Synthesis and antibacterial activities of new dibenzothiazepine derivatives

1196-1201A number of substituted dibenzo[b,f][1,4]thiazepines analogues carrying heterocyclic and aliphatic moiety attached to C-11 position have been synthesized and evaluated their antibacterial activities against gram positive and gram negative bacteria. Derivatives of imidazole, 2-methyl imidazole and pyrrolidine exhibit significant antibacterial activities

Decolorization and biodegradation of azo dye, reactive blue 59 by aerobic granules

The present study deals with development of aerobic granules from textile wastewater sludge and challenged with different concentration of reactive blue 59 (RB59) to test their dye degradation potential. The granules efficiently degraded reactive blue 59 and also sustained higher dye loading of up to 5.0 g l−1. The significant induction of enzymes azoreductase and cytochrome P-450 indicated their prominent role in the dye degradation while genotoxicity studies demonstrated that the biotransformed product of the dye as non-toxic. The microbial community of the textile dyes degrading aerobic sludge granules analyzed by polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE), revealed significantly diverse dye degrading microbial community belonging to alpha-, beta-, and gamma-proteobacteria

Problem Solving and Environmentally Benign Approach toward Diversity Oriented Synthesis of Novel 2‑Amino-3-phenyl (or Alkyl) Sulfonyl‑4<i>H</i>‑chromenes at Ambient Temperature

A problem solving, environmentally benign, and diversity oriented protocol has been described for multicomponent synthesis of medicinally privileged 2-amino-3-phenyl (or methyl) sulfonyl-4<i>H</i>-chromenes by one-pot, three component condensation among aldehydes, phenyl (or methyl) sulphonyl acetonitrile, and α-naphthol, 3-dimethylamino phenol, 4-hydroxy-<i>N</i>-methyl-quinoline-2-one as well as 4-hydroxycarbazole, using diethylamine as an efficient organo catalyst. The catalyst employed is commercially available, inexpensive, and nontoxic. Ambient reaction conditions, very high yields, wide scope, and avoidance of conventional isolation as well as chromatographic purification have improved the practical utility of this protocol manifold