The Unique Frequency Spectrum of the Blazhko RRc Star LS Her

The Blazhko effect in RR Lyrae stars is still poorly understood theoretically. Stars with multiple Blazhko periods or in which the Blazhko effect itself varies are particularly challenging. This study investigates the Blazhko effect in the RRc star LS Her. Detailed VRI CCD photometry has been performed on 63 nights during six months. LS Her is confirmed to have a Blazhko period of 12.75+/-0.02 days. However, where normally the side frequencies of the Blazhko triplet are expected, an equidistant group of three frequencies is found on both sides of the main pulsation frequency. As a consequence the period and amplitude of the Blazhko effect itself vary in a cycle of 109+/-4 days. LS Her is a unique object turning out to be very important in the verification of the theories for the Blazhko effect.Comment: Accepted for publication in MNRA

The Mid-Infrared Instrument for the James Webb Space Telescope, III: MIRIM, The MIRI Imager

In this article, we describe the MIRI Imager module (MIRIM), which provides broad-band imaging in the 5 - 27 microns wavelength range for the James Webb Space Telescope. The imager has a 0"11 pixel scale and a total unobstructed view of 74"x113". The remainder of its nominal 113"x113" field is occupied by the coronagraphs and the low resolution spectrometer. We present the instrument optical and mechanical design. We show that the test data, as measured during the test campaigns undertaken at CEA-Saclay, at the Rutherford Appleton Laboratory, and at the NASA Goddard Space Flight Center, indicate that the instrument complies with its design requirements and goals. We also discuss the operational requirements (multiple dithers and exposures) needed for optimal scientific utilization of the MIRIM.Comment: 29 pages, 9 figure

Variable turbulent convection as the cause of the Blazhko effect - testing the Stothers model

The amplitude and phase modulation observed in a significant fraction of the RR Lyrae variables - the Blazhko effect - represents a long-standing enigma in stellar pulsation theory. No satisfactory explanation for the Blazhko effect has been proposed so far. In this paper we focus on the Stothers (2006) idea, in which modulation is caused by changes in the structure of the outer convective zone, caused by a quasi-periodically changing magnetic field. However, up to this date no quantitative estimates were made to investigate whether such a mechanism can be operational and whether it is capable of reproducing the light variation we observe in Blazhko variables. We address the latter problem. We use a simplified model, in which the variation of turbulent convection is introduced into the non-linear hydrodynamic models in an ad hoc way, neglecting interaction with the magnetic field. We study the light curve variation through the modulation cycle and properties of the resulting frequency spectra. Our results are compared with Kepler observations of RR Lyr. We find that reproducing the light curve variation, as is observed in RR Lyr, requires a huge modulation of the mixing length, of the order of +/-50 per cent, on a relatively short time-scale of less than 40 days. Even then, we are not able to reproduce neither all the observed relations between modulation components present in the frequency spectrum, nor the relations between Fourier parameters describing the shape of the instantaneous light curves.Comment: 17 pages, 13 figures, accepted for publication in MNRAS; for associated animation, see http://homepage.univie.ac.at/radek.smolec/publications/KASC11a

Survival following coronary angioplasty versus coronary artery bypass surgery in anatomic subsets in which coronary artery bypass surgery improves survival compared with medical therapy Results from the Bypass Angioplasty Revascularization Investigation (BARI)

AbstractOBJECTIVESWe sought to compare survival after coronary artery bypass graft (CABG) and percutaneous transluminal coronary angioplasty (PTCA) in high-risk anatomic subsets.BACKGROUNDCompared with medical therapy, CABG decreases mortality in patients with three-vessel disease and two-vessel disease involving the proximal left anterior descending artery (LAD), particularly if left ventricular (LV) dysfunction is present. How survival after PTCA and CABG compares in these high-risk anatomic subsets is unknown.METHODSIn the Bypass Angioplasty Revascularization Investigation (BARI), 1,829 patients with multivessel disease were randomized to an initial strategy of PTCA or CABG between 1988 and 1991. Stents and IIb/IIIa inhibitors were not utilized. Since patients in BARI with diabetes mellitus had greater survival with CABG, separate analyses of patients without diabetes were performed.RESULTSSeven-year survival among patients with three-vessel disease undergoing PTCA and CABG (n = 754) was 79% versus 84% (p = 0.06), respectively, and 85% versus 87% (p = 0.36) when only non-diabetics (n = 592) were analyzed. In patients with three-vessel disease and reduced LV function (ejection fraction <50%), seven-year survival was 70% versus 74% (p = 0.6) in all PTCA and CABG patients (n = 176), and 82% versus 73% (p = 0.29) among non-diabetic patients (n = 124). Seven-year survival was 87% versus 84% (p = 0.9) in all PTCA and CABG patients (including diabetics) with two-vessel disease involving the proximal LAD (n = 352), and 78% versus 71% (p = 0.7) in patients with two-vessel disease involving the proximal LAD with reduced LV function (n = 72).CONCLUSIONIn high–risk anatomic subsets in which survival is prolonged by CABG versus medical therapy, revascularization by PTCA and CABG yielded equivalent survival over seven years

