Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits : A Multi-Ethnic Meta-Analysis of 45,891 Individuals

J. Kaprio, S. Ripatti ja M.-L. Lokki työryhmien jäseniä.Peer reviewe

Adaptation of pandemic H2N2 influenza A viruses in humans

The 1957 A/H2N2 influenza virus caused an estimated 2 million fatalities during the pandemic. Since viruses of the H2 subtype continue to infect avian species and pigs, the threat of reintroduction into humans remains. To determine factors involved in the zoonotic origin of the 1957 pandemic, we performed analyses on genetic sequences of 175 newly sequenced human and avian H2N2 virus isolates and all publicly available influenza virus genomes

Top quark physics at hadron colliders

The top quark, discovered at the FERMILAB TEVATRON collider in 1995, is the heaviest known elementary particle. Today, ten years later, still relatively little is known about its properties. The strong and weak interactions of the top quark are not nearly as well studied as those of the other quarks and leptons. The strong interaction is most directly measured in top quark pair production. The weak interaction is measured in top quark decay and single top quark production, which remains thus far unobserved. The large top-quark mass of about 175 GeV/c2 suggests that it may play a special role in nature. It behaves differently from all other quarks due to its large mass and its correspondingly short lifetime. The top quark decays before it hadronises, passing its spin information on to its decay products. Therefore, it is possible to measure observables that depend on the top quark spin, providing a unique environment for tests of the Standard Model and for searches for physics beyond the Standard Model. This report summarises the latest measurements and studies of top quark properties and rare decays from the TEVATRON in Run II. With more than 1 fb-1 of luminosity delivered to each experiment, CDF and DO, top quark physics at the TEVATRON is at a turning point from first studies to precision measurements with sensitivity to new physics. An outlook onto top quark physics at the Large Hadron Collider (LHC) at CERN, planned to begin operation in the year 2007, is also given

Review of Particle Physics

This biennial review summarizes much of Particle Physics. Using data from previous editions, plus 1900 new measurements from 700 papers, we list, evaluate, and average measured properties of gauge bosons, leptons, quarks, mesons, and baryons. We also summarize searches for hypothetical particles such as Higgs bosons, heavy neutrinos, and supersymmetric particles. All the particle properties and search limits are listed in Summary Tables. We also give numerous tables, figures, formulae, and reviews of topics such as the Standard Model, particle detectors, probability, and statistics. A booklet is available containing the Summary Tables and abbreviated versions of some of the other sections of this full Review. © 1996 The American Physical Society

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expression quantitative trait locus (eQTL) colocalizations and then add chromatin interaction data to narrow the search for functional genes. Polygenic enrichment analysis across 697 annotations from a host of tissues and cell types confirms the central role of the liver in lipid levels and highlights the selective enrichment of adipose-specific chromatin marks in high-density lipoprotein cholesterol and triglycerides. Overlapping transcription factor (TF) binding sites with lipid-associated loci identifies TFs relevant in lipid biology. In addition, we present an integrative framework to prioritize causal variants at GWAS loci, producing a comprehensive list of candidate causal genes and variants with multiple layers of functional evidence. We highlight two of the prioritized genes, CREBRF and RRBP1, which show convergent evidence across functional datasets supporting their roles in lipid biology. © 2022 American Society of Human Genetic