HH 223: a parsec-scale H2 outflow in the star-forming region L723

The dark cloud Lynds 723 (L723) is a low-mass star-forming region where one of the few known cases of a quadrupolar CO outflow has been reported. Two recent works have found that the radio continuum source VLA 2, towards the centre of the CO outflow, is actually a multiple system of young stellar objects (YSOs). Several line-emission nebulae that lie projected on the east-west CO outflow were detected in narrow-band Halpha and [SII] images. The spectra of the knots are characteristic of shock-excited gas (Herbig-Haro spectra), with supersonic blueshifted velocities, which suggests an optical outflow also powered by the VLA 2 YSO system of L723. We imaged a field of ~5' X 5' centred on HH 223, which includes the whole region of the quadrupolar CO outflow with nir narrow-band filters . The H2 line-emission structures appear distributed over a region of 5.5' (0.5 pc for a distance of 300 pc) at both sides of the VLA 2 YSO system, with an S-shape morphology, and are projected onto the east-west CO outflow. Most of them were resolved in smaller knotty substructures. The [FeII] emission only appears associated with HH 223. An additional nebular emission from the continuum in Hc and Kc appears associated with HH 223-K1, the structure closest to the VLA 2 YSO system, and could be tracing the cavity walls. We propose that the H2 structures form part of a large-scale near-infrared outflow, which is also associated with the VLA 2 YSO system. The current data do not allow us to discern which of the YSOs of VLA 2 is powering this large scale optical/near-infrared outflow.Comment: Accepted for A&A http://dx.doi.org/10.1051/0004-6361/201015125 12 pages, 9 figure

V-Shape Liquid Crystal-Based Retromodulator Air to Ground Optical Communications

This paper describes the use of a 2D liquid crystal retro-modulator as a free space, wireless, optical link. The retro-modulator is made up of a retro-reflecting cornercube onto which 2 cascaded V-shape smectics liquid crystal modulators are mounted. The communication link differs with respect to more conventional optical links in not using amplitude (nor frequency) modulation, but instead state-of-polarisation (SOP) modulation known as Polarisation Shift Keying (PolSK). PolSK has the advantage over amplitude modulation, that it is less sensitive to changes in the visibility of the atmosphere, and increases inherently the bandwidth of the link. The implementation of PolSK both in liquid crystal based and in retro-modulated communication are novelties

Supersymmetric spin chains with nonmonotonic dispersion relation: criticality and entanglement entropy

We study the critical behavior and the ground-state entanglement of a large class of su(1|1) supersymmetric spin chains with a general (not necessarily monotonic) dispersion relation. We show that this class includes several relevant models, with both short-and long-range interactions of a simple form. We determine the low temperature behavior of the free energy per spin, and deduce that the models considered have a critical phase in the same universality class as a (1 + 1)-dimensional conformal field theory (CFT) with central charge equal to the number of connected components of the Fermi sea. We also study the Renyi entanglement entropy of the ground state, deriving its asymptotic behavior as the block size tends to infinity. In particular, we show that this entropy exhibits the logarithmic growth characteristic of (1 + 1)-dimensional CFTs and one-dimensional (fermionic) critical lattice models, with a central charge consistent with the low-temperature behavior of the free energy. Our results confirm the widely believed conjecture that the critical behavior of fermionic lattice models is completely determined by the topology of their Fermi surface

A duality principle for the multi-block entanglement entropy of free fermion systems

The analysis of the entanglement entropy of a subsystem of a one-dimensional quantum system is a powerful tool for unravelling its critical nature. For instance, the scaling behaviour of the entanglement entropy determines the central charge of the associated Virasoro algebra. For a free fermion system, the entanglement entropy depends essentially on two sets, namely the set A of sites of the subsystem considered and the set K of excited momentum modes. In this work we make use of a general duality principle establishing the invariance of the entanglement entropy under exchange of the sets A and K to tackle complex problems by studying their dual counterparts. The duality principle is also a key ingredient in the formulation of a novel conjecture for the asymptotic behavior of the entanglement entropy of a free fermion system in the general case in which both sets A and K consist of an arbitrary number of blocks. We have verified that this conjecture reproduces the numerical results with excellent precision for all the configurations analyzed. We have also applied the conjecture to deduce several asymptotic formulas for the mutual and r-partite information generalizing the known ones for the single block case

