Discrete symmetries studies at KLOE-2

The KLOE and KLOE-2 experiments at the Laboratori Nazionali di Frascati (Italy) collected almost 8 fb−1 of integrated luminosity at the energy equal to the mass of ϕ meson. The excellent time resolution of the electromagnetic calorimeter and the very good accuracy on both momentum and vertex reconstruction of the tracking system allow to study discrete symmetries to the utmost precision as well as light meson spectroscopy, dark forces searches, hadronic cross-section measurements and studies of γγ-physics. CPT symmetry test with the lepton charge asymmetry measured in KS semileptonic decays with 1.7 fb−1 of KLOE data, tests of time reversal and CPT in transitions in ϕ→KSKL→πev, 3π0(2π0)$\phi \to {K_S}{K_L} \to \pi ev,\,3{\pi ^0}(2{\pi ^0})$ decays with newly acquired data with the KLOE-2 detector will be presented and discussed

Surface area or diameter – which factor really determines the antibacterial activity of silver nanoparticles grown on TiO₂ coatings?

Titanium dioxide coatings were prepared on Si wafers using the sol–gel method. Four different types of coatings with silver nanoparticles (AgNPs) were synthesized. The diameter and surface density of AgNPs were conditioned by the concentration of Ag+ ions in the initial solution, time and UV illumination source. The bactericidal activity of AgNPs on the titanium dioxide coatings against the S. aureus strain were calculated as the percentage of the inhibition of bacterial growth after 24 hour incubation of microorganisms at 37°C on TiO₂ coatings with AgNPs. Control samples were coated with titanium dioxide without AgNPs. We concluded that the titanium dioxide coatings modified with silver nanoparticles had a high antibacterial activity. Moreover, we demonstrated strong dependence between surface areas of AgNPs and inhibition of bacterial growth. The obtained results evidence that the surface area of AgNPs grown on titanium dioxide coatings is a major factor determining their antimicrobial potential

Structure in parasite component communities in wild rodents: predictability, stability, associations and interactions or pure randomness?

Experimental data establish that interactions exist between species of intestinal helminths during concurrent infections in rodents, the strongest effects being mediated through the host’s immune responses. Detecting immune-mediated relationships in wild rodent populations has been fraught with problems and published data do not support a major role for interactions in structuring helminth communities. Helminths in wild rodents show predictable patterns of seasonal, host age-dependent and spatial variation in species richness and in abundance of core species. When these are controlled for, patterns of co-infection compatible with synergistic interactions can be demonstrated. At least one of these, the positive relationship between Heligmosomoides polygyrus and species richness of other helminths has been demonstrated in three totally independent data-sets. Collectively, they explain only a small percentage of the variance/deviance in abundance data and at this level are unlikely to play a major role in structuring helminth communities, although they may be important in the more heavily infected wood mice. Current worm burdens underestimate the possibility that earlier interactions through the immune system have taken place, and therefore interactions may have a greater role to play than is immediately evident from current worm burdens. Longitudinal studies are proposed to resolve this issue

The effect of tyrosine kinase inhibitors, tyrphostins: AG1024 and SU1498, on autocrine growth of prostate cancer cells (DU145).

It is well established that autocrine growth of human prostate cancer cell line DU145 is dependent on TGF (EGF)/EGFR loop. However, the participation of several other growth factors in proliferation of DU145 cells has been also proposed. We employed two selective tyrosine kinase inhibitors (tyrphostins): AG1024 (an IGFIR inhibitor) and SU1498 (a VEGFR2 inhibitor) for growth regulation of DU145 cells, cultured in chemically defined DMEM/F12 medium. Both the tested compounds inhibited autocrine growth of DU145 cells at similar concentration values (IC50 approximately 2.5 microM). The tyrphostins arrested cell growth of DU145 in G1 phase, similarly as inhibitors of EGFR. However, in contrast to selective inhibitors of EGFR, neither AG1024, nor SU1498 (at concentration < or =10 microM) decreased the viability of the investigated cells. These results strongly suggest that autocrine growth of DU145 cells is stimulated by, at least, three autocrine loops: TGFalpha(EGF)/EGFR, IGFII/IGFIr and VEGF/VEGFR2(VEGFR1). These data support the hypothesis of multi-loops growth regulation of metastatic prostate cancer cell lines

The effect of tyrosine kinase inhibitors, tyrphostins : AG1024 and SU1498, on autocrine growth of prostate cancer cells (DU145)

It is well established that autocrine growth of human prostate cancer cell line DU145 is dependent on TGF (EGF)/EGFR loop. However, the participation of several other growth factors in proliferation of DU145 cells has been also proposed. We employed two selective tyrosine kinase inhibitors (tyrphostins): AG1024 (an IGFIR inhibitor) and SU1498 (a VEGFR2 inhibitor) for growth regulation of DU145 cells, cultured in chemically defined DMEM/F12 medium. Both the tested compounds inhibited autocrine growth of DU145 cells at similar concentration values (IC50 approximately 2.5 microM). The tyrphostins arrested cell growth of DU145 in G1 phase, similarly as inhibitors of EGFR. However, in contrast to selective inhibitors of EGFR, neither AG1024, nor SU1498 (at concentration &lt; or =10 microM) decreased the viability of the investigated cells. These results strongly suggest that autocrine growth of DU145 cells is stimulated by, at least, three autocrine loops: TGFalpha(EGF)/EGFR, IGFII/IGFIr and VEGF/VEGFR2(VEGFR1). These data support the hypothesis of multi-loops growth regulation of metastatic prostate cancer cell lines

Binge‑watching w perspektywie kultur telewizyjnych

W niniejszym artykule spróbuję zastanowić się, czy binge‑watching, jako nowa kulturowa praktyka oglądania treści telewizyjnych, przyczynia się do zmiany środowiska medialnego, a tym samym stanowi znacznik kultury czy też kultur telewizyjnych. Ramę analizy stanowi zmiana praktyk w kulturze popularnej związanych z coraz większą popularnością usług streamingowych i poszerzającą się władzą konsumenta. Z jednej strony przyjrzę się napadowemu oglądaniu jako zjawisku globalnemu, z drugiej zaś wezmę pod uwagę różnice regionalne lub lokalne z nim związane. Spróbuję określić zróżnicowane wzorce jego użycia