3,844 research outputs found
Physiology of the visual control system
Neurophysiological aspects of eye movement in visual control system with differentiation of version and vergenc
PSR J1024–0719: A Millisecond Pulsar in an Unusual Long-period Orbit
PSR J1024–0719 is a millisecond pulsar that was long thought to be isolated. However, puzzling results concerning its velocity, distance, and low rotational period derivative have led to a reexamination of its properties. We present updated radio timing observations along with new and archival optical data which show that PSR J1024–0719 is most likely in a long-period (2–20 kyr) binary system with a low-mass (≈0.4 M⊙), low-metallicity (z ≈ -0.9 dex) main-sequence star. Such a system can explain most of the anomalous properties of this pulsar. We suggest that this system formed through a dynamical exchange in a globular cluster that ejected it into a halo orbit, which is consistent with the low observed metallicity for the stellar companion. Further astrometric and radio timing observations such as measurement of the third period derivative could strongly constrain the range of orbital parameters
Prion Protein Misfolding
The crucial event in the development of transmissible spongiform encephalopathies (TSEs) is the conformational change of a host-encoded membrane protein - the cellular PrPC - into a disease associated, fibril-forming isoform PrPSc. This conformational transition from the α-helix-rich cellular form into the mainly β-sheet containing counterpart initiates an ‘autocatalytic’ reaction which leads to the accumulation of amyloid fibrils in the central nervous system (CNS) and to neurodegeneration, a hallmark of TSEs
Discovery of 36 eclipsing EL CVn binaries found by the Palomar Transient Factory
We report the discovery and analysis of 36 new eclipsing EL CVn-type
binaries, consisting of a core helium-composition pre-white dwarf and an
early-type main-sequence companion, more than doubling the known population of
these systems. We have used supervised machine learning methods to search 0.8
million lightcurves from the Palomar Transient Factory, combined with SDSS,
Pan-STARRS and 2MASS colours. The new systems range in orbital periods from
0.46-3.8 d and in apparent brightness from ~14-16 mag in the PTF or
filters. For twelve of the systems, we obtained radial velocity
curves with the Intermediate Dispersion Spectrograph at the Isaac Newton
Telescope. We modelled the lightcurves, radial velocity curves and spectral
energy distributions to determine the system parameters. The radii (0.3-0.7
) and effective temperatures (8000-17000 K) of the
pre-He-WDs are consistent with stellar evolution models, but the masses
(0.12-0.28 ) show more variance than models predicted. This
study shows that using machine learning techniques on large synoptic survey
data is a powerful way to discover substantial samples of binary systems in
short-lived evolutionary stages
Evaluation of the angiotensin II receptor blocker azilsartan medoxomil in African-American patients with hypertension
The efficacy and safety of azilsartan medoxomil (AZL-M) were evaluated in African-American patients with hypertension in a 6-week, double-blind, randomized, placebo-controlled trial, for which the primary end point was change from baseline in 24-hour mean systolic blood pressure (BP). There were 413 patients, with a mean age of 52years, 57% women, and baseline 24-hour BP of 146/91mmHg. Treatment differences in 24-hour systolic BP between AZL-M 40mg and placebo (-5.0mmHg; 95% confidence interval, -8.0 to -2.0) and AZL-M 80mg and placebo (-7.8mmHg; 95% confidence interval, -10.7 to -4.9) were significant (P.001 vs placebo for both comparisons). Changes in the clinic BPs were similar to the ambulatory BP results. Incidence rates of adverse events were comparable among the treatment groups, including those of a serious nature. In African-American patients with hypertension, AZL-M significantly reduced ambulatory and clinic BPs in a dose-dependent manner and was well tolerated
The OmegaWhite Survey for Short-Period Variable Stars IV: Discovery of the warm DQ white dwarf OW J175358.85-310728.9
We present the discovery and follow-up observations of the second known
variable warm DQ white dwarf OW J175358.85-310728.9 (OW J1753-3107). OW
J1753-3107 is the brightest of any of the currently known warm or hot DQ and
was discovered in the OmegaWhite Survey as exhibiting optical variations on a
period of 35.5452 (2) mins, with no evidence for other periods in its light
curves. This period has remained constant over the last two years and a
single-period sinusoidal model provides a good fit for all follow-up light
curves. The spectrum consists of a very blue continuum with strong absorption
lines of neutral and ionised carbon, a broad He I 4471 A line, and possibly
