8 research outputs found
Dental Caries and Periodontal Disease in Children and Adolescents with Inflammatory Bowel Disease: A Case-Control Study
Background:Previous reports have demonstrated a higher prevalence of
dental caries and periodontal disease in adults with inflammatory bowel
disease (IBD), but similar data in children and adolescents do not
exist. The aim of the study was to evaluate the status of dental caries,
oral hygiene, gingival status and periodontal treatment needs of
children with IBD.Methods:In this case-control study, 55 children on
remission from a single outpatient IBD clinic, aged 4 to 18 years (12.27
3.67 yr) and 55 matched systemically healthy controls of a dental
practice were assessed prospectively. The evaluation included medical
history, dental questionnaire in both groups, and previous and current
medical therapy of children with IBD. Additionally, the decayed,
missing, and filled tooth (dmf-t or DMF-T), simplified gingival, plaque
control record and community periodontal treatment needs indices were
evaluated.Results:Children with IBD compared with controls had a
statistically significant (P < 0.001) higher dmf-t (2.95 versus 0.91) or
DMF-T (5.81 versus 2.04) index and a higher gingival inflammation
(simplified gingival, 40% versus 24%) although the respectively dental
plaque index showed no significant difference (plaque control record,
42% versus 41%). Also, the community periodontal treatment needs was
significantly higher compared with controls (P < 0.001); most of the
patients with IBD needed treatment of gingivitis (47% versus 4%), and
none of them had healthy periodontium (0% versus 69%).Conclusions:The
results of this case-control study demonstrate a higher frequency of
dental caries, more clinical signs of gingival inflammation, and
increased periodontal treatment needs in children and adolescents with
IBD despite similar oral hygiene status
Dental Caries and Periodontal Disease in Children and Adolescents with Inflammatory Bowel Disease
Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial
Early increase of soluble urokinase plasminogen activator receptor (suPAR) serum levels is indicative of increased risk of progression of coronavirus disease 2019 (COVID-19) to respiratory failure. The SAVE-MORE double-blind, randomized controlled trial evaluated the efficacy and safety of anakinra, an IL-1 alpha/beta inhibitor, in 594 patients with COVID-19 at risk of progressing to respiratory failure as identified by plasma suPAR >= 6 ng ml(-1), 85.9% (n = 510) of whom were receiving dexamethasone. At day 28, the adjusted proportional odds of having a worse clinical status (assessed by the 11-point World Health Organization Clinical Progression Scale (WHO-CPS)) with anakinra, as compared to placebo, was 0.36 (95% confidence interval 0.26-0.50). The median WHO-CPS decrease on day 28 from baseline in the placebo and anakinra groups was 3 and 4 points, respectively (odds ratio (OR) = 0.40, P < 0.0001); the respective median decrease of Sequential Organ Failure Assessment (SOFA) score on day 7 from baseline was 0 and 1 points (OR = 0.63, P = 0.004). Twenty-eight-day mortality decreased (hazard ratio = 0.45, P = 0.045), and hospital stay was shorter.The SAVE-MORE phase 3 study demonstrates the efficacy of anakinra, an IL-1 alpha/beta inhibitor, in patients with COVID-19 and high serum levels of soluble plasminogen activator receptor
Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial
Early increase of soluble urokinase plasminogen activator receptor
(suPAR) serum levels is indicative of increased risk of progression of
coronavirus disease 2019 (COVID-19) to respiratory failure. The
SAVE-MORE double-blind, randomized controlled trial evaluated the
efficacy and safety of anakinra, an IL-1 alpha/beta inhibitor, in 594
patients with COVID-19 at risk of progressing to respiratory failure as
identified by plasma suPAR >= 6 ng ml(-1), 85.9% (n = 510) of whom were
receiving dexamethasone. At day 28, the adjusted proportional odds of
having a worse clinical status (assessed by the 11-point World Health
Organization Clinical Progression Scale (WHO-CPS)) with anakinra, as
compared to placebo, was 0.36 (95% confidence interval 0.26-0.50). The
median WHO-CPS decrease on day 28 from baseline in the placebo and
anakinra groups was 3 and 4 points, respectively (odds ratio (OR) =
0.40, P < 0.0001); the respective median decrease of Sequential Organ
Failure Assessment (SOFA) score on day 7 from baseline was 0 and 1
points (OR = 0.63, P = 0.004). Twenty-eight-day mortality decreased
(hazard ratio = 0.45, P = 0.045), and hospital stay was shorter.
The SAVE-MORE phase 3 study demonstrates the efficacy of anakinra, an
IL-1 alpha/beta inhibitor, in patients with COVID-19 and high serum
levels of soluble plasminogen activator receptor
Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis
International audienc
Accuracy in Diagnosis of Celiac Disease Without Biopsies in Clinical Practice
The guidelines of the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition allow for diagnosis of celiac disease without biopsies in children with symptoms and levels of immunoglobulin A against tissue-transglutaminase (TGA-IgA) 10-fold or more the upper limit of normal (ULN), confirmed by detection of endomysium antibodies (EMA) and positivity for HLA-DQ2/DQ8. We performed a large, international prospective study to validate this approach