Regional Aspects of Nosocomial Infection As a Medical and Social Problem

Prevention of nosocomial infection (NI) is an important medical and socioeconomic problem. And though certain organizational and practical measures are implemented in Russia every year to reduce NIs, the problem is still relevant from medical and social points of view. The risk of infection are both for patients and medical workers. In Russia, the minimum economic damage caused by NIs is 2.5–5 billion rubles annually. According to the Office of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare in the Republic of Mordovia, the total incidence of NI in the region is at a low level. The incidence rate was 0.01 per 1000 patients in hospitals. The dynamics of the last five years demonstrates a decrease in hospital-acquired infections. In the dynamics of the last five years, incidence rates of purulent-septic infections of newborns and postpartum women, postoperative purulent-septic complications and post-injection complications had an unstable downward trend. Thus, purulent-septic infections of newborns and postpartum women and postoperative infections are dominated in the structure of nosocomial infections. Analysis of dynamics of morbidity in recent years in the Republic of Mordovia suggests that the measures taken to prevent NI are quite effective and are manifested with consistently low rates

Electrophysiological Parameters of Sinus Node Function in Patients with Paroxysmal Tachyarrhythmias

to analyze the indicators of the function of the sinus node in patients of young age with paroxysmal tachycardia. Methods: study included 11 patients with suspected paroxysmal tachycardia, with an average age of 17±28. The basis for holding transesophageal electrophysiological study (TE EPS) was the clinical and electrophysiological characteristics of paroxysmal tachycardia. According to the results of Holter monitoring ECG (HM ECG) analyzed the minimum and maximum heart rate, number of ventricular and supraventricular arrhythmias, presence of pauses, rhythm and episodes of paroxysmal tachycardia. According to CHP, EFI estimated the initial heart rate (HR), recovery time of sinus node function (RTSNF), corrected recovery time of sinus node function (CRTSNF), point of Wenkebach (p. W), duration of the effective refractory period of the atrioventricular connections, presence of aberrant complexes and episodes of paroxysmal tachycardias before and after administration of atropine at a dose of 0.02 mg/kg. Results: Complaints characteristic of the tachyarrhythmia was diagnosed in 9 patients, episodes of heart rate more than 150 beats per minute in 7 patients. When conducting TE EPS obtained the following results: episodes of supraventricular tachycardia provoked in 8 patients (in two cases of paroxysmal tachycardia managed to provoke only after administration of atropine). Three of them have shimmer and atrial flutter episodes reciprocal tachycardia in five. Three patients provoke paroxysmal tachycardia failed, but they showed a shortening of the PQ interval and the appearance of aberrant QRS complexes when stimulated. In patients with paroxysmal SVT signs of sinus node dysfunction was detected in 6 patients, in the form of episodes of sinus arrhythmia (4 patients), migration pacemaker the atria (4 patients), sinoatrial blockade of II degree (3 patients), blockade of legs of bunch of gisa (2 patients), atrioventricular block degree II-III (1 patient), RTSNF more than 1500 MS in 1 patient, CRTSNF greater than 500 msec in 3 patients. Conclusion: in 6 of 9 patients with supraventricular paroxysmal tachycardia revealed signs of sinus node dysfunction, probably has a vagotonic in nature

The Interstellar Medium of Quiescent Galaxies and its Evolution With Time

We characterise the basic far-IR (FIR) properties and the gas mass fraction of massive ( ~ 11.0) quiescent galaxies (QGs) and explore how these evolve from z = 2.0 to the present day. We use robust, multi-wavelength (mid- to far-IR and sub-millimetre to radio) stacking ensembles of homogeneously selected and mass complete samples of log(M*/Msun) > 10.8 QGs. We find that the dust to stellar mass ratio (Md/M*) rises steeply as a function of redshift up to z~1.0 and then remains flat at least out to z = 2.0. Using Md as a proxy of gas mass (Mgas), we find a similar trend for the evolution of the gas mass fraction (fgas) with z > 1.0 QGs having fgas ~ 7.0% (for solar metallicity). This fgas is 3 - 10 times lower than that of normal star forming galaxies (SFGs) at their corresponding redshift but ~3 and ~10 times larger compared to that of z = 0.5 and local QGs. Furthermore, the inferred gas depletion time scales are comparable to that of local SFGs and systematically longer than that of main sequence galaxies at their corresponding redshifts. Our analysis also reveals that the average dust temperature (Td) of massive QGs remains roughly constant ( = 21.0 \pm 2.0K) at least out to z ~ 2.0 and is substantially colder (~ 10K) compared to that of z > 0 SFGs. This motivated us to construct and release a redshift-invariant template IR SED, that we use to make predictions for ALMA observations and to explore systematic effects in the Mgas estimates of massive, high-z QGs. Finally, we discuss how a simple model that considers progenitor-bias can effectively reproduce the observed evolution of Md/M* and fgas. Our results indicate universal initial interstellar medium conditions for quenched galaxies and a large degree of uniformity in their internal processes across cosmic time.Comment: Accepted for publication in A&

