834 research outputs found

    Features of metrology when evaluating sports results

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    Multilevel intellectual approach to HTTP-requests legitimacy validation

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    In the paper a multilevel intellectual approach to HTTP-requests legitimacy validation is proposed. The approach is devised for HTTP-flood DDoS-attacks detection and prevention in telecommunication networks with a web-server as the target attack object. The analysis of HTTP-requests attributes and their signatures is provided. On the basis of the analysis the attributes are separated into several levels that allow us to design a flow analyzer in a form of the multilevel block. Due to a multilevel structure of the flow analyzer a minimization of resources, spent for a request handling, is achieved

    Stress-strain state of the mine massif around the chambers of the second stage of mining

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    A stress-strain state of the rock mass around the chambers of the second stage of mining was analyzed with the help of thermodynamic method. This study is the question of the day as the ore reserves in the chambers of the second stage of mining are, as a rule, extracted being surrounded by the filling mass, and due to this the highest rates of the ore losses and contamination with the filling mass are observed. In connection with this, the study of the stress-strained state of the filling mass and establishment of a method for improving the massif stability presents a great interest today. A calculation scheme for modeling thermodynamic processes in the rock mass around the chambers was developed with the purpose to study the stress field and determine principles of radial stress changing in the filling mass of the surrounding chamber. A chamber in the layer at the depth of 740-840 m was simulated with the following average geotechnical conditions: depth of the extraction chamber, angle of the deposit depression, horizontal thickness of deposit, rock strength in the hanging layer against uniaxial compression, rock strength in the bottom layer against uniaxial compression, and stowing strength against uniaxial compression. The study determined areas with tensile stress in the rocks of the bottom layer, ore mass and filling mass, and their parameters (size, maximum tension) and formulated empirical equations for the dependences between radial tensions and distance to the chambers