13 research outputs found
Effects of a Heavy Backpack on Lower Extremity Joint Mechanics During Gait
- Publication venue
- Digital Commons IC
- Publication date
- 12/04/2018
- Field of study
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
- Author
- Abner Erin
- Adams Hieab H
- Adams Perrie M.
- Aguilar Miquel
- Ahmad Shahzad
- Al-Chalabi Ammar
- Albert Marilyn S.
- Albin Roger L.
- Allen Mariet
- Alvarez Victoria
- Amin Najaf
- Amouyel Philippe
- Apostolova Liana G.
- Arcaro Marina
- Arnold Steven E.
- Aspelund Thor
- Asthana Sanjay
- Atwood Craig S.
- Bacq Delphine
- Badarinarayan Nandini
- Baldwin Clinton T.
- Barber Imelda S.
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Beach Thomas G.
- Becker James T.
- Beecham Gary W.
- Beekly Duane
- Behrens Timothy W.
- Beiser Alexa S.
- Bellenguez Céline
- Benito Yoland Aladro
- Bennett David A.
- Berr Claudine
- Bigio Eileen H.
- Bird Thomas D.
- Bis Joshua C.
- Blacker Deborah
- Blesa Rafael
- Boada Merce
- Boccardi Virginia
- Boerwinkle Eric
- Boeve Bradley F.
- Boland Anne
- Bonuccelli Ubaldo
- Bosco Paolo
- Bossù Paola
- Bowen James D.
- Boxer Adam
- Braae Anne
- Braddel Amy
- Bras Jose
- Brayne Carol
- Brice Alexis
- Brody Jennifer A
- Brookes Keeley
- Brown Kristelle
- Brundin Rosemarie
- Bruni Amalia Cecilia
- Bullido María J.
- Burgess Jeremy D.
- Burke James R.
- Burns Jeffrey M.
- Buxbaum Joseph D.
- Caffarra Paolo
- Cairns Nigel J.
- Caltagirone Carlo
- Campion Dominique
- Cantwell Laura B.
- Cao Chuanhai
- Carlson Chris S.
- Carlsson Cynthia M.
- Carney Regina M.
- Carrasquillo Minerva M.
- Carrell David
- Carroll Steven L.
- Cecchetti Roberta
- Chakrabarty Paramita
- Chapman Jade
- Chen Yuning
- Choi Seung-Hoan
- Chouraki Vincent
- Chui Helena C.
- Ciaramella Antonio
- Clarimón Jordi
- Clark David G.
- Collinge John
- Combarros Onofre
- Concari Letizia
- Corcoran Chris
- Coto Eliecer
- Craig David
- Crane Paul K.
- Cribbs David H.
- Crocco Elizabeth A.
- Cruchaga Carlos
- Cupidi Chiara
- Cupples L Adrienne
- Daniele Antonio
- Daniilidou Makrina
- Dartigues Jean-François
- De Deyn Peter P.
- De Jager Philip L
- Decarli Charles
- Deleuze Jean-François
- Denning Nicola
- Derbois Céline
- Dermecourt Vincent
- Destefano Anita L.
- Diaz Carolina Ceballos
- Dichgans Martin
- Dick Malcolm
- Dickson Dennis W
- Dombroski Beth
- Doody Rachelle S.
- Duara Ranjan
- Dubois Bruno
- Dufouil Carole
- Dulary Cécile
- Dunstan Melanie
- Dupuis Josée
- Eiriksdottir Gudny
- Emilsson Valur
- Engelborghs Sebastien
- Epelbaum Jacques
- Ertekin-Taner Nilufer
- Escott-Price Valentina
- Evans Denis A.
- Faber Kelley M.
- Fairchild Thomas J.
- Fairén Mònica Díez
- Fallon Kenneth B.
- Fardo David W.
- Farlow Martin R.
- Farrer Lindsay A.
- Fenoglio Chiara
- Fernadez Carmen Muñoz
- Ferris Steven
- Fievet Nathalie
- Fitzpatrick Annette L.
- Fornage Myriam
- Foroud Tatiana M.
- Forsell Charlotte
- Forstner Andreas J.
- Fortea Juan
- Fox Nick C.
- Frank-García Ana
- Fratiglioni Laura
- Frosch Matthew P.
- Funk Cory C.
- Galasko Douglas R.
- Galimberti Daniela
- Gallo Maura
- Garcia Florentino Sanchez
- Garcia Melissa E.
- Garzia Fabienne
- Gearing Marla
- Gerrish Amy
- Geschwind Daniel H.
- Ghetti Bernardino
- Giedraitis Vilmantas
- Giegling Ina
- Gilbert John R.
- Gill Michael
- Goate Alison M.
- Golamaully Feroze
- Golde Todd E.
- Graff Caroline
- Graff-Radford Neill R.
- Graham Robert R
- Green Robert C.
- Grenier-Boley Benjamin
- Grove Megan L.
- Growdon John H.
- Gu Wei
- Gudnason Vilmundur
- Guerreiro Rita
- Haapasalo Annakaisa
- Haines Jonathan L.
- Hakonarson Hakon
- Hamilton Ronald L.
- Hamilton-Nelson Kara L.
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
- Hardy John
- Harold Denise
- Harrell Lindy E.
- Hartmann Annette M.
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Henández Isabel
- Herms Stefan
- Heun Reinhard
- Hill Matt
- Hiltunen Mikko
- Himali Jayanadra J.
- Hodges Angela
- Hoffmann Per
- Hofman Albert
- Holmes Clive
- Honig Lawrence S.
- Huebinger Ryan M.
- Huentelman Matthew J.
- Hughes Joseph T.
- Hulette Christine M.
- Hyman Bradley T.
- Ikram M Arfan
- Ingelsson Martin
- Jakobsdottir Johanna
- Jarvik Gail P.
- Jessen Frank
- Jian Xueqiu
- Jin Lee-Way
- Johnston Janet
- Jones Lesley
- Jr W T Longstreth
- Jun Gyungah
- Kamboh M Ilyas
- Karydas Anna
- Katz Mindy J.
- Kauwe John Keoni
- Kaye Jeffrey A.
- Keene C Dirk
- Keller Lina
- Kilander Lena
- Kim Ronald
- Kinhult-Stählbom Anne
- Kloszewska Iwona
- Koivisto Anne Maria
- Kornhuber Johannes
- Kowall Neil W.
- Kramer Joel H.
- Kukull Walter A.
- Kunkle Brian W.
- Kuzma Amanda B.
- Laferla Frank M.
- Lah James J.
- Lambert Jean-Charles
- Lannfelt Lars
- Larson Eric B.
- Lawlor Brian
- Leber Markus
- Leverenz James B.
- Levey Allan I.
- Levy Daniel
- Li Ge
- Li Hongdong
- Li Shuo
- Lieberman Andrew P.
- Lilius Lena
- Lin Honghuang
- Lipton Richard B.
- Lleó Alberto
- Lopez Oscar L.
- Lord Jenny
- Lovestone Simon
- Lunetta Kathryn L.
- Lupton Michelle K.
- Lyketsos Constantine G.
- Lynch Aoibhinn
- Maier Wolfgang
- Majounie Elisa
- Malamon John
- Maletta Raffaele Giovanni
- Mancuso Michelangelo
- Marshall Rachel
- Marson Daniel C.
- Martin Eden R.
- Martiniuk Frank
- Mash Deborah C.
- Masliah Eliezer
- Masullo Carlo
- Mayeux Richard
- Mayhaus Manuel
- McCormick Wayne C.
- McCurry Susan M.
- McDavid Andrew N.
- McGuinness Bernadette
- McKee Ann C.
- Mead Simon
- Mecocci Patrizia
- Medway Christopher
- Meggy Alun
- Mesulam Marsel
- Miller Bruce L.