Integral Field Spectroscopy Of The Brightest Knots Of Hh 223 In L723

HH 223 is the optical counterpart of a larger scale H2 outflow, driven by the protostellar source VLA 2A, in L723. Its poorly collimated and rather chaotic morphology suggested the Integral Field Spectroscopy (IFS) as an appropriate option to map the emission for deriving the physical conditions and the kinematics. Here we present new results based on the IFS observations made with the INTEGRAL system at the WHT. The brightest knots of HH 223 (\sim16 arcsec, 0.02 pc at a distance of 300 pc) were mapped with a single pointing in the spectral range 6200-7700 A. We obtained the emission-line intensity maps for Halpha, [NII] 6584 A and [SII] 6716, 6731 A, and explored the distribution of the excitation and electron density from [NII]/Halpha, [SII]/Halpha, and [SII] 6716/6731 line-ratio maps. Maps of the radial velocity field were obtained. We analysed the 3D-kinematics by combining the knot radial velocities, derived from IFS data, with the knot proper motions derived from multi-epoch, narrow-band images. The intensity maps built from IFS data reproduced well the morphology found in the narrow-band images. We checked the results obtained from previous long-slit observations with those derived from IFS spectra extracted with a similar spatial sampling. At the positions intersected by the slit, the physical conditions and kinematics derived from IFS are compatible with those derived from long-slit data. In contrast, significant discrepancies were found when the results from long-slit data were compared with the ones derived from IFS spectra extracted at positions shifted a few arcsec from those intersected by the slit. This clearly revealed IFS observations as the best choice to get a reliable picture of the HH emission properties.Comment: 9 pages, 8 figures; Accepted for MNRA

The nature of HH 223 from long-slit spectroscopy

HH 223 is a knotty, wiggling nebular emission of ~30" length found in the L723 star-forming region. It lies projected onto the largest blueshifted lobe of the cuadrupolar CO outflow powered by a low-mass YSO system embedded in the core of L723. We analysed the physical conditions and kinematics along HH 223 with the aim of disentangling whether the emission arises from shock-excited, supersonic gas characteristic of a stellar jet, or is only tracing the wall cavity excavated by the CO outflow. We performed long-slit optical spectroscopy along HH 223, crossing all the bright knots (A to E) and part of the low-brightness emission nebula (F filament). One spectrum of each knot, suitable to characterize the nature of its emission, was obtained. The physical conditions and the radial velocity of the HH 223 emission along the slits were also sampled at smaller scale (0.6") than the knot sizes. {The spectra of all the HH 223 knots appear as those of the intermediate/high excitation Herbig-Haro objects. The emission is supersonic, with blueshifted peak velocities ranging from -60 to -130 km/s. Reliable variations in the kinematics and physical conditions at smaller scale that the knot sizes are also found. The properties of the HH 223 emission derived from the spectroscopy confirm the HH nature of the object, the supersonic optical outflow most probably also being powered by the YSOs embedded in the L723 core.Comment: A&A accepte

Disulfide Engineered Lipase to Enhance the Catalytic Activity: A Structure-Based Approach on BTL2

Enhancement, control, and tuning of hydrolytic activity and specificity of lipases are major goals for the industry. Thermoalkaliphilic lipases from the I.5 family, with their native advantages such as high thermostability and tolerance to alkaline pHs, are a target for biotechnological applications. Although several strategies have been applied to increase lipases activity, the enhancement through protein engineering without compromising other capabilities is still elusive. Lipases from the I.5 family suffer a unique and delicate double lid restructuration to transition from a closed and inactive state to their open and enzymatically active conformation. In order to increase the activity of the wild type Geobacillus thermocatenulatus lipase 2 (BTL2) we rationally designed, based on its tridimensional structure, a mutant (ccBTL2) capable of forming a disulfide bond to lock the open state. ccBTL2 was generated replacing A191 and F206 to cysteine residues while both wild type C64 and C295 were mutated to serine. A covalently immobilized ccBTL2 showed a 3.5-fold increment in esterase activity with 0.1% Triton X-100 (2336 IU mg-1) and up to 6.0-fold higher with 0.01% CTAB (778 IU mg-1), both in the presence of oxidizing sulfhydryl agents, when compared to BTL2. The remarkable and industrially desired features of BTL2 such as optimal alkaliphilic pH and high thermal stability were not affected. The designed disulfide bond also conferred reversibility to the enhancement, as the increment on activity observed for ccBTL2 was controlled by redox pretreatments. MD simulations suggested that the most stable conformation for ccBTL2 (with the disulfide bond formed) was, as we predicted, similar to the open and active conformation of this lipase.Financial and logistic support from Colombian Universidad del Valle and COLCIENCIAS (CI 71083-Grant 745-2016-Project 110671250425), Spanish CICYT project BIO-2005-6018576, BFU2017-90030-P, and BFU2011-25326, B. Di G. In addition, thanks to the Spanish MINECO for a FPU fellowship.S