L of the second stage of mining. The areas of destructive deformation and their dimensions in the stowing mass around the chambers of the second stage of mining at the level 740-840 m were established. Maximum values are defined for the stresses acting in the stowing mass which, exceeding the ultimate strength, cause the mass failure into the space of the chamber of the second stage. In order to prevent the stowing mass failure it is recommended to make a consolidating layer of the solid stowing at the 2/3 height of the chamber in order to resist the high tensile stresses and to ensure the mass stability

    Complex application of certain micronatrients in men with androgen deficiency and pathosprimes

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    A complex approach was made for the deactivation of deuterine micronutrients, which include antioxidant and metabolic metabolism, in individuals with androgen deficiency and idiopathic pathospermia. It has been shown that is using the complex preparation Β«FEROLLΒ» for 60 days leads to increase the parameters of the spermogram to normal values on the background of normal androgen levels of blood in these patients

    Numerical modelling of massif zonal structuring around underground working

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    Purpose. To identify indicators of massif zonal structuring around underground working using numerical modeling techniques. Methods. Research into massif zonal structuring was performed using finite element method and thermodynamic method by which the size and number of zones formed around development workings and stopes have been simulated. Findings. The ratio of zones’ vertical and horizontal semiaxes in the massif has been established and reliability of the obtained results was determined. The prospects of new modeling techniques for the study of massif zonal structuring parameters around underground workings have been identified. Originality. The opportunities for wide application of numerical simulation methods to study the phenomenon of zonal encapsulation by the massif of underground workings have been revealed. Practical implications. The sizes and shapes of zones in the massif around workings were determined and requirements were formulated stating that synergetic research methods should allow to more accurately determine the number, size and shape of zones, as well as fading sinusoidal stress and massif strain domains.