- Miller Carol A.
- Miller Joshua W.
- Moebus Susanne
- Montine Thomas J.
- Moreno-Grau Sonia
- Morgan Kevin
- Morgan Taniesha
- Morris John C.
- Mosley Thomas H.
- Mukherjee Shubhabrata
- Munger Ron
- Murrell Jill R.
- Myers Amanda J.
- Nacmias Benedetta
- Naj Adam C
- Naranjo Maria Candida Deniz
- Norton Maria
- Nöthen Markus M.
- O'Bryant Sid
- O'Donnell Christopher J.
- O'Donovan Michael C.
- Olaso Robert
- Olichney John M.
- Orfei Maria Donata
- Ortega-Cubero Sara
- Owen Michael J.
- Pankratz Vernon S.
- Panza Francesco
- Parisi Joseph E.
- Pasquier Florence
- Passmore Peter
- Pastor Pau
- Patel Yogen
- Paulson Henry L.
- Pericak-Vance Margaret A.
- Perry William
- Peskind Elaine
- Peters Oliver
- Petersen Ronald C.
- Pichler Sabrina
- Pierce Aimee
- Pilotto Alberto
- Poon Wayne W.
- Potter Huntington
- Powell John
- Price Nathan D.
- Proitsi Petra
- Psaty Bruce M.
- Qu Liming
- Quinn Joseph F.
- Raj Ashok
- Ramirez Alfredo
- Raskind Murray
- Raybould Rachel
- Reiman Eric M.
- Reisberg Barry
- Reisch Joan S.
- Reitz Christiane
- Riedel-Heller Steffi
- Riemenschneider Matthias
- Ringman John M.
- Ritchie Karen
- Rivadeneira Fernando
- Roberson Erik D.
- Rogaeva Ekaterina
- Rosen Howard J.
- Rosenberg Roger N.
- Rotter Jerome I.
- Royall Donald R.
- Rubinsztein David C
- Ruiz Agustin
- Rujescu Dan
- Sacchinelli Eleonora
- Sager Mark A.
- Sano Mary
- Satizabal Claudia L.
- Saykin Andrew J.
- Scarpini Elio
- Schellenberg Gerard D.
- Scherer Martin
- Schmidt Helena
- Schmidt Reinhold
- Schneider Julie A.
- Schneider Lon S.
- Seeley William W.
- Septier Gislain
- Seripa Davide
- Serpente Maria
- Seshadri Sudha
- Shaw Christopher E.
- Sims Rebecca
- Sleegers Kristel
- Smith Albert V.
- Smith Amanda G.
- Soininen Hilkka
- Solfrizzi Vincenzo
- Sonnen Joshua A.
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spalletta Gianfranco
- Spina Salvatore
- Squassina Alessio
- St George-Hyslop Peter
- Stern Robert A.
- Sussams Rebecca
- Swerdlow Russell H.
- Sánchez-Juan Pascual
- Tanzi Rudolph E.
- Tarraga Lluis
- Taylor Sarah
- Thomas Charlene
- Thomas Rhodri
- Thonberg Hakan
- Thornton-Wells Tricia A.
- Todd Stephen
- Trojanowski John Q.
- Troncoso Juan C.
- Tschanz Joann
- Tsolaki Magda
- Tsuang Debby W.
- Turton James
- Tzourio Christophe
- Tzourio Christophe
- Uitterlinden Andre G.
- Uphill James
- Urbano Maria
- Valladares Otto
- Van Broeckhoven Christine
- Van Deerlin Vivianna M.
- Van Der Lee Sven J
- Van Duijn Cornelia M.
- Van Eldik Linda J.
- Vandenberghe Rik
- Vardarajan Badri N.
- Vellas Bruno
- Vinters Harry V.
- Vonsattel Jean Paul
- Vronskaya Maria
- Wallon David
- Wang Li-San
- Wang Xue
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- White Charles C.
- Whitehead Patrice
- Wilhelmsen Kirk C.
- Williams Julie
- Williamson Jennifer
- Wingo Thomas S.
- Winslow Ashley R.
- Wolters Frank J
- Woltjer Randall L.
- Wright Clinton B.
- Wu Chuang-Kuo
- Yang Qiong
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zhao Yi
- Publication venue
- Publication date
- 01/01/2017
- Field of study
We identified rare coding variants associated with Alzheimer’s disease (AD) in a 3-stage case-control study of 85,133 subjects. In stage 1, 34,174 samples were genotyped using a whole-exome microarray. In stage 2, we tested associated variants (P<1×10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, an additional 14,997 samples were used to test the most significant stage 2 associations (P<5×10-8) using imputed genotypes. We observed 3 novel genome-wide significant (GWS) AD associated non-synonymous variants; a protective variant in PLCG2 (rs72824905/p.P522R, P=5.38×10-10, OR=0.68, MAFcases=0.0059, MAFcontrols=0.0093), a risk variant in ABI3 (rs616338/p.S209F, P=4.56×10-10, OR=1.43, MAFcases=0.011, MAFcontrols=0.008), and a novel GWS variant in TREM2 (rs143332484/p.R62H, P=1.55×10-14, OR=1.67, MAFcases=0.0143, MAFcontrols=0.0089), a known AD susceptibility gene. These protein-coding changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified AD risk genes. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to AD development
Recommended from our members
Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel A Meta-analysis
- Author
- Abner Erin
- Adams L.D
- Adams Perrie, M
- Albert Marilyn S
- Albin Roger, L
- Apostolova Liana, G
- Arnold Steven, E
- Asthana Sanjay
- Atwood Craig, S
- Ayodele Temitope
- Baldwin Clinton, T
- Barber Robert, C
- Barnes Lisa L
- Barral Sandra
- Beach Thomas, G
- Becker James, T
- Beecham Gary, W
- Bennett David A
- Bigio Eileen, H
- Bird Thomas, D
- Blacker Deborah
- Boeve Bradley, F
- Bowen James, D
- Boxer Adam
- Brewer James B
- Burke James, R
- Burns Jeffrey, M
- Buxbaum Joe D
- Byrd Goldie S
- Cairns Nigel, J
- Cantwell Laura B
- Cao Chuanhai
- Carlsson Cynthia, M
- Carney Regina, M
- Carrasquillo Minerva, M
- Chui Helena C
- Chung Jaeyoon
- Craft Suzanne
- Crane Paul K
- Cribbs David, H
- Cruchaga Carlos
- Cuccaro Michael L
- De Jager Phil L
- DeCarli Charles
- Dick Malcom
- Dickson Dennis, W
- Doody Rachelle S
- Duara Ranjan
- Ertekin-Taner Nilufer
- Evans Denis A
- Faber Kelley, M
- Fairchild Thomas, J
- Fallin M. Daniele
- Fallon Kenneth, B
- Fardo David, W
- Farlow Martin, R
- Farrer Lindsay A
- Ferris Steven
- Foroud Tatiana M
- Frosch Matthew, P
- Galasko Douglas, R
- Gearing Marla
- Geschwind Daniel, H
- Ghetti Bernardino
- Gilbert John, R
- Go Rodney C. P
- Goate Alison M
- Golde Todd E
- Grabowski Thomas J
- Graff-Radford Neill R
- Green Robert, C
- Growdon John, H
- Haines Jonathan L
- Hakonarson Hakon
