The Defying Expectations exhibition at the Brontë Parsonage Museum: a reflection on contemporary curatorial practices

© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis GroupThis article reflects on the curatorial practices in the Brontë Parsonage Museum’s 2022 Defying Expectations costume exhibition, to assess its strengths and weaknesses and to identify opportunities for similar exhibitions to be launched and improved upon in the future. The Defying Expectations exhibition included interactive art installations, recreations and illustrative reconstructions alongside traditional display methods, and this article evaluates the effectiveness of such a blended approach. Written from the perspective of a museum professional, the article considers how the exhibition developed contemporary curatorial practices and its legacy. Drawing on heritage studies and curatorship, the article juxtaposes information gleaned from literary analysis with an assessment of material culture. It assesses the exhibition’s aim of reinterpreting Brontë’s reputation as choosing plain and practical clothing by foregrounding her interest in colourful and multicultural textiles, which raises questions of individual, local and national identity as well as regarding the effects of colonisation.Unfunde

Judicial Perspective Panel 2015

A transcript of the Judicial Perspective Panel Event at Belmont University College of Law Symposium

Building an Engineering Honors Curriculum: Collegiate Consistency with Individual Flexibility

Recently, Honors at Iowa developed a curriculum that all student members must complete to graduate with University Honors. The curriculum has two primary components; the first is building knowledge through course work and the second is the application of knowledge through hands on learning experiences. Because, however, the engineering undergraduate curriculum is more structured and sequential in nature than the curriculum of the other undergraduate colleges, a distinct honors engineering curriculum was developed collaboratively between the College of Engineering and the University Honors Program. This engineering-specific honors curriculum maintained the key features of course work and experience-based learning valued by engineering and honors, but allowed for unique out-of-class experiences available to University of Iowa engineering students to be woven into the curriculum. The standard Honors curriculum for undergraduates at Iowa is 12 credit hours of honors coursework and 12 credit hours of experience-based learning. The 12 credits of coursework are commonly completed early in the students’ education through honors offerings of general education courses. In contrast, the experiential component is most commonly pursued by upper class students and includes opportunities such as Honors in the major, research, study abroad, internships, and a variety of types of courses such as teaching practica, service learning, and graduate courses. This standard 12/12 Honors curriculum is still available to engineering honors students, but many engineering students’ schedules are limited in flexibility, and the number of honors offerings that fit their needs is also limited. To maintain consistency in University Honors across the colleges and also accommodate the emphasis in engineering on applied learning, the College of Engineering and Honors Program agreed to reduce the required number of hours of honors coursework and increase proportionately the amount of experience-based learning in the honors curriculum. This has become known as the Engineering Alternative and highlights more out-of-class opportunities that provide discipline-specific learning. For example, engineering students can count leadership positions in engineering student organizations for honors credit because these organizations incorporate a project with faculty oversight. Engineering honors students may also deepen their knowledge and help other students by serving as tutors or by participating in other service roles in the College of Engineering. These opportunities are in addition to the standard experiential learning options of honors in the major, research, study abroad, and internships. Together, the varied options of the Honors Engineering Alternative curriculum allow students great flexibility in completing University Honors that is of equivalent depth to the 12/12 standard Honors Curriculum. The result of the collaboration between Honors and the College of Engineering is an honors curriculum that meets the general requirements of the Honors curriculum but also is flexible enough to accommodate the more structured and sequential nature of the engineering curriculum

A horizon scan of issues affecting UK forest management within 50 years

Forests are in the spotlight: they are expected to play a pivotal role in our response to society’s greatest challenges, such as the climate and biodiversity crises. Yet, the forests themselves, and the sector that manages them, face a range of interrelated threats and opportunities. Many of these are well understood, even if the solutions remain elusive. However, there are also emerging trends that are currently less widely appreciated. We report here the results of a horizon scan to identify developing issues likely to affect UK forest management within the next 50 years. These are issues that are presently under-recognized but have potential for significant impact across the sector and beyond. As the forest management sector naturally operates over long timescales, the importance of using good foresight is self-evident. We followed a tried-and-tested horizon scanning methodology involving a diverse Expert Panel to collate and prioritize a longlist of 180 issues. The top 15 issues identified are presented in the Graphical Abstract. The issues represent a diverse range of themes, within a spectrum of influences from environmental shocks and perturbations to changing political and socio-economic drivers, with complex emerging interactions between them. The most highly ranked issue was ‘Catastrophic forest ecosystem collapse’, reflecting agreement that not only is such collapse a likely prospect but it would also have huge implications across the sector and wider society. These and many of the other issues are large scale, with far-reaching implications. We must be careful to avoid inaction through being overwhelmed, or indeed to merely focus on ‘easy wins’ without considering broader ramifications. Our responses to each of the challenges and opportunities highlighted must be synergistic and coherent, involving landscape-scale planning. A more adaptive approach to forest management will be essential, encouraging continual innovation and learning. The 15 horizon scan issues presented here are a starting point on which to build further research, prompt debate and action, and develop evidence-based policy and practice. We hope that this stimulates greater recognition of how our forests and sector may need to change to be fit for the future. In some cases, these changes will need to be fundamental and momentous

Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine

Despite rapid technical progress and demonstrable effectiveness for some types of diagnosis and therapy, much remains to be learned about clinical genome and exome sequencing (CGES) and its role within the practice of medicine. The Clinical Sequencing Exploratory Research (CSER) consortium includes 18 extramural research projects, one National Human Genome Research Institute (NHGRI) intramural project, and a coordinating center funded by the NHGRI and National Cancer Institute. The consortium is exploring analytic and clinical validity and utility, as well as the ethical, legal, and social implications of sequencing via multidisciplinary approaches; it has thus far recruited 5,577 participants across a spectrum of symptomatic and healthy children and adults by utilizing both germline and cancer sequencing. The CSER consortium is analyzing data and creating publically available procedures and tools related to participant preferences and consent, variant classification, disclosure and management of primary and secondary findings, health outcomes, and integration with electronic health records. Future research directions will refine measures of clinical utility of CGES in both germline and somatic testing, evaluate the use of CGES for screening in healthy individuals, explore the penetrance of pathogenic variants through extensive phenotyping, reduce discordances in public databases of genes and variants, examine social and ethnic disparities in the provision of genomics services, explore regulatory issues, and estimate the value and downstream costs of sequencing. The CSER consortium has established a shared community of research sites by using diverse approaches to pursue the evidence-based development of best practices in genomic medicine

A horizon scan of issues affecting UK forest management within 50 years

Forests are in the spotlight: they are expected to play a pivotal role in our response to society’s greatest challenges, such as the climate and biodiversity crises. Yet, the forests themselves, and the sector that manages them, face a range of interrelated threats and opportunities. Many of these are well understood, even if the solutions remain elusive. However, there are also emerging trends that are currently less widely appreciated. We report here the results of a horizon scan to identify developing issues likely to affect UK forest management within the next 50 years. These are issues that are presently under-recognized but have potential for significant impact across the sector and beyond. As the forest management sector naturally operates over long timescales, the importance of using good foresight is self-evident. We followed a tried-and-tested horizon scanning methodology involving a diverse Expert Panel to collate and prioritize a longlist of 180 issues. The top 15 issues identified are presented in the Graphical Abstract. The issues represent a diverse range of themes, within a spectrum of influences from environmental shocks and perturbations to changing political and socio-economic drivers, with complex emerging interactions between them. The most highly ranked issue was ‘Catastrophic forest ecosystem collapse’, reflecting agreement that not only is such collapse a likely prospect but it would also have huge implications across the sector and wider society. These and many of the other issues are large scale, with far-reaching implications. We must be careful to avoid inaction through being overwhelmed, or indeed to merely focus on ‘easy wins’ without considering broader ramifications. Our responses to each of the challenges and opportunities highlighted must be synergistic and coherent, involving landscape-scale planning. A more adaptive approach to forest management will be essential, encouraging continual innovation and learning. The 15 horizon scan issues presented here are a starting point on which to build further research, prompt debate and action, and develop evidence-based policy and practice. We hope that this stimulates greater recognition of how our forests and sector may need to change to be fit for the future. In some cases, these changes will need to be fundamental and momentous

A horizon scan of issues affecting UK forest management within 50 years

Forests are in the spotlight: they are expected to play a pivotal role in our response to society’s greatest challenges, such as the climate and biodiversity crises. Yet, the forests themselves, and the sector that manages them, face a range of interrelated threats and opportunities. Many of these are well understood, even if the solutions remain elusive. However, there are also emerging trends that are currently less widely appreciated. We report here the results of a horizon scan to identify developing issues likely to affect UK forest management within the next 50 years. These are issues that are presently under-recognized but have potential for significant impact across the sector and beyond. As the forest management sector naturally operates over long timescales, the importance of using good foresight is self-evident. We followed a tried-and-tested horizon scanning methodology involving a diverse Expert Panel to collate and prioritize a longlist of 180 issues. The top 15 issues identified are presented in the Graphical Abstract. The issues represent a diverse range of themes, within a spectrum of influences from environmental shocks and perturbations to changing political and socio-economic drivers, with complex emerging interactions between them. The most highly ranked issue was ‘Catastrophic forest ecosystem collapse’, reflecting agreement that not only is such collapse a likely prospect but it would also have huge implications across the sector and wider society. These and many of the other issues are large scale, with far-reaching implications. We must be careful to avoid inaction through being overwhelmed, or indeed to merely focus on ‘easy wins’ without considering broader ramifications. Our responses to each of the challenges and opportunities highlighted must be synergistic and coherent, involving landscape-scale planning. A more adaptive approach to forest management will be essential, encouraging continual innovation and learning. The 15 horizon scan issues presented here are a starting point on which to build further research, prompt debate and action, and develop evidence-based policy and practice. We hope that this stimulates greater recognition of how our forests and sector may need to change to be fit for the future. In some cases, these changes will need to be fundamental and momentous

Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial

Background Neutrophil serine proteases are involved in the pathogenesis of COVID-19 and increased serine protease activity has been reported in severe and fatal infection. We investigated whether brensocatib, an inhibitor of dipeptidyl peptidase-1 (DPP-1; an enzyme responsible for the activation of neutrophil serine proteases), would improve outcomes in patients hospitalised with COVID-19. Methods In a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial, across 14 hospitals in the UK, patients aged 16 years and older who were hospitalised with COVID-19 and had at least one risk factor for severe disease were randomly assigned 1:1, within 96 h of hospital admission, to once-daily brensocatib 25 mg or placebo orally for 28 days. Patients were randomly assigned via a central web-based randomisation system (TruST). Randomisation was stratified by site and age (65 years or ≥65 years), and within each stratum, blocks were of random sizes of two, four, or six patients. Participants in both groups continued to receive other therapies required to manage their condition. Participants, study staff, and investigators were masked to the study assignment. The primary outcome was the 7-point WHO ordinal scale for clinical status at day 29 after random assignment. The intention-to-treat population included all patients who were randomly assigned and met the enrolment criteria. The safety population included all participants who received at least one dose of study medication. This study was registered with the ISRCTN registry, ISRCTN30564012. Findings Between June 5, 2020, and Jan 25, 2021, 406 patients were randomly assigned to brensocatib or placebo; 192 (47·3%) to the brensocatib group and 214 (52·7%) to the placebo group. Two participants were excluded after being randomly assigned in the brensocatib group (214 patients included in the placebo group and 190 included in the brensocatib group in the intention-to-treat population). Primary outcome data was unavailable for six patients (three in the brensocatib group and three in the placebo group). Patients in the brensocatib group had worse clinical status at day 29 after being randomly assigned than those in the placebo group (adjusted odds ratio 0·72 [95% CI 0·57–0·92]). Prespecified subgroup analyses of the primary outcome supported the primary results. 185 participants reported at least one adverse event; 99 (46%) in the placebo group and 86 (45%) in the brensocatib group. The most common adverse events were gastrointestinal disorders and infections. One death in the placebo group was judged as possibly related to study drug. Interpretation Brensocatib treatment did not improve clinical status at day 29 in patients hospitalised with COVID-19

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Great (≥Mw8.0) megathrust earthquakes and the subduction of excess sediment and bathymetrically smooth seafloor

Using older and in part fl awed data, Ruff (1989) suggested that thick sediment entering the subduction zone (SZ) smooths and strengthens the trench-parallel distribution of interplate coupling. This circumstance was conjectured to favor rupture continuation and the generation of high-magnitude (≥Mw8.0) interplate thrust (IPT) earthquakes. Using larger and more accurate compilations of sediment thickness and instrumental (1899 to January 2013) and pre-instrumental era (1700–1898) IPTs (n = 176 and 12, respectively), we tested if a compelling relation existed between where IPT earthquakes ≥Mw7.5 occurred and where thick (≥1.0 km) versus thin (≤1.0 km) sedimentary sections entered the SZ. Based on the new compilations, a statistically supported statement (see Summary and Conclusions) can be made that high-magnitude earthquakes are most prone to nucleate at well-sedimented SZs. For example, despite the 7500 km shorter global length of thicksediment trenches, they account for ~53% of instrumental era IPTs ≥Mw8.0, ~75% ≥Mw8.5, and 100% ≥Mw9.1. No megathrusts >Mw9.0 ruptured at thin-sediment trenches, whereas three occurred at thick-sediment trenches (1960 Chile Mw9.5, 1964 Alaska Mw9.2, and 2004 Sumatra Mw9.2). However, large Mw8.0–9.0 IPTs commonly (n = 23) nucleated at thin-sediment trenches. These earthquakes are associated with the subduction of low-relief ocean floor and where the debris of subduction erosion thickens the plate-separating subduction channel. The combination of low bathymetric relief and subduction erosion is inferred to also produce a smooth trench-parallel distribution of coupling posited to favor the characteristic lengthy rupturing of highmagnitude IPT earthquakes. In these areas subduction of a weak sedimentary sequence further enables rupture continuatio