Compiling distributed C++

technical reportDistributed C++ (DC++) is a language for writing parallel applications on loosely coupled distributed systems in C++. Its key idea is to extend the C++ class into 3 categories: gateway classes which act as communication and synchronization entry points between abstract processors, classes whose instances may be passed by value between abstract processors via gateways, and vanilla C++ classes. DC++ code is compiled to C++ code with calls to the DC++ runtime system. The DC++ compiler wraps gateway classes with handle classes so that remote procedure calls are transparent. It adds static variables to value classes and produces code which is used to marshal and unmarshal arguments when these value classes are used in remote procedure calls. Value classes are deep copied and preserve structure sharing. This paper shows DC++ compilation and performance

High Mortality of a Population of Cowbirds Wintering at Columbus, Ohio

High mortality was experienced during two heavy rainfalls by a wintering population of Cowbirds in Columbus, Ohio. Their death was associated with a soaking of their feathers, and their inability to fly and to remain on their perches in the roost. Causes of death may be associated with the lowering of their body temperature, enhanced by bathing in streams containing detergents

Resilience in high-risk adolescents of mothers with recurrent depressive disorder: the contribution of fathers

This study examines the role of paternal emotional support as a resilience promoter in offspring of mothers with depression by considering the role of fathers’ mental health and the quality of the couple relationship. Two hundred and sixty-five mothers with recurrent unipolar depression, partners and adolescents from Wales were assessed. Paternal emotional support, couple relationship quality, and paternal depression were assessed at baseline; adolescent mental health symptoms were assessed using the Child and Adolescent Psychiatric Assessment at follow-up. Results showed evidence of an indirect pathway whereby couple relationship quality predicted paternal emotional support (β=-.21, 95% CI [-.34, -.08]; p=.002) which in turn predicted adolescent depression (β=-.18, 95% CI [-.33, -.04]; p=.02), but not disruptive behaviours (β=-.10, 95% CI [-.26, .40]; p=.21), after controlling for relevant confounders. The findings highlight that fathers and the broader family system play an important role in enhancing resilience to depression symptoms in at-risk adolescents

Type Ia Supernovae Selection and Forecast of Cosmology Constraints for the Dark Energy Survey

We present the results of a study of selection criteria to identify Type Ia supernovae photometrically in a simulated mixed sample of Type Ia supernovae and core collapse supernovae. The simulated sample is a mockup of the expected results of the Dark Energy Survey. Fits to the MLCS2k2 and SALT2 Type Ia supernova models are compared and used to help separate the Type Ia supernovae from the core collapse sample. The Dark Energy Task Force Figure of Merit (modified to include core collapse supernovae systematics) is used to discriminate among the various selection criteria. This study of varying selection cuts for Type Ia supernova candidates is the first to evaluate core collapse contamination using the Figure of Merit. Different factors that contribute to the Figure of Merit are detailed. With our analysis methods, both SALT2 and MLCS2k2 Figures of Merit improve with tighter selection cuts and higher purities, peaking at 98% purity.Comment: submitted to JCAP, 23 pages, 36 picture

Monitoring processed, mature Human Immunodeficiency Virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen

Protease inhibitors (PIs) block HIV-1 maturation into an infectious virus particle by inhibiting the protease processing of gag and gag-pol precursor proteins. We have used a simple anti-HIV-1 p24 Western blot to monitor the processing of p55(gag )precursor into the mature p24 capsid immediately following the first dosage of a PI-containing treatment regimen. Evidence of PI activity was observed in plasma virus as early as 72 hours post treatment-initiation and was predictive of plasma viral RNA decrease at 4 weeks

The c2d Spitzer Spectroscopic Survey of Ices Around Low-Mass Young Stellar Objects. IV. NH3 and CH3OH

NH3 and CH3OH are key molecules in astrochemical networks leading to the formation of more complex N- and O-bearing molecules, such as CH3CN and HCOOCH3. Despite a number of recent studies, little is known about their abundances in the solid state. (...) In this work, we investigate the ~ 8-10 micron region in the Spitzer IRS (InfraRed Spectrograph) spectra of 41 low-mass young stellar objects (YSOs). These data are part of a survey of interstellar ices in a sample of low-mass YSOs studied in earlier papers in this series. We used both an empirical and a local continuum method to correct for the contribution from the 10 micron silicate absorption in the recorded spectra. In addition, we conducted a systematic laboratory study of NH3- and CH3OH-containing ices to help interpret the astronomical spectra. We clearly detect a feature at ~9 micron in 24 low-mass YSOs. Within the uncertainty in continuum determination, we identify this feature with the NH3 nu_2 umbrella mode, and derive abundances with respect to water between ~2 and 15%. Simultaneously, we also revisited the case of CH3OH ice by studying the nu_4 C-O stretch mode of this molecule at ~9.7 micron in 16 objects, yielding abundances consistent with those derived by Boogert et al. 2008 (hereafter paper I) based on a simultaneous 9.75 and 3.53 micron data analysis. Our study indicates that NH3 is present primarily in H2O-rich ices, but that in some cases, such ices are insufficient to explain the observed narrow FWHM. The laboratory data point to CH3OH being in an almost pure methanol ice, or mixed mainly with CO or CO2, consistent with its formation through hydrogenation on grains. Finally, we use our derived NH3 abundances in combination with previously published abundances of other solid N-bearing species to find that up to 10-20 % of nitrogen is locked up in known ices.Comment: 31 pages, 15 figures, accepted for publication in Ap