- Hall Kathleen S
- Hamilton Ronald, L
- Hamilton-Nelson Kara L
- Hardy John
- Harrell Lindy, E
- Henderson Victor W
- Hendrie Hugh C
- Honig Lawrence, S
- Huebinger Ryan, M
- Huentelman Matthew, J
- Hulette Christine, M
- Hyman Bradley T
- Jarvik Gail, P
- Jean-Francois Melissa
- Jin Lee-Way
- Jun Gyungah R
- Kamboh M. Ilyas
- Karydas Anna
- Katz Mindy, J
- Kauwe John, S.K
- Kaye Jeffrey A
- Keene C. Dirk
- Kim Ronald
- Klein Hans-Ulrich
- Kowall Neil W
- Kramer Joel, H
- Kukull Walter A
- Kunkle Brian W
- Kuzma Amanda B
- LaFerla Frank M
- Lah James, J
- Larson Eric B
- Leung Yuk Ye
- Leverenz James B
- Levey Allan I
- Li Ge
- Lieberman Andrew, P
- Lipton Richard, B
- Logue Mark W
- Lopez Oscar L
- Lunetta Kathryn L
- Lyketsos Constantine, G
- Malamon John
- Manly Jennifer J
- Marson Daniel, C
- Martin Eden R
- Martinez Izri
- Martiniuk Frank
- Masliah Eliezer
- Mayeux Richard
- McCormick Wayne, C
- McCurry Susan, M
- McDavid Andrew, N
- McDonough Stefan
- McKee Ann, C
- Mesulam Marsel
- Mez Jesse
- Miller Bruce L
- Miller Bruce, L
- Miller Carol, A
- Montine Thomas, J
- Morris John C
- Mukherjee Shubhabrata
- Myers Amanda, J
- Naj Adam C
- Obisesan Thomas O
- Olichney John, M
- O’Bryant Sid, E
- Parisi Joseph, E
- Paulson Henry L
- Pericak-Vance Margaret A
- Peskind Elaine
- Petersen Ronald C
- Pierce Aimee
- Poon Wayne, W
- Potter Huntington
- Qu Liming
- Quinn Joseph, F
- Raj Ashok
- Raskind Murray
- Reiman Eric M
- Reisberg Barry
- Reisch Joan, S
- Reitz Christiane
- Ringman John, M
- Roberson Erik, D
- Rogaeva Ekaterina
- Rosen Howard, J
- Rosenberg Roger N
- Royall Donald, R
- Sager Mark, A
- Sano Mary
- Saykin Andrew J
- Schellenberg Gerard D
- Schmidt Michael
- Schneider Julie, A
- Schneider Lon, S
- Seeley William, W
- Small Scott
- Small Scott A
- Sonnen Joshua, A
- Spina Salvatore
- St George-Hyslop Peter
- Starks Takiyah D
- Stern Robert, A
- Strittmatter Stephen M
- Swerdlow Russell H
- Tanzi Rudolph, E
- Trojanowski John Q
- Troncoso Juan, C
- Tsuang Debby, W
- Valladares Otto
- Van Deerlin Vivianna, M
- Van Eldik Linda J
- Vance Jeffery M
- Vardarajan Badri, N
- Vassar Robert
- Vinters Harry, V
- Vonsattel Jean Paul
- Wang Li-San
- Weintraub Sandra
- Welsh-Bohmer Kathleen, A
- Wilhelmsen Kirk, C
- Williamson Jennifer
- Wingo Thomas, S
- Wisniewski Thomas
- Woltjer Randall, L
- Wu Chuang-Kuo
- Younkin Steven, G
- Yu Chang-En
- Yu Lei
- Zhao Yi
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Recommended from our members
Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer’s disease: the Alzheimer’s Disease Genetics Consortium
- Author
- Abner Erin
- Adams Perrie M.
- Aguirre Alyssa
- Albert Marilyn S.
- Albin Roger L.
- Allen Mariet
- Alvarez Lisa
- Apostolova Liana G.
- Arnold Steven E.
- Asthana Sanjay
- Atwood Craig S.
- Ayres Gayle
- Baldwin Clinton T.
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Bazemore Katrina
- Beach Thomas G.
- Becker James T.
- Beecham Gary W.
- Beekly Duane
- Benchek Penelope
- Benitez Bruno A.
- Bennett David
- Bertelson John
- Bird Thomas D.
- Blacker Deborah
- Boeve Bradley F.
- Bowen James D.
- Boxer Adam
- Brewer James
- Burke James R.
- Burns Jeffrey M.
- Bush William S.
- Buxbaum Joseph D.
- Cairns Nigel J.
- Cantwell Laura B.
- Cao Chuanhai
- Carlson Christopher S.
- Carlsson Cynthia M.
- Carney Regina M.
- Carrasquillo Minerva M.
- Chasse Scott
- Chesselet Marie-Francoise
- Chin Nathaniel A.
- Chui Helena C.
- Chung Jaeyoon
- Craft Suzanne
- Crane Paul K.
- Cribbs David H.
- Crocco Elizabeth A.
- Cruchaga Carlos
- Cuccaro Michael L.
- Cullum Munro
- Darby Eveleen
- Davis Barbara
- De Jager Philip L.
- DeCarli Charles
- DeToledo John
- Dick Malcolm
- Dickson Dennis W.
- Dombroski Beth A.
- Doody Rachelle S.
- Duara Ranjan
- Ertekin-Taner NIlüfer
- Evans Denis A.
- Faber Kelley M.
- Fairchild Thomas J.
- Fallon Kenneth B.
- Fardo David W.
- Farlow Martin R.
- Farrell John J.
- Farrer Lindsay A.
- Fernandez-Hernandez Victoria
- Ferris Steven
- Foroud Tatiana M.
- Frosch Matthew P.
- Fulton-Howard Brian
- Galasko Douglas R.
- Gamboa Adriana
- Gearing Marla
- Geschwind Daniel H.
- Ghetti Bernardino
- Gilbert John R.
- Goate Alison M.
- Grabowski Thomas J.
- Graff-Radford Neill R.
- Green Robert C.
- Growdon John H.
- Grunin Michelle A.
- Haines Jonathan L.
- Hakonarson Hakon
- Hall James
- Hamilton Ronald L.
- Hamilton-Nelson Kara L.
- Harari Oscar
- Hardy John
- Harrell Lindy E.
- Haut Jacob
- Head Elizabeth
- Henderson Victor W.
- Hernandez Michelle
- Hohman Timothy
- Honig Lawrence S.
- Huebinger Ryan M.
- Huentelman Matthew J.
- Hulette Christine M.
- Hyman Bradley T.
- Hynan Linda S.
- Ibanez Laura
- Iqbal Taha
- Jarvik Gail P.
- Jayadev Suman
- Jin Lee-Way
- Johnson Kim
- Johnson Leigh
- Jun Gyungah R.
- Kamboh M. Ilyas
- Karydas Anna M.
- Katz Mindy J.
- Kauwe John S.
- Kaye Jeffrey A.
- Keene C. Dirk
- Khaleeq Aisha
- Kim Ronald
- Knebl Janice
- Kowall Neil W.
- Kramer Joel H.
- Kuksa Pavel P.
- Kukull Walter A.
- Kunkle Brian W.
- Kushch Nicholas
- Kuzma Amanda B.
- LaFerla Frank M.
- Lah James J.
- Larson Eric B.
- Lee Wan-Ping
- Lerner Alan
- Leung Yuk Yee
- Leverenz James B.
- Levey Allan I.
- Li Donghe
- Lieberman Andrew P.
- Lipton Richard B.
- Logue Mark
- Lopez Oscar L.
- Lucio da Fonseca Eder
- Lunetta Kathryn L.
- Lyketsos Constantine G.
- Mains Douglas
- Margaret Flanagan E.
- Marson Daniel C.
- Martin Eden R R.
- Martiniuk Frank
- Mash Deborah C.
- Masliah Eliezer
- Massman Paul
- Masurkar Arjun
- Mayeux Richard
- McCormick Wayne C.
- McCurry Susan M.
- McDavid Andrew N.