Early- and late-stage mergers among main sequence and starburst galaxies at 0.2 ≤ z ≤ 2

We investigate the fraction of close pairs and morphologically identified mergers on and above the star-forming main sequence (MS) at 0.2 ≤ z ≤2.0. The novelty of our work lies in the use of a non-parametric morphological classification performed on resolved stellar mass maps, reducing the contamination by non-interacting, high-redshift clumpy galaxies. We find that the merger fraction rapidly rises to ≥70 per cent above the MS, implying that - already at z ≳ 1 - starburst (SB) events (∆MS ≥ 0.6) are almost always associated with a major merger (1:1 to 1:6 mass ratio). The majority of interacting galaxies in the SB region are morphologically disturbed, late-stage mergers. Pair fractions show little dependence on MS offset and pairs are more prevalent than late-stage mergers only in the lower half of the MS. In our sample, major mergers on the MS occur with a roughly equal frequency of ̃5-10 per cent at all masses ≳ 1010 M☉. The MS major merger fraction roughly doubles between z = 0.2 and 2, with morphological mergers driving the overall increase at z ≳ 1. The differential redshift evolution of interacting pairs and morphologically classified mergers on the MS can be reconciled by evolving observability time-scales for both pairs and morphological disturbances. The observed variation of the late-stage merger fraction with ∆MS follows the perturbative 2-Star Formation Mode model, where any MS galaxy can experience a continuum of different star formation rate enhancements. This points to an SB-merger connection not only for extreme events, but also more moderate bursts which merely scatter galaxies upward within the MS, rather than fully elevating them above it

Biocompatibility assessment of coatings obtained in argon and nitrogen atmospheres for TiNi materials

This work aims to study the cytocompatibility of protective coatings obtained in argon and nitrogen atmospheres on a TiNi surface. Particular attention is paid to comparing the interaction of cell culture with coatings and an uncoated TiNi sample, using for comparison the number of viable cells on the surface, the phase composition, structure, wettability, surface charge and topography. The Ti/Ni/Ti nanolaminate was deposited on a TiNi substrate by magnetron sputtering. Reaction annealing of Ti/Ni/Ti nanolaminate on a TiNi substrate, when heated to 900 ◦C in argon, leads to the formation of a dense two-layer coating 2.0–2.1 µm thick: layer I (TiO + Ti2N), layer II (Ti4Ni2 O(N)). Reaction annealing in nitrogen leads to the formation of a thin three-layer nanocoating 250 nm thick: I (TiO2 + TiN), II (Ti4Ni2N(O) + Ti3Ni4), III (TiN). The coating synthesized in nitrogen is more favorable for cell attachment and proliferation because of the moderately hydrophilic rough surface and mixed phase composition of titanium nitrides and oxides

Submillimetre compactness as a critical dimension to understand the main sequence of star-forming galaxies

We study the interstellar medium (ISM) properties as a function of the molecular gas size for 77 infrared-selected galaxies at z ∼ 1.3, having stellar masses 109.4 ≲ M⋆ ≲ 1012.0 M⊙ and star formation rates 12 ≲ SFRFIR ≲ 1000 M⊙ yr−1. Molecular gas sizes are measured on ALMA images that combine CO(2-1), CO(5-4), and underlying continuum observations, and include CO(4-3), CO(7-6) + [CI](3P2 − 3P1), [CI](3P1 − 3P0) observations for a subset of the sample. The ≳46 per cent of our galaxies have a compact molecular gas reservoir, and lie below the optical discs mass–size relation. Compact galaxies on and above the main sequence have higher CO excitation and star formation efficiency than galaxies with extended molecular gas reservoirs, as traced by CO(5-4)/CO(2-1) and CO(2-1)/LIR, SF ratios. Average CO + [CI] spectral line energy distributions indicate higher excitation in compacts relative to extended sources. Using CO(2-1) and dust masses as molecular gas mass tracers, and conversion factors tailored to their ISM conditions, we measure lower gas fractions in compact main-sequence galaxies compared to extended sources. We suggest that the submillimetre compactness, defined as the ratio between the molecular gas and the stellar size, is an unavoidable information to be used with the main sequence offset to describe the ISM properties of galaxies, at least above M⋆ ≥ 1010.6 M⊙, where our observations fully probe the main sequence scatter. Our results are consistent with mergers driving the gas in the nuclear regions, enhancing the CO excitation and star formation efficiency. Compact main-sequence galaxies are consistent with being an early post-starburst population following a merger-driven starburst episode, stressing the important role of mergers in the evolution of massive galaxies