ЦСль. Π’Ρ‹ΡΠ²ΠΈΡ‚ΡŒ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈ зонального структурирования массива Π²ΠΎΠΊΡ€ΡƒΠ³ ΠΏΠΎΠ΄Π·Π΅ΠΌΠ½Ρ‹Ρ… Π²Ρ‹Ρ€Π°Π±ΠΎΡ‚ΠΎΠΊ с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ числСнных ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² модСлирования. ΠœΠ΅Ρ‚ΠΎΠ΄ΠΈΠΊΠ°. ИсслСдованиС зонального структурирования массива Π²Ρ‹ΠΏΠΎΠ»Π½ΡΠ»ΠΎΡΡŒ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ ΠΊΠΎΠ½Π΅Ρ‡Π½Ρ‹Ρ… элСмСнтов ΠΈ тСрмодинамичСским ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ, с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… смодСлированы Ρ€Π°Π·ΠΌΠ΅Ρ€Ρ‹ ΠΈ количСство Π·ΠΎΠ½, Ρ„ΠΎΡ€ΠΌΠΈΡ€ΡƒΡŽΡ‰ΠΈΡ…ΡΡ Π²ΠΎΠΊΡ€ΡƒΠ³ ΠΏΠΎΠ΄Π³ΠΎΡ‚ΠΎΠ²ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… ΠΈ очистных Π²Ρ‹Ρ€Π°Π±ΠΎΡ‚ΠΎΠΊ. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. УстановлСно ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠ΅ Π²Π΅Ρ€Ρ‚ΠΈΠΊΠ°Π»ΡŒΠ½Ρ‹Ρ… ΠΈ Π³ΠΎΡ€ΠΈΠ·ΠΎΠ½Ρ‚Π°Π»ΡŒΠ½Ρ‹Ρ… полуосСй Π·ΠΎΠ½ Π² массивС ΠΈ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Π° Π΄ΠΎΡΡ‚ΠΎΠ²Π΅Ρ€Π½ΠΎΡΡ‚ΡŒ ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Ρ… Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΎΠ². Раскрыты пСрспСктивы создания Π½ΠΎΠ²Ρ‹Ρ… ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² модСлирования для исслСдования ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€ΠΎΠ² зонального структурирования массива Π²ΠΎΠΊΡ€ΡƒΠ³ ΠΏΠΎΠ΄Π·Π΅ΠΌΠ½Ρ‹Ρ… Π²Ρ‹Ρ€Π°Π±ΠΎΡ‚ΠΎΠΊ. Научная Π½ΠΎΠ²ΠΈΠ·Π½Π°. Раскрыты возмоТности ΡˆΠΈΡ€ΠΎΠΊΠΎ примСняСмых числСнных ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² модСлирования для исслСдования Ρ„Π΅Π½ΠΎΠΌΠ΅Π½Π° зонального капсулирования массивом ΠΏΠΎΠ΄Π·Π΅ΠΌΠ½Ρ‹Ρ… Π²Ρ‹Ρ€Π°Π±ΠΎΡ‚ΠΎΠΊ. ΠŸΡ€Π°ΠΊΡ‚ΠΈΡ‡Π΅ΡΠΊΠ°Ρ Π·Π½Π°Ρ‡ΠΈΠΌΠΎΡΡ‚ΡŒ. УстановлСны Ρ€Π°Π·ΠΌΠ΅Ρ€Ρ‹ ΠΈ Ρ„ΠΎΡ€ΠΌΠ° Π·ΠΎΠ½ Π² массивС Π²ΠΎΠΊΡ€ΡƒΠ³ Π²Ρ‹Ρ€Π°Π±ΠΎΡ‚ΠΎΠΊ ΠΈ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Ρ‹ трСбования ΠΊ синСргСтичСским ΠΌΠ΅Ρ‚ΠΎΠ΄Π°ΠΌ исслСдования, Π·Π°ΠΊΠ»ΡŽΡ‡Π°ΡŽΡ‰ΠΈΠ΅ΡΡ Π² возмоТностях Π±ΠΎΠ»Π΅Π΅ Ρ‚ΠΎΡ‡Π½ΠΎΠ³ΠΎ опрСдСлСния количСства, Ρ€Π°Π·ΠΌΠ΅Ρ€ΠΎΠ² ΠΈ Ρ„ΠΎΡ€ΠΌΡ‹ Π·ΠΎΠ½, Π° Ρ‚Π°ΠΊΠΆΠ΅ ΡΠΈΠ½ΡƒΡΠΎΠΈΠ΄Π°Π»ΡŒΠ½ΠΎ-Π·Π°Ρ‚ΡƒΡ…Π°ΡŽΡ‰ΠΈΡ… напряТСний ΠΈ ΠΊΠΎΠ»ΡŒΡ†Π΅Π²Ρ‹Ρ… областСй Π΄Π΅Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΠΉ массива.