- McDonough Stefan
- McKee Ann C.
- Mesulam Marsel
- Mez Jesse B.
- Miller Bruce L.
- Miller Carol A.
- Miller Joshua W.
- Montine Thomas J.
- Monuki Edwin S.
- Morris John C.
- Mukherjee Shubhabrata
- Myers Amanda J.
- Naj Adam C.
- Nguyen Trung
- Olichney John M.
- Ory Marcia
- O’Bryant Sid
- Palmer Ellen L.
- Palmer Raymond
- Parisi Joseph E.
- Pathak Omkar
- Paulson Henry L.
- Pavlik Valory
- Paydarfar David
- Perez Victoria
- Pericak-Vance Margaret A.
- Peskind Elaine
- Petersen Ronald C.
- Pierce Aimee
- Pillai Jagan
- Polk Marsha
- Poon Wayne W.
- Potter Huntington
- Qu Liming
- Quiceno Mary
- Quinn Joseph F.
- Raj Ashok
- Rajabli Farid
- Raskind Murray
- Reiman Eric M.
- Reisberg Barry
- Reisch Joan S.
- Reitz Christiane
- Ringman John M.
- Roberson Erik D.
- Rodriguear Monica
- Rogaeva Ekaterina
- Rosen Howard J.
- Rosenberg Roger N.
- Royall Donald R.
- Sager Mark A.
- Sano Mary
- Saykin Andrew J.
- Schellenberg Gerard D.
- Schneider Julie A.
- Schneider Lon S.
- Seeley William W.
- Sha Jin
- Sherva Richard M.
- Slifer Susan H.
- Small Scott
- Smith Amanda G.
- Smith Janet P.
- Song Yeunjoo E.
- Sonnen Joshua A.
- Spina Salvatore
- St George-Hyslop Peter
- Stern Robert A.
- Stevens Alan B.
- Strittmatter Stephen M.
- Sultzer David
- Swerdlow Russell H.
- Tanzi Rudolph E.
- Tilson Jeffrey L.
- Tosto Giuseppe
- Trojanowski John Q.
- Troncoso Juan C.
- Tsuang Debby W.
- Valladares Otto
- Van Deerlin Vivianna M.
- van Eldik Linda J.
- Vance Jeffery M.
- Vardarajan Badri N.
- Vassar Robert
- Vinters Harry V.
- Vonsattel Jean-Paul
- Wang Li-San
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- Wheeler Nicholas R.
- Whitehead Patrice L.
- Wijsman Ellen M.
- Wilhelmsen Kirk C.
- Williams Benjamin
- Williamson Jennifer
- Wilms Henrik
- Wingo Thomas S.
- Wisniewski Thomas
- Woltjer Randall L.
- Woon Martin
- Wright Clinton B.
- Wu Chuang-Kuo
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zhang Xiaoling
- Zhao Yi
- Zhu Congcong
- Zhu Xiongwei
- Publication venue
- Cold Spring Harbor Laboratory
- Publication date
- 08/07/2023
- Field of study
Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in non-European ancestry groups in genome-wide association studies (GWAS). We constructed and analyzed a multi-ancestry GWAS dataset in the Alzheimer’s Disease (AD) Genetics Consortium (ADGC) to test for novel shared and ancestry-specific AD susceptibility loci and evaluate underlying genetic architecture in 37,382 non-Hispanic White (NHW), 6,728 African American, 8,899 Hispanic (HIS), and 3,232 East Asian individuals, performing within-ancestry fixed-effects meta-analysis followed by a cross-ancestry random-effects meta-analysis. We identified 13 loci with cross-ancestry associations including known loci at/near
CR1
,
BIN1
,
TREM2
,
CD2AP
,
PTK2B
,
CLU
,
SHARPIN
,
MS4A6A
,
PICALM
,
ABCA7
,
APOE
and two novel loci not previously reported at 11p12 (
LRRC4C
) and 12q24.13 (
LHX5-AS1
). Reflecting the power of diverse ancestry in GWAS, we observed the
SHARPIN
locus using 7.1% the sample size of the original discovering single-ancestry GWAS (n=788,989). We additionally identified three GWS ancestry-specific loci at/near (
PTPRK
(
P
=2.4×10
-8
) and
GRB14
(
P
=1.7×10
-8
) in HIS), and
KIAA0825
(
P
=2.9×10
-8
in NHW). Pathway analysis implicated multiple amyloid regulation pathways (strongest with
P
adjusted
=1.6×10
-4
) and the classical complement pathway (
P
adjusted
=1.3×10
-3
). Genes at/near our novel loci have known roles in neuronal development (
LRRC4C, LHX5-AS1
, and
PTPRK
) and insulin receptor activity regulation (
GRB14
). These findings provide compelling support for using traditionally-underrepresented populations for gene discovery, even with smaller sample sizes
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A\u3b2, tau, immunity and lipid processing
- Author
- Abner Erin
- Adams Hieab H.
- Adams Perrie M.
- Ahmad Shahzad
- Al-Chalabi Ammar
- Albert Marilyn S.
- Albin Roger L.
- Allen Mariet
- Alvarez Ignacio
- Alvarez Victoria
- Amin Najaf
- Amlie-Wolf Alexandre
- Amouyel Phillippe
- Apostolova Liana G.
- Arnold Steven E.
- Aspelund Thor
- Asthana Sanjay
- Atwood Craig S.
- Avramidou Despoina
- Bacq Delphine
- Badarinarayan Nandini
- Baldwin Clinton T.
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Bass Nicholas J.
- Bayer Anthony
- Beach Thomas G.
- Becker James T.
- Beecham Gary W.
- Beekly Duane
- Beiser Alexa S.
- Bellenguez Celine
- Ben-Shlomo Yoav
- Benito Yolanda A.
- Bennett David
- Berr Claudine
- Bigio Eileen H.
- Bird Thomas D.
- Bis Joshua C.
- Bisceglio Gina
- Blacker Deborah
- Boada Merce
- Boccardi Virginia
- Boerwinkle Eric
- Boeve Bradley F.
- Boland Anne
- Bonuccelli Ubaldo
- Bosco Paola
- Bossu Paola
- Bowen James D.
- Boxer Adam
- Bras Jose
- Brayne Carol
- Brice Alexis
- Brody Jennifer A.
- Brown Kristelle
- Brundin Rosemarie
- Bruni Amalia Cecilia
- Bullido Maria J.
- Burke James R.
- Burns Jeffrey M.
- Bush Will S.
- Butkiewicz Mariusz
- Buxbaum Joseph D.
- Caffarra Paolo
- Cairns Nigel J.
- Caltagirone Carlo
- Campion Dominique
- Cantwell Laura B.
- Cao Chuanhai
- Carlson Chris S.
- Carlsson Cynthia M.
- Carney Regina M.
- Carracedo Angel
- Carrasquillo Minerva M.
- Cecchetti Roberta
- Chen Yuning
- Choi Seung-Hoan
- Chouraki Vincent
- Chui Helena C.
- Ciaramella Antonio
- Clarimon Jordi
- Clarke Robert
- Collinge John
- Concari Letizia
- Corcoran Chris
- Coto Eliecer
- Craig David
- Crane Paul K.
- Cribbs David H.
- Crocco Elizabeth A.
- Cruchaga Carlos
- Cuccaro Michael L.
- Cupidi Chiara
- Cupples L. Adrienne
- Cushion Thomas D.
- Damotte Vincent
- Daniele Antonio
- Daniilidou Makrina
- Dartigues Jean-Francois
- De Deyn Peter Paul
- De Jager Phil L.
- de Rojas Itziar
- Debette Stphanie
- DeCarli Charles
- Del Zompo Maria
- Deleuze Jean-Francois
- Deloukas Panagiotis
- Denning Nicola
- Deramecourt Vincent
- DeStefano Anita L.
