A Census of Star-Forming Galaxies at z = 1-3 in the Subaru Deep Field

Several UV and near-infrared color selection methods have identified galaxies at z = 1-3. Since each method suffers from selection biases, we have applied three leading techniques (Lyman break, BX/BM, and BzK selection) simultaneously in the Subaru Deep Field. This field has reliable ({\Delta}z/(1 + z) = 0.02--0.09) photometric redshifts for ~53,000 galaxies from 20 bands (1500{\AA}--2.2{\mu}m). The BzK, LBG, and BX/BM samples suffer contamination from z<1 interlopers of 6%, 8%, and 20%, respectively. Around the redshifts where it is most sensitive (z~1.9 for star-forming BzK, z~1.8 for z~2 LBGs, z~1.6 for BM, and z~2.3 for BX), each technique finds 60-80% of the census of the three methods. In addition, each of the color techniques shares 75-96% of its galaxies with another method, which is consistent with previous studies that adopt identical criteria on magnitudes and colors. Combining the three samples gives a comprehensive census that includes ~90% of z-phot = 1-3 galaxies, using standard magnitude limits similar to previous studies. In fact, we find that among z = 1-2.5 galaxies in the color selection census, 81-90% of them can be selected by just combining the BzK selection with one of the UV techniques (z~2 LBG or BX and BM). The average galaxy stellar mass, reddening and SFRs all decrease systematically from the sBzK population to the LBGs, and to the BX/BMs. The combined color selections yield a total cosmic SFR density of 0.18 $\pm$ 0.03 M_sun yr^{-1} Mpc^{-3} for K_AB <= 24. We find that 65% of the star formation is in galaxies with E(B-V) > 0.25 mag, even though they are only one-fourth of the census by number.Comment: 26 pages, 30 figures, 9 tables, emulateapj format. Modified to match the final ApJ versio

Utility of Whole Genome Sequencing in Assessing and Enhancing Partner Notification of Neisseria gonorrhoeae Infection

Background: Gonorrhea is a sexually transmitted infection of global concern. We investigated whole genome sequencing (WGS) as a tool to measure and enhance partner notification (PN) in gonorrhea management. / Methods: Between May-November 2018, all N. gonorrhoeae isolated from patients attending Leeds Sexual Health, UK, underwent WGS. Reports listing sequences within 20 single nucleotide polymorphisms (SNPs) of study isolates within a database containing select isolates from April 1 2016 to November 15 2018 were issued to clinicians. The proportion of cases with a potential transmission partner identified by PN was determined from patient and PN data. WGS reports were reviewed to identify additional cases within ≤6 SNPs and verified for PN concordance. / Results: 380 isolates from 377 cases were successfully sequenced; 292 had traceable/contactable partners and 69 (18%) had a potential transmission partner identified by PN. Concordant PN and WGS links were identified in 47 partner pairs. Of 308 cases with no transmission partner by PN, 185 (60%) had a case within ≤6 SNPs; examination of these cases’ PN data identified seven partner pairs with previously unrecognized PN link, giving a total of 54 pairs; all had ≤4 SNP differences. WGS clusters confirmed gaps in partner finding, at individual and group levels. Despite the clinic providing sexual health services to the whole city, 35 cases with multiple partners had no genetically related case, suggesting multiple undiagnosed infections. / Conclusions: WGS could improve gonorrhea PN and control by identifying new links and clusters with significant gaps in partner finding

Star Formation Rates and Metallicities of K-selected Star Forming Galaxies at z~2

We present spectroscopy of 15 star-forming BzK galaxies (sBzKs) with K(AB)<23 in the Subaru Deep Field, for which Halpha and some other emission lines are detected in 0.9 to 2.3 micron spectra with a resolution of R=500. Using Halpha luminosities, we obtain star formation rates (SFRs), and then specific SFRs (SSFRs) dividing SFRs by stellar masses, which are derived from SED fitting to BVRi'z'K photometry. It is found that sBzKs with higher stellar masses have larger SFRs. A negative correlation is seen between stellar mass and SSFR, which is consistent with the previous results for z~2 galaxies. This implies that a larger growth of stellar mass occurs in less massive galaxies. In addition, gas-phase oxygen abundances, 12+log(O/H), are derived from the ratio of NII(lambda 6584) to Halpha using the N2 index method. We have found a correlation between stellar mass and oxygen abundance in the sense that more massive sBzKs tend to be more metal rich, which is qualitatively consistent with the relation for UV-selected z~2 galaxies. However, the metallicity of the sBzKs is ~0.2 dex higher than that of UV-selected galaxies with similar stellar masses, which is significant considering the small uncertainties. The sBzKs in our sample have redder R-K colors than the UV-selected galaxies. This galaxy color-dependence in the oxygen abundance may be caused by older or dustier galaxies having higher metallicities at z~2.Comment: 20 pages, 13 figures, 2 tables, accepted for publication in The Astrophysical Journa

Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/β-catenin signalling pathway

Objectives: Interaction between neoplastic and stromal cells plays an important role in tumour progression. It was recently found that WNT2 was frequently overexpressed in fibroblasts isolated from tumour tissue tumour fibroblasts (TF) compared with fibroblasts from non-tumour tissue normal fibroblasts in oesophageal squamous cell carcinoma (OSCC). This study aimed to investigate the effect of TF-secreted Wnt2 in OSCC development via the tumour - stroma interaction. Methods: Quantitative PCR, western blotting, immunohistochemistry and immunofluorescence were used to study the expression pattern of Wnt2 and its effect on the Wnt/β-catenin pathway. A Wnt2-secreting system was established in Chinese hamster ovary cells and its conditioned medium was used to study the role of Wnt2 in cell proliferation and invasion. Results: Expression of Wnt2 could only be detected in TF but not in OSCC cancer cell lines. In OSCC tissues, Wnt2 (+) cells were mainly detected in the boundary between stroma and tumour tissue or scattered within tumour tissue. In this study, Wnt2-positive OSCC was defined when five or more Wnt2(+) cells were observed in 2003X microscopy field. Interestingly, Wnt2-positive OSCC (22/51 cases) was significantly associated with lymph node metastases (p=0.001), advanced TNM stage (p=0.001) and disease-specific survival (p<0.0001). Functional study demonstrated that secreted Wnt2 could promote oesophageal cancer cell growth by activating the Wnt/β-catenin signalling pathway and subsequently upregulated cyclin D1 and c-myc expression. Further study found that Wnt2 could enhance cell motility and invasiveness by inducing epithelial-mesenchymal transition. Conclusions: TF-secreted Wnt2 acts as a growth and invasion-promoting factor through activating the canonical Wnt/β-catenin signalling pathway in oesophageal cancer cells.published_or_final_versio

The Bayes factor and its implementation in JASP: A practical primer

Statistical inference plays a critical role in modern scientific research, however, the dominant method for statistical inference in science, null hypothesis significance testing (NHST), is often misunderstood and misused, which leads to unreproducible findings. To address this issue, researchers propose to adopt the Bayes factor as an alternative to NHST. The Bayes factor is a principled Bayesian tool for model selection and hypothesis testing, and can be interpreted as the strength for both the null hypothesis H0 and the alternative hypothesis H1 based on the current data. Compared to NHST, the Bayes factor has the following advantages: it quantifies the evidence that the data provide for both the H0 and the H1, it is not “violently biased” against H0, it allows one to monitor the evidence as the data accumulate, and it does not depend on sampling plans. Importantly, the recently developed open software JASP makes the calculation of Bayes factor accessible for most researchers in psychology, as we demonstrated for the t-test. Given these advantages, adopting the Bayes factor will improve psychological researchers’ statistical inferences. Nevertheless, to make the analysis more reproducible, researchers should keep their data analysis transparent and open

Structural and infrared absorption properties of self-organized InGaAs GaAs quantum dots multilayers

Self-organized InGaAs/GaAs quantum dots (QDs) stacked multilayers have been prepared by solid source molecular beam epitaxy. Cross-sectional transmission electron microscopy shows that the InGaAs QDs are nearly perfectly vertically aligned in the growth direction [100]. The filtering effect on the QDs distribution is found to be the dominant mechanism leading to vertical alignment and a highly uniform size distribution. Moreover, we observe a distinct infrared absorption from the sample in the range of 8.6-10.7 mu m. This indicates the potential of QDs multilayer structure for use as infrared photodetector

High star formation activity in the central region of a distant cluster at z=1.46

We present an unbiased deep [OII] emission survey of a cluster XMMXCS J2215.9-1738 at z=1.46, the most distant cluster to date with a detection of extended X-ray emission. With wide-field optical and near-infrared cameras (Suprime-Cam and MOIRCS, respectively) on Subaru telescope, we performed deep imaging with a narrow-band filter NB912 (lambda_c=9139A, Delta_lambda=134A) as well as broad-band filters (B, z', J and Ks). From the photometric catalogues, we have identified 44 [OII] emitters in the cluster central region of 6'x6' down to a dust-free star formation rate of 2.6 Msun/yr (3 sigma). Interestingly, it is found that there are many [OII] emitters even in the central high density region. In fact, the fraction of [OII] emitters to the cluster members as well as their star formation rates and equivalent widths stay almost constant with decreasing cluster-centric distance up to the cluster core. Unlike clusters at lower redshifts (z<1) where star formation activity is mostly quenched in their central regions, this higher redshift 2215 cluster shows its high star formation activity even at its centre, suggesting that we are beginning to enter the formation epoch of some galaxies in the cluster core eventually. Moreover, we find a deficit of galaxies on the red sequence at magnitudes fainter than ~M*+0.5 on the colour-magnitude diagram. This break magnitude is brighter than that of lower redshift clusters, and it is likely that we are seeing the formation phase of more massive red galaxies in the cluster core at z~1. These results may indicate inside-out and down-sizing propagation of star formation activity in the course of cluster evolution.Comment: 12 pages, 9 figures, 1 table, accepted for publication in MNRA