weaker hydrogen lines. The C I lines are Zeeman split, and indicate the
presence of a strong magnetic field. Using spectral Paschen-Back model
descriptions, we determine that OW J1753-3107 exhibits the following physical
parameters: T_eff = 15430 K, log(g) = 9.0, log(N(C)/N(He)) = -1.2, and the mean
magnetic field strength is B_z =2.1 MG. This relatively low temperature and
carbon abundance (compared to the expected properties of hot DQs) is similar to
that seen in the other warm DQ SDSS J1036+6522. Although OW J1753-3107 appears
to be a twin of SDSS J1036+6522, it exhibits a modulation on a period slightly
longer than the dominant period in SDSS J1036+6522 and has a higher carbon
abundance. The source of variations is uncertain, but they are believed to
originate from the rotation of the magnetic white dwarf.Comment: 11 pages, 8 figures, 7 tables. Accepted for publication by MNRA
Impairment of Sexual Life in 3,485 Dermatological Outpatients From a Multicentre Study in 13 European Countries
Skin conditions may have a strong impact on patients' sexual life, and thus influence personal relationships. Sexual issues are difficult to discuss directly in clinical practice, and a mediated instrument may be useful to capture such information. In this study item 9 of the Dermatology Life Quality Index was used to collect information on sexual impact of several skin conditions in 13 European countries. Among 3,485 patients, 23.1% reported sexual problems. The impairment was particularly high in patients with hidradenitis suppurativa, prurigo, blistering disorders, psoriasis, urticaria, eczema, infections of the skin, or pruritus. Sexual impact was strongly associated with depression, anxiety, and suicidal ideation. It was generally more frequent in younger patients and was positively correlated with clinical severity and itch. It is important to address the issue of sexual well-being in the evaluation of patients with skin conditions, since it is often linked to anxiety, depression, and even suicidal ideation.Peer reviewedFinal Published versio
Census of the Local Universe (CLU) Narrow-Band Survey I: Galaxy Catalogs from Preliminary Fields
We present the Census of the Local Universe (CLU) narrow-band survey to
search for emission-line (\ha) galaxies. CLU-\ha~has imaged 3 of
the sky (26,470~deg) with 4 narrow-band filters that probe a distance out
to 200~Mpc. We have obtained spectroscopic follow-up for galaxy candidates in
14 preliminary fields (101.6~deg) to characterize the limits and
completeness of the survey. In these preliminary fields, CLU can identify
emission lines down to an \ha~flux limit of
~ at 90\% completeness, and recovers 83\%
(67\%) of the \ha~flux from catalogued galaxies in our search volume at the
=2.5 (=5) color excess levels. The contamination from galaxies
with no emission lines is 61\% (12\%) for =2.5 (=5). Also, in
the regions of overlap between our preliminary fields and previous
emission-line surveys, we recover the majority of the galaxies found in
previous surveys and identify an additional 300 galaxies. In total, we
find 90 galaxies with no previous distance information, several of which are
interesting objects: 7 blue compact dwarfs, 1 green pea, and a Seyfert galaxy;
we also identified a known planetary nebula. These objects show that the
CLU-\ha~survey can be a discovery machine for objects in our own Galaxy and
extreme galaxies out to intermediate redshifts. However, the majority of the
CLU-\ha~galaxies identified in this work show properties consistent with normal
star-forming galaxies. CLU-\ha~galaxies with new redshifts will be added to
existing galaxy catalogs to focus the search for the electromagnetic
counterpart to gravitational wave events.Comment: 28 pages, 22 figures, 4 tables (Accepted to ApJ
Substellar companions and the formation of hot subdwarf stars
"Copyright 2011 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics."We give a brief review over the observational evidence for close substellar companions to hot subdwarf stars. The formation of these core helium-burning objects requires huge mass loss of their red giant progenitors. It has been suggested that besides stellar companions substellar objects in close orbits may be able to trigger this mass loss. Such objects can be easily detected around hot subdwarf stars by medium or high resolution spectroscopy with an RV accuracy at the km s(-1)-level. Eclipsing systems of Vir type stick out of transit surveys because of their characteristic light curves. The best evidence that substellar objects in close orbits around sdBs exist and that they are able to trigger the required mass loss is provided by the eclipsing system SDSS J0820+0008, which was found in the course of the MUCHFUSS project. Furthermore, several candidate systems have been discovered.Final Accepted Versio
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