The Ideal of Beauty and Harmony in the European Fine Art

As a higher form of mastering the world following the laws of beauty, the best works of the European art do not just bring in some aesthetic pleasure but also help to understand (and create) the beautiful. In this research, using comparative, typological, descriptive, visual, philosophical, theological, and artistic analysis methods an analysis of the selected pieces, from the ancient times till present was made. It was traced that the ideal of beauty and harmony largely depended on the peculiarities of each historical period. Development of spiritual culture of the European continent nations underwent many stages: from primitive art through the ancient times and till modernism. In each period fixed rules and norms shaped up the ideal of beauty and harmony, which can be understood only through immersing into a certain epoch via analysis and study of a specific piece of art. Scientific novelty of the results obtained lies in the fact that materials about the ideal of beauty and harmony in the aesthetics of the European art are added to art criticism as universal general human values. The ideal of beauty and harmony over the whole historical period, as exemplified by preserved monuments, can be traced in all art forms, in particular, in sacral art

Assessment of adaptability parameters in hulled oat germplasm accessions in terms of their yield in the environments of Kirov Province

Background. Studying the gene pool of a crop under specific soil and climate conditions makes it possible to predict the breeding value of germplasm, while its subsequent inclusion in the breeding process ensures the development of adaptable cultivars capable of implementing their productive potential in large-scale agriculture.Materials and methods. Stability (Si2) and plasticity (bi; PUSS), Ambient Condition Index (Ij), Homeostatic (Hom), Stress Resistance, and Stability Index (Is) were calculated for 12 hulled oat (Avena sativa L.) accessions at the FARC of North-East.Results. Accessions 2981 IG100720 (USA) and k-15293 BORYNA (Poland) showed the best stress resistance, while the highest genetic flexibility was observed in 2981 IG100720 (USA), 3007 IG100848 (Germany), 5330 СSI  590/05,  and k-15178 ‘Begunok’ (Russia). Sources of intensive-type hulled oats: k-15330 CSI 590/05 (Russia) (bi = 1.36)  and  k-15331 CSI 2167/03 (Russia) (bi = 1.60),  were  identified for their higher yield values: 856 and 889 g/m2 under improved growing conditions in 2017, and 365 and 285 g/m2 under dry conditions in 2016, respectively. Medium-intensive accessions k-15178 ‘Begunok’ (Russia) (bi = 1.07), and ‘Skrokolik’ (k-15321, Russia) (bi = 0.97) were identified for the best plasticity. The reference cv. ‘Krechet’ (Si2 = 0.06) demonstrated high yield stability.Conclusion. Sources were selected for hulled oat breeding: 2981 IG100720 (USA), 3007 IG100848 (Germany), and k-15293 BORYNA (Poland), with high stress resistance and plasticity, and plastic sources k-15178 ‘Begunok’ and k-15321 ‘Skrokolik’ (Russia), with stable high yield under varying environmental conditions

Structures of the (Imidazole)nH+ ... Ar (n=1,2,3) complexes determined from IR spectroscopy and quantum chemical calculations

Here, we present new cryogenic infrared spectra of the (Imidazole)$_{n}H^+$ (n=1,2,3) ions. The data was obtained using helium tagging infrared predissociation spectroscopy. The new results were compared with the data obtained by Gerardi et al. (Chem. Phys. Lett. 501:172–178, 2011) using the same technique but with argon as a tag. Comparison of the two experiments, assisted by theoretical calculations, allowed us to evaluate the preferable attachment positions of argon to the (Imidazole)$_{n}H^+$ frame. Argon attaches to nitrogen-bonded hydrogen in the case of the (Imidazole)$H^+$ ion, while in (Imidazole)$_{2}H^+$ and (Imidazole)$_{3}H^+$ the preferred docking sites for the argon are in the center of the complex. This conclusion is supported by analyzing the spectral features attributed to the N–H stretching vibrations. Symmetry adapted perturbation theory (SAPT) analysis of the non-covalent forces between argon and the (Imidazole)$_{n}H^+$ (n=1,2,3) frame revealed that this switch of docking preference with increasing complex size is caused by an interplay between induction and dispersion interactions

