Externality in Hegel\u27s Philosophy of Nature

The topic of my dissertation is the metaphysics of laws of nature in Hegel’s philosophy of nature. I argue that Hegel differentiates laws of nature from norms of culture through a concept of “externality,” according to which the universals or laws of nature stand outside of, apart from, independent from their particulars. He contrasts this with norms of culture, where the universals are internal to the particulars, such that in culture the particular events or actions shape the norms, whereas in nature, the laws remain the same through their independence from the particular events. I then address the consequences this particular understanding of “externality” has for Hegel’s philosophy of nature, including its rejection of the role of induction in favor of a transcendental arguments for the laws of nature given only the idea that nature is this externalized structure; a metaphysical realist position about the existence of nature as entailed by an idealist epistemology pertaining to the laws and universals of nature; and finally, a defense of specific theories, universals, or laws of nature, which are derived from those a priori transcendental arguments. I conclude that while Hegel’s philosophy of nature is a necessary consequence of his epistemological assumptions, which are plausible and defensible in their own right, these assumptions ultimately commit Hegel to problematic claims regarding the particular structures in nature. In particular, I show how Hegel’s epistemology is fundamentally committed to a specific understanding of life and health that has since been challenged by evolutionary biology

829 hectares of preventive archaeological magnetometry surveys in Ireland: upscaling data collection and interpretation strategies

We present examples of preventive archaeology magnetometer surveys at macro scale. Qfield can be used for effective landscape documentation to allow better data analysis, even if done by another team. We show how to improve the reusability of datasets for future Big Data research methods

Tetra-amelia and lung hypo/aplasia syndrome: New case report and review

Tetra-amelia is a rare malformation that may be associated with other anomalies and is usually inherited in an autosomal recessive pattern. We describe a fetus, born to a nonconsanguineous couple, with tetra-amelia, bilateral cleft lip and palate and bilateral lung agenesis, without other anomalies. Karyotype was normal (46,XX) and premature centromere separation was excluded. No mutation was identified upon molecular analysis of WNT3, HS6ST1, and HS6ST3. We reviewed the literature and the differential diagnosis to clarify the clinical delineation of conditions associated with tetra-amelia. The present report describes the sixth family with this pattern of malformations and reinforces the evidence that the ldquotetra-amelia and lung hypo/aplasia syndromerdquo is a distinct autosomal recessive condition, with no identified gene thus far. © 2008 Wiley-Liss, Inc

Diagnosis, management, and outcomes of patients with syncope and bundle branch block

Although patients with syncope and bundle branch block (BBB) are at high risk of developing atrio-ventricular block, syncope may be due to other aetiologies. We performed a prospective, observational study of the clinical outcomes of patients with syncope and BBB following a systematic diagnostic approach. Patients with ≥1 syncope in the last 6 months, with QRS duration ≥120 ms, were prospectively studied following a three-phase diagnostic strategy: Phase I, initial evaluation; Phase II, electrophysiological study (EPS); and Phase III, insertion of an implantable loop recorder (ILR). Overall, 323 patients (left ventricular ejection fraction 56 ± 12%) were studied. The aetiological diagnosis was established in 267 (82.7%) patients (102 at initial evaluation, 113 upon EPS, and 52 upon ILR) with the following aetiologies: bradyarrhythmia (202), carotid sinus syndrome (20), ventricular tachycardia (18), neurally mediated (9), orthostatic hypotension (4), drug-induced (3), secondary to cardiopulmonary disease (2), supraventricular tachycardia (1), bradycardia-tachycardia (1), and non-arrhythmic (7). A pacemaker was implanted in 220 (68.1%), an implantable cardioverter defibrillator in 19 (5.8%), and radiofrequency catheter ablation was performed in 3 patients. Twenty patients (6%) had died at an average follow-up of 19.2 ± 8.2 months. In patients with syncope, BBB, and mean left ventricular ejection fraction of 56 ± 12%, a systematic diagnostic approach achieves a high rate of aetiological diagnosis and allows to select specific treatment

Complex polarity: building multicellular tissues through apical membrane traffic

The formation of distinct subdomains of the cell surface is crucial for multicellular organism development. The most striking example of this is apical-basal polarization. What is much less appreciated is that underpinning an asymmetric cell surface is an equally dramatic intracellular endosome rearrangement. Here, we review the interplay between classical cell polarity proteins and membrane trafficking pathways, and discuss how this marriage gives rise to cell polarization. We focus on those mechanisms that regulate apical polarization, as this is providing a number of insights into how membrane traffic and polarity are regulated at the tissue level