Design and operation of a field telescope for cosmic ray geophysical tomography

International audienceThe cosmic ray muon tomography gives an access to the density structure of geological targets. In the present article we describe a muon telescope adapted to harsh environmental conditions. In particular the design optimizes the total weight and power consumption to ease the deployment and increase the autonomy of the detector. The muon telescopes consist of at least two scintillator detection matrices readout by photosensors via optical fibres. Two photosensor options have been studied. The baseline option foresees one multianode photomultiplier (MAPM) per matrix. A second option using one multipixel photon counter (MPPC) per bar is under development. The readout electronics and data acquisition system developed for both options are detailed. We present a first data set acquired in open-sky conditions compared with the muon flux detected across geological objects

A Digital Framework to Build, Visualize and Analyze a Gene Expression Atlas with Cellular Resolution in Zebrafish Early Embryogenesis

A gene expression atlas is an essential resource to quantify and understand the multiscale processes of embryogenesis in time and space. The automated reconstruction of a prototypic 4D atlas for vertebrate early embryos, using multicolor fluorescence in situ hybridization with nuclear counterstain, requires dedicated computational strategies. To this goal, we designed an original methodological framework implemented in a software tool called Match-IT. With only minimal human supervision, our system is able to gather gene expression patterns observed in different analyzed embryos with phenotypic variability and map them onto a series of common 3D templates over time, creating a 4D atlas. This framework was used to construct an atlas composed of 6 gene expression templates from a cohort of zebrafish early embryos spanning 6 developmental stages from 4 to 6.3 hpf (hours post fertilization). They included 53 specimens, 181,415 detected cell nuclei and the segmentation of 98 gene expression patterns observed in 3D for 9 different genes. In addition, an interactive visualization software, Atlas-IT, was developed to inspect, supervise and analyze the atlas. Match-IT and Atlas-IT, including user manuals, representative datasets and video tutorials, are publicly and freely available online. We also propose computational methods and tools for the quantitative assessment of the gene expression templates at the cellular scale, with the identification, visualization and analysis of coexpression patterns, synexpression groups and their dynamics through developmental stages

Anomalies of noble gases and self-potential associated with fractures and fluid dynamics in a horizontal borehole, Mont Terri Underground Rock Laboratory

Before the excavation of the new gallery Ga08 in the Mont Terri Underground Rock Laboratory (Switzerland), which joined the existing gallery Ga04 in 2008, the end-face of gallery Ga04 was instrumented in 2007 to characterize the evolution of the rock mass with geochemical and geophysical methods. The noble gas content of a 12-m long horizontal borehole evidenced that desaturation processes occurred in the first 2 m, where pre-existing fractures accommodated the stress change during excavation of gallery Ga04 four years before. These first 2 m are associated with the so-called Excavation Damaged Zone (EDZ). As an inflow of pore water was observed in this borehole few weeks after its drilling, continuous self-potential (SP) measurements were performed to characterize its dynamics. After the drilling of new sub-horizontal boreholes in the end-face, strong localized variations of SP occurred. The comparison with the geological features of the rock mass suggests that these dynamic anomalies have to be associated with fluid circulation in pre-existing tectonic fractures that were primarily reactivated by the excavation of the gallery Ga04 and subsequently by the drilling operations

Anomalies of noble gases and self-potential associated with fractures and fluid dynamics in a horizontal borehole, Mont Terri Underground Rock Laboratory

Before the excavation of the new gallery Ga08 in the Mont Terri Underground Rock Laboratory (Switzerland), which joined the existing gallery Ga04 in 2008, the end-face of gallery Ga04 was instrumented in 2007 to characterize the evolution of the rock mass with geochemical and geophysical methods. The noble gas content of a 12-m long horizontal borehole evidenced that desaturation processes occurred in the first 2 m, where pre-existing fractures accommodated the stress change during excavation of gallery Ga04 four years before. These first 2 m are associated with the so-called Excavation Damaged Zone (EDZ). As an inflow of pore water was observed in this borehole few weeks after its drilling, continuous self-potential (SP) measurements were performed to characterize its dynamics. After the drilling of new sub-horizontal boreholes in the end-face, strong localized variations of SP occurred. The comparison with the geological features of the rock mass suggests that these dynamic anomalies have to be associated with fluid circulation in pre-existing tectonic fractures that were primarily reactivated by the excavation of the gallery Ga04 and subsequently by the drilling operations

Abrupt changes of hydrothermal activity in a lava dome detected by combined seismic and muon monitoring

Abstract The recent 2014 eruption of the Ontake volcano in Japan recalled that hydrothermal fields of moderately active volcanoes have an unpredictable and hazardous behavior that may endanger human beings. Steam blasts can expel devastating ejecta and create craters of several tens of meters. The management of such hydrothermal events in populated areas is problematic because of their very short time of occurrence. At present no precursory signal is clearly identified as a potential warning of imminent danger. Here we show how the combination of seismic noise monitoring and muon density tomography allows to detect, with an unprecedented space and time resolution, the increase of activity (at timescales of few hours to few days) of a hydrothermal spot located 50 to 100 m below the summit of an active volcano, the La Soufrière of Guadeloupe, in the Lesser Antilles. We show how the combination of those two methods improves the risk evaluation of short-term hazards and the localization of the involved volumes in the volcano. We anticipate that the deployment of networks of various sensors including temperature probes, seismic antennas and cosmic muon telescopes around such volcanoes could valuably contribute to early warning decisions

Outil de traçabilité complet d'une unité de préparation de chimiothérapies anticancereuses. Développement et plus-value pharmaceutique

Septièmes Journées de la Société Française de Pharmacie Oncologique (SFPO), Mandelieu, 15 et 16 Octobre.L'Unité de Biopharmacie Clinique Oncologique de l'Hôpital Bretonneau (CHRU Tours) réalise 25 000 préparations/an dans le respect des bonnes pratiques de préparation. Cette unité certifiée en 2007 a développé avec l'école polytechnique le logiciel "Pilote" permettant d'enregistrer toutes les opérations garantissant une traçabilité totale de la validation pharmaceutique à la réception dans le service de soin