- Dichgans Martin
- Dick Malcolm
- Dickson Dennis W.
- Diez-Fairen Monica
- Dombroski Beth A.
- Doody Rachelle S.
- Drichel Dmitriy
- Duara Ranjan
- Dubois Bruno
- Dufouil Carole
- Eiriksdottir Gudny
- Engelborghs Sebastiaan
- Epelbaum Jacques
- Ertekin-Taner Nilifur
- Escott-Price Valentina
- Evans Denis A.
- Faber Kelley M.
- Fairchild Thomas J.
- Fallon Kenneth B.
- Fardo David W.
- Farlow Martin R.
- Farrer Lindsay A.
- Ferris Steven
- Feulner Thomas
- Fievet Nathalie
- Fin Bertrand
- Fisher Elizabeth
- Fitzpatrick Annette L.
- Fornage Myriam
- Foroud Tatiana M.
- Fox Nick C.
- Fratiglioni Laura
- Frisardi Vincenza
- Frizatti Aura
- Froelich Lutz
- Frosch Matthew P.
- Galasko Douglas R.
- Galimberti Daniela
- Gallacher John
- Gallo Maura
- Garcia Melissa E.
- Garnier Jean-Guillaume
- Garzia Fabienne
- Gearing Marla
- Germanou Antonia
- Gerrish Amy
- Geschwind Daniel H.
- Ghetti Bernardino
- Giedraitis Vilmantas
- Giegling Ina
- Gilbert John R.
- Gill Michael
- Gkatzima Olymbia
- Goate Alison M.
- Graff Caroline
- Graff-Radford Neill R.
- Green Robert C.
- Grenier-Boley Benjamin
- Growdon John H.
- Grozeva Detelina
- Gu Wei
- Gudnason Vilmundur
- Guerreiro Rita
- Gwilliam Rhian
- Haapasalo Annakaisa
- Haines Jonathan L.
- Hakonarson Hakon
- Hamilton Ronald L.
- Hamilton-Nelson Kara L.
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
- Hardy John
- Harold Denise
- Harrell Lindy E.
- Hartmann Annette M.
- Helisalmi Seppo
- Hernandez Isabel
- Heun Reinhard
- Heuser Isabella
- Hiltunen Mikko
- Himali Jayanadra J.
- Hodges Angela
- Hofer Edith
- Hoffmann Per
- Hollingworth Paul
- Holmans Peter A.
- Holmes Clive
- Honig Lawrence S.
- Hooper Nigel M.
- Huebinger Ryan M.
- Huell Michael
- Huentelman Matthew J.
- Hughes Joseph T.
- Hulette Christine M.
- Hyman Bradley T.
- Ikram M. Arfan
- Ingelsson Martin
- Jakobsdottir Johanna
- Jarvik Gail P.
- Jessen Frank
- Jian Xueqiu
- Jin Lee-Way
- Joeckel Karl-Heinz
- Johnston Janet A.
- Jones Lesley
- Jun Gyungah R.
- Kamboh M. Ilyas
- Karamujic-Comic Hata
- Karydas Anna
- Katz Mindy J.
- Kauwe John S. K.
- Kawalia Amit
- Kaye Jeffrey A.
- Keene C. Dirk
- Kehoe Patrick G.
- Keller Lina
- Kilander Lena
- Kim Ronald
- Klopp Norman
- Kloszewska Iwona
- Koelsch Heike
- Koivisto Anne Maria
- Kornhuber Johannes
- Koutroumani Maria
- Kowall Neil W.
- Kramer Joel H.
- Kukull Walter A.
- Kunkle Brian W.
- Kuzma Amanda B.
- LaFerla Frank M.
- Lah James J.
- Lambert Jean-Charles
- Lannfelt Lars
- Larson Eric B.
- Launer Lenore J.
- Lawlor Brian
- Leber Markus
- Leonenko Ganna
- Leverenz James B.
- Levey Allan, I
- Li Shuo
- Lieberman Andrew P.
- Lin Honghuang
- Lipton Richard B.
- Livingston Gill
- Lleo Alberto
- Longstreth W. T., Jr.
- Lopez Oscar L.
- Lord Jenny
- Love Seth
- Lovestone Simon
- Lunetta Kathryn L.
- Lupton Michelle K.
- Lyketsos Constantine G.
- Lynch Aoibhinn
- Ma Li
- Maier Wolfgang
- Malamon John
- Maletta Raffaele Giovanni
- Mancuso Michelangelo
- Mann David
- Marshall Rachel
- Marson Daniel C.
- Martin Eden R.
- Martiniuk Frank
- Mash Deborah C.
- Masliah Eliezer
- Masullo Carlo
- Mateo Ignacio
- Mayeux Richard
- Mayhaus Manuel
- Mayo Kevin
- McCormick Wayne C.
- McCurry Susan M.
- McDavid Andrew N.
- McGuinness Bernadette
- McKee Ann C.
- McQuillin Andrew
- Mead Simon
- Mecocci Patrizia
- Medway Christopher
- Meggy Alun
- Menzies Georgina E.
- Meslage Stphane
- Mesulam Marsel
- Miller Bruce L.
- Miller Carol A.
- Miller Joshua W.
- Moebus Susanne
- Montine Thomas J.
- Moreno-Grau Sonia
- Morgan Kevin
- Morgan Taniesha
- Morris John
- Morris John C.
- Mosley Thomas H.
- Moutet Marie-Laure
- Mukherjee Shubhabrata
- Munger Ron
- Munoz-Fernadez Carmen
- Myers Amanda J.
- Nacmias Benedetta
- Naj Adam C.
- Naranjo Maria Candida Deniz
- Nicolas Gael
- Noethen Markus M.
- O'Bryant Sid
- O'Donovan Michael C.
- Olaso Robert
- Olichney John M.
- Orellana Adelina
- Orfei Maria Donata
- Owen Michael J.
- Panza Francesco
- Parisi Joseph E.
- Pasquier Florence
- Passmore Peter
- Pastor Pau
- Patel Yogen
- Paulson Henry L.
- Pericak-Vance Margaret A.
- Perry William R.
- Peskind Elaine
- Peters Oliver
- Petersen Ronald C.
- Pickering-Brown Stuart
- Pierce Aimee
- Pilotto Alberto
- Poon Wayne W.
- Potter Huntington
- Powell John F.
- Proitsi Petra
- Psaty Bruce M.
- Qu Liming
- Quinn Joseph F.
- Quintela Ines
- Raj Ashok
- Ramirez Alfredo
- Raskind Murray
- Raybould Rachel
- Real Luis M.
- Reiman Eric M.
- Reisberg Barry
- Reisch Joan S.
- Reitz Christiane
- Riedel-Heller Steffi
- Riemenschneider Matthias
- Ringman John M.
- Ritchie Karen
- Rivadeneira Fernando
- Roberson Erik D.
- Rodriguez-Rodriguez Eloy
- Rogaeva Ekaterina
- Roschupkin Gena
- Rosen Howard J.
- Rosenberg Roger N.
- Rossor Martin
- Rotter Jerome, I
- Royall Donald R.
- Rubinsztein David C.
- Ruiz Agustin
- Russo Giancarlo
- Ryan Natalie S.
- Saba Yasaman
- Sacchinelli Eleonora
- Sager Mark A.
- Salani Francesca
- Sanchez-Garcia Florentino
- Sanchez-Juan Pascual
- Sano Mary
- Sarnowski Chloe
- Saykin Andrew J.
- Scarpini Elio
- Schellenberg Gerard D.
- Scherer Martin
- Schmidt Helena
- Schmidt Reinhold
- Schneider Julie A.
- Schneider Lori S.
