Emoterapia

Treball Final de Grau en Comunicació Audiovisual. Codi: Curs: 2013/2014Emoterapia es un cortometraje de ficción que se ha realizado para sensibilizar a la sociedad de las consecuencias negativas de las nuevas tecnologías (TIC) en las relaciones interpersonales. Su finalidad es múltiple: criticar la necesidad del uso constante de las TIC, concienciar a la sociedad de sus efectos nocivos y denunciar el doble rasero existente respecto a dicho tema. Mediante una idea y su posterior desarrollo en guión, el proyecto fue creciendo hasta convertirse en una obra audiovisual en la que se criticaba abiertamente la adicción a las TICs en general y al WhatsApp en particular por parte de un gran estrato de la sociedad. Esta pequeña investigación, a la que apunta -como demanda- el cortometraje en tono de comedia, es vital para poder mejorar como sociedad y continuar avanzando hacia el futuro, en una época en la que las TICs dominan el panorama comunicativo.Emoterapia is a fiction short film, which has been created to heighten the awareness in society about the negative consequences of the new technologies (ITCs) in the interpersonal relationships. Its finality is multiple: critic the need of constant use of ITCs, concienciate the society about its bad effects and denounce the double standard existing about this topic. Thanks to an idea and its later development into a screenplay, the project was rounded out until it became an audiovisual project where the ITCs addition in general and to WhatsApp in particular by a wide part of the society are openly critiqued. This small research, pointed to –as it is required- the short film in a humorous tone, is vital to be able to improve as a society and to continue moving forwards towards the future, in period in ITCs dominate the communicative world

Discourses of Inclusion and Diversity among Educators of the Municipal Network of Early Childhood Education Schools in Vitoria-Gasteiz

[ES] En este artículo, se presenta un análisis de los discursos en torno a la inclusión compartidos por las educadoras de la Red Municipal de Escuelas Infantiles (RMEI) de Vitoria-Gasteiz a lo largo de las distintas fases de un proceso de investigación acción en que participaron para elaborar el documento base (DB) para su nuevo Proyecto Educativo (PE). El objetivo del artículo es analizar cualitativamente las actitudes y percepciones de las educadoras hacia la educación inclusiva y la diversidad, que emanan de los discursos compartidos en las reflexiones grupales. Los resultados del análisis muestran que en los discursos de las educadoras aparecen seis líneas temáticas relativas a la educación inclusiva y la diversidad: una escuela en la que prima la acogida y el acompañamiento; escuela para todas y todos; centrada en el desarrollo integral y personalizado de la niña o el niño; con espacios, materiales y tiempos pensados para los niños y las niñas; formada por un equipo educativo comprometido, coordinado y preparado para responder a la diversidad; y, finalmente, abierta a las familias y la comunidad. En la discusión se hace hincapié en la importancia de incluir estos aspectos en la formación inicial y permanente del profesorado.[EN] In this article, the analysis of the discourses around inclusion shared by the educators of the Municipal Network of Early Childhood Education Schools in Vitoria-Gasteiz is presented. The purpose of this article to make a qualitative analysis on the educators’ attitudes and perceptions, considering inclusive education and diversity, issued from the shared discourses during group reflections. Results show that six topics related to inclusive education and diversity emerge from teachers’ discourses: a school where welcoming and nurture are prioritized; school for all; focused on the child’s integral personalised development; with spaces, materials and time thought for the child; consisted of a committed and coordinated educational team prepared to respond to diversity; and, finally, open to families and the community. During the discussion, it is underlined the relevance of including these aspects in initial and in-service training