The ALMA-ALPAKA survey I: high-resolution CO and [CI] kinematics of star-forming galaxies at z = 0.5-3.5

Spatially-resolved studies of the kinematics of galaxies provide crucial insights into their assembly and evolution, enabling to infer the properties of the dark matter halos, derive the impact of feedback on the ISM, characterize the outflow motions. To date, most of the kinematic studies at z=0.5-3.5 were obtained using emission lines tracing the warm, ionized gas. However, whether these provide an exhaustive or only a partial view of the dynamics of galaxies and of the properties of the ISM is still debated. Complementary insights on the cold gas kinematics are therefore needed. We present ALPAKA, a project aimed at gathering high-resolution observations of CO and [CI] emission lines of star-forming galaxies at z=0.5-3.5 from the ALMA public archive. With 147 hours of total integration time, ALPAKA assembles ~0.25'' observations for 28 star-forming galaxies, the largest sample with spatially-resolved cold gas kinematics as traced by either CO or [CI] at z>0.5. By combining multi-wavelength ancillary data, we derive the stellar masses ($M_{\star}$) and star-formation rates (SFR) for our targets, finding values of $M_{\star}\gtrsim 10^{10}$ M$_{\odot}$ and SFR of 10-3000 M$_{\odot}$/yr. A large fraction of ALPAKA galaxies (19/28) lie in overdense regions (clusters, groups, and protoclusters). We exploit the ALMA data to infer their dynamical state and we find that 19/28 ALPAKA galaxies are rotating disks, 2 are interacting systems, while for the remaining 7 sources the classification is uncertain. The disks have velocity dispersion values that are typically larger in the innermost regions than in the outskirts, with a median value for the entire disk sample of 35$^{+11}_{-9}$ km/s. Despite the bias of our sample towards galaxies hosting very energetic mechanisms, the ALPAKA disks have high ratios of ordered-to-random motion ($V/\sigma$) with a median value of 9$^{+7}_{-2}$.Comment: 35 pages, 23 figures, 5 tables; submitted to A&A. The data and the outputs of the kinematic analysis will be made available at https://alpaka-survey.github.io/index.html once the paper is accepted. Comments are welcom

The ALMA-ALPAKA survey:I. High-resolution CO and [CI] kinematics of star-forming galaxies at z = 0.5- 3.5

Context. Spatially resolved studies of the kinematics of galaxies provide crucial insights into their assembly and evolution, enabling one to infer the properties of the dark matter halos, derive the impact of feedback on the interstellar medium (ISM), as well as measure and characterize the outflow motions. To date, most of the kinematic studies at z = 0.5 - 3.5 have been obtained using emission lines tracing the warm, ionized gas (e.g., Hα, [OII], and [OIII]). However, whether these provide an exhaustive or only a partial view of the dynamics of galaxies and of the properties of the ISM is still debated. Complementary insights into the cold gas kinematics are therefore needed. Aims. We present the Archival Large Program to Advance Kinematic Analysis (ALPAKA), a project aimed at gathering high-resolution observations of CO and [CI] emission lines of star-forming galaxies at z = 0.5 - 3.5 from the Atacama Large Millimeter Array (ALMA) public archive. With ≈ 147 h of total integration time, ALPAKA assembles ∼0.25″ observations for 28 star-forming galaxies, which is the largest sample with spatially resolved cold gas kinematics as traced by either CO or [CI] at z ≳ 0.5, spanning 7 Gyr of cosmic history. A large fraction of ALPAKA galaxies (19 out of 28) lie in overdense regions (clusters, groups, and protoclusters). Methods. By combining multiwavelength ground- and space-based ancillary data, we derived the stellar masses (M∗) and star-formation rates (SFRs) for the ALPAKA targets. We exploited the ALMA data to infer the dynamical state of the ALPAKA galaxies and derive their rotation curves and velocity dispersion profiles using 3DBAROLO. Results. ALPAKA probes the massive (M∗ ≳ 1010 MO), actively star-forming (SFR ≈ 10 - 3000 MO yr-1) part of the population of galaxies at z ∼ 0.5 - 3.5. Based on our kinematic classification, we find that 19 out of 28 ALPAKA galaxies are rotating disks, two are interacting systems, while for the remaining seven sources the classification is uncertain. The disks have velocity dispersion values that are typically larger in the innermost regions than in the outskirts, with a median value for the entire disk sample of 35-9+11 km s-1.</p