- Schott Jonathan M.
- Seeley William W.
- Seshadri Sudha
- Shaw Christopher E.
- Sims Rebecca
- Singleton Andrew B.
- Sleegers Kristel
- Slifer Susan
- Smith A. David
- Smith Albert, V
- Smith Amanda G.
- Soininen Hilkka
- Solfrizzi Vincenzo
- Song Yuenjoo
- Sonnen Joshua A.
- Sorbi Sandro
- Sordon Sabrina
- Spalletta Gianfranco
- Spina Salvatore
- Squassina Alessio
- St George-Hyslop Peter
- Stern Robert A.
- Sussams Rebecca
- Swerdlow Russell H.
- Tang Mitchell
- Tanzi Rudolph E.
- Tarraga Lluis
- Thonberg Hakan
- Trojanowski John Q.
- Troncoso Juan C.
- Tschanz JoAnn
- Tsolaki Magda
- Tsuang Debby W.
- Turton James
- Uitterlinden A. G. Andre
- Uphill James
- Valladares Otto
- Van Broeckhoven Christine
- Van Deerlin Vivianna M.
- van den Bussche Hendrik
- van der Lee Sven J.
- van Duijn Cornelia M.
- Van Eldik Linda J.
- Vance Jeffery M.
- Vandenberghe Rik
- Vardarajan Badri N.
- Vardy Emma
- Vellas Bruno
- Vinters Harry V.
- Voijnovic Dina
- Vonsattel Jean Paul
- Vronskaya Maria
- Wallon David
- Wang Li-San
- Warden Donald
- Warner Nick
- Warren Jason D.
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- White Charles C.
- Whitehead Patrice
- Wichmann H-Erich
- Wilcock Gordon
- Wilhelmsen Kirk C.
- Williams Julie
- Williamson Jennifer
- Wiltfang Jens
- Wingo Thomas S.
- Woltjer Randall L.
- Wright Clinton B.
- Wu Chuang-Kuo
- Yang Qiong
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zhao Yi
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (Nature Genetics, (2019), 51, 3, (414-430), 10.1038/s41588-019-0358-2)
- Author
- Abner Erin
- Adams Hieab H.
- Adams Perrie M.
- Ahmad Shahzad
- Al-Chalabi Ammar
- Albert Marilyn S.
- Albin Roger L.
- Allen Mariet
- Alvarez Ignacio
- Alvarez Victoria
- Amin Najaf
- Amlie-Wolf Alexandre
- Amouyel Phillippe
- Apostolova Liana G.
- Arnold Steven E.
- Aspelund Thor
- Asthana Sanjay
- Atwood Craig S.
- Avramidou Despoina
- Bacq Delphine
- Badarinarayan Nandini
- Baldwin Clinton T.
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Bass Nicholas J.
- Bayer Anthony
- Beach Thomas G.
- Becker James T.
- Beecham Gary W.
- Beekly Duane
- Beiser Alexa S.
- Bellenguez Céline
- Ben-Shlomo Yoav
- Benito Yolanda A.
- Bennett David
- Berr Claudine
- Bigio Eileen H.
- Bird Thomas D.
- Bis Joshua C.
- Bisceglio Gina
- Blacker Deborah
- Boada Merce
- Boccardi Virginia
- Boerwinkle Eric
- Boeve Bradley F.
- Boland Anne
- Bonuccelli Ubaldo
- Bosco Paola
- Bossù Paola
- Bowen James D.
- Boxer Adam
- Bras Jose
- Brayne Carol
- Brice Alexis
- Brody Jennifer A.
- Brown Kristelle
- Brundin Rose Marie
- Bruni Amalia Cecilia
- Bullido Maria J.
- Burke James R.
- Burns Jeffrey M.
- Bush Will S.
- Butkiewicz Mariusz
- Buxbaum Joseph D.
- Caffarra Paolo
- Cairns Nigel J.
- Caltagirone Carlo
- Campion Dominique
- Cantwell Laura B.
- Cao Chuanhai
- Carlson Chris S.
- Carlsson Cynthia M.
- Carney Regina M.
- Carracedo Ángel
- Carrasquillo Minerva M.
- Cecchetti Roberta
- Chen Yuning
- Choi Seung Hoan
- Chouraki Vincent
- Chui Helena C.
- Ciaramella Antonio
- Clarimon Jordi
- Clarke Robert
- Collinge John
- Concari Letizia
- Corcoran Chris
- Coto Eliecer
- Craig David
- Crane Paul K.
- Cribbs David H.
- Crocco Elizabeth A.
- Cruchaga Carlos
- Cuccaro Michael L.
- Cupidi Chiara
- Cupples L. Adrienne
- Cushion Thomas D.
- Damotte Vincent
- Daniele Antonio
- Daniilidou Makrina
- Dartigues Jean Francois
- De Deyn Peter P.
- De Jager Phil L.
- de Rojas Itziar
- Debette Stéphanie
- DeCarli Charles
- Del Zompo Maria
- Deleuze Jean Francois
- Deloukas Panagiotis
- Denning Nicola
- Deramecourt Vincent
- DeStefano Anita L.
- Dichgans Martin
- Dick Malcolm
- Dickson Dennis W.
- Diez-Fairen Monica
- Dombroski Beth A.
- Doody Rachelle S.
- Drichel Dmitriy
- Duara Ranjan
- Dubois Bruno
- Dufouil Carole
- Eiriksdottir Gudny
- Engelborghs Sebastiaan
- Epelbaum Jacques
- Ertekin-Taner Nilifur
- Escott-Price Valentina
- Evans Denis A.
- Faber Kelley M.
- Fairchild Thomas J.
- Fallon Kenneth B.
- Fardo David W.
- Farlow Martin R.
- Farrer Lindsay A.
- Ferris Steven
- Feulner Thomas
- Fievet Nathalie
- Fin Bertrand
- Fisher Elizabeth
- Fitzpatrick Annette L.
- Fornage Myriam
- Foroud Tatiana M.
- Fox Nick C.
- Fratiglioni Laura
- Frisardi Vincenza
- Frizatti Aura
- Frosch Matthew P.
- Frölich Lutz
- Galasko Douglas R.
- Galimberti Daniela
- Gallacher John
- Gallo Maura
- Garcia Melissa E.
- Garnier Jean Guillaume
- Garzia Fabienne
- Gearing Marla
- George-Hyslop Peter St
- Germanou Antonia
- Gerrish Amy
- Geschwind Daniel H.
- Ghetti Bernardino
- Giedraitis Vilmantas
- Giegling Ina
- Gilbert John R.
- Gill Michael
- Gkatzima Olymbia
- Goate Alison M.
- Graff Caroline
- Graff-Radford Neill R.
- Green Robert C.
- Grenier-Boley Benjamin
- Growdon John H.
- Grozeva Detelina
- Gu Wei
- Gudnason Vilmundur
- Guerreiro Rita
- Gwilliam Rhian
- Haapasalo Annakaisa
- Haines Jonathan L.
- Hakonarson Hakon
- Hamilton Ronald L.
- Hamilton-Nelson Kara L.
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
- Hardy John
- Harold Denise
- Harrell Lindy E.
- Hartmann Annette M.
- Helisalmi Seppo
- Hernández Isabel
- Heun Reinhard
- Heuser Isabella
- Hiltunen Mikko
- Himali Jayanadra J.
- Hodges Angela
- Hofer Edith
- Hoffmann Per
- Hollingworth Paul
- Holmans Peter A.
- Holmes Clive
- Honig Lawrence S.
- Hooper Nigel M.
- Huebinger Ryan M.
- Huentelman Matthew J.
- Hughes Joseph T.
- Hulette Christine M.
- Hyman Bradley T.