Early development of non-hodgkin lymphoma following initiation of newer class antiretroviral therapy among HIV-infected patients - implications for immune reconstitution

<p>Abstract</p> <p>Background</p> <p>In the HAART era, the incidence of HIV-associated non-Hodgkin lymphoma (NHL) is decreasing. We describe cases of NHL among patients with multi-class antiretroviral resistance diagnosed rapidly after initiating newer-class antiretrovirals, and examine the immunologic and virologic factors associated with potential IRIS-mediated NHL.</p> <p>Methods</p> <p>During December 2006 to January 2008, eligible HIV-infected patients from two affiliated clinics accessed Expanded Access Program antiretrovirals of raltegravir, etravirine, and/or maraviroc with optimized background. A NHL case was defined as a pathologically-confirmed tissue diagnosis in a patient without prior NHL developing symptoms after starting newer-class antiretrovirals. Mean change in CD4 and log₁₀VL in NHL cases compared to controls was analyzed at week 12, a time point at which values were collected among all cases.</p> <p>Results</p> <p>Five cases occurred among 78 patients (mean incidence = 64.1/1000 patient-years). All cases received raltegravir and one received etravirine. Median symptom onset from newer-class antiretroviral initiation was 5 weeks. At baseline, the median CD4 and VL for NHL cases (n = 5) versus controls (n = 73) were 44 vs.117 cells/mm3 (p = 0.09) and 5.2 vs. 4.2 log₁₀(p = 0.06), respectively. The mean increase in CD4 at week 12 in NHL cases compared to controls was 13 (n = 5) vs. 74 (n = 50)(p = 0.284). Mean VL log₁₀reduction in NHL cases versus controls at week 12 was 2.79 (n = 5) vs. 1.94 (n = 50)(p = 0.045).</p> <p>Conclusions</p> <p>An unexpectedly high rate of NHL was detected among treatment-experienced patients achieving a high level of virologic response with newer-class antiretrovirals. We observed trends toward lower baseline CD4 and higher baseline VL in NHL cases, with a significantly greater decline in VL among cases by 12 weeks. HIV-related NHL can occur in the setting of immune reconstitution. Potential immunologic, virologic, and newer-class antiretroviral-specific factors associated with rapid development of NHL warrants further investigation.</p

Sex differences in professional help seeking among adult black Americans

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44020/1/10464_2004_Article_BF00915210.pd

Religiosity and decreased risk of substance use disorders: is the effect mediated by social support or mental health status?

The negative association between religiosity (religious beliefs and church attendance) and the likelihood of substance use disorders is well established, but the mechanism(s) remain poorly understood. We investigated whether this association was mediated by social support or mental health status. We utilized cross-sectional data from the 2002 National Survey on Drug Use and Health (n = 36,370). We first used logistic regression to regress any alcohol use in the past year on sociodemographic and religiosity variables. Then, among individuals who drank in the past year, we regressed past year alcohol abuse/dependence on sociodemographic and religiosity variables. To investigate whether social support mediated the association between religiosity and alcohol use and alcohol abuse/dependence we repeated the above models, adding the social support variables. To the extent that these added predictors modified the magnitude of the effect of the religiosity variables, we interpreted social support as a possible mediator. We also formally tested for mediation using path analysis. We investigated the possible mediating role of mental health status analogously. Parallel sets of analyses were conducted for any drug use, and drug abuse/dependence among those using any drugs as the dependent variables. The addition of social support and mental health status variables to logistic regression models had little effect on the magnitude of the religiosity coefficients in any of the models. While some of the tests of mediation were significant in the path analyses, the results were not always in the expected direction, and the magnitude of the effects was small. The association between religiosity and decreased likelihood of a substance use disorder does not appear to be substantively mediated by either social support or mental health status