The explorer in English fiction

Although there have been a number of critical works on the novel given over to topics such as adventure, colonization or the politics of the frontier, a comparative study of novels in which an encounter with unknown territory holds central importance has till now been lacking. My aim in this thesis is to analyse and relate a variety of texts which show representatives of a home culture in confrontation with terra incognita or unfamiliar peoples. There is, as it turns out, a strong family resemblance between the novels that fall into this category whether they belong, like Robinson Crusoe, Coral Island or Lord of the Flies, to the "desert island" tradition where castaways have exploration thrust upon them or present, as in the case of Moby Dick, The Lost World or Voss, ventures deliberately undertaken. There are frequent indications, too, that many of the novelists in question are aware of working within a particular, subsidiary genre. This means, in sum, even when it comes to texts as culturally remote as, say, Captain Singleton and Heart of Darkness that there is firm ground for comparison. The emphasis of this study is, in consequence, historical as well as critical. In order to show that many conventions which are recurrent in the fiction inhere in the actual business of coming to grips with the unknown, I begin with a theoretical introduction illustrated chiefly from the writings of explorers. Travelogues reveal how large a part projection plays in every rendering of unvisited places. So much is imported that one might hypothesize, for the sake of a model, a single locality returning a stream of widely divergent images over the lapse of years. In effect it is possible to demonstrate a shift of cultural assumptions by juxtaposing, for example, a passage that tricks out a primeval forest in all the iconography of Eden with one written three centuries later in which - from essentially the same scene - the author paints a picture of Malthusian struggle and survival of the fittest. And since the explorer is not only inclined to embody his image of the natural man in the people he meets beyond the frontiers of his own culture, but is likely also to read his own emancipation from the constraints of polity in terms of a return to an underlying nature, the concern with genesis is one that recurs with particular persistence in texts dealing with exploration. With varying degrees of awareness novelists have responded, ever since Defoe, to the idea that the encounter with the unfamiliar mirrors the identity of the explorer. Their presentations of terra incognita register the crucial phases of social history - the institution of mercantilism, the rise and fall of empire - but generally in relation to psychological and metaphysical questions of a perennial kind. The nature of man is a theme that proves, indeed, remarkably tenacious in these works, for a reason Lawrence notes in Kangaroo: "There is always something outside our universe. And it is always at the doors of the innermost, sentient soul"

The Explorer in English Fiction

Although there have been a number of critical works on the novel given over to topics such as adventure, colonization or the politics of the frontier, a comparative study of novels in which an encounter with unknown territory holds central importance has till now been lacking. My aim in this thesis is to analyse and relate a variety of texts which show representatives of a home culture in confrontation with terra incognita or unfamiliar peoples. There is, as it turns out, a strong family resemblance between the novels that fall into this category whether they belong, like Rohinson Crusoe, Coral Island or Lord of the Flies, to the "desert island" tradition where castaways have exploration thrust upon them or present, as in the case of Moby Dick, The Lost World or Voss, ventures deliberately undertaken. There are frequent indications, too, that many of the novelists in question are aware of working within a particular, subsidiary genre. This means, in sum, even when it comes to texts as culturally remote as, say, Captain Singleton and Heart of Darkness that there is firm ground for comparison. The emphasis of this study is, in consequence, historical as well as critical. In order to show that many conventions which are recurrent in the fiction inhere in the actual business of coming to grips with the unknown, I begin with a theoretical introduction illustrated chiefly from the writings of explorers. Travelogues reveal how large a part projection plays in every rendering of unvisited places. So much is imported that one might hypothesize, for the sake of a model, a single locality returning a stream of widely divergent images over the lapse of years. In effect it is possible to demonstrate a shift of cultural assumptions by juxtaposing, for example, a passage that tricks out a primeval forest in all the iconography of Eden with one written three centuries later in which - from essentially the same scene - the author paints a picture of Malthusian struggle and survival of the fittest. And since the explorer is not only inclined to embody his image of the natural man in the people, he meets beyond the frontiers of his own culture but is likely also to read his own emancipation from the constraints of polity in terms of a return to an underlying nature, the concern with genesis is one that recurs with particular persistence in texts dealing with exploration. With varying degrees of awareness novelists have responded, ever since Defoe, to the idea that the encounter with the unfamiliar mirrors the identity of the explorer. Their presentations of terra incognita register the crucial phases of social history - the institution of mercantilism, the rise and fall of empire - but generally in relation to psychological and metaphysical questions of a perennial kind. The nature of man is a theme that proves, indeed, remarkably tenacious in these works, for a reason Lawrence notes in Kangaroo: "There is always something outside our universe. And it is always at the doors of the innermost, sentient soul". After the introductory chapter I proceed chronologically with the four novelists who have contributed most, in my view, to the genre - Defoe, Melville, Conrad, Patrick White. In each case I deal principally with two texts: Robinson Crusoe, Captain Singleton; Typee, Moby Dick; An Outcast of the Islands, Heart of Darkness; Voss and A Fringe of Leaves. Wealth of reference is often a mark of literary stature, and in following these books any attentive reader is led from Genesis to Aboriginal myths of creation, from Hobbes to Rousseau and Darwin. Major works have a way, too, of declaring their genetic traits. Allusions to Rasselas and The Ancient Mariner, for instance, spell out Melville's glorious debts to diverse traditions, while his hybrid forms record the impact of a scientific spirit that did much to transform travel writing. I draw on accounts by explorers throughout, not only where immediate sources are concerned (Woodes Rogers, Stanley, Leichhardt, etc.), but so as to trace the correspondence between the non-fictional and novelistic realms. And although my comments on them tend to be brief, novels about exploration by writers other than the principal four come in for discussion when pertinent to the issues at hand: so Verne and Haggard, for example, provide a perspective to Conrad's treatment of recidivism in Heart of Darkness, while Coetzee and Brink supply comparisons with Patrick White's handling of the return to polity in A Fringe of Leaves (I976), a text even more fully receptive than Voss to the culture it penetrates