ΠœΠ΅Ρ‚Π°. Виявити ΠΏΠΎΠΊΠ°Π·Π½ΠΈΠΊΠΈ зонального структурування масиву Π½Π°Π²ΠΊΠΎΠ»ΠΎ ΠΏΡ–Π΄Π·Π΅ΠΌΠ½ΠΈΡ… Π²ΠΈΡ€ΠΎΠ±ΠΎΠΊ Π·Π° допомогою Ρ‡ΠΈΡΠ΅Π»ΡŒΠ½ΠΈΡ… ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ–Π² модСлювання. ΠœΠ΅Ρ‚ΠΎΠ΄ΠΈΠΊΠ°. ДослідТСння зонального структурування масиву виконувалося ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ ΠΊΡ–Π½Ρ†Π΅Π²ΠΈΡ… Π΅Π»Π΅ΠΌΠ΅Π½Ρ‚Ρ–Π² Ρ– Ρ‚Π΅Ρ€ΠΌΠΎΠ΄ΠΈΠ½Π°ΠΌΡ–Ρ‡Π½ΠΈΠΌ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ, Π·Π° допомогою яких Π·ΠΌΠΎΠ΄Π΅Π»ΡŒΠΎΠ²Π°Π½Ρ– Ρ€ΠΎΠ·ΠΌΡ–Ρ€ΠΈ Ρ‚Π° ΠΊΡ–Π»ΡŒΠΊΡ–ΡΡ‚ΡŒ Π·ΠΎΠ½, які Ρ„ΠΎΡ€ΠΌΡƒΡŽΡ‚ΡŒΡΡ Π½Π°Π²ΠΊΠΎΠ»ΠΎ ΠΏΡ–Π΄Π³ΠΎΡ‚ΠΎΠ²Ρ‡ΠΈΡ… ΠΉ очисних Π²ΠΈΡ€ΠΎΠ±ΠΎΠΊ. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΈ. ВстановлСно Π²Ρ–Π΄Π½ΠΎΡˆΠ΅Π½Π½Ρ Π²Π΅Ρ€Ρ‚ΠΈΠΊΠ°Π»ΡŒΠ½ΠΈΡ… Ρ– Π³ΠΎΡ€ΠΈΠ·ΠΎΠ½Ρ‚Π°Π»ΡŒΠ½ΠΈΡ… напіввісСй Π·ΠΎΠ½ Ρƒ масиві Ρ‚Π° Π²ΠΈΠ·Π½Π°Ρ‡Π΅Π½Π° Π΄ΠΎΡΡ‚ΠΎΠ²Ρ–Ρ€Π½Ρ–ΡΡ‚ΡŒ ΠΎΡ‚Ρ€ΠΈΠΌΠ°Π½ΠΈΡ… Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ–Π². Π ΠΎΠ·ΠΊΡ€ΠΈΡ‚ΠΎ пСрспСктиви створСння Π½ΠΎΠ²ΠΈΡ… ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ–Π² модСлювання для дослідТСння ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€Ρ–Π² зонального структурування масиву Π½Π°Π²ΠΊΠΎΠ»ΠΎ ΠΏΡ–Π΄Π·Π΅ΠΌΠ½ΠΈΡ… Π²ΠΈΡ€ΠΎΠ±ΠΎΠΊ. Наукова Π½ΠΎΠ²ΠΈΠ·Π½Π°. Π ΠΎΠ·ΠΊΡ€ΠΈΡ‚ΠΎ моТливості ΡˆΠΈΡ€ΠΎΠΊΠΎ застосованих Ρ‡ΠΈΡΠ΅Π»ΡŒΠ½ΠΈΡ… ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ–Π² модСлювання для дослідТСння Ρ„Π΅Π½ΠΎΠΌΠ΅Π½Π° зонального ΠΊΠ°ΠΏΡΡƒΠ»ΡŽΠ²Π°Π½Π½Ρ масивом ΠΏΡ–Π΄Π·Π΅ΠΌΠ½ΠΈΡ… Π²ΠΈΡ€ΠΎΠ±ΠΎΠΊ. ΠŸΡ€Π°ΠΊΡ‚ΠΈΡ‡Π½Π° Π·Π½Π°Ρ‡ΠΈΠΌΡ–ΡΡ‚ΡŒ. ВстановлСно Ρ€ΠΎΠ·ΠΌΡ–Ρ€ΠΈ Ρ– Ρ„ΠΎΡ€ΠΌΡƒ Π·ΠΎΠ½ Ρƒ масиві Π½Π°Π²ΠΊΠΎΠ»ΠΎ Π²ΠΈΡ€ΠΎΠ±ΠΎΠΊ Ρ‚Π° Π²ΠΈΠ·Π½Π°Ρ‡Π΅Π½ΠΎ Π²ΠΈΠΌΠΎΠ³ΠΈ Π΄ΠΎ синСргСтичних ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ–Π² дослідТСння, Ρ‰ΠΎ ΠΏΠΎΠ»ΡΠ³Π°ΡŽΡ‚ΡŒ Ρƒ моТливості Π±Ρ–Π»ΡŒΡˆ Ρ‚ΠΎΡ‡Π½ΠΎΠ³ΠΎ визначСння ΠΊΡ–Π»ΡŒΠΊΠΎΡΡ‚Ρ–, Ρ€ΠΎΠ·ΠΌΡ–Ρ€Ρ–Π² Ρ– Ρ„ΠΎΡ€ΠΌΠΈ Π·ΠΎΠ½, Π° Ρ‚Π°ΠΊΠΎΠΆ ΡΠΈΠ½ΡƒΡΠΎΡ—Π΄Π°Π»ΡŒΠ½ΠΎ-Π·Π³Π°ΡΠ°ΡŽΡ‡ΠΈΡ… Π½Π°ΠΏΡ€ΡƒΠΆΠ΅Π½ΡŒ Ρ‚Π° ΠΊΡ–Π»ΡŒΡ†Π΅Π²ΠΈΡ… областСй Π΄Π΅Ρ„ΠΎΡ€ΠΌΠ°Ρ†Ρ–ΠΉ масиву.Π—Π° прСдоставлСнныС ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΎΠΊΠ°Π·Π°Π½Π½ΡƒΡŽ ΠΏΠΎΠ΄Π΄Π΅Ρ€ΠΆΠΊΡƒ ΠΏΡ€ΠΈ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ тСорСтичСских исслСдований с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ тСрмодинамичСского ΠΌΠ΅Ρ‚ΠΎΠ΄Π° Π°Π²Ρ‚ΠΎΡ€Ρ‹ Π²Ρ‹Ρ€Π°ΠΆΠ°ΡŽΡ‚ Π±Π»Π°Π³ΠΎΠ΄Π°Ρ€Π½ΠΎΡΡ‚ΡŒ Π·Π°Π²Π΅Π΄ΡƒΡŽΡ‰Π΅ΠΌΡƒ ΠΊΠ°Ρ„Π΅Π΄Ρ€Ρ‹ ΠΏΠΎΠ΄Π·Π΅ΠΌΠ½ΠΎΠΉ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ мСстороТдСний ΠΏΠΎΠ»Π΅Π·Π½Ρ‹Ρ… ископаСмых ГосударствСнного Π’Π£Π— β€œΠšΡ€ΠΈΠ²ΠΎΡ€ΠΎΠΆΡΠΊΠΈΠΉ Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½Ρ‹ΠΉ унивСрситСт” Π’.А. ΠšΠ°Π»ΠΈΠ½ΠΈΡ‡Π΅Π½ΠΊΡƒ

    TO THE QUESTION OF THE VOLTAGE STABILITY ENSURING FOR COMPLEX MONITORING SYSTEMS OF METAL’S STATUS

