Synthesis of Some Novel Fused Substituted 3-(4-substitutedphenyl)-6,6-diphenyl-3,3a dihydroimidazo [2',1':2,3][1,3] thiazolo[4,5-c][1,2] Isoxazoles

The present study describes the synthesis of some novel arylidene cyclic chalcones 2-(4-substituted benzylidene)-6,6-diphenylimidazo[2,1-b][1,3]thiazole-3,5-diones and their transformation to 3-(4-substitutedphenyl)-6,6-diphenyl-3,3a- dihydroimidazo[2´,1´:2,3][1,3]thiazolo[4,5-c][1,2]oxazol-7(6H)-ones via cyclization using hydroxylamine hydrochloride. The starting chalcones have been synthesized by the condensation of various aromatic aldehydes and methylene entity of synthesized imidazothiazole-3,5-diones which were obtained by the cyclization of 5,5-diphenyl-2-thioxoimidazolidin-4-ones and chloroacetic acid. The intermediate 5,5-diphenyl-2-thioxoimidazolidin-4-ones have been synthesized by the condensation of α-diketone (benzil) with thiourea in presence of ethanolic alkali followed by Pinacol-Pinacolone rearrangement. Structures of all the newly synthesized compounds were confirmed by chemical, analytical and spectral data.Fil: Dangi, R. R.. Mody University Of Science And Technology; IndiaFil: Kumari, Maya. Mody University Of Science And Technology; IndiaFil: Khyaliya, Priyanka. Mody University Of Science And Technology; IndiaFil: Parellada, Eduardo Alberto. Universidad Nacional de Santiago del Estero. Instituto de Bionanotecnología del Noa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Bionanotecnología del Noa; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica. Cátedra de Química Orgánica III; ArgentinaFil: Neske, Adriana Neske. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica. Cátedra de Química Orgánica III; ArgentinaFil: Ameta, K. L.. Mody University Of Science And Technology; Indi

Montmorrilonite K10 catalyzed efficient synthesis of some 4'-nitrochalcones and their 1, 3, 5-triaryl-2-pyrazolines and in vitro antimicrobial evaluation

An expeditious synthesis of some 4´-nitrochalcones (3a-n) and their subsequent facile one-pot transformation to 1, 3,5-triaryl-2-pyrazolines (4a-n) has been carried out using montmorrilonite K10 via microwave mediated solvent free protocol.An emphasis is given to highlighting the greenness of the processes, and a fair comparison is also provided between differentinorganic solid supports as catalysts. Both conventional as well as non-conventional approaches have been explored bycomparing the reaction conditions and yields. The newly synthesized pyrazolines were studied for their in vitro antimicrobialevaluation against bacterial strains Bacillus pumilus and Escherichia coli and fungal strains Aspergillus niger and Penicilliumchrysogenum. Findings of biological evaluation highlighted 4b, 4e, 4j and 4m as potential new leads in the search of newantimicrobial agents. The structures of newly synthesized compounds have been established on the basis of elemental analysisand spectroscopic studies.Fil: Ameta, K. L.. Faculty Of Arts, Science & Commerce, Mody University Of; IndiaFil: Rathore, Nitu S.. Faculty Of Arts, Science & Commerce, Mody University Of; IndiaFil: Kumari, Maya. Faculty Of Arts, Science & Commerce, Mody University Of; IndiaFil: Khyaliya, Priyanka. University of Science and Technology; IndiaFil: Dangi R. R.. Faculty Of Arts, Science & Commerce, Mody University Of; IndiaFil: Parellada, Eduardo Alberto. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica. Cátedra de Química Orgánica III; Argentina. Universidad Nacional de Santiago del Estero. Instituto de Bionanotecnología del Noa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Bionanotecnología del Noa; ArgentinaFil: Neske, Adriana. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica. Cátedra de Química Orgánica III; Argentin

Synthetic bis- and mono-chalcones with insecticide effects on Spodoptera frugiperda (Lepidoptera: Noctuidae)

This is the first report on the antifeedant, toxic and nutritional effects produced by the synthetic chalcones on the lepidopteran Spodoptera frugiperda followed by structure-activity relationship. Bis (5a-c) and mono (8a-d) chalcones have been synthesized via Claisen-Schmidt condensation and have been purified and characterized. The mono chalcones 8b and 8d displayed toxic effects on early larval instars when incorporated to the larval diet at 100 µg per g of diet (40 and 60%, respectively) and low adults emergency with malformations leading to death. The remaining chalcones 8a, 8c, 5a, 5b and 5c do not displayed toxic effects at the same dose. The evaluation of nutritional indices indicated that 8a and 8c were the only tested chalcones to produce decrease in the growth rate and to reduce the efficiency with which larvae converted ingested food into biomass.Fil: Ruiz Hidalgo, José. Universidad Nacional de Santiago del Estero. Instituto de Bionanotecnología del Noa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Bionanotecnología del Noa; ArgentinaFil: Santillan, Melina del Huerto. Universidad Nacional de Tucumán; ArgentinaFil: Parellada, Eduardo Alberto. Universidad Nacional de Santiago del Estero. Instituto de Bionanotecnología del Noa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Bionanotecnología del Noa; ArgentinaFil: Khyaliya, Priyanka. Mody University Of Science And Technology; IndiaFil: Neske, Adriana. Universidad Nacional de Tucumán; ArgentinaFil: Ameta, Keshav Lalit. Mody University Of Science And Technology; Indi