- Hüll Michael
- Ikram M. Arfan
- Ingelsson Martin
- Jakobsdottir Johanna
- Jarvik Gail P.
- Jessen Frank
- Jian Xueqiu
- Jin Lee Way
- Johnston Janet A.
- Jones Lesley
- Jun Gyungah R.
- Jöckel Karl Heinz
- Kamboh M. Ilyas
- Karamujić-Čomić Hata
- Karydas Anna
- Katz Mindy J.
- Kauwe John S.K.
- Kawalia Amit
- Kaye Jeffrey A.
- Keene C. Dirk
- Kehoe Patrick G.
- Keller Lina
- Kilander Lena
- Kim Ronald
- Klopp Norman
- Kloszewska Iwona
- Koivisto Anne Maria
- Kornhuber Johannes
- Koutroumani Maria
- Kowall Neil W.
- Kramer Joel H.
- Kukull Walter A.
- Kunkle Brian W.
- Kuzma Amanda B.
- Kölsch Heike
- LaFerla Frank M.
- Lah James J.
- Lambert Jean Charles
- Lannfelt Lars
- Larson Eric B.
- Launer Lenore J.
- Lawlor Brian
- Leber Markus
- Leonenko Ganna
- Leverenz James B.
- Levey Allan I.
- Li Shuo
- Lieberman Andrew P.
- Lin Honghuang
- Lipton Richard B.
- Livingston Gill
- Lleo Alberto
- Longstreth W. T.
- Lopez Oscar L.
- Lord Jenny
- Love Seth
- Lovestone Simon
- Lunetta Kathryn L.
- Lupton Michelle K.
- Lyketsos Constantine G.
- Lynch Aoibhinn
- Ma Li
- Maier Wolfgang
- Malamon John
- Maletta Raffaele Giovanni
- Mancuso Michelangelo
- Mann David
- Marshall Rachel
- Marson Daniel C.
- Martin Eden R.
- Martiniuk Frank
- Mash Deborah C.
- Masliah Eliezer
- Masullo Carlo
- Mateo Ignacio
- Mayeux Richard
- Mayhaus Manuel
- Mayo Kevin
- McCormick Wayne C.
- McCurry Susan M.
- McDavid Andrew N.
- McGuinness Bernadette
- McKee Ann C.
- McQuillin Andrew
- Mead Simon
- Mecocci Patrizia
- Medway Christopher
- Meggy Alun
- Menzies Georgina E.
- Meslage Stéphane
- Mesulam Marsel
- Miller Bruce L.
- Miller Carol A.
- Miller Joshua W.
- Moebus Susanne
- Montine Thomas J.
- Moreno-Grau Sonia
- Morgan Kevin
- Morgan Taniesha
- Morris John C.
- Morris John C.
- Mosley Thomas H.
- Moutet Marie Laure
- Mukherjee Shubhabrata
- Munger Ron
- Munoz-Fernadez Carmen
- Myers Amanda J.
- Nacmias Benedetta
- Naj Adam C.
- Naranjo Maria Candida Deniz
- Nicolas Gael
- Nöthen Markus M.
- Olaso Robert
- Olichney John M.
- Orellana Adelina
- Orfei Maria Donata
- Owen Michael J.
- O’Bryant Sid
- O’Donovan Michael C.
- Panza Francesco
- Parisi Joseph E.
- Pasquier Florence
- Passmore Peter
- Pastor Pau
- Patel Yogen
- Paulson Henry L.
- Pericak-Vance Margaret A.
- Perry William R.
- Peskind Elaine
- Peters Oliver
- Petersen Ronald C.
- Pickering-Brown Stuart
- Pierce Aimee
- Pilotto Alberto
- Poon Wayne W.
- Potter Huntington
- Powell John F.
- Proitsi Petra
- Psaty Bruce M.
- Qu Liming
- Quinn Joseph F.
- Quintela Inés
- Raj Ashok
- Ramirez Alfredo
- Raskind Murray
- Raybould Rachel
- Real Luis M.
- Reiman Eric M.
- Reisberg Barry
- Reisch Joan S.
- Reitz Christiane
- Riedel-Heller Steffi
- Riemenschneider Matthias
- Ringman John M.
- Ritchie Karen
- Rivadeneira Fernando
- Roberson Erik D.
- Rodriguez-Rodriguez Eloy
- Rogaeva Ekaterina
- Rosen Howard J.
- Rosenberg Roger N.
- Roshchupkin Gennady
- Rossor Martin
- Rotter Jerome I.
- Royall Donald R.
- Rubinsztein David C.
- Ruiz Agustin
- Russo Giancarlo
- Ryan Natalie S.
- Saba Yasaman
- Sacchinelli Eleonora
- Sager Mark A.
- Salani Francesca
- Sanchez-Garcia Florentino
- Sanchez-Juan Pascual
- Sano Mary
- Sarnowski Chloe
- Saykin Andrew J.
- Scarpini Elio
- Schellenberg Gerard D.
- Scherer Martin
- Schmidt Helena
- Schmidt Reinhold
- Schneider Julie A.
- Schneider Lori S.
- Schott Jonathan M.
- Seeley William W.
- Seshadri Sudha
- Shaw Christopher E.
- Sims Rebecca
- Singleton Andrew B.
- Sleegers Kristel
- Slifer Susan
- Smith A. David
- Smith Albert V.
- Smith Amanda G.
- Soininen Hilkka
- Solfrizzi Vincenzo
- Song Yuenjoo
- Sonnen Joshua A.
- Sorbi Sandro
- Sordon Sabrina
- Spalletta Gianfranco
- Spina Salvatore
- Squassina Alessio
- Stern Robert A.
- Sussams Rebecca
- Swerdlow Russell H.
- Tang Mitchell
- Tanzi Rudolph E.
- Tarraga Lluís
- Thonberg Hakan
- Trojanowski John Q.
- Troncoso Juan C.
- Tschanz Jo Ann
- Tsolaki Magda
- Tsuang Debby W.
- Turton James
- Uitterlinden A. G.Andre
- Uphill James
- Valladares Otto
- Van Broeckhoven Christine
- Van Deerlin Vivianna M.
- van den Bussche Hendrik
- van der Lee Sven J.
- van Duijn Cornelia M.
- Van Eldik Linda J.
- Vance Jeffery M.
- Vandenberghe Rik
- Vardarajan Badri N.
- Vardy Emma
- Vellas Bruno
- Vinters Harry V.
- Voijnovic Dina
- Vonsattel Jean Paul
- Vronskaya Maria
- Wallon David
- Wang Li San
- Warden Donald
- Warner Nick
- Warren Jason D.
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- White Charles C.
- Whitehead Patrice
- Wichmann H. Erich
- Wilcock Gordon
- Wilhelmsen Kirk C.
- Williams Julie
- Williamson Jennifer
- Wiltfang Jens
- Wingo Thomas S.
- Woltjer Randall L.
- Wright Clinton B.
- Wu Chuang Kuo
- Yang Qiong
- Younkin Steven G.