The infrared JHK light curves of RR Lyr

We present infrared JHK time series photometry of the variable star RR Lyr, that allow us to construct the first complete and accurate infrared light curves for this star. The derived mean magnitudes are =6.74 +/- 0.02, =6.60 +/- 0.03 and =6.50 +/- 0.02. The magnitude is used to estimate the reddening, the mass, the mean luminosity and temperature of this variable star. The use of these RR Lyr data provide a more accurate absolute calibration of the P-L_K-[Fe/H] relation, and a distance modulus (m-M)_0=18.48 +/- 0.11 to the globular cluster Reticulum in the LMC.Comment: 6 pages, 2 figures, accepted for publication by MNRA

MAGE-A cancer/testis antigens inhibit MDM2 ubiquitylation function and promote increased levels of MDM4

Melanoma antigen A (MAGE-A) proteins comprise a structurally and biochemically similar sub-family of Cancer/Testis antigens that are expressed in many cancer types and are thought to contribute actively to malignancy. MAGE-A proteins are established regulators of certain cancer-associated transcription factors, including p53, and are activators of several RING finger-dependent ubiquitin E3 ligases. Here, we show that MAGE-A2 associates with MDM2, a ubiquitin E3 ligase that mediates ubiquitylation of more than 20 substrates including mainly p53, MDM2 itself, and MDM4, a potent p53 inhibitor and MDM2 partner that is structurally related to MDM2. We find that MAGE-A2 interacts with MDM2 via the N-terminal p53-binding pocket and the RING finger domain of MDM2 that is required for homo/hetero-dimerization and for E2 ligase interaction. Consistent with these data, we show that MAGE-A2 is a potent inhibitor of the E3 ubiquitin ligase activity of MDM2, yet it does not have any significant effect on p53 turnover mediated by MDM2. Strikingly, however, increased MAGE-A2 expression leads to reduced ubiquitylation and increased levels of MDM4. Similarly, silencing of endogenous MAGE-A expression diminishes MDM4 levels in a manner that can be rescued by the proteasomal inhibitor, bortezomid, and permits increased MDM2/MDM4 association. These data suggest that MAGE-A proteins can: (i) uncouple the ubiquitin ligase and degradation functions of MDM2; (ii) act as potent inhibitors of E3 ligase function; and (iii) regulate the turnover of MDM4. We also find an association between the presence of MAGE-A and increased MDM4 levels in primary breast cancer, suggesting that MAGE-A-dependent control of MDM4 levels has relevance to cancer clinically

Functional Magnetic Resonance Imaging in Conscious Animals: A New Tool in Behavioural Neuroscience Research

Functional magnetic resonance imaging (fMRI) is a unique window to the brain, enabling scientists to follow changes in brain activity in response to hormones, ageing, environment, drugs of abuse and other stimuli. In this review, we present a general background to fMRI and the different imaging modalities that can be used in fMRI studies. Included are examples of the application of fMRI in behavioural neuroscience research, along with discussion of the advantages and disadvantages of this technology

JWST/MIRI coronagraphic performances as measured on-sky

Characterization of directly imaged exoplanets is one of the most eagerly anticipated science functions of the James Webb Space Telescope. MIRI, the mid-IR instrument has the capability to provide unique spatially resolved photometric data points in a spectral range never achieved so far for such objects. We aim to present the very first on-sky contrast measurements of the MIRI's coronagraphs. In addition to a classical Lyot coronagraph at the longest wavelength, this observing mode implements the concept of the four quadrant phase mask for the very first time in a space telescope. We observed single stars together with a series of reference stars to measure raw contrasts as they are delivered on the detector, as well as reference subtracted contrasts. MIRI's coronagraphs achieve raw contrasts greater than $10^3$ at the smallest angular separations (within $1''$) and about $10^5$ further out (beyond $5\sim6''$). Subtracting the residual diffracted light left unattenuated by the coronagraph has the potential to bring the final contrast down to the background and detector limited noise floor at most angular separations (a few times $10^4$ at less than $1''$). MIRI coronagraphs behave as expected from simulations. In particular the raw contrasts for all four coronagraphs are fully consistent with the diffractive model. Contrasts obtained with subtracting reference stars also meet expectations and are fully demonstrated for two four quadrant phase masks (F1065C and F1140C). The worst contrast, measured at F1550C, is very likely due to a variation of the phase aberrations at the primary mirror during the observations, and not an issue of the coronagraph itself. We did not perform reference star subtraction with the Lyot mask at F2300C, but we anticipate that it would bring the contrast down to the noise floor.Comment: submitted to A&