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    The paper considers one of the tasks that need to be solved when developing complex monitoring systems of metal’s status, which is to ensure the stability of the supply voltage, and the results of compensatory voltage stabilizer development are given. The analysis results of the adopted circuit solutions correctness are shown and the conformity of the stabilized power supply parameters to the given conditions is proved.The paper considers one of the tasks that need to be solved when developing complex monitoring systems of metal’s status, which is to ensure the stability of the supply voltage, and the results of compensatory voltage stabilizer development are given. The analysis results of the adopted circuit solutions correctness are shown and the conformity of the stabilized power supply parameters to the given conditions is proved

    ДослідТСння Π²ΠΏΠ»ΠΈΠ²Ρƒ Π½ΠΎΠ²ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠ±Ρ–Π½ΠΎΠ²Π°Π½ΠΎΠ³ΠΎ ΠΊΡ€Π΅ΠΌΡƒ Π”Π΅Ρ€ΠΌΠ°Π»Ρ–ΠΏΠΎΡ—Π½ Π½Π° ΠΏΡ€ΠΎΠ½ΠΈΠΊΠ½Ρ–ΡΡ‚ΡŒ судинної стінки

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    Topicality. The problem of treating wounds, including burns, remains relevant in modern medicine. For today in the arsenal of doctors there is a wide choice of medicines for treatment of wound process, however none of them is universal, and their effects are far from optimal. This makes it necessary to search for and develop new drugs for pharmacotherapy of the wound process.Aim. To study the capillary-firming activity of new cream on the model of increased permeability of the vessels of the abdominal wall in rats caused by various phlogogens.Materials and methods. With the purpose of in-depth study of the effect of the cream on the exudative component of the inflammatory reaction, experiments were conducted to determine its effect on the permeability of the vessels of the abdominal wall, which was caused by the administration of solutions of histamine, formalin, carrageenan, egg protein. By the difference in time of staining of the papules, after the introduction of the dye, the conclusion was made about the effect of the cream on vascular permeability.Results and discussion. The presence of new vascular stabilizing action in the new combined cream has been established due to the stabilization of the cell membranes and suppression of the activity of the inflammatory mediators that are formed as a result of cyclo- and lipoxygenase metabolism of arachidonic acid and, thereby, reduce the permeability of the vascular wall, which is an