The evolution of business ethics in China and the United States: convergence, divergence or crossvergence?

This study presents a cross-temporal comparison of managerial ethics in China and the US. Although it is well established that cross-cultural differences exist in business ethics and that culture and values in a society may evolve over time, little attention has been paid to the longitudinal changes in such cross-cultural differences that might have occurred over time. Building on the three different perspectives on values evolution, namely, convergence, divergence, and crossvergence, we investigate whether and how cross-cultural differences in managerial ethical decision-making and the associated moral philosophy have changed in China and the US over a decade between the mid-1990s and the mid-2000s. Our analysis reveals that the difference in Chinese and American managers’ ethical decision-making evolved in many different directions over the decade, lending support to the crossvergence perspective. Interestingly, however, we discover that the divergence outlook prevails when it comes to the moral philosophies behind their decision-making. These findings provide critical insights into cross-cultural as well cross-temporal evolution in business ethics in a world of increasing cross-cultural and multicultural interactions. 本文对中美两国经理人员的商业伦理决策进行了跨期比较研究。已有研究普遍认为，商业伦理中存在着跨文化差异，且一个社会的文化和价值观会随着时间的推移而演化。但是，相关研究对这种跨文化差异随着时间的推移而发生纵向变化的关注相对较少。基于价值观演化的三种不同视角——趋同、趋异和交叉融合，我们研究了在20世纪90年代中期至21世纪最初十年的中期这一阶段，中美两国经理人员的商业伦理决策和相关道德哲学的跨文化差异的纵向变化。我们的分析表明，在这十年中，中美两国经理人员的商业伦理决策差异在多个不同方向上演化，存在着交叉融合。然而，有趣的是，我们也发现，当涉及到商业伦理决策背后深层次的道德哲学时，相互间的差异点占了上风。这些发现为在全球日益增多的跨文化和多元文化互动中深度认识商业伦理的跨文化和跨时间演化提供了重要见解

A Laminin G-EGF-Laminin G Module in Neurexin IV Is Essential for the Apico-Lateral Localization of Contactin and Organization of Septate Junctions

Septate junctions (SJs) display a unique ultrastructural morphology with ladder-like electron densities that are conserved through evolution. Genetic and molecular analyses have identified a highly conserved core complex of SJ proteins consisting of three cell adhesion molecules Neurexin IV, Contactin, and Neuroglian, which interact with the cytoskeletal FERM domain protein Coracle. How these individual proteins interact to form the septal arrays that create the paracellular barrier is poorly understood. Here, we show that point mutations that map to specific domains of neurexin IV lead to formation of fewer septae and disorganization of SJs. Consistent with these observations, our in vivo domain deletion analyses identified the first Laminin G-EGF-Laminin G module in the extracellular region of Neurexin IV as necessary for the localization of and association with Contactin. Neurexin IV protein that is devoid of its cytoplasmic region is able to create septae, but fails to form a full complement of SJs. These data provide the first in vivo evidence that specific domains in Neurexin IV are required for protein-protein interactions and organization of SJs. Given the molecular conservation of SJ proteins across species, our studies may provide insights into how vertebrate axo-glial SJs are organized in myelinated axons

OPEN COMMUNITY HEALTH: WORKSHOP REPORT

This report summarizes key outcomes from a workshop on open community health conducted at the University of Nebraska at Omaha in April 2018. Workshop members represented research and practice communities across Citizen Science, Open Source, and Wikipedia. The outcomes from the workshop include (1) comparisons among these communities, (2) how a shared understanding and assessment of open community health can be developed, and (3) a taxonomical comparison to begin a conversation between these communities that have developed disparate languages

Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer

<p>Abstract</p> <p>Purpose</p> <p>To determine whether functional proteomics improves breast cancer classification and prognostication and can predict pathological complete response (pCR) in patients receiving neoadjuvant taxane and anthracycline-taxane-based systemic therapy (NST).</p> <p>Methods</p> <p>Reverse phase protein array (RPPA) using 146 antibodies to proteins relevant to breast cancer was applied to three independent tumor sets. Supervised clustering to identify subgroups and prognosis in surgical excision specimens from a training set (n = 712) was validated on a test set (n = 168) in two cohorts of patients with primary breast cancer. A score was constructed using ordinal logistic regression to quantify the probability of recurrence in the training set and tested in the test set. The score was then evaluated on 132 FNA biopsies of patients treated with NST to determine ability to predict pCR.</p> <p>Results</p> <p>Six breast cancer subgroups were identified by a 10-protein biomarker panel in the 712 tumor training set. They were associated with different recurrence-free survival (RFS) (log-rank p = 8.8 E-10). The structure and ability of the six subgroups to predict RFS was confirmed in the test set (log-rank p = 0.0013). A prognosis score constructed using the 10 proteins in the training set was associated with RFS in both training and test sets (p = 3.2E-13, for test set). There was a significant association between the prognostic score and likelihood of pCR to NST in the FNA set (p = 0.0021).</p> <p>Conclusion</p> <p>We developed a 10-protein biomarker panel that classifies breast cancer into prognostic groups that may have potential utility in the management of patients who receive anthracycline-taxane-based NST.</p

