Searching for molecular outflows in Hyper-Luminous Infrared Galaxies

We present constraints on the molecular outflows in a sample of five Hyper-Luminous Infrared Galaxies using Herschel observations of the OH doublet at 119 {\mu}m. We have detected the OH doublet in three cases: one purely in emission and two purely in absorption. The observed emission profile has a significant blueshifted wing suggesting the possibility of tracing an outflow. Out of the two absorption profiles, one seems to be consistent with the systemic velocity while the other clearly indicates the presence of a molecular outflow whose maximum velocity is about ~1500 km/s. Our analysis shows that this system is in general agreement with previous results on Ultra-luminous Infrared Galaxies and QSOs, whose outflow velocities do not seem to correlate with stellar masses or starburst luminosities (star formation rates). Instead the galaxy outflow likely arises from an embedded AGN.Comment: Accepted for publication in MNRAS. 13 pages, 11 figures, 4 table

Spatially resolved analysis of superluminous supernovae PTF 11hrq and PTF 12dam host galaxies

Superluminous supernovae (SLSNe) are the most luminous supernovae in the Universe. They are found in extreme star-forming galaxies and are probably connected with the death of massive stars. One hallmark of very massive progenitors would be a tendency to explode in very dense, UV-bright and blue regions. In this paper, we investigate the resolved host galaxy properties of two nearby hydrogen-poor SLSNe, PTF 11hrq and PTF 12dam. For both galaxies Hubble Space Telescope multifilter images were obtained. Additionally, we perform integral field spectroscopy of the host galaxy of PTF 11hrq using the Very Large Telescope Multi Unit Spectroscopic Explorer (VLT/MUSE), and investigate the line strength, metallicity and kinematics. Neither PTF 11hrq nor PTF 12dam occurred in the bluest part of their host galaxies, although both galaxies have overall blue UV-to-optical colours. The MUSE data reveal a bright starbursting region in the host of PTF 11hrq, although far from the SN location. The SN exploded close to a region with disturbed kinematics, bluer colour, stronger [O III] and lower metallicity. The host galaxy is likely interacting with a companion. PTF 12dam occurred in one of the brightest pixels, in a starbursting galaxy with a complex morphology and a tidal tail, where interaction is also very likely. We speculate that SLSN explosions may originate from stars generated during star formation episodes triggered by interaction. High-resolution imaging and integral field spectroscopy are fundamental for a better understanding of SLSNe explosion sites and how star formation varies across their host galaxies

The Kinase PDK1 Is Essential for B-Cell Receptor Mediated Survival Signaling

Phosphoinositide-dependent kinase 1 (PDK1) plays an important role in integrating the T cell antigen receptor (TCR) and CD28 signals to achieve efficient NF-κB activation. PDK1 is also an important regulator of T cell development, mediating pre-TCR induced proliferation signals. However, the role of PDK1 in B cell antigen receptor (BCR) signaling and B cell development remains largely unknown. In this study we provide genetic evidence supporting the role of PDK1 in B cell survival. We found PDK1 is required for BCR mediated survival in resting B cells, likely through regulation of Foxo activation. PDK1-dependent signaling to NF-κB is not crucial to resting B cell viability. However, PDK1 is necessary for triggering NF-κB during B cell activation and is required for activated B cell survival. Together these studies demonstrate that PDK1 is essential for BCR-induced signal transduction to Foxo and NF-κB and is indispensable for both resting and activated B cell survival