ПЕРСПЕКТИВЫ ИННОВАЦИОННОГО РАЗВИТИЯ ОТЕЧЕСТВЕННОГО НЕФТЕГАЗОВОГО КОМПЛЕКСА

The New industrialization of the Russian economy is not possible without the formation of forward-looking strategy of innovative development of oil and gas complex, combining related industries. Oil and gas complex of Russia, its fi elds and infrastructure – is key to the territorial integrity of the country, the guarantor of stable functioning of the economy, the most important component of export potential and low-income. During the past decades, a combination of favorable external conditions for the activities of oil and gas companies such as easily recoverable reserves and long-term prospect of rising prices for raw materials – allow these companies do not pay enough attention to the innovation component. The approaching exhaustion of Russian stocks in the «easy» oil and toughening global competition for energy resources and technology made such an inertial approach to innovation is inadmissible; sanctions and the fall in world prices for hydrocarbons requires the development strategy of innovative development of oil and gas based approach combining resource and innovative potential of Russia.Objective: To analyze opportunities for integration into a coherent innovation strategy of fundamental and applied research of Russian scientists, including IPNG Russian Academy of Sciences, Institute of Economic Forecasting, and other scientifi c organizations.Objectives: To propose a mechanism of management of development based management model basic technical and economic parameters of oil and (or) gas through its full life cycle, as well as to demonstrate the possibility of forming a strategic decision of a higher level, combining new technologies and market management methods.Methodology: systematic approach, investment analysis, models of the full life cycle of natural and man-made objects, the fundamentals of feasibility and tax planning.Practical application of the results of this work: management model of oil and gas deposits «4D» can be expanded and adapted to the practical problems enterprises and oil and gas companies on the basis of the construction and use of the model of «4D + e». In the initial stages of the possible use of such a model in a pilot mode for managing the development of small and medium-sized fi elds.Новая индустриализация экономики России невозможна без формирования перспективнойстратегии инновационного развития нефтегазового комплекса, объединяющего смежные отрасли. Нефтегазовый комплекс России, его месторождения и инфраструктура – это залог территориальной целостности страны, гарант устойчивого функционирования экономики, важнейшая составляющая экспортного потенциала и бюджетных доходов. В течение предшествующих десятилетий, сочетание благоприятных внешних условий для деятельности нефтяных и газовых компаний, таких как легко извлекаемые запасы и долгосрочная перспектива роста цен на сырье, – позволяли этим компаниям не уделять должного внимания инновационной составляющей. Приближающееся в России исчерпание запасов «легкой» нефти и ужесточение глобальной конкуренции за технологии и энергоносители сделали подобный инерционный подход к инновациям неприемлемым; санкции и падение мировых цен на углеводороды требуют разработки стратегии инновационного развития нефтегазового комплекса на основе подхода, объединяющего ресурсный и инновационный потенциал России. Цель: анализ возможностей интеграции в целостную инновационную стратегию фундаментальных и прикладных разработок Российских ученых, включая ИПНГ РАН, ИНП РАН и других научных организаций.Задачи статьи: предложить механизм управления развитием на основе модели управления основными технико-экономическими параметрами месторождения нефти и (или) газа в рамках его полного жизненного цикла, а также продемонстрировать возможности формирования стратегических решений более высокого уровня, объединяющих новые технологии и рыночные методы управления.Методология: системный подход, инвестиционный анализ, модели полного жизненного цикла природно-техногенных объектов, основы технико-экономического и налогового планирования.Практическое применение результатов данной работы: Модель управления разработкой нефтяной и газовой залежи «4Д» может быть расширена и адаптирована под практические задачи предприятий и компаний нефтегазового комплекса на основе построения и использования модели «4Д+Е». На начальных этапах возможно использование подобной модели в пилотном режиме, для управления разработкой малых и средних месторождений

Enhanced Aggression, Reduced Self-Grooming Behavior and Altered 5-HT Regulation in the Frontal Cortex in Mice Lacking Trace Amine-Associated Receptor 1 (TAAR1)

The Trace Amine-Associated Receptor 1 (TAAR1) is one of the six functional receptors belonging to the family of monoamine-related G protein-coupled receptors (TAAR1-TAAR9) found in humans. However, the exact biological mechanisms of TAAR1 central and peripheral action remain to be fully understood. TAAR1 is widely expressed in the prefrontal cortex and several limbic regions, interplaying with the dopamine system to modulate the reward circuitry. Recent clinical trials suggest the efficacy of TAAR1 agonists as potential novel antipsychotic agents. Here, we characterize behavioral and neurochemical phenotypes of TAAR1 knockout mice, focusing on aggression and self-grooming behavior that both strongly depend on the monoaminergic signaling and cortico-striatal and cortico-limbic circuits. Overall, we report increased aggression in these knockout mice in the resident-intruder test, accompanied by reduced self-grooming behavior in the novelty-induced grooming test, and by higher cortical serotonin (5-HT) tissue levels. Further studies are necessary to explore whether TAAR1-based therapies can become potential novel treatments for a wide range of neuropsychiatric disorders associated with aggression. © 2022 by the authors.Applied Genetics MIPT, (075-15-2021-684)Suzhou University of Science and TechnologyThis study was supported by the project ID: 93018770 of St. Petersburg State University. K.A.D., A.V.K. and N.A.K. are supported by the project ID: 93020614 of St. Petersburg State University. A.V.K. partially used the facilities and equipment of the Resource Fund of Applied Genetics MIPT (support grant 075-15-2021-684). His contribution was partially supported by the Neurobiology Program of Sirius University of Science and Technology

