Real-world efficacy and safety of Ledipasvir plus Sofosbuvir and Ombitasvir/Paritaprevir/Ritonavir +/- Dasabuvir combination therapies for chronic hepatitis C: A Turkish experience

Background/Aims: This study aimed to evaluate the real-life efficacy and tolerability of direct-acting antiviral treatments for patients with chronic hepatitis C (CHC) with/without cirrhosis in the Turkish population.Material and Methods: A total of 4,352 patients with CHC from 36 different institutions in Turkey were enrolled. They received ledipasvir (LDV) and sofosbuvir (SOF)+/- ribavirin (RBV) ombitasvir/paritaprevir/ritonavir +/- dasabuvir (PrOD)+/- RBV for 12 or 24 weeks. Sustained virologic response (SVR) rates, factors affecting SVR, safety profile, and hepatocellular cancer (HCC) occurrence were analyzed.Results: SVR12 was achieved in 92.8% of the patients (4,040/4,352) according to intention-to-treat and in 98.3% of the patients (4,040/4,108) according to per-protocol analysis. The SVR12 rates were similar between the treatment regimens (97.2%-100%) and genotypes (95.6%-100%). Patients achieving SVR showed a significant decrease in the mean serum alanine transaminase (ALT) levels (50.90 +/- 54.60 U/L to 17.00 +/- 14.50 U/L) and model for end-stage liver disease (MELD) scores (7.51 +/- 4.54 to 7.32 +/- 3.40) (p<0.05). Of the patients, 2 were diagnosed with HCC during the treatment and 14 were diagnosed with HCC 37.0 +/- 16.0 weeks post-treatment. Higher initial MELD score (odds ratio [OR]: 1.92, 95% confidence interval [CI]: 1.22-2.38; p=0.023]), higher hepatitis C virus (HCV) RNA levels (OR: 1.44, 95% CI: 1.31-2.28; p=0.038), and higher serum ALT levels (OR: 1.38, 95% CI: 1.21-1.83; p=0.042) were associated with poor SVR12. The most common adverse events were fatigue (12.6%), pruritis (7.3%), increased serum ALT (4.7%) and bilirubin (3.8%) levels, and anemia (3.1%).Conclusion: LDV/SOF or PrOD +/- RBV were effective and tolerable treatments for patients with CHC and with or without advanced liver disease before and after liver transplantation. Although HCV eradication improves the liver function, there is a risk of developing HCC.Turkish Association for the Study of The Liver (TASL

Argon laser trabeküloplastide beş yıllık sonuçlarımız

Bu tezin, veri tabanı üzerinden yayınlanma izni bulunmamaktadır. Yayınlanma izni olmayan tezlerin basılı kopyalarına Üniversite kütüphaneniz aracılığıyla (TÜBESS üzerinden) erişebilirsiniz.38 ÖZET 1986 - 1989 yıllan arasında Ege Üniversitesi Tıp fakültesi Göz Hastalıkları Anabilim dalı glokom biriminde glokom tanısı alıp, argon laser trabeküloplasti yapılan ve en az 5 yıl takip edilen 178 olgunun 205 gözü retrospektif olarak değerlendirildi. Laser tedavisi yapılan gözlerin 188'I primer açık açılı glokom, 9'u pigmenter glokom ve 8'I psodoexfoliatif glokomdu. ALT öncesi veya daha az tıbbi tedavi ile göz içi basıncında 5 mrnHg veya daha fazla azalma ile birlikte, göz içi basıncı 20 mmHg'nın altında tutulan olgular başarılı olarak kabul edildi. Çalışmamızda ALT'nin başarısı 3. ayda % 82.9, 1. yılda % 38.2, 3. yılda % 19.2 ve 5. yılda % 12.7 olarak saptand

Biogas Production from Chicken Manure

Traditionally, animal manures are burned for heating in Turkey. It is also used as soil conditioner which has adverse environmental effects. Although, the use of renewable energy sources in Turkey is very limited, the application studies on biogas production from animal manure are increasing. 25-30% of total animal manures produced in Turkey are composed of chicken manure. The works on biogas production from chicken manure are very limited in Turkey. In this paper, biogas production studies from chicken manure in Turkey and in the World are reviewed

ASSESSMENT OF HEALTH-RELATED QUALITY OF LIFE IN CHRONIC HEPATITIS B INFECTION PATIENTS IN TURKEY: A MULTICENTER STUDY

EASL International Liver Congress -- APR 13-17, 2016 -- Barcelona, SPAINbalkan, ilker inanc/0000-0002-8977-5931; Altindis, Mustafa/0000-0003-0411-9669;WOS: 000398711700582…EAS

Polyarteritis nodosa: lessons from 25 years of experience

Objectives: Polyarteritis nodosa is a necrotising vasculitis of predominantly medium size vessels. The present study aimed to summarise the characteristics of PAN patients, and also analyse the trend of decreasing PAN frequency in the last 25 years. Methods: PAN patients followed up between 1990 and 2015 were included. The demographics, clinical findings and outcomes were retrospectively evaluated. Results: One hundred thirty-three patients, including 66 children, were enrolled in the study. Among 133 patients, 86 (64.7%) had fever, 108 (81.2%) had skin involvement, 54 (40.6%) had renal involvement, 43 (32.3%) had neurological involvement, 32 (24.1%) had gastrointestinal involvement, 10 (7.5%) had cardiac involvement, 6 (4.5%) had pulmonary involvement. The median (minimum-maximum) leukocyte count, erythrocyte sedimentation rate and C-reactive protein levels at the time of diagnosis were 10400 (6100-32000)/mm3, 58 (2-132) mm/h and 5.22 (0-46) mg/dL, respectively. All patients were ANCA negative. Hepatitis serology was analysed in 121 patients and found positive in 13 of them. MEFV mutations were screened among 65 patients, 24 of them had mutations in at least one allele. Biopsy was performed in 109 patients and angiography was performed in 92 patients. The number of PAN patients declined significantly after 2010. 9 patients were re-categorised as DADA2 after 2014 and no patient were diagnosed with FMF+PAN after 2008. Conclusions: Our results suggest a decrease in PAN in our country which may be due to improved healthcare and dissecting mimicking diseases. Further prospective studies with prolonged follow-up could help us to better understand the disease characteristics.PubMe