important component of the pharmacodynamics of the investigational pharmacological preparation, which is proposed for inflammatory-destructive processes.Conclusions. The ability of the test cream to reduce vascular permeability when introducing various phlogogenic substances indicates a multicomponent anti-inflammatory effect, which is associated with the antioxidant and membrane-stabilizing properties of the active substances of the cream.ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ. ΠŸΡ€ΠΎΠ±Π»Π΅ΠΌΠ° лСчСния Ρ€Π°Π½, Π² Ρ‚ΠΎΠΌ числС ΠΎΠΆΠΎΠ³ΠΎΠ²Ρ‹Ρ…, остаСтся Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΠΉ Π² соврСмСнной ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½Π΅. На сСгодняшний дСнь Π² арсСналС Π²Ρ€Π°Ρ‡Π΅ΠΉ Π΅ΡΡ‚ΡŒ большой Π²Ρ‹Π±ΠΎΡ€ лСкарствСнных ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ² для лСчСния Ρ€Π°Π½Π΅Π²ΠΎΠ³ΠΎ процСсса, ΠΎΠ΄Π½Π°ΠΊΠΎ Π½ΠΈ ΠΎΠ΄ΠΈΠ½ ΠΈΠ· Π½ΠΈΡ… Π½Π΅ являСтся ΡƒΠ½ΠΈΠ²Π΅Ρ€ΡΠ°Π»ΡŒΠ½Ρ‹ΠΌ, Π° ΠΈΡ… эффСкты Π΄Π°Π»Π΅ΠΊΠΈ ΠΎΡ‚ ΠΎΠΏΡ‚ΠΈΠΌΠ°Π»ΡŒΠ½Ρ‹Ρ…. Π­Ρ‚ΠΎ обусловливаСт Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎΡΡ‚ΡŒ поиска ΠΈ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ Π½ΠΎΠ²Ρ‹Ρ… лСкарствСнных ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ² для Ρ„Π°Ρ€ΠΌΠ°ΠΊΠΎΡ‚Π΅Ρ€Π°ΠΏΠΈΠΈ Ρ€Π°Π½Π΅Π²ΠΎΠ³ΠΎ процСсса.ЦСль Ρ€Π°Π±ΠΎΡ‚Ρ‹ Π·Π°ΠΊΠ»ΡŽΡ‡Π°Π»Π°ΡΡŒ Π² ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠΈ ΠΊΠ°ΠΏΠΈΠ»Π»ΡΡ€ΠΎΡƒΠΊΡ€Π΅ΠΏΠ»ΡΡŽΡ‰Π΅ΠΉ активности Π½ΠΎΠ²ΠΎΠ³ΠΎ ΠΊΡ€Π΅ΠΌΠ° Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½Π½ΠΎΠΉ проницаСмости сосудов Π±Ρ€ΡŽΡˆΠ½ΠΎΠΉ стСнки Ρƒ крыс, Π²Ρ‹Π·Π²Π°Π½Π½ΠΎΠΉ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹ΠΌΠΈ Ρ„Π»ΠΎΠ³ΠΎΠ³Π΅Π½Π°ΠΌΠΈ.ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. Π‘ Ρ†Π΅Π»ΡŒΡŽ ΡƒΠ³Π»ΡƒΠ±Π»Π΅Π½Π½ΠΎΠ³ΠΎ изучСния влияния ΠΊΡ€Π΅ΠΌΠ° Π½Π° экссудативный ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚ Π²ΠΎΡΠΏΠ°Π»ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ Ρ€Π΅Π°ΠΊΡ†ΠΈΠΈ ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ экспСримСнты ΠΏΠΎ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΡŽ Π΅Π³ΠΎ влияния Π½Π° ΠΏΡ€ΠΎΠ½ΠΈΡ†Π°Π΅ΠΌΠΎΡΡ‚ΡŒ сосудов Π±Ρ€ΡŽΡˆΠ½ΠΎΠΉ стСнки, ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΠ΅ ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠΉ Π²Ρ‹Π·Ρ‹Π²Π°Π»ΠΈ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ΠΌ растворов гистамина, Ρ„ΠΎΡ€ΠΌΠ°Π»ΠΈΠ½Π°, ΠΊΠ°Ρ€Π°Π³Π΅Π½ΠΈΠ½Π°, яичного Π±Π΅Π»ΠΊΠ°. По Ρ€Π°Π·Π½ΠΈΡ†Π΅ Π²ΠΎ Π²Ρ€Π΅ΠΌΠ΅Π½ΠΈ ΠΎΠΊΡ€Π°ΡˆΠΈΠ²Π°Π½ΠΈΡ ΠΏΠ°ΠΏΡƒΠ» послС ввСдСния краситСля Π΄Π΅Π»Π°Π»ΠΈ Π²Ρ‹Π²ΠΎΠ΄ ΠΎ влиянии ΠΊΡ€Π΅ΠΌΠ° Π½Π° ΡΠΎΡΡƒΠ΄ΠΈΡΡ‚ΡƒΡŽ ΠΏΡ€ΠΎΠ½ΠΈΡ†Π°Π΅ΠΌΠΎΡΡ‚ΡŒ.