Strukturierung von Maßnahmen zur Verbesserung intra-organisationaler Online-Kollaboration

Im Zuge der digitalen Transformation ergeben sich für Organisationen ständig neue Möglichkeiten, ihre Geschäftsprozesse mithilfe digitaler Tools zu verbessern (Thornley et al., 2019). Die COVID-19-Pandemie beschleunigte diesen Transformationsprozess und löste für viele Büroangestellte einen abrupten Wechsel zur Heimarbeit aus (Galanti et al., 2021; Nagel, 2020). Folglich mussten viele Unternehmen ihre Arbeitsorganisation reformieren, was zu verstärktem Einsatz von Informations- und Kommunikationstechnik am Arbeitsplatz und damit zu einem hohen Maß an intraorganisationaler Online-Kollaboration (IOC) führte (Sunday AGBA et al., 2020). ... ]Aus: Einleitung

Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency disorders.

Common Variable Immunodeficiency Disorders (CVIDs) are the most prevalent cause of primary antibody failure. CVIDs are highly variable and a genetic causes have been identified in <5% of patients. Here, we performed whole genome sequencing (WGS) of 34 CVID patients (94% sporadic) and combined them with transcriptomic profiling (RNA-sequencing of B cells) from three patients and three healthy controls. We identified variants in CVID disease genes TNFRSF13B, TNFRSF13C, LRBA and NLRP12 and enrichment of variants in known and novel disease pathways. The pathways identified include B-cell receptor signalling, non-homologous end-joining, regulation of apoptosis, T cell regulation and ICOS signalling. Our data confirm the polygenic nature of CVID and suggest individual-specific aetiologies in many cases. Together our data show that WGS in combination with RNA-sequencing allows for a better understanding of CVIDs and the identification of novel disease associated pathways

Charakterisierung der Gleichtaktstörquellen eines Pulswechselrichters zur Bewertung von Entstörfiltern im Traktionsnetz elektrischer Kfz-Antriebe

Dieser Beitrag zeigt eine Methode zur Bestimmung der Eingangsimpedanzen eines Pulswechselrichters über die Messung der Streuparameter des passiven Prüflings. Eine Analyse der Kurvenverläufe und der dominanten Einflussfaktoren erlaubt eine einfache und schnelle Netzwerkmodellierung von Hochvolt-Pulswechselrichter. Bei einer Nachfolgegeneration von Hochvolt-Pulswechselrichter kann dieses Netzwerkmodell ohne weitere Validierungsmessung direkt an die neuen Gegebenheiten angepasst werden. Zeitbereichmessungen der Störspannung bei unterschiedlichen Kabelbaumeingangsimpedanzen ermöglichen einen Rückschluss auf die Quellimpedanz der Gleichtaktstörquellen innerhalb des Prüflings. Diese ergeben eine hohe Übereinstimmung zwischen der Eingangsimpedanz des passiven Prüflings mit der Quellimpedanz in einem typischen Betriebspunkt. Da die passiven Bauelemente die Quellimpedanz dominieren, haben die schaltenden Leistungshalbleiter einen geringen Einfluss auf den Verlauf der Quellimpedanz und bestimmen lediglich die Amplitude der idealen Störspannungsquelle des Thevenin-Äquivalents. Die Messung des Vorwarts-Transmissionsfaktor einer Filtermaßnahme im Ω-System ist nicht ausreichend, um die Einfugedampfung von Entstörmaßnahmen in Hochvoltsystemen abschatzen zu können. Die Messungen von Quellimpedanz sowie Eingangsimpedanz des Hochvoltkabelbaums zeigen, dass diese signifikant von 50 Ω abweichen. Das fuhrt zu einer erheblichen Veränderung der Einfugedampfung eines Entstörfilters im Hochvoltbordnetz verglichen mit der im 50 Ω-System. Da die Last- und Quellimpedanzen die Ursache dieser Abweichung sind, lasst sich die Einfugedampfung in Abhängigkeit der Impedanzverhältnisse berechnen. Die vorgestellte Methode erlaubt es, aus der Kenntnis der Netzimpedanzen sowie der Streuparameter eines Filters die Einfügedämpfung für beliebige Systeme zu bestimmen und damit elektromagnetische Verträglichkeitsmaßnahmen für Hochvoltsysteme zu optimieren, bevor es zu Abnahmemessungen gekommen ist. Der aufwendige und wenig effiziente Ansatz des Trial-and-Error, welcher mangels Alternativen durchaus verbreitet ist, lässt sich damit vermeiden

Unit cell of a Penning micro-trap quantum processor

Trapped ions in radio-frequency traps are among the leading approaches for realizing quantum computers, due to high-fidelity quantum gates and long coherence times. However, the use of radio-frequencies presents a number of challenges to scaling, including requiring compatibility of chips with high voltages, managing power dissipation and restricting transport and placement of ions. By replacing the radio-frequency field with a 3 T magnetic field, we here realize a micro-fabricated Penning ion trap which removes these restrictions. We demonstrate full quantum control of an ion in this setting, as well as the ability to transport the ion arbitrarily in the trapping plane above the chip. This unique feature of the Penning micro-trap approach opens up a modification of the Quantum CCD architecture with improved connectivity and flexibility, facilitating the realization of large-scale trapped-ion quantum computing, quantum simulation and quantum sensing