First principles calculations of the atomic and electronic structure of F centers in bulk and on the (001) surface of SrTiO3

The atomic and electronic structure, formation energy, and the energy barriers for migration have been calculated for the neutral O vacancy point defect F center in cubic SrTiO3 employing various implementations of density functional theory DFT. Both bulk and TiO2-terminated 001 surface F centers have been considered. Supercells of different shapes containing up to 320 atoms have been employed. The limit of an isolated single oxygen vacancy in the bulk corresponds to a 270-atom supercell, in contrast to commonly used supercells containing 40–80 atoms. Calculations carried out with the hybrid B3PW functional show that the F center level approaches the conduction band bottom to within 0.5 eV, as the supercell size increases up to 320 atoms. The analysis of the electronic density maps indicates, however, that this remains a small-radius center with the two electrons left by the missing O ion being redistributed mainly between the vacancy and the 3d z2 atomic orbitals of the two nearest Ti ions. As for the dynamical properties, the calculated migration energy barrier in the low oxygen depletion regime is predicted to be 0.4 eV. In contrast, the surface F center exhibits a more delocalized character, which leads to significantly reduced ionization and migration energies. Results obtained are compared with available experimental data

Safety of assisted reproductive techniques in young women harboring germline pathogenic variants in BRCA1/2 with a pregnancy after prior history of breast cancer

Breast cancer fertility; Pregnancy; SurvivalFertilidad y cáncer de mama; Embarazo; SupervivenciaFertilitat i càncer de mama; Embaràs; SupervivènciaBackground Knowledge is growing on the safety of assisted reproductive techniques (ART) in cancer survivors. No data exist, however, for the specific population of breast cancer patients harboring germline BRCA1/2 pathogenic variants. Patients and methods This is a multicenter retrospective cohort study across 30 centers worldwide including women diagnosed at ≤40 years with stage I-III breast cancer, between January 2000 and December 2012, harboring known germline BRCA1/2 pathogenic variants. Patients included in this analysis had a post-treatment pregnancy either achieved through use of ART (ART group) or naturally (non-ART group). ART procedures included ovulation induction, ovarian stimulation for in vitro fertilization or intracytoplasmic sperm injection, and embryo transfer under hormonal replacement therapy. Results Among the 1424 patients registered in the study, 168 were eligible for inclusion in the present analysis, of whom 22 were in the ART group and 146 in the non-ART group. Survivors in the ART group conceived at an older age compared with those in the non-ART group (median age: 39.7 versus 35.4 years, respectively). Women in the ART group experienced more delivery complications compared with those in the non-ART group (22.1% versus 4.1%, respectively). No other apparent differences in obstetrical outcomes were observed between cohorts. The median follow-up from pregnancy was 3.4 years (range: 0.8-8.6 years) in the ART group and 5.0 years (range: 0.8-17.6 years) in the non-ART group. Two patients (9.1%) in the ART group experienced a disease-free survival event (specifically, a locoregional recurrence) compared with 40 patients (27.4%) in the non-ART group. In the ART group, no patients deceased compared with 10 patients (6.9%) in the non-ART group. Conclusion This study provides encouraging safety data on the use of ART in breast cancer survivors harboring germline pathogenic variants in BRCA1/2, when natural conception fails or when they opt for ART in order to carry out preimplantation genetic testing.The present work was supported by the Italian Association for Cancer Research (‘Associazione Italiana per la Ricerca sul Cancro’, AIRC; MFAG 2020 ID 24698) and the Italian Ministry of Health (5 × 1000 funds 2017). MC and ID acknowledge the Fonds National de la Recherche Scientifique (FNRS and Télévie 7.6508.20) and Fonds Erasme for their financial support

Taller metalúrgico de fines del bronce en Guadix (Granada): contribución a la contextualización de las fibulas de codo tipo Huelva en Andalucía Oriental

This paper exposes partially the excavation carried out in a property of the street San Miguel of Guadix (Granada). Sorne remains of ovens connected with metallurgic activities and related to archaeological context of the Final Bronze Age were discovered. The relation between pottery and metallurgy, and the appearance of an 'elbow' type fibulae Huelva type allows to enlarge toward the Granadine Highplateau the great importance of metallurgy from the Vega de Granada at the end of the prehistory.Este trabajo expone parcialmente la excavación realizada en una finca de la calle San Miguel de Guadix. En ella se hallaron restos estructurales de hornos relacionados con actividades metalúrgicas propias de un contexto arqueológico del Bronce Final. La conexión de restos cerámicos y metálicos, junto a una fibula de codo tipo Huelva, permite ampliar hacia las altiplanicies granadinas la importancia metalúrgica de la Vega de Granada a fines de la prehistoria