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΠΈ ΠΈΡ… обсуТдСниС. УстановлСно Π½Π°Π»ΠΈΡ‡ΠΈΠ΅ Ρƒ Π½ΠΎΠ²ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΊΡ€Π΅ΠΌΠ° ΡΠΎΡΡƒΠ΄ΠΈΡΡ‚ΠΎΡΡ‚Π°Π±ΠΈΠ»ΠΈΠ·ΠΈΡ€ΡƒΡŽΡ‰Π΅Π³ΠΎ дСйствия Π·Π° счСт стабилизации ΠΌΠ΅ΠΌΠ±Ρ€Π°Π½Ρ‹ ΠΊΠ»Π΅Ρ‚ΠΎΠΊ ΠΈ подавлСния активности ΠΌΠ΅Π΄ΠΈΠ°Ρ‚ΠΎΡ€ΠΎΠ² воспалСния, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ ΠΎΠ±Ρ€Π°Π·ΡƒΡŽΡ‚ΡΡ Π² Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π΅ Ρ†ΠΈΠΊΠ»ΠΎ- ΠΈ липооксигСназного ΠΌΠ΅Ρ‚Π°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° Π°Ρ€Π°Ρ…ΠΈΠ΄ΠΎΠ½ΠΎΠ²ΠΎΠΉ кислоты ΠΈ благодаря этому ΡΠ½ΠΈΠΆΠ°Ρ‚ΡŒ ΠΏΡ€ΠΎΠ½ΠΈΡ†Π°Π΅ΠΌΠΎΡΡ‚ΡŒ сосудистой стСнки, Ρ‡Ρ‚ΠΎ являСтся Π²Π°ΠΆΠ½ΠΎΠΉ ΡΠΎΡΡ‚Π°Π²Π»ΡΡŽΡ‰Π΅ΠΉ Ρ„Π°Ρ€ΠΌΠ°ΠΊΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ исслСдуСмого фармакологичСского ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Π° ΠΊΠ°ΠΊ срСдства, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΉ прСдлагаСтся ΠΏΡ€ΠΈ Π²ΠΎΡΠΏΠ°Π»ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ-дСструктивных процСссах.Π’Ρ‹Π²ΠΎΠ΄Ρ‹. Π‘ΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡ‚ΡŒ исслСдуСмого ΠΊΡ€Π΅ΠΌΠ° ΡƒΠΌΠ΅Π½ΡŒΡˆΠ°Ρ‚ΡŒ ΡΠΎΡΡƒΠ΄ΠΈΡΡ‚ΡƒΡŽ ΠΏΡ€ΠΎΠ½ΠΈΡ†Π°Π΅ΠΌΠΎΡΡ‚ΡŒ ΠΏΡ€ΠΈ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… Ρ„Π»ΠΎΠ³ΠΎΠ³Π΅Π½Π½Ρ‹Ρ… вСщСств ΡΠ²ΠΈΠ΄Π΅Ρ‚Π΅Π»ΡŒΡΡ‚Π²ΡƒΠ΅Ρ‚ ΠΎ ΠΌΠ½ΠΎΠ³ΠΎΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚Π½ΠΎΠΌ ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΌ дСйствии, ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠ΅ связано с антиоксидантными ΠΈ ΠΌΠ΅ΠΌΠ±Ρ€Π°Π½ΠΎΡΡ‚Π°Π±ΠΈΠ»ΠΈΠ·ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠΌΠΈ свойствами Π΄Π΅ΠΉΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΡ… вСщСств ΠΊΡ€Π΅ΠΌΠ°.ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ–ΡΡ‚ΡŒ. ΠŸΡ€ΠΎΠ±Π»Π΅ΠΌΠ° лікування Ρ€Π°Π½, Π·ΠΎΠΊΡ€Π΅ΠΌΠ° ΠΎΠΏΡ–ΠΊΠΎΠ²ΠΈΡ…, Π·Π°Π»ΠΈΡˆΠ°Ρ”Ρ‚ΡŒΡΡ Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΡŽ Π² сучасній ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½Ρ–. На Ρ‚Π΅ΠΏΠ΅Ρ€Ρ–ΡˆΠ½Ρ–ΠΉ час Π² арсСналі Π»Ρ–ΠΊΠ°Ρ€Ρ–Π² Ρ” Π²Π΅Π»ΠΈΠΊΠΈΠΉ Π²ΠΈΠ±Ρ–Ρ€ Π»Ρ–ΠΊΠ°Ρ€ΡΡŒΠΊΠΈΡ… ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Ρ–Π² для лікування Ρ€Π°Π½ΠΎΠ²ΠΎΠ³ΠΎ процСсу, ΠΎΠ΄Π½Π°ΠΊ ΠΆΠΎΠ΄Π΅Π½ Π· Π½ΠΈΡ… Π½Π΅ Ρ” ΡƒΠ½Ρ–Π²Π΅Ρ€ΡΠ°Π»ΡŒΠ½ΠΈΠΌ, Π° Ρ—Ρ… Π΅Ρ„Π΅ΠΊΡ‚ΠΈ Π΄Π°Π»Π΅ΠΊΡ– Π²Ρ–Π΄ ΠΎΠΏΡ‚ΠΈΠΌΠ°Π»ΡŒΠ½ΠΈΡ…. Π¦Π΅ Π·ΡƒΠΌΠΎΠ²Π»ΡŽΡ” Π½Π΅ΠΎΠ±Ρ…Ρ–Π΄Π½Ρ–ΡΡ‚ΡŒ ΠΏΠΎΡˆΡƒΠΊΡƒ Ρ– Ρ€ΠΎΠ·Ρ€ΠΎΠ±ΠΊΠΈ Π½ΠΎΠ²ΠΈΡ… Π»Ρ–ΠΊΠ°Ρ€ΡΡŒΠΊΠΈΡ… ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Ρ–Π² для Ρ„Π°Ρ€ΠΌΠ°ΠΊΠΎΡ‚Π΅Ρ€Π°ΠΏΡ–Ρ— Ρ€Π°Π½ΠΎΠ²ΠΎΠ³ΠΎ процСсу.