НОВЫЙ ВИД РОДА PELIOSANTHES (ASPARAGACEAE) ИЗ ВЬЕТНАМА

A new species, Peliosanthes micrantha (Asparagaceae, incl. Convallariaceae s. str.) is described and illustrated. Description of this local endemic is accompanied with a standard citation of type specimen, morphological diagnosis, etymology of specific epithet, data on ecology and distribution, and a short taxonomic remark.В статье приведено иллюстрированное описание узкоэндемичного вида – Peliosanthes micrantha (Asparagaceae, incl. Convallariaceae s. str.), сопровождающееся краткими сведениями о типе, этимологии видового названия, экологии, распространении и его родстве

New approaches to the implementation of state regulation

© Medwell Journals, 2017. The method of forecasting the results of the industrial enterprise activity functioning in the conditions of new paternalistic economy is worked out. This method is based on the assessment of current results of this activity on the existing tendencies of development, dynamics of macroenvironment of the economic entity and also a complex assessment of current state and prospects of development of the enterprise. All this have found their application in scenario forecasting the results of the activity of the enterprises of the Russian industrial complex

Delayed clusters accompanying nonmesonic weak decay of the Λ\Lambda-hypernuclei: a clue to nonleptonic processes

The nonmesonic decay of $\Lambda$-hypernuclei provides access to the nonleptonic weak decay process $\Lambda N \to NN$, which is achievable only through the observation of hypernuclear ground-state decays. We continue the discussion of some specific cases which make it possible to detect a few exclusive transitions, namely, the stripping of nucleon from the ground state results in a resonance state decaying via emission of two clusters. Delayed clusters accompanying weak decay of light hypernuclei give a unique information on spin dependence of the weak decay matrix elements.Comment: Presented at International Bogolyubov Conference "Problems of Theoretical and Mathematical Physics" (dedicated to the 100th anniversary of the birth of N.N.~Bogolyubov) Dubna, Russia, August 21 - 27, 200

Genetic homogenisation of two major orchid viruses through global trade‐based dispersal of their hosts

Orchid viruses are capable of causing flower deformities and death, which can se‐ verely impact the horticultural industry and wild orchid conservation. Here we show how two of these quickly evolving viruses display few genetic differences since their first emergence, across countries and host plants. This is concerning as, despite bios‐ ecurity regulations to control the movement of orchids and their related pathogens, these patterns are suggestive of rapid and regular international movement of horti‐ cultural material. Poor biosecurity practices could threaten the orchid horticultural industry and result in the accidental translocation or reintroduction of infected plant material intended to recover wild populations

Аспекты патогенеза эмфиземы легких у больных ХОБЛ

Histological and immunohistochemical investigations of lung tissue specimens were performed in 9 patients with COPD underwent lung volume reduction surgery. Lung tissue specimens of died persons without lung and heart pathology were as controls. Tissue expressions of endothelial growth factor (EGF), type 9 matrix metalloproteinase, type 1 matrix metalloproteinase (TIMP-1) tissue inhibitor, and transforming growth factor β1 (TGF β-1) have been studied. Patents with severe emphysema typically had focal interstitial fibrosis, interalveolar septa infiltrated with interstitial macrophages and lymphocytes, hypertrophy of media and proliferation of intima in the vascular wall, and arteriolar muscularization. There was significantly higher expression of EGF and TIMM-1 in the lung tissue of these patients compared with controls; this could confirm the presence of compensatory mechanisms of lung parenchyma destruction. Strong correlations were found between expression of EGF and TGF β-1, EGF and TIMP-1 which demonstrated a relationship between angiogenesis, proteolysis and fibrogenesis in development of emphysema.Проведено патогистологическое и иммуногистохимическое исследование ткани легких 9 больных ХОБЛ, подвергшихся хирургической редукции объема легких. В качестве сравнения использовались кусочки легких умерших насильственной смертью без патологии легких и сердца. Изучалась тканевая экспрессия фактора роста эндотелия (ЭФР), матриксной металлопротеиназы 9-го типа, тканевого ингибитора металлопротеиназ 1-го типа (ТИМП-1), трансформирующего фактора роста β-1 (ТФР β-1). Установлено, что для больных тяжелой эмфиземой легких характерны очаговый интерстициальный фиброз, инфильтрация межальвеолярных перегородок альвеолярными макрофагами и лимфоцитами, изменения сосудов с гипертрофией медии, пролиферацией интимы, мускуляризацией артериол. В ткани легких больных тяжелой эмфиземой наблюдалась достоверно более высокая экспрессия ЭФР и ТИМП-1, чем в группе контроля, что подтверждает существование механизмов компенсации деструктивных процессов паренхимы легких. Обнаружены сильные прямые корреляционные связи между экспрессией ЭФР с ТФР β-1 и ЭФР с ТИМП-1, свидетельствующие о зависимости процессов ангиогенеза, протеолиза и фиброгенеза в патогенезе эмфиземы

Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study

We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts. A total of 1141 respiratory physicians and 34 IPF experts participated. Participants evaluated 60 cases of interstitial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (\u3baw). Prognostic discrimination between IPF and other ILDs was used to validate diagnostic accuracy for first-choice diagnoses of IPF and were compared using the Cindex. A total of 404 physicians completed the study. Agreement for IPF diagnosis was higher among expert physicians (\u3baw=0.65, IQR 0.53-0.72, p20 years of experience (C-index=0.72, IQR 0.0-0.73, p=0.229) and non-university hospital physicians with more than 20 years of experience, attending weekly MDT meetings (C-index=0.72, IQR 0.70-0.72, p=0.052), did not differ significantly (p=0.229 and p=0.052 respectively) from the expert panel (C-index=0.74 IQR 0.72-0.75). Experienced respiratory physicians at university-based institutions diagnose IPF with similar prognostic accuracy to IPF experts. Regular MDT meeting attendance improves the prognostic accuracy of experienced non-university practitioners to levels achieved by IPF experts

Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials.

Funder: laura and john arnold foundationBACKGROUND: Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, https://doi.org/10.17605/OSF.IO/GEHFX ). METHODS: In this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the Hartung-Knapp-Sidik-Jonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence. RESULTS: A total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 published with 13,287 patients). 32 trials enrolled only hospitalized patients (including 3 with only intensive care unit patients). Risk of bias was low for 29/33 trials. Of 8495 patients who received convalescent plasma, 1997 died (23%), and of 7982 control patients, 1952 died (24%). The combined risk ratio for all-cause mortality was 0.97 (95% confidence interval: 0.92; 1.02) with between-study heterogeneity not beyond chance (I2 = 0%). The RECOVERY trial had 69.8% and the unpublished evidence 25.3% of the weight in the meta-analysis. CONCLUSIONS: Convalescent plasma treatment of patients with COVID-19 did not reduce all-cause mortality. These results provide strong evidence that convalescent plasma treatment for patients with COVID-19 should not be used outside of randomized trials. Evidence synthesis from collaborations among trial investigators can inform both evidence generation and evidence application in patient care