Plan estratégico para la empresa San Antonio Trade SAC

El presente documento se basa en la elaboración del “Plan Estratégico para la empresa San Antonio Trade SAC”, con una propuesta de cinco años (2020 – 2025), para establecerla como una de las tres principales empresas comercializadoras de vehículos a nivel de la región norte en el Perú, así como ser reconocida por sus altos estándares de calidad, satisfacción y reconocimiento de sus clientes y sus colaboradores. Se pretende consolidar y posicionar a la empresa a largo plazo. El plan a ejecutar se desarrolla utilizando el Modelo Secuencial de Planeamiento Estratégico elaborado por D’Alessio. Los cinco objetivos de largo plazo alineados en la visión de la empresa son: (a) para el año 2025 lograr una ROA de 6.5%; (b) lograr un crecimiento promedio anual de las ventas de 40% como mínimo en los próximos cinco años hasta el año 2025; (c) al 2025, se debe tener como mínimo un 95% en el índice de satisfacción de los clientes; (d) para el año 2025, desarrollar una cultura organizacional basada en la calidad como valor fundamental a través de la implementación del 100% del programa Ser Nissan; (e) para el año 2025 lograr un incremento en la facturación del Servicio Posventa en un 100%. Las estrategias escogidas, de acuerdo al análisis de la empresa fueron la ampliación de la cartera de clientes particulares, implementación de Centros Especializados de Servicio Descentralizados en distritos de las ciudades donde San Antonio tienen la concesión de Nissan, generar un panel de monitoreo de manera transversal entre áreas para mejor comunicación y seguimiento al cliente en cada etapa del proceso de venta y la creación de un área responsable para el manejo de licitaciones con el estado y ventas corporativas. Desarrollando estas estrategias lograremos cumplir con los objetivos y la misión y visión planteada para San Antonio Trade.This document is based on the elaboration of the "Strategic Plan for the company San Antonio Trade SAC", with a five-year proposal (2020 - 2025), to establish it as one of the three main vehicle marketing companies in the region north in Peru, as well as being recognized for its high standards of quality, satisfaction and recognition of its clients and its collaborators. The aim is to consolidate and position the company in the long term. The plan to be executed is developed using the Sequential Model of Strategic Planning elaborated by D’Alessio. The five long-term objectives aligned in the company's vision are: (a) by 2025 achieve a ROA of 6.5%; (b) achieve an average annual sales growth of at least 40% in the next five years until 2025; (c) to 2025, you must have at least 95% in the customer satisfaction index; (d) by 2025, develop an organizational culture based on quality as a fundamental value through the implementation of 100% of the Ser Nissan program; (e) by 2025 achieve an increase in the billing of the After-Sales Service by 100%. The strategies chosen, according to the analysis of the company, were the expansion of the portfolio of private clients, implementation of Specialized Decentralized Service Centers in districts of the cities where San Antonio have the Nissan concession, generate a monitoring panel in a transversal manner between areas for better communication and customer follow-up at each stage of the sales process and the creation of a responsible area for managing tenders with the state and corporate sales. By developing these strategies we will achieve the objectives and the mission and vision set forth for San Antonio TradeTesi

Cognitive Abilities in Agents

The aim of this chapter is to describe the cognitive abilities deployed on agents and multi-agent systems by using examples from applications carried out by the authors. Particularly, the following agent abilities are reviewed: problem solving, memory, decision making and learning capabilities. These abilities, which involve most of the research done in Artificial Intelligence during decades of dealing with isolated agents, are revised in order to incorporate the interaction of agents in a multi-agent environment. The results of incorporating such capabilities to agents are the enhancement of the generality and flexibility of the systems

Association of Sleep Duration and Quality With Subclinical Atherosclerosis.

BACKGROUND Sleep duration and quality have been associated with increased cardiovascular risk. However, large studies linking objectively measured sleep and subclinical atherosclerosis assessed in multiple vascular sites are lacking. OBJECTIVES The purpose of this study was to evaluate the association of actigraphy-measured sleep parameters with subclinical atherosclerosis in an asymptomatic middle-aged population, and investigate interactions among sleep, conventional risk factors, psychosocial factors, dietary habits, and inflammation. METHODS Seven-day actigraphic recording was performed in 3,974 participants (age 45.8 4.3 years; 62.6% men) from the PESA (Progression of Early Subclinical Atherosclerosis) study. Four groups were defined: very short sleep duration 8 h. Sleep fragmentation index was defined as the sum of the movement index and fragmentation index. Carotid and femoral 3-dimensional vascular ultrasound and cardiac computed tomography were performed to quantify noncoronary atherosclerosis and coronary calcification. RESULTS When adjusted for conventional risk factors, very short sleep duration was independently associated with a higher atherosclerotic burden with 3-dimensional vascular ultrasound compared to the reference group (odds ratio: 1.27; 95% confidence interval: 1.06 to 1.52; p ¼ 0.008). Participants within the highest quintile of sleep fragmentation presented a higher prevalence of multiple affected noncoronary territories (odds ratio: 1.34; 95% confidence interval: 1.09 to 1.64; p ¼ 0.006). No differences were observed regarding coronary artery calcification score in the different sleep groups. CONCLUSIONS Lower sleeping times and fragmented sleep are independently associated with an increased risk of subclinical multiterritory atherosclerosis. These results highlight the importance of healthy sleep habits for the prevention of cardiovascular disease. (J Am Coll Cardiol 2019;73:134–44) © 2019 Published by Elsevier on behalf of the American College of Cardiology Foundation.post-print454 K

The impact of type 2 immunity and allergic diseases in atherosclerosis.