Penning micro-trap for quantum computing

Trapped ions in radio-frequency traps are among the leading approaches for realizing quantum computers, because of high-fidelity quantum gates and long coherence times1–3. However, the use of radio-frequencies presents several challenges to scaling, including requiring compatibility of chips with high voltages4, managing power dissipation5 and restricting transport and placement of ions6. Here we realize a micro-fabricated Penning ion trap that removes these restrictions by replacing the radio-frequency field with a 3 T magnetic field. We demonstrate full quantum control of an ion in this setting, as well as the ability to transport the ion arbitrarily in the trapping plane above the chip. This unique feature of the Penning micro-trap approach opens up a modification of the quantum charge-coupled device architecture with improved connectivity and flexibility, facilitating the realization of large-scale trapped-ion quantum computing, quantum simulation and quantum sensing

Ten years of research on synergisms and antagonisms in chemical mixtures: A systematic review and quantitative reappraisal of mixture studies

Background Several reviews of synergisms and antagonisms in chemical mixtures have concluded that synergisms are relatively rare. However, these reviews focused on mixtures composed of specific groups of chemicals, such as pesticides or metals and on toxicity endpoints mostly relevant to ecotoxicology. Doubts remain whether these findings can be generalised. A systematic review not restricted to specific chemical mixtures and including mammalian and human toxicity endpoints is missing. Objectives We conducted a systematic review and quantitative reappraisal of 10 years’ of experimental mixture studies to investigate the frequency and reliability of evaluations of mixture effects as synergistic or antagonistic. Unlike previous reviews, we did not limit our efforts to certain groups of chemicals or specific toxicity outcomes and covered mixture studies relevant to ecotoxicology and human/mammalian toxicology published between 2007 and 2017. Data sources, eligibility criteria We undertook searches for peer-reviewed articles in PubMed, Web of Science, Scopus, GreenFile, ScienceDirect and Toxline and included studies of controlled exposures of environmental chemical pollutants, defined as unintentional exposures leading to unintended effects. Studies with viruses, prions or therapeutic agents were excluded, as were records with missing details on chemicals’ identities, toxicities, doses, or concentrations. Study appraisal and synthesis methods To examine the internal validity of studies we developed a risk-of-bias tool tailored to mixture toxicology. For a subset of 388 entries that claimed synergisms or antagonisms, we conducted a quantitative reappraisal of authors’ evaluations by deriving ratios of predicted and observed effective mixture doses (concentrations). Results Our searches produced an inventory of 1220 mixture experiments which we subjected to subgroup analyses. Approximately two thirds of studies did not incorporate more than 2 components. Most experiments relied on low-cost assays with readily quantifiable endpoints. Important toxicity outcomes of relevance for human risk assessment (e.g. carcinogenicity, genotoxicity, reproductive toxicity, immunotoxicity, neurotoxicity) were rarely addressed. The proportion of studies that declared additivity, synergism or antagonisms was approximately equal (one quarter each); the remaining quarter arrived at different evaluations. About half of the 1220 entries were rated as “definitely” or “probably” low risk of bias. Strikingly, relatively few claims of synergistic or antagonistic effects stood up to scrutiny in terms of deviations from expected additivity that exceed the boundaries of acceptable between-study variability. In most cases, the observed mixture doses were not more than two-fold higher or lower than the predicted additive doses. Twenty percent of the entries (N = 78) reported synergisms in excess of that degree of deviation. Our efforts of pinpointing specific factors that predispose to synergistic interactions confirmed previous concerns about the synergistic potential of combinations of triazine, azole and pyrethroid pesticides at environmentally relevant doses. New evidence of synergisms with endocrine disrupting chemicals and metal compounds such as chromium (VI) and nickel in combination with cadmium has emerged. Conclusions, limitations and implications These specific cases of synergisms apart, our results confirm the utility of default application of the dose (concentration) addition concept for predictive assessments of simultaneous exposures to multiple chemicals. However, this strategy must be complemented by an awareness of the synergistic potential of specific classes of chemicals. Our conclusions only apply to the chemical space captured in published mixture studies which is biased towards relatively well-researched chemicals.European Commission, Directorate-General Joint Research Centre, Service Contract CCR.F.933992.X

A mixed methods PAR study investigating social capital as a resource for Black and other racially minoritised communities in the UK:A study protocol