The effect of active galactic nuclei on the cold interstellar medium in distant star-forming galaxies

In the framework of a systematic study with the ALMA interferometer of IR-selected main-sequence and starburst galaxies at z ∼ 1 − 1.7 at typical ∼1″ resolution, we report on the effects of mid-IR- and X-ray-detected active galactic nuclei (AGN) on the reservoirs and excitation of molecular gas in a sample of 55 objects. We find widespread detectable nuclear activity in ∼30% of the sample. The presence of dusty tori influences the IR spectral energy distribution of galaxies, as highlighted by the strong correlation among the AGN contribution to the total IR luminosity budget (fAGN = LIR,  AGN/LIR), its hard X-ray emission, and the Rayleigh-Jeans to mid-IR (S1.2 mm/S24 μm) observed color, with evident consequences on the ensuing empirical star formation rate estimates. Nevertheless, we find only marginal effects of the presence and strength of AGN on the carbon monoxide CO (J = 2, 4, 5, 7) or neutral carbon ([C I](3P1  −  3P0), [C I](3P2  −  3P1)) line luminosities and on the derived molecular gas excitation as gauged by line ratios and the full spectral line energy distributions. The [C I] and CO emission up to J = 5, 7 thus primarily traces the properties of the host in typical IR luminous galaxies. However, our analysis highlights the existence of a large variety of line luminosities and ratios despite the homogeneous selection. In particular, we find a sparse group of AGN-dominated sources with the highest LIR,  AGN/LIR,  SFR ratios, ≳3, that are more luminous in CO (5−4) than what is predicted by the L′CO(5-4)−LIR, SFR relation, which might be the result of the nuclear activity. For the general population, our findings translate into AGN having minimal effects on quantities such as gas and dust fractions and star formation efficiencies. If anything, we find hints of a marginal tendency of AGN hosts to be compact at far-IR wavelengths and to display 1.8 times larger dust optical depths. In general, this is consistent with a marginal impact of the nuclear activity on the gas reservoirs and star formation in average star-forming AGN hosts with LIR > 5 × 1011 L⊙, typically underrepresented in surveys of quasars and submillimeter galaxies

CO emission in distant galaxies on and above the main sequence

We present the detection of multiple carbon monoxide CO line transitions with ALMA in a few tens of infrared-selected galaxies on and above the main sequence at z = 1.1−1.7. We reliably detected the emission of CO (5−4), CO (2−1), and CO (7−6)+[C I](3P2 − 3P1) in 50, 33, and 13 galaxies, respectively, and we complemented this information with available CO (4 − 3) and [C I](3P1 − 3P0) fluxes for part of the sample, and by modeling of the optical-to-millimeter spectral energy distribution. We retrieve a quasi-linear relation between LIR and CO (5 − 4) or CO (7 − 6) for main-sequence galaxies and starbursts, corroborating the hypothesis that these transitions can be used as star formation rate (SFR) tracers. We find the CO excitation to steadily increase as a function of the star formation efficiency, the mean intensity of the radiation field warming the dust (hUi), the surface density of SFR (ΣSFR), and, less distinctly, with the distance from the main sequence (∆MS). This adds to the tentative evidence for higher excitation of the CO+[C I] spectral line energy distribution (SLED) of starburst galaxies relative to that for main-sequence objects, where the dust opacities play a minor role in shaping the high-J CO transitions in our sample. However, the distinction between the average SLED of upper main-sequence and starburst galaxies is blurred, driven by a wide variety of intrinsic shapes. Large velocity gradient radiative transfer modeling demonstrates the existence of a highly excited component that elevates the CO SLED of high-redshift main-sequence and starbursting galaxies above the typical values observed in the disk of the Milky Way. This excited component is dense and it encloses ∼50% of the total molecular gas mass in main-sequence objects. We interpret the observed trends involving the CO excitation as to be mainly determined by a combination of large SFRs and compact sizes, as a large ΣSFR is naturally connected with enhanced dense molecular gas fractions and higher dust and gas temperatures, due to increasing ultraviolet radiation fields, cosmic ray rates, as well as dust and gas coupling. We release the full data compilation and the ancillary information to the community