Allergic diseases are allergen-induced immunological disorders characterized by the development of type 2 immunity and IgE responses. The prevalence of allergic diseases has been on the rise alike cardiovascular disease (CVD), which affects arteries of different organs such as the heart, the kidney and the brain. The underlying cause of CVD is often atherosclerosis, a disease distinguished by endothelial dysfunction, fibrofatty material accumulation in the intima of the artery wall, smooth muscle cell proliferation, and Th1 inflammation. The opposed T-cell identity of allergy and atherosclerosis implies an atheroprotective role for Th2 cells by counteracting Th1 responses. Yet, the clinical association between allergic disease and CVD argues against it. Within, we review different phases of allergic pathology, basic immunological mechanisms of atherosclerosis and the clinical association between allergic diseases (particularly asthma, atopic dermatitis, allergic rhinitis and food allergy) and CVD. Then, we discuss putative atherogenic mechanisms of type 2 immunity and allergic inflammation including acute allergic reactions (IgE, IgG1, mast cells, macrophages and allergic mediators such as vasoactive components, growth factors and those derived from the complement, contact and coagulation systems) and late phase inflammation (Th2 cells, eosinophils, type 2 innate-like lymphoid cells, alarmins, IL-4, IL-5, IL-9, IL-13 and IL-17).Severo Ochoa Center of Excellence, Grant/Award Number: CEX2020-001041- S; Pro CNIC Foundation; Ministerio de Ciencia e Innovación; Ministry of Science and Innovation, Grant/ Award Number: PID2019-110369RB- I00; European Commission, Grant/Award Number: ERC-CoG 819775 and H2020-HEALTH 945118; Spanish Ministry of Universities; Ayudas Margarita Salas para la Formación de Jóvenes Doctores—Universidad Autónoma de Madrid, Grant/ Award Number: CA1/RSUE/2021–00577; Formación de Profesorado Universitario, Grant/Award Number: FPU16/03953; Sociedad Española de Alergología e Inmunología Clínica (SEAIC), Grant/ Award Number: BECA20A9; New Frontiers in Research Fund, Grant/ Award Number: NFRFE-2019- 00083; The Nutricia Research Foundation, Grant/Award Number: NRF-2021- 13; Instituto de Salud Carlos III, Grant/Award Number: PI21/00158, PI21/01126, CP20/00043, PI18/01467, PI19/00044, RD16/0006/0015 and RD21/0002/0008; Severo Ochoa Program, Grant/Award Number: AEI/SEV-2017- 0712S

The impact of type 2 immunity and allergic diseases in atherosclerosis.

Allergic diseases are allergen-induced immunological disorders characterized by the development of type 2 immunity and IgE responses. The prevalence of allergic diseases has been on the rise alike cardiovascular disease (CVD), which affects arteries of different organs such as the heart, the kidney and the brain. The underlying cause of CVD is often atherosclerosis, a disease distinguished by endothelial dysfunction, fibrofatty material accumulation in the intima of the artery wall, smooth muscle cell proliferation, and Th1 inflammation. The opposed T-cell identity of allergy and atherosclerosis implies an atheroprotective role for Th2 cells by counteracting Th1 responses. Yet, the clinical association between allergic disease and CVD argues against it. Within, we review different phases of allergic pathology, basic immunological mechanisms of atherosclerosis and the clinical association between allergic diseases (particularly asthma, atopic dermatitis, allergic rhinitis and food allergy) and CVD. Then, we discuss putative atherogenic mechanisms of type 2 immunity and allergic inflammation including acute allergic reactions (IgE, IgG1, mast cells, macrophages and allergic mediators such as vasoactive components, growth factors and those derived from the complement, contact and coagulation systems) and late phase inflammation (Th2 cells, eosinophils, type 2 innate-like lymphoid cells, alarmins, IL-4, IL-5, IL-9, IL-13 and IL-17).N

Genetic and clinical characterization of a novel FH founder mutation in families with hereditary leiomyomatosis and renal cell cancer syndrome

Hereditary leiomyomatosis and renal cell cancer syndrome is a rare autosomal dominant hereditary syndrome. Previously, we published the largest cohort of FH mutation carriers in Spain and observed a highly recurrent missense heterozygous variant, FH(NM_000143.4):c.1118A > G p.(Asn373Ser), in 104 individuals from 31 apparently unrelated families. Here, we aimed to establish its founder effect and characterize the associated clinical phenotype. Results Haplotype analysis confirmed that families shared a common haplotype (32/38 markers) spanning 0.61-0.82 Mb, indicating this recurrent variant was inherited from a founder ancestor. Cutaneous and uterine leiomyomatosis were diagnosed in 64.6% (64/99) and 98% (50/51) of patients, respectively, and renal cell cancer was present in 10.4% (10/96). The pathogenic FH_c.1118A > G variant is a Spanish founder mutation that originated 12-26 generations ago. We estimate that the variant may have appeared between 1370 and 1720. Individuals carrying this founder mutation had similar frequency of renal cell cancer and a higher frequency of renal cysts and leiomyomas than those in other cohorts of this syndrome. Conclusions In the Spanish province of Alicante there is a high prevalence of HLRCC because of the founder mutation FH c.1118A > G; p.(Asn373Ser). The characterization of founder mutations provides accurate and specific information regarding their penetrance and expressivity. In individuals with suspected HLRCC from the province of Alicante, genetic testing by direct analysis of the founder FH c.1118A > G; p.(Asn373Ser) mutation may be a faster and more efficient diagnostic tool compared with complete gene sequencing

Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome in Spain: Clinical and Genetic Characterization

Simple Summary Hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome is a very rare hereditary disorder characterized by cutaneous leiomyomas (CLMs), uterine leiomyomas (ULMs), renal cysts (RCys) and renal cell cancer (RCC), with no data on its prevalence worldwide. No genotype-phenotype associations have been described. The aim of our study was to describe the genotypic and phenotypic features of the largest series of patients with HLRCC from Spain reported to date. Of 27 FH germline pathogenic variants, 12 were not previously reported in databases. Patients with missense pathogenic variants showed higher frequencies of CLMs, ULMs and RCys, than those with loss-of-function variants. The frequency of RCCs (10.9%) was lower than those reported in the previously published series. Hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) is a very rare hereditary disorder characterized by cutaneous leiomyomas (CLMs), uterine leiomyomas (ULMs), renal cysts (RCys) and renal cell cancers (RCCs). We aimed to describe the genetics, clinical features and potential genotype-phenotype associations in the largest cohort of fumarate hydratase enzyme mutation carriers known from Spain using a multicentre, retrospective study of individuals with a genetic or clinical diagnosis of HLRCC. We collected clinical information from medical records, analysed genetic variants and looked for genotype-phenotype associations. Analyses were performed using R 3.6.0. software. We included 197 individuals: 74 index cases and 123 relatives. CLMs were diagnosed in 65% of patients, ULMs in 90% of women, RCys in 37% and RCC in 10.9%. Twenty-seven different pathogenic variants were detected, 12 (44%) of them not reported previously. Patients with missense pathogenic variants showed higher frequencies of CLMs, ULMs and RCys, than those with loss-of-function variants (p = 0.0380, p = 0.0015 and p = 0.024, respectively). This is the first report of patients with HLRCC from Spain. The frequency of RCCs was lower than those reported in the previously published series. Individuals with missense pathogenic variants had higher frequencies of CLMs, ULMs and RCys

Association Between a Social-Business Eating Pattern and Early Asymptomatic Atherosclerosis.

BACKGROUND: The importance of a healthy diet in relation to cardiovascular health promotion is widely recognized. Identifying specific dietary patterns related to early atherosclerosis would contribute greatly to inform effective primary prevention strategies. OBJECTIVES: This study sought to quantify the association between specific dietary patterns and presence and extent of subclinical atherosclerosis in a population of asymptomatic middle-aged adults. METHODS: The PESA (Progression of Early Subclinical Atherosclerosis) study enrolled 4,082 asymptomatic participants 40 to 54 years of age (mean age 45.8 years; 63% male) to evaluate the presence of subclinical atherosclerosis in multiple vascular territories. A fundamental objective of this cohort study was to evaluate the life-style-related determinants, including diet, on atherosclerosis onset and development. We conducted a cross-sectional analysis of baseline data, including detailed information on dietary habits obtained as part of the overall life-style and risk factor assessment, as well as a complete vascular imaging study that was performed blinded to the clinical information. RESULTS: Most PESA participants follow a Mediterranean (40% of participants) or a Western (41%) dietary pattern. A new pattern, identified among 19% of participants, was labeled as a social-business eating pattern, characterized by a high consumption of red meat, pre-made foods, snacks, alcohol, and sugar-sweetened beverages and frequent eating-out behavior. Participants following this pattern presented a significantly worse cardiovascular risk profile and, after adjustment for risk factors, increased odds of presenting subclinical atherosclerosis (odds ratio: 1.31; 95% confidence interval: 1.06 to 1.63) compared with participants following a Mediterranean diet. CONCLUSIONS: A new social-business eating pattern, characterized by high consumption of red and processed meat, alcohol, and sugar-sweetened beverages, and by frequent snacking and eating out as part of an overall unhealthy life-style, is associated with an increased prevalence, burden, and multisite presence of subclinical atherosclerosis. (Progression of Early Subclinical Atherosclerosis [PESA]; NCT01410318)