Modeling Extragalactic Foregrounds and Secondaries for Unbiased Estimation of Cosmological Parameters From Primary CMB Anisotropy

Using the latest physical modeling and constrained by the most recent data, we develop a phenomenological parameterized model of the contributions to intensity and polarization maps at millimeter wavelengths from external galaxies and Sunyaev-Zeldovich effects. We find such modeling to be necessary for estimation of cosmological parameters from Planck data. For example, ignoring the clustering of the infrared background would result in a bias in n_s of 7 sigma. We show that the simultaneous marginalization over a full foreground model can eliminate such biases, while increasing the statistical uncertainty in cosmological parameters by less than 20%. The small increases in uncertainty can be significantly reduced with the inclusion of higher-resolution ground-based data. The multi-frequency analysis we employ involves modeling 46 total power spectra and marginalization over 17 foreground parameters. We show that we can also reduce the data to a best estimate of the CMB power spectra, and just two principal components (with constrained amplitudes) describing residual foreground contamination.Comment: 17 pages, 7 figures, submitted to Ap

The role of histone arginine methylation in gene expression of airway smooth muscle cells in asthma

Introduction and objectives: Asthma is estimated to affect at least 300 million people globally. About 25% of the patients do not respond to therapy; therefore we need to develop novel treatments. ASM cells have a crucial role in asthma, contributing to airway remodelling, inflammation and airflow obstruction. We have previously shown that epigenetic histone modifications, particularly histone lysine acetylation and methylation regulate the secretion of inflammatory mediators from ASM cells. Here we tested the hypothesis that histone arginine changes are also involved. Protein arginine N-methyltransferases (PRMTs) are the enzymes which catalyse histone arginine methylation (HRme, the addition of a methyl group to arginine residues on the N-terminal tails of histones), and inhibiting them represents a strategy to reduce the secretion of inflammatory mediators from ASM cells. Methods: Studies were performed in cultured human ASM cells from asthmatic and non-asthmatic donors at passage 6. PRMT expression in human ASM cells was investigated by qPCR. Protein levels of four PRMTs in human ASM cells were investigated by western blotting. The effect of inhibiting PRMTs on the secretion of eotaxin, IL-6, CXCL8 and IP-10 from healthy ASM cells, under basal conditions and following stimulation with TNF-α (1ng/ml), was investigated by ELISA. Results: We found that ASM cells express the PRMT1, PRMT2, PRMT3, CARM1, PRMT5, PRMT6, PRMT7 and FBX011 mRNA and PRMT1, CARM1, PRMT5, and PRMT6 protein. The analysis showed no difference in the levels of expression between cells isolated from asthmatic and non-asthmatic donors. Two PRMT inhibitors, namely TCE5003 – a PRMT1 inhibitor, and 217531 - a CARM1 inhibitor, significantly reduced the secretion of inflammatory mediators from ASM cells. Conclusions: ASM cells express a number of PRMTs at mRNA and protein levels. The inhibition of PRMTs results in the reduced secretion of inflammatory mediators from ASM cells. PRMTs may have an important role in regulating chemokine production from ASM cells in asthma, and are a promising target for future investigations in asthma

The pressure profiles of hot gas in local galaxy groups

Recent measurements of the Sunyaev-Zel'dovich (SZ) angular power spectrum from the South Pole Telescope (SPT) and the Atacama Cosmology Telescope (ACT) demonstrate the importance of understanding baryon physics when using the SZ power spectrum to constrain cosmology. This is challenging since roughly half of the SZ power at l=3000 is from low-mass systems with 10^13 h^-1 M_sun < M_500 < 1.5x10^14 h^-1 M_sun, which are more difficult to study than systems of higher mass. We present a study of the thermal pressure content for a sample of local galaxy groups from Sun et al. (2009). The group Y_{sph, 500} - M_500 relation agrees with the one for clusters derived by Arnaud et al. (2010). The group median pressure profile also agrees with the universal pressure profile for clusters derived by Arnaud et al. (2010). With this in mind, we briefly discuss several ways to alleviate the tension between the measured low SZ power and the predictions from SZ templates.Comment: 5 pages, 2 color figures, ApJL in pres