Fashion design in a multicultural space

The collective monograph contains the results of the synthesis of theoretical materials, as well as the authors` applied research developments on the design of the clothes of different assortment and purpose, made from different materials considering the modern scientific methods

ОРТОТОПИЧЕСКАЯ ТРАНСПЛАНТАЦИЯ ПЕЧЕНИ: РОЛЬ ИНТЕРВЕНЦИОННОЙ РАДИОЛОГИИ

To study therapeutic modalities of interventional radiology in patients (pts) before and after orthotopic liver trans- plantation (OLT). OLT was performed in 53 pts between 1998 and 2008. Endovascular treatments were performed in 20 pts. Pre-OLT interventional procedures included transcatheter arterial chemoembolization (5 patients) and TIPS (8 patients). Post-OLT procedures were: dilatation or/and stenting of biliary strictures (4), stenting of IVC (2), balloon dilatation of cava-caval anastomosis (1), partial splenic embolization (PSE) in steel syndrome (1). All IR procedures were technically successful. There was no mortality or serious complication. After chemoemboliza- tion, there was partial tumor response in all 5 patients with HCC; two successfully transplanted are alive without recurrence in 11 and 15 months. After TIPS, 3 pts underwent OLT. Satisfactory biliary passage was achieved in all pts with strictures. Clinical symptoms and liver function improved in three pts with venous strictures. After PSE, steal syndrome regressed rapidly. All pts are asymptomatic and well in 5–24 mo after IR treatment. IR procedures prolong long-term patient survival before OLT and may improve outcomes in pts after OLT. В работе обсуждается эффективность интервенционных радиологических процедур у больных перед и после ортотопической трансплантации печени (ОТП). За период 1998–2008 гг. ОТП выполнена 53 паци- ентам. Лечебные эндоваскулярные вмешательства осуществлены у 20 из этих больных. Предоперацион- ные процедуры выполнены у 13 пациентов: масляная химиоэмболизация печеночной артерии (МХЭПА, n = 5), наложение внутрипеченочного портокавального шунта (TIPS, n = 8). У 7 больных произведены 8 послеоперационных вмешательств: дренирование и/или стентирование желчных протоков (n = 4), ре- канализация и стентирование стеноза/окклюзии нижней полой вены (НПВ, n = 2), баллонная дилатация кава-кавального анастомоза (n = 1), эмболизация селезеночной артерии (n = 1). После МХЭПА отмечено уменьшение злокачественной опухоли или замедление ее роста у всех 5 пациентов, ОТП к настоящему времени осуществлена у 3 из них. В результате TIPS снижение портальной гипертензии произошло у всех больных, ОТП выполнена в 3 наблюдениях. Все послеоперационные процедуры были также технически и клинически успешны. Методы интервенционной радиологии позволяют продлить время ожидания до- норской печени у больных, которым требуется ОТП. Рентгеноэндоваскулярные вмешательства позволяют устранить послеоперационные билиарные и сосудистые стриктуры, а также другие осложнения ОТП.

May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension

Aims Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening worldwide. The 2018 campaign was expanded, aiming to include more participants and countries. Methods and results Eighty-nine countries participated in MMM 2018. Volunteers (≥18 years) were recruited through opportunistic sampling at a variety of screening sites. Each participant had three BP measurements and completed a questionnaire on demographic, lifestyle, and environmental factors. Hypertension was defined as a systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg, or taking antihypertensive medication. In total, 74.9% of screenees provided three BP readings. Multiple imputation using chained equations was used to impute missing readings. 1 504 963 individuals (mean age 45.3 years; 52.4% female) were screened. After multiple imputation, 502 079 (33.4%) individuals had hypertension, of whom 59.5% were aware of their diagnosis and 55.3% were taking antihypertensive medication. Of those on medication, 60.0% were controlled and of all hypertensives, 33.2% were controlled. We detected 224 285 individuals with untreated hypertension and 111 214 individuals with inadequately treated (systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg) hypertension. Conclusion May Measurement Month expanded significantly compared with 2017, including more participants in more countries. The campaign identified over 335 000 adults with untreated or inadequately treated hypertension. In the absence of systematic screening programmes, MMM was effective at raising awareness at least among these individuals at risk