9 research outputs found
ChemInform Abstract: Diastereoselective Total Synthesis of Piperidine Alkaloids: (2R,5R)-5-Hydroxyhomopipecolic Acid (I) and (2R,5R,8R)-5-Hydroxysedamine (II).
Preparation of 1-deoxynojirimycin controlled release matrix pellets of capsules and evaluation in vitro-in vivo to enhance bioavailability
A General Approach to Various Five- and Six-Membered gem-Difluoroheterocycles Application to the Synthesis of Fluorinated Analogues of Sedamine
International audienceA new synthesis of a group of O-, S- and N-heterocycles with a gem-difluoro group in position to the heteroatom has been developed, starting from easily accessible gem-difluoro propargylic derivatives. This tandem process involves a base-induced isomerization followed by an intramolecular 1,4 hetero-Michael addition. This methodology is suitable for the preparation of five- and six-membered heterocycles and it has been successfully applied to the synthesis of the 3,3-difluoro analogues of (+/-)-sedamine III, (+/-)-allosedamine V, (+/-)-norallosedamine II, and (+/-)-norsedamine IV