ΠœΠ΅Ρ‚Π° Ρ€ΠΎΠ±ΠΎΡ‚ΠΈ полягала Ρƒ Π²ΠΈΠ²Ρ‡Π΅Π½Π½Ρ– ΠΊΠ°ΠΏΡ–Π»ΡΡ€ΠΎΠ·ΠΌΡ–Ρ†Π½ΡŽΠ²Π°Π»ΡŒΠ½ΠΎΡ— активності Π½ΠΎΠ²ΠΎΠ³ΠΎ ΠΊΡ€Π΅ΠΌΡƒ Π½Π° ΠΌΠΎΠ΄Π΅Π»Ρ– ΠΏΡ–Π΄Π²ΠΈΡ‰Π΅Π½ΠΎΡ— проникності судин Ρ‡Π΅Ρ€Π΅Π²Π½ΠΎΡ— стінки Ρƒ Ρ‰ΡƒΡ€Ρ–Π², Π²ΠΈΠΊΠ»ΠΈΠΊΠ°Π½ΠΎΡ— Ρ€Ρ–Π·Π½ΠΈΠΌΠΈ Ρ„Π»ΠΎΠ³ΠΎΠ³Π΅Π½Π°ΠΌΠΈ.ΠœΠ°Ρ‚Π΅Ρ€Ρ–Π°Π»ΠΈ Ρ‚Π° ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈ. Π— ΠΌΠ΅Ρ‚ΠΎΡŽ ΠΏΠΎΠ³Π»ΠΈΠ±Π»Π΅Π½ΠΎΠ³ΠΎ вивчСння Π²ΠΏΠ»ΠΈΠ²Ρƒ ΠΊΡ€Π΅ΠΌΡƒ Π½Π° Сксудативний ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚ Π·Π°ΠΏΠ°Π»ΡŒΠ½ΠΎΡ— Ρ€Π΅Π°ΠΊΡ†Ρ–Ρ— ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ СкспСримСнти Π· визначСння ΠΉΠΎΠ³ΠΎ Π²ΠΏΠ»ΠΈΠ²Ρƒ Π½Π° ΠΏΡ€ΠΎΠ½ΠΈΠΊΠ½Ρ–ΡΡ‚ΡŒ судин Ρ‡Π΅Ρ€Π΅Π²Π½ΠΎΡ— стінки, підвищСння якої Π²ΠΈΠΊΠ»ΠΈΠΊΠ°Π»ΠΈ ввСдСнням Ρ€ΠΎΠ·Ρ‡ΠΈΠ½Ρ–Π² гістаміну, Ρ„ΠΎΡ€ΠΌΠ°Π»Ρ–Π½Ρƒ, ΠΊΠ°Ρ€Π°Π³Π΅Π½Ρ–Π½Ρƒ, яєчного Π±Ρ–Π»ΠΊΠ°. Π—Π° Ρ€Ρ–Π·Π½ΠΈΡ†Π΅ΡŽ Π² часі профарбовування ΠΏΠ°ΠΏΡƒΠ» після ввСдСння Π±Π°Ρ€Π²Π½ΠΈΠΊΠ° Ρ€ΠΎΠ±ΠΈΠ»ΠΈ висновок ΠΏΡ€ΠΎ Π²ΠΏΠ»ΠΈΠ² ΠΊΡ€Π΅ΠΌΡƒ Π½Π° судинну ΠΏΡ€ΠΎΠ½ΠΈΠΊΠ½Ρ–ΡΡ‚ΡŒ. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΈ Ρ‚Π° Ρ—Ρ… обговорСння. ВстановлСна Π½Π°ΡΠ²Π½Ρ–ΡΡ‚ΡŒ Ρƒ Π½ΠΎΠ²ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠ±Ρ–Π½ΠΎΠ²Π°Π½ΠΎΠ³ΠΎ ΠΊΡ€Π΅ΠΌΡƒ ΡΡƒΠ΄ΠΈΠ½ΠΎΡΡ‚Π°Π±Ρ–Π»Ρ–Π·ΡƒΠ²Π°Π»ΡŒΠ½ΠΎΡ— Π΄Ρ–Ρ— Π·Π° Ρ€Π°Ρ…ΡƒΠ½ΠΎΠΊ стабілізації ΠΌΠ΅ΠΌΠ±Ρ€Π°Π½ΠΈ ΠΊΠ»Ρ–Ρ‚ΠΈΠ½ Ρ‚Π° пригнічСння активності ΠΌΠ΅Π΄Ρ–Π°Ρ‚ΠΎΡ€Ρ–Π² запалСння, Ρ‰ΠΎ ΡƒΡ‚Π²ΠΎΡ€ΡŽΡŽΡ‚ΡŒΡΡ внаслідок Ρ†ΠΈΠΊΠ»ΠΎ- Ρ‚Π° ліпооксигСназного ΠΌΠ΅Ρ‚Π°Π±ΠΎΠ»Ρ–Π·ΠΌΡƒ Π°Ρ€Π°Ρ…Ρ–Π΄ΠΎΠ½ΠΎΠ²ΠΎΡ— кислоти Ρ‚Π° завдяки Ρ†ΡŒΠΎΠΌΡƒ Π·Π½ΠΈΠΆΡƒΠ²Π°Ρ‚ΠΈ ΠΏΡ€ΠΎΠ½ΠΈΠΊΠ½Ρ–ΡΡ‚ΡŒ судинної стінки, Ρ‰ΠΎ Ρ” ваТливою складовою Ρ„Π°Ρ€ΠΌΠ°ΠΊΠΎΠ΄ΠΈΠ½Π°ΠΌΡ–ΠΊΠΈ дослідТуваного Ρ„Π°Ρ€ΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½ΠΎΠ³ΠΎ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Ρƒ як засоба, який ΠΏΡ€ΠΎΠΏΠΎΠ½ΡƒΡ”Ρ‚ΡŒΡΡ ΠΏΡ€ΠΈ запально-дСструктивних процСсах.Висновки. Π—Π΄Π°Ρ‚Π½Ρ–ΡΡ‚ΡŒ дослідТуваного ΠΊΡ€Π΅ΠΌΡƒ Π·ΠΌΠ΅Π½ΡˆΡƒΠ²Π°Ρ‚ΠΈ судинну ΠΏΡ€ΠΎΠ½ΠΈΠΊΠ½Ρ–ΡΡ‚ΡŒ ΠΏΡ€ΠΈ Π²Π²Π΅Π΄Π΅Π½Π½Ρ– Ρ€Ρ–Π·Π½ΠΎΠΌΠ°Π½Ρ–Ρ‚Π½ΠΈΡ… Ρ„Π»ΠΎΠ³ΠΎΠ³Π΅Π½Π½ΠΈΡ… Ρ€Π΅Ρ‡ΠΎΠ²ΠΈΠ½ ΡΠ²Ρ–Π΄Ρ‡ΠΈΡ‚ΡŒ ΠΏΡ€ΠΎ Π±Π°Π³Π°Ρ‚ΠΎΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚Ρƒ ΠΏΡ€ΠΎΡ‚ΠΈΠ·Π°ΠΏΠ°Π»ΡŒΠ½Ρƒ Π΄Ρ–ΡŽ, пов’язану Π· антиоксидантними Ρ– ΠΌΠ΅ΠΌΠ±Ρ€Π°Π½ΠΎΡΡ‚Π°Π±Ρ–Π»Ρ–Π·ΡƒΠ²Π°Π»ΡŒΠ½ΠΈΠΌΠΈ властивостями Π΄Ρ–ΡŽΡ‡ΠΈΡ… Ρ€Π΅Ρ‡ΠΎΠ²ΠΈΠ½ ΠΊΡ€Π΅ΠΌΡƒ
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