Delayed appearance and evolution of coronal lines in the TDE AT2019qiz

Tidal disruption events (TDEs) occur when a star gets torn apart by a supermassive black hole as it crosses its tidal radius. We present late-time optical and X-ray observations of the nuclear transient AT2019qiz, which showed the typical signs of an optical-UV transient class commonly believed to be TDEs. Optical spectra were obtained 428, 481, and 828 rest-frame days after optical light-curve peak, and a UV/X-ray observation coincided with the later spectrum. The optical spectra show strong coronal emission lines, including [Fe VII], [Fe X], [Fe XI], and [Fe XIV]. The Fe lines rise and then fall, except [Fe XIV] that appears late and rises. We observe increasing flux of narrow H α and H β and a decrease in broad H α flux. The coronal lines have full width at half-maximum ranging from ∼150−300 km s−1, suggesting they originate from a region between the broad- and narrow-line emitting gas. Between the optical flare and late-time observation, the X-ray spectrum softens dramatically. The 0.3–1 keV X-ray flux increases by a factor of ∼50, while the hard X-ray flux decreases by a factor of ∼6. Wide-field Infrared Survey Explorer fluxes also rose over the same period, indicating the presence of an infrared echo. With AT2017gge, AT2019qiz is one of two examples of a spectroscopically confirmed optical-UV TDE showing delayed coronal line emission, supporting speculations that Extreme Coronal Line Emitters in quiescent galaxies can be echos of unobserved past TDEs. We argue that the coronal lines, narrow lines, and infrared emission arise from the illumination of pre-existing material likely related to either a previous TDE or active galactic nucleus activity

Folate catabolites in spot urine as non-invasive biomarkers of folate status during habitual intake and folic acid supplementation.

Folate status, as reflected by red blood cell (RCF) and plasma folates (PF), is related to health and disease risk. Folate degradation products para-aminobenzoylglutamate (pABG) and para-acetamidobenzoylglutamate (apABG) in 24 hour urine have recently been shown to correlate with blood folate. Since blood sampling and collection of 24 hour urine are cumbersome, we investigated whether the determination of urinary folate catabolites in fasted spot urine is a suitable non-invasive biomarker for folate status in subjects before and during folic acid supplementation. Immediate effects of oral folic acid bolus intake on urinary folate catabolites were assessed in a short-term pre-study. In the main study we included 53 healthy men. Of these, 29 were selected for a 12 week folic acid supplementation (400 µg). Blood, 24 hour and spot urine were collected at baseline and after 6 and 12 weeks and PF, RCF, urinary apABG and pABG were determined. Intake of a 400 µg folic acid bolus resulted in immediate increase of urinary catabolites. In the main study pABG and apABG concentrations in spot urine correlated well with their excretion in 24 hour urine. In healthy men consuming habitual diet, pABG showed closer correlation with PF (rs = 0.676) and RCF (rs = 0.649) than apABG (rs = 0.264, ns and 0.543). Supplementation led to significantly increased folate in plasma and red cells as well as elevated urinary folate catabolites, while only pABG correlated significantly with PF (rs = 0.574) after 12 weeks. Quantification of folate catabolites in fasted spot urine seems suitable as a non-invasive alternative to blood or 24 hour urine analysis for evaluation of folate status in populations consuming habitual diet. In non-steady-state conditions (folic acid supplementation) correlations between folate marker (RCF, PF, urinary catabolites) decrease due to differing kinetics

Influences of Excluded Volume of Molecules on Signaling Processes on Biomembrane

We investigate the influences of the excluded volume of molecules on biochemical reaction processes on 2-dimensional surfaces using a model of signal transduction processes on biomembranes. We perform simulations of the 2-dimensional cell-based model, which describes the reactions and diffusion of the receptors, signaling proteins, target proteins, and crowders on the cell membrane. The signaling proteins are activated by receptors, and these activated signaling proteins activate target proteins that bind autonomously from the cytoplasm to the membrane, and unbind from the membrane if activated. If the target proteins bind frequently, the volume fraction of molecules on the membrane becomes so large that the excluded volume of the molecules for the reaction and diffusion dynamics cannot be negligible. We find that such excluded volume effects of the molecules induce non-trivial variations of the signal flow, defined as the activation frequency of target proteins, as follows. With an increase in the binding rate of target proteins, the signal flow varies by i) monotonically increasing; ii) increasing then decreasing in a bell-shaped curve; or iii) increasing, decreasing, then increasing in an S-shaped curve. We further demonstrate that the excluded volume of molecules influences the hierarchical molecular distributions throughout the reaction processes. In particular, when the system exhibits a large signal flow, the signaling proteins tend to surround the receptors to form receptor-signaling protein clusters, and the target proteins tend to become distributed around such clusters. To explain these phenomena, we analyze the stochastic model of the local motions of molecules around the receptor.Comment: 31 pages, 10 figure