Open ventral hernia repair with a composite ventral patch : final results of a multicenter prospective study

Background: This study assessed clinical outcomes, including safety and recurrence, from the two-year follow-up of patients who underwent open ventral primary hernia repair with the use of the Parietex (TM) Composite Ventral Patch (PCO-VP). Methods: A prospective single-arm, multicenter study of 126 patients undergoing open ventral hernia repair for umbilical and epigastric hernias with the PCO-VP was performed. Results: One hundred twenty-six subjects (110 with umbilical hernia and 16 with epigastric hernia) with a mean hernia diameter of 1.8cm (0.4-4.0) were treated with PCO-VP. One hundred subjects completed the two-year study. Cumulative hernia recurrence was 3.0% (3/101; 95%CI: 0.0-6.3%) within 24months. Median Numeric Rating Scale pain scores improved from 2 [0-10] at baseline to 0 [0-3] at 1 month (P<0.001) and remained low at 24months 0 [0-6] (P<0.001). 99% (102/103) of the patients were satisfied with their repair at 24months postoperative. Conclusions: The use of PCO-VP to repair primary umbilical and epigastric defects yielded a low recurrence rate, low postoperative and chronic pain, and high satisfaction ratings, confirming that PCO-VP is effective for small ventral hernia repair in the two-year term after implantation. Trial registration: The study was registered publically at clinicaltrials.gov (NCT01848184 registered May 7, 2013)

Effects of Intermittent Pneumatic Compression on Delayed Onset Muscle Soreness (DOMS) in Long Distance Runners

International Journal of Exercise Science 13(2): 75-86, 2020. The purpose of this study was to observe the effectiveness of intermittent pneumatic compression (IPC) on reducing C-reactive protein (CRP) and DOMS after long distance running.Ten distance runners, five males and five females, ages 20-53 years performed two 20-mile runs at 70% VO2max. Each run was followed by either no treatment (control) or IPC treatment for five consecutive days. For the IPC run, participants were treated for one hour immediately following the run and daily for five more days thereafter. On control runs, participants did not receive any treatment. Serum CRP was measured pre- and post-run, and daily thereafter for five days for both trials. Results indicated no significant difference (p \u3e 0.05) between control and treatment runs in CRP levels. Subjective pain ratings indicated no significant difference in pain between control and treatment runs. In conclusion, there appear to be no substantial benefits of IPC in promoting recovery

Fun versus Practical: Physiological Responses and Preference of Exercise Equipment

The elliptical cross trainer has become a popular a mode of exercise, but can only be used indoors. The StreetStrider was designed as an outdoor elliptical-bike. PURPOSE: The purpose of this study is to determine whether the elliptical or the StreetStrider was more enjoyable, and to compare the physiological variables for energy expenditure, heart rate (HR), VO2, and Rate of Perceived Exertion (RPE). METHODS: Thirty participants (15 male, 15 female, mean age=22±2) from Cleveland State University exercised for 20 minutes at 75% of their age predicted maximal heart rate on the StreetStrider and elliptical. Energy expenditure was measured with a COSMED K4b metabolic system. Participants’ RPE was recorded every five minutes using the Borg Scale for Rate of Perceived Exertion. Data was analyzed using SPSS version 18. A paired sample t-test compared physiological responses. A one-way ANOVA analyzed gender differences. A significance level of .05 was used to determine significance. RESULTS: No significant differences were shown in energy expenditure (p=.930), HR (p=.098), or in average RPE (p=.529) between the exercise trials. A preference survey concluded that most subjects found the StreetStrider more enjoyable than the elliptical. CONCLUSION: The StreetStrider is more enjoyable than the elliptical and as effective in energy expenditure, and could serve as a substitute for the elliptical.https://engagedscholarship.csuohio.edu/u_poster_2014/1034/thumbnail.jp

Comparison of Electronic and Mechanical Handgrip Devices in Lowering Blood Pressure

