaks to a neural resource involved in action perception that is shared only with syntactically organized sound, not a simple auditory distraction. This promising behavioral data warrants follow-up neuropsychological experimentation with explicit-task paradigms
The gray matter volume of the amygdala is correlated with the perception of melodic intervals: a voxel-based morphometry study
Music is not simply a series of organized pitches, rhythms, and timbres, it is capable of evoking emotions. In the present study, voxel-based morphometry (VBM) was employed to explore the neural basis that may link music to emotion. To do this, we identified the neuroanatomical correlates of the ability to extract pitch interval size in a music segment (i.e., interval perception) in a large population of healthy young adults (N = 264). Behaviorally, we found that interval perception was correlated with daily emotional experiences, indicating the intrinsic link between music and emotion. Neurally, and as expected, we found that interval perception was positively correlated with the gray matter volume (GMV) of the bilateral temporal cortex. More important, a larger GMV of the bilateral amygdala was associated with better interval perception, suggesting that the amygdala, which is the neural substrate of emotional processing, is also involved in music processing. In sum, our study provides one of first neuroanatomical evidence on the association between the amygdala and music, which contributes to our understanding of exactly how music evokes emotional responses
An Animal Model of Cutaneous Cyst Development Enables the Identification of Three Quantitative Trait Loci, Including the Homologue of a Human Locus (TRICY1)
Brief Summary Using inbred BN and LE/Stm rats susceptible and resistant, respectively, to chemically induced cutaneous cyst development we were able to further unveil the genetic architecture of inherited multiple cyst formation. N-methyl-N-nitrosourea-treated (BN x LE) F2 intercross rats proved to develop differential numbers of cutaneous cysts, demonstrating epidermal, trichilemmal and verrucous keratinization types. Male rats developed significantly more cysts per animal than females. QTL interval mapping yielded three loci on rat chromosomes 1, 8 and 11 (Ccd1, Ccd2, Ccd3) linked to cutaneous cyst formation. Ccd2 proved to be homologous to the human TRICY1 region which could further be narrowed down by genome comparison in both species. It contains 11 genes with evidence of expression in human keratinocytes.Non peer reviewe
The impact of music on learning and consolidation of novel words
Music can be a powerful mnemonic device, as shown by a body of literature demonstrating that listening to text sung to a familiar melody results in better memory for the words compared to conditions where they are spoken. Furthermore, patients with a range of memory impairments appear to be able to form new declarative memories when they are encoded in the form of lyrics in a song, while unable to remember similar materials after hearing them in the spoken modality. Whether music facilitates the acquisition of completely new information, such as new vocabulary, remains unknown. Here we report three experiments in which adult participants learned novel words in the spoken or sung modality. While we found no benefit of musical presentation on free recall or recognition memory of novel words, novel words learned in the sung modality were more strongly integrated in the mental lexicon compared to words learned in the spoken modality. This advantage for the sung words was only present when the training melody was familiar. The impact of musical presentation on learning therefore appears to extend beyond episodic memory and can be reflected in the emergence and properties of new lexical representations
Development of Standard Methods to Estimate Manure Production and Nutrient Characteristics From Dairy Cattle
Total collection data from many universities were pooled for statistical analyses to evaluate existing data from dairy animals and determine if one or more modifications were needed for Standard Table D384.1. Many of these studies were carried out to evaluate nutritional characteristics associated with different diets. The data collected were sufficient to evaluate total manure, total and volatile solids, and N excretion values. Some experiments had sufficient number of samples analyzed to evaluate P, K, Ca, Mg, Na, Cl, S, and micro-elements. Statistical analyses were conducted to determine if a single column value was appropriate and define the regression equations necessary to estimate excretions if the assumptions of the column inputs were not met. The results indicate that separate classifications are needed for replacement heifers and mature animals. Final classifications for replacement heifers included: milk fed calves, weaned calves weighing less than 274 kg, heifers weighing between 273 and 613 kg, and veal calves. Additionally, classifications for lactating and dry animals are needed. Previously, the estimates for manure production and nutrient excretion were based on body weight. These findings indicate that a better predictor for lactating cattle is daily milk production instead of body weight. Milk production drives feed intake in the lactating animal. It is most appropriate that estimated manure and nutrient excretion values reflect the relationship between feed intake, milk production (nutrient utilization) and nutrient excretion
Effects of Aesthetic Chills on a Cardiac Signature of Emotionality
Previous studies have shown that a cardiac signature of emotionality (referred
to as EK, which can be computed from the standard 12 lead electrocardiogram,
ECG), predicts inter-individual differences in the tendency to experience and
express positive emotion. Here, we investigated whether EK values can be
transiently modulated during stimulation with participant-selected music
pieces and film scenes that elicit strongly positive emotion. The phenomenon
of aesthetic chills, as indicated by measurable piloerection on the forearm,
was used to accurately locate moments of peak emotional responses during
stimulation. From 58 healthy participants, continuous EK values, heart rate,
and respiratory frequency were recorded during stimulation with film scenes
and music pieces, and were related to the aesthetic chills. EK values, as well
as heart rate, increased significantly during moments of peak positive emotion
accompanied by piloerection. These results are the first to provide evidence
for an influence of momentary psychological state on a cardiac signature of
emotional personality (as reflected in EK values). The possibility to modulate
ECG amplitude signatures via stimulation with emotionally significant music
pieces and film scenes opens up new perspectives for the use of emotional peak
experiences in the therapy of disorders characterized by flattened
emotionality, such as depression or schizoid personality disorder
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