Properties of star-forming galaxies in a cluster and its surrounding structure at z=1.46

We conduct a narrow-band imaging survey of [OII] emitters over a 32'x23' area in and around the XMMXCS J2215.9-1738 cluster at z=1.46 with Subaru/Suprime-Cam, and select 380 [OII] emitting galaxies down to 1.4E-17 erg/s/cm2. Among them, 16 [OII] emitters in the cluster central region are confirmed by NIR spectroscopy with Subaru/MOIRCS. We find that [OII] emitters are distributed along filamentary large-scale structures around the cluster. The z'-K vs K colour-magnitude diagram shows that a significantly higher fraction of [OII] emitters is seen on the red sequence in the cluster core than in other environments we define in this paper. It is likely that these red galaxies are nearly passively evolving galaxies which host [OII] emitting AGNs, rather than dust-reddened star-forming galaxies. We argue therefore that AGN feedback may be one of the critical processes to quench star formation in massive galaxies in high density regions. We also find that the cluster has experienced high star formation activities at rates comparable to that in the field at z=1.46. In addition, a mass-metallicity relation exists in the cluster at z=1.46, which is similar to that of star-forming galaxies in the field at z~2. These results all suggest that at z~1.5 star formation activity in the cluster core becomes as high as those in low density environments and there is apparently not yet a strong environmental dependence, except for the red emitters.Comment: 19 pages, 17 figures, 4 tables, accepted for publication in MNRA

Avoidable readmission in Hong Kong - system, clinician, patient or social factor?

<p>Abstract</p> <p>Background</p> <p>Studies that identify reasons for readmissions are gaining importance in the light of the changing demographics worldwide which has led to greater demand for hospital beds. It is essential to profile the prevalence of avoidable readmissions and understand its drivers so as to develop possible interventions for reducing readmissions that are preventable. The aim of this study is to identify the magnitude of avoidable readmissions, its contributing factors and costs in Hong Kong.</p> <p>Methods</p> <p>This was a retrospective analysis of 332,453 inpatient admissions in the Medical specialty in public hospital system in Hong Kong in year 2007. A stratified random sample of patients with unplanned readmission within 30 days after discharge was selected for medical record reviews. Eight physicians reviewed patients' medical records and classified whether a readmission was avoidable according to an assessment checklist. The results were correlated with hospital inpatient data.</p> <p>Results</p> <p>It was found that 40.8% of the 603 unplanned readmissions were judged avoidable by the reviewers. Avoidable readmissions were due to: clinician factor (42.3%) including low threshold for admission and premature discharge etc.; patient factor (including medical and health factor) (41.9%) such as relapse or progress of previous complaint, and compliance problems etc., followed by system factor (14.6%) including inadequate discharge planning, inadequate palliative care/terminal care, etc., and social factor (1.2%) such as carer system, lack of support and community services. After adjusting for patients' age, gender, principal diagnosis at previous discharge and readmission hospitals, the risk factors for avoidable readmissions in the total population i.e. all acute care admissions irrespective of whether there was a readmission or not, included patients with a longer length of stay, and with higher number of hospitalizations and attendance in public outpatient clinics and Accident and Emergency departments in the past 12 months. In the analysis of only unplanned readmissions, it was found that the concordance of the principal diagnosis for admission and readmission, and shorter time period between discharge and readmission were associated with avoidable readmissions.</p> <p>Conclusions</p> <p>Our study found that almost half of the readmissions could have been prevented. They had been mainly due to clinician and patient factors, in particular, both of which were intimately related to clinical management and patient care. These readmissions could be prevented by a system of ongoing clinical review to examine the clinical practice/decision for discharge, and improving clinical care and enhancing patient knowledge of the early warning signs for relapse. The importance of adequate and appropriate ambulatory care to support the patients in the community was also a key finding to reduce avoidable readmissions. Education on patient self-management should also be enhanced to minimize the patient factors with regard to avoidable readmission. Our findings thus provide important insights into the development of an effective discharge planning system which should place patients and carers as the primacy focus of care by engaging them along with the healthcare professionals in the whole discharge planning process.</p