Hypertension causes billions of deaths per year (Millar et al., 2013). The Zona PlusTM is an expensive tool designed to lower blood pressure (BP) using isometric exercise. This exercise may be achieved using a less expensive Handgrip Dynamometer. PURPOSE: The purpose of this research is to determine if the Zona or Handgrip Dynamometer is more efficient at lowering BP and most cost effective for patients. METHODS: Twenty subjects used the Zona and twenty subjects used the dynamometer three times per week for six weeks. BP was taken once per week prior to the treatment. A maximum voluntary contraction (MVC) was recorded for each hand before every treatment. Participants were required to hold the handgrip at 30% of their MVC for four two-minute contractions. A paired samples T test was used to analyze changes in participants’ BP. A one-way ANOVA was used to compare the BP changes between the Zona and the Handgrip. RESULTS: The results indicated no significant changes in participants’ pre- and post- treatment after training when using the Zona for either stolic (p=0.225) or diastolic BP (p=1.000). There was also no significant difference in participants’ post treatment systolic BP (p=0.199), however, the post treatment for diastolic increased significantly (p=0.027 BP between those that used the Zona PlusTM and Handgrip Dynamometer. CONCLUSION: Though the Dynamometer is more cost efficient, neither the Zona nor the Dynamometer resulted in lowered BP.https://engagedscholarship.csuohio.edu/u_poster_2014/1037/thumbnail.jp

Anchoring Hepatic Gene Expression with Development of Fibrosis and Neoplasia in a Toxicant-induced Fish Model of Liver Injury

ABSTRACT Fish have been used as laboratory models to study hepatic development and carcinogenesis but not for pathogenesis of hepatic fibrosis. In this study, a dimethylnitrosamine-induced fish model of hepatic injury was developed in Japanese medaka (Oryzias latipes) and gene expression was anchored with the development of hepatic fibrosis and neoplasia. Exposed livers exhibited mild hepatocellular degenerative changes 2 weeks&apos; postexposure. Within 6 weeks, hepatic fibrosis/cirrhosis was evident with development of neoplasia by 10 weeks. Stellate cell activation and development of fibrosis was associated with upregulation of transforming growth factor beta 1 (tgfb1), tgfb receptor 2, mothers against decapentaplegic homolog 3 (smad3a), smad3b, beta-catenin (ctnnb1), myc, matrix metalloproteinase (mmp2), mmp14a, mmp14b, tissue inhibitors of metalloproteinase (timp) 2a, timp2b, timp3, collagen type I alpha 1a (col1a1a), and col1a1b and a less pronounced increase in mmp13 and col4a1 expression. Tgfb receptor I expression was unchanged. Immunohistochemistry suggested that biliary epithelial cells and stellate cells were the main producers of TGF-b1. This study identified a group of candidate genes likely to be involved in the development of hepatic fibrosis and demonstrated that the TGF-b pathway likely plays a major role in the pathogenesis. These results support the medaka as a viable fish model of hepatic fibrosis

The porin and the permeating antibiotic: A selective diffusion barrier in gram-negative bacteria

Gram-negative bacteria are responsible for a large proportion of antibiotic resistant bacterial diseases. These bacteria have a complex cell envelope that comprises an outer membrane and an inner membrane that delimit the periplasm. The outer membrane contains various protein channels, called porins, which are involved in the influx of various compounds, including several classes of antibiotics. Bacterial adaptation to reduce influx through porins is an increasing problem worldwide that contributes, together with efflux systems, to the emergence and dissemination of antibiotic resistance. An exciting challenge is to decipher the genetic and molecular basis of membrane impermeability as a bacterial resistance mechanism. This Review outlines the bacterial response towards antibiotic stress on altered membrane permeability and discusses recent advances in molecular approaches that are improving our knowledge of the physico-chemical parameters that govern the translocation of antibiotics through porin channel

Sensitivity to Gravitational Waves from Compact Binary Coalescences Achieved during LIGO's Fifth and Virgo's First Science Run

We summarize the sensitivity achieved by the LIGO and Virgo gravitational wave detectors for compact binary coalescence (CBC) searches during LIGO's fifth science run and Virgo's first science run. We present noise spectral density curves for each of the four detectors that operated during these science runs which are representative of the typical performance achieved by the detectors for CBC searches. These spectra are intended for release to the public as a summary of detector performance for CBC searches during these science runs.Comment: 12 pages, 5 figure