The effects of single-sex versus coeducational schools on adolescent peer victimization and perpetration

Bullying is a growing public health concern for South Korean adolescents. In our quantitative investigation, we analyze the frequency with which Korean adolescents in single-sex versus coeducational schools are targets of or engage in three peer aggressive behaviors (verbal, relational (social exclusion), and physical (including theft)). We use two nationally representative datasets, the 2011 Trends in International Mathematics and Science Study (TIMSS) and the 2005 Korea Education Longitudinal Study (KELS), and rely on propensity score matching (PSM). For adolescent girls, we find that being in all-girls schools mitigates both their exposure to and engagement in peer victimization. For adolescent boys, we find that boys in all-boys schools have significantly higher odds of experiencing more frequent verbal and physical attacks versus their counterparts in coeducational schools. Our findings strongly suggest that interventions to mitigate peer victimization and aggression in Korea should consider the gendered schooling contexts in which they are implemented

25th annual computational neuroscience meeting: CNS-2016

The same neuron may play different functional roles in the neural circuits to which it belongs. For example, neurons in the Tritonia pedal ganglia may participate in variable phases of the swim motor rhythms [1]. While such neuronal functional variability is likely to play a major role the delivery of the functionality of neural systems, it is difficult to study it in most nervous systems. We work on the pyloric rhythm network of the crustacean stomatogastric ganglion (STG) [2]. Typically network models of the STG treat neurons of the same functional type as a single model neuron (e.g. PD neurons), assuming the same conductance parameters for these neurons and implying their synchronous firing [3, 4]. However, simultaneous recording of PD neurons shows differences between the timings of spikes of these neurons. This may indicate functional variability of these neurons. Here we modelled separately the two PD neurons of the STG in a multi-neuron model of the pyloric network. Our neuron models comply with known correlations between conductance parameters of ionic currents. Our results reproduce the experimental finding of increasing spike time distance between spikes originating from the two model PD neurons during their synchronised burst phase. The PD neuron with the larger calcium conductance generates its spikes before the other PD neuron. Larger potassium conductance values in the follower neuron imply longer delays between spikes, see Fig. 17.Neuromodulators change the conductance parameters of neurons and maintain the ratios of these parameters [5]. Our results show that such changes may shift the individual contribution of two PD neurons to the PD-phase of the pyloric rhythm altering their functionality within this rhythm. Our work paves the way towards an accessible experimental and computational framework for the analysis of the mechanisms and impact of functional variability of neurons within the neural circuits to which they belong

Acquired In-process Research Development and Earnings Management

New accounting standards, namely SFAS 141 and 142, were adopted in 2001. The release of these two regulations offers a unique opportunity to explore how managers have changed their earnings manipulation behaviour by using In-process Research and Development (IPR&amp;D) costs. In this study, we examine whether and how the amount of IPR&amp;D at the acquisition deals is associated with discretionary accruals, which serve as a proxy for earnings management. We use a sample of firms reporting acquired IPR&amp;D over the period 1993-2007 with a matched group based on size and industry. Our results provide evidence that managers strategically use the IPR&amp;D costs as an income-decreasing earnings management tool, and SFAS 141 and 142 effectively reduced the use of IPR&amp;D costs to manipulate earnings. Furthermore, we examine the effect of SFAS 141R, which was adopted in 2008, on earnings management by using IPR&amp;D. We use a sample of firms reporting acquired IPR&amp;D at the firm level over the period 1993-2011 with a matched group based on size and industry. Results indicate that IPR&amp;D is no longer related to income-decreasing earnings management after the adoption of SFAS 141R. These findings can help accounting regulators determine how to curb the misleading use of IPR&amp;D for earnings management purposes