The Variable Reflection Nebula Cepheus A East

We report K'-band imaging observations of the reflection nebula associated with Cepheus A East covering the time interval from 1990 to 2004. Over this time the reflection nebula shows variations of flux distribution, which we interpret as the effect of inhomogeneous and varying extinction in the light path from the illuminating source HW2 to the reflection nebula. The obscuring material is located within typical distances of approximately 10 AU from the illuminating source.Comment: 22 pages, including 6 figures, accepted for publication in The Astronomical Journa

A Photometrically and Morphologically Variable Infrared Nebula in L483

We present narrow and broad K-band observations of the Class 0/I source IRAS 18148-0440 that span 17 years. The infrared nebula associated with this protostar in the L483 dark cloud is both morphologically and photometrically variable on a time scale of only a few months. This nebula appears to be an infrared analogue to other well-known optically visible variable nebulae associated with young stars, such as Hubble's Variable Nebula. Along with Cepheus A, this is one of the first large variable nebulae to be found that is only visible in the infrared. The variability of this nebula is most likely due to changing illumination of the cloud rather than any motion of the structure in the nebula. Both morphological and photometric changes are observed on a time scale only a few times longer than the light crossing time of the nebula, suggesting very rapid intrinsic changes in the illumination of the nebula. Our narrow-band observations also found that H_2 knots are found nearly twice as far to the east of the source as to its west, and that H_2 emission extends farther east of the source than the previously known CO outflow.Comment: 19 pages, 6 figures, 1 tabl

Investigating genome wide dna methylation in airway smooth muscle cells from asthmatic and non-asthmatic donors

Rationale: Genetic mechanisms fail to fully explain asthma pathogenesis and environmental factors are considered to play an important role. Environmental factors may lead to permanent changes in epigenetic patterns and contribute to asthma. Epigenetics is the study of heritable changes in gene expression that are not due to changes in DNA sequence. DNA methylation is a reversible modification of DNA structure in which a methyl group is added to cytosine residues. Parental smoking affects the methylation of buccal cell DNA from children and children with early onset wheeze have an altered blood DNA methylation profile to healthy individuals. No studies have compared DNA methylation profiles in the disease relevant cell type of airway smooth muscle (ASM) cells. Methods: DNA was isolated from ASM cells at passage 5 and bisulphite treated to convert epigenetic information into sequence-based information. Site specific, quantitative genome wide methylation was determined using the Illumina 450K Infinium Methylation BeadChip array. Hits were validated by Pyrosequencing. RNA was extracted simultaneously for mRNA expression analysis by real time PCR. Results: There were no independent CpG sites associated with asthmatic status of ASM cells following multiple test correction. Without correction over 13000 CpG sites showed a significant difference in methylation (linear modelling, p value >0.05) between asthmatic and non-asthmatic cells, and a biologically relevant difference in methylation of greater that 10% (β value >0.1 ). 10 of these sites were selected as top hits. 7 sites positively validated by pyrosequencing. They were associated with 7 different genes; LGALS3BP, ATP11A, ZNF696, KLF6, TBX1, RUNX3, and SPINT2. Expression of these genes was measured in ASM cells isolated from asthmatic and non-asthmatic donors. LGALS3BP expression was undetectable while ATP11A and ZNF696 displayed no difference in expression between cells from asthmatic and non-asthmatic donors. KLF6 and SPINT2 showed a trend towards increased expression in cells from asthmatic donors while RUNX3 and TBX1 showed a trend towards decreased expression. Conclusions: Differences in CpG methylation exist between ASM isolated from asthmatic and non-asthmatic donors. Future work will focus on identifying differentially methylated regions of DNA and further defining the association to gene and protein expression

Measurements of Secondary Cosmic Microwave Background Anisotropies with the South Pole Telescope

We report cosmic microwave background (CMB) power spectrum measurements from the first 100 sq. deg. field observed by the South Pole Telescope (SPT) at 150 and 220 GHz. On angular scales where the primary CMB anisotropy is dominant, ell ~< 3000, the SPT power spectrum is consistent with the standard LambdaCDM cosmology. On smaller scales, we see strong evidence for a point source contribution, consistent with a population of dusty, star-forming galaxies. After we mask bright point sources, anisotropy power on angular scales of 3000 50 at both frequencies. We combine the 150 and 220 GHz data to remove the majority of the point source power, and use the point source subtracted spectrum to detect Sunyaev-Zel'dovich (SZ) power at 2.6 sigma. At ell=3000, the SZ power in the subtracted bandpowers is 4.2 +/- 1.5 uK^2, which is significantly lower than the power predicted by a fiducial model using WMAP5 cosmological parameters. This discrepancy may suggest that contemporary galaxy cluster models overestimate the thermal pressure of intracluster gas. Alternatively, this result can be interpreted as evidence for lower values of sigma8. When combined with an estimate of the kinetic SZ contribution, the measured SZ amplitude shifts sigma8 from the primary CMB anisotropy derived constraint of 0.794 +/- 0.028 down to 0.773 +/- 0.025. The uncertainty in the constraint on sigma8 from this analysis is dominated by uncertainties in the theoretical modeling required to predict the amplitude of the SZ power spectrum for a given set of cosmological parameters.Comment: 28 pages, 11 figures, submitted to Ap