Understanding how different Black and other racially minoritised communities thrive is an emerging priority area in mental health promotion. Literature demonstrates health benefits of social capital (social resources embedded within social networks). However, its effects are not always positive, particularly for certain subpopulations who are already disadvantaged. The CONtributions of social NEtworks to Community Thriving (CONNECT) study will use Participatory Action Research (PAR) to investigate social capital as a resource that benefits (or hinders) racially minoritised communities and their mental health. The CONNECT study was designed within a partnership with community organisations and responds to local policy in two South-East London Boroughs, thereby providing potential channels for the action component of PAR. Taking an anti-racism lens, we acknowledge the underpinning role of racism in creating health inequities. We apply an intersectional framework to be considerate of overlapping forms of oppression such as age, gender, socioeconomic status, and sexual orientation as an essential part of developing effective strategies to tackle health inequities. Key components of this mixed methods PAR study include (1) involving racialised minority community members as peer researchers in the team (2) collecting and analysing primary qualitative data via interviews, photovoice, and community mapping workshops, (3) developing relevant research questions guided by peer researchers and collaborating organisations and analysing secondary quantitative data accordingly, (4) integrating qualitative and quantitative phases, and (5) working closely with community and policy partners to act on our findings and use our research for social change. The PAR approach will allow us to engage community (voluntary sector and government) and academic partners in decision making and help address imbalances in power and resource allocation. Knowledge generated through this collaborative approach will contribute to existing community initiatives, policies, and council strategies. This will ensure the views and experiences of racially minoritised communities drive the changes we are collaboratively committed to achieving.<br/

Physiological modes of action across species and toxicants : the key to predictive ecotoxicology

As ecotoxicologists we strive for a better understanding of how chemicals affect our environment. Humanity needs tools to identify those combinations of man-made chemicals and organisms most likely to cause problems. In other words: which of the millions of species are at risk from pollution? And which of the tens of thousands of chemicals contribute most to the risk? We identified our poor knowledge on physiological modes of action (how a chemical affects the energy allocation in an organism), and how they vary across species and toxicants, as a major knowledge gap. We also find that the key to predictive ecotoxicology is the systematic, rigorous characterization of physiological modes of action because that will enable more powerful in vitro to in vivo toxicity extrapolation and in silico ecotoxicology. In the near future, we expect a step change in our ability to study physiological modes of action by improved, and partially automated, experimental methods. Once we have populated the matrix of species and toxicants with sufficient physiological mode of action data we can look for patterns, and from those patterns infer general rules, theory and models

Postcolonial healing landscapes and mental health in a remote Indigenous community in subarctic Ontario, Canada

The concept of therapeutic landscape is concerned with a holistic, socio-ecological model of health, but most studies have attempted to explore land-health links from a Western perspective. On an Indigenous reserve in Northern Ontario, part of the Canadian subarctic, we explore the importance of spaces and places in creating postcolonial therapeutic landscapes to treat the wounds inflicted by colonialism. The aim of this research is to gain insight from views and experiences of First Nations residents living on reservations that are undergoing a process of regaining traditional spiritual beliefs and teachings to construct therapeutic spaces to face mental health problems caused by legal opioid analgesic abuse. This qualitative study used semi-structured interviews with Cree and Ojibwe participants to understand how they are reconnecting with earth, spirituality and traditional animist beliefs on their way to recovery. We find that practices such as taking part in ceremonies and ritual spaces, and seeking knowledge and advice from Elders assist with personal healing and enable Indigenous people to be physically and mentally healthy. Our research findings provide important insights into the relationship between space, healing and culture as determinants of health and well-being and document some key factors that contribute to substance abuse recovery.This work was supported by the Ministry of Education and Science (Spain) [I + D+i SEJ2005-09344/SOCI]; Social Sciences and Humanities Research Council (Canada) [I + D+i CURA/NORTHERN]

The EuroFlow PID Orientation Tube for Flow Cytometric Diagnostic Screening of Primary Immunodeficiencies of the Lymphoid System

In the rapidly evolving field of primary immunodeficiencies (PID), the EuroFlow consortium decided to develop a PID orientation and screening tube that facilitates fast, standardized, and validated immunophenotypic diagnosis of lymphoid PID, and allows full exchange of data between centers. Our aim was to develop a tool that would be universal for all lymphoid PIDs and offer high sensitivity to identify a lymphoid PID (without a need for specificity to diagnose particular PID) and to guide and prioritize further diagnostic modalities and clinical management. The tube composition has been defined in a stepwise manner through several cycles of design-testing-evaluation-redesign in a multicenter setting. Equally important appeared to be the standardized pre-analytical procedures (sample preparation and instrument setup), analytical procedures (immunostaining and data acquisition), the software analysis (a multidimensional view based on a reference database in Infinicyt software), and data interpretation. This standardized EuroFlow concept has been tested on 250 healthy controls and 99 PID patients with defined genetic defects. In addition, an application of new EuroFlow software tools with multidimensional pattern recognition was designed with inclusion of maturation pathways in multidimensional patterns (APS plots). The major advantage of the EuroFlow approach is that data can be fully exchanged between different laboratories in any country of the world, which is especially of interest for the PID field, with generally low numbers of cases per center