- Yu Chang En
- Yu Lei
- Zhao Yi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/09/2019
- Field of study
An amendment to this paper has been published and can be accessed via a link at the top of the paper
Author Correction: Genetic meta-analysis of diagnosed Alzheimer\u27s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
- Author
- Abner Erin
- Adams Hieab H
- Adams Perrie M
- Ahmad Shahzad
- Al-Chalabi Ammar
- Albert Marilyn S
- Albin Roger L
- Allen Mariet
- Alvarez Ignacio
- Alvarez Victoria
- Amin Najaf
- Amlie-Wolf Alexandre
- Amouyel Phillippe
- Apostolova Liana G
- Arnold Steven E
- Aspelund Thor
- Asthana Sanjay
- Atwood Craig S
- Avramidou Despoina
- Bacq Delphine
- Badarinarayan Nandini
- Baldwin Clinton T
- Barber Robert C
- Barnes Lisa L
- Barral Sandra
- Bass Nicholas J
- Bayer Anthony
- Beach Thomas G
- Becker James T
- Beecham Gary W
- Beekly Duane
- Beiser Alexa S
- Bellenguez Céline
- Ben-Shlomo Yoav
- Benito Yolanda A
- Bennett David
- Berr Claudine
- Bigio Eileen H
- Bird Thomas D
- Bis Joshua C
- Bisceglio Gina
- Blacker Deborah
- Boada Merce
- Boccardi Virginia
- Boerwinkle Eric
- Boeve Bradley F
- Boland Anne
- Bonuccelli Ubaldo
- Bosco Paola
- Bossù Paola
- Bowen J D
- Boxer Adam
- Bras Jose
- Brayne Carol
- Brice Alexis
- Brody Jennifer A
- Brown Kristelle
- Brundin RoseMarie
- Bruni Amalia Cecilia
- Bullido Maria J
- Burke James R
- Burns Jeffrey M
- Bush Will S
- Butkiewicz Mariusz
- Buxbaum Joseph D
- Caffarra Paolo
- Cairns Nigel J
- Caltagirone Carlo
- Campion Dominique
- Cantwell Laura B
- Cao Chuanhai
- Carlson Chris S
- Carlsson Cynthia M
- Carney Regina M
- Carracedo Ángel
- Carrasquillo Minerva M
- Cecchetti Roberta
- Chen Yuning
- Choi Seung-Hoan
- Chouraki Vincent
- Chui Helena C
- Ciaramella Antonio
- Clarimon Jordi
- Clarke Robert
- Collinge John
- Concari Letizia
- Corcoran Chris
- Coto Eliecer
- Craig David
- Crane Paul K
- Cribbs David H
- Crocco Elizabeth A
- Cruchaga Carlos
- Cuccaro Michael L
- Cupidi Chiara
- Cupples L Adrienne
- Cushion Thomas D
- Damotte Vincent
- Daniele Antonio
- Daniilidou Makrina
- Dartigues Jean-Francois
- De Deyn Peter P
- De Jager Phil L
- de Rojas Itziar
- Debette Stéphanie
- DeCarli Charles
- Del Zompo Maria
- Deleuze Jean-Francois
- Deloukas Panagiotis
- Denning Nicola
- Deramecourt Vincent
- DeStefano Anita L
- Dichgans Martin
- Dick Malcolm
- Dickson Dennis W
- Diez-Fairen Monica
- Dombroski Beth A
- Doody Rachelle S
- Drichel Dmitriy
- Duara Ranjan
- Dubois Bruno
- Dufouil Carole
- Eiriksdottir Gudny
- Engelborghs Sebastiaan
- Epelbaum Jacques
- Ertekin-Taner Nilifur
- Escott-Price Valentina
- Evans Denis A
- Faber Kelley M
- Fairchild Thomas J
- Fallon Kenneth B
- Fardo David W
- Farlow Martin R
- Farrer Lindsay A
- Ferris Steven
- Feulner Thomas
- Fievet Nathalie
- Fin Bertrand
- Fisher Elizabeth
- Fitzpatrick Annette L
- Fornage Myriam
- Foroud Tatiana M
- Fox Nick C
- Fratiglioni Laura
- Frisardi Vincenza
- Frizatti Aura
- Frosch Matthew P
- Frölich Lutz
- Galasko Douglas R
- Galimberti Daniela
- Gallacher John
- Gallo Maura
- Garcia Melissa E
- Garnier Jean-Guillaume
- Garzia Fabienne
- Gearing Marla
- George-Hyslop Peter St
- Germanou Antonia
- Gerrish Amy
- Geschwind Daniel H
- Ghetti Bernardino
- Giedraitis Vilmantas
- Giegling Ina
- Gilbert John R
- Gill Michael
- Gkatzima Olymbia
- Goate Alison M
- Graff Caroline
- Graff-Radford Neill R
- Green Robert C
- Grenier-Boley Benjamin
- Growdon John H
- Grozeva Detelina
- Gu Wei
- Gudnason Vilmundur
- Guerreiro Rita
- Gwilliam Rhian
- Haapasalo Annakaisa
- Haines Jonathan L
- Hakonarson Hakon
- Hamilton Ronald L
- Hamilton-Nelson Kara L
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
- Hardy John
- Harold Denise
- Harrell Lindy E
- Hartmann Annette M
- Helisalmi Seppo
- Hernández Isabel
- Heun Reinhard
- Heuser Isabella
- Hiltunen Mikko
- Himali Jayanadra J
- Hodges Angela
- Hofer Edith
- Hoffmann Per
- Hollingworth Paul
- Holmans Peter A
- Holmes Clive
- Honig Lawrence S
- Hooper Nigel M
- Huebinger Ryan M
- Huentelman Matthew J
- Hughes Joseph T
- Hulette Christine M
- Hyman Bradley T
- Hüll Michael
- Ikram M Arfan
- Ingelsson Martin
- Jakobsdottir Johanna
- Jarvik Gail P
- Jessen Frank
- Jian Xueqiu
- Jin Lee-Way
- Johnston Janet A
- Jones Lesley
- Jun Gyungah R
- Jöckel Karl-Heinz
- Kamboh M Ilyas
- Karamujić-Čomić Hata
- Karydas Anna
- Katz Mindy J
- Kauwe John S K
- Kawalia Amit
- Kaye Jeffrey A
- Keene C Dirk
- Kehoe Patrick G
- Keller Lina
- Kilander Lena
- Kim Ronald
- Klopp Norman
- Kloszewska Iwona
- Koivisto Anne Maria
- Kornhuber Johannes
- Koutroumani Maria
- Kowall Neil W
- Kramer Joel H
- Kukull Walter A
- Kunkle Brian W
- Kuzma Amanda B
- Kölsch Heike
- LaFerla Frank M
- Lah James J
- Lambert Jean-Charles
- Lannfelt Lars
- Larson Eric B
- Launer Lenore J
- Lawlor Brian
- Leber Markus
- Leonenko Ganna
- Leverenz James B
- Levey Allan I
- Li Shuo
- Lieberman Andrew P
- Lin Honghuang
- Lipton Richard B
- Livingston Gill
- Lleo Alberto
- Longstreth W T
- Lopez Oscar L
- Lord Jenny
- Love Seth
- Lovestone Simon
- Lunetta Kathryn L
- Lupton Michelle K
- Lyketsos Constantine G
- Lynch Aoibhinn
- Ma Li
- Maier Wolfgang
- Malamon John
- Maletta Raffaele Giovanni
- Mancuso Michelangelo
- Mann David
- Marshall Rachel
- Marson Daniel C
- Martin Eden R
- Martiniuk Frank
- Mash Deborah C
- Masliah Eliezer
- Masullo Carlo
- Mateo Ignacio
- Mayeux Richard
- Mayhaus Manuel
- Mayo Kevin
- McCormick Wayne C
- McCurry Susan M
- McDavid Andrew N
- McGuinness Bernadette
- McKee Ann C
- McQuillin Andrew
- Mead Simon
- Mecocci Patrizia
- Medway Christopher
- Meggy Alun
- Menzies Georgina E
- Meslage Stéphane
- Mesulam Marsel
- Miller Bruce L
- Miller Carol A
- Miller Joshua W
- Moebus Susanne
- Montine Thomas J
- Moreno-Grau Sonia
- Morgan Kevin
- Morgan Taniesha
- Morris John
- Morris John C
- Mosley Thomas H
- Moutet Marie-Laure
- Mukherjee Shubhabrata
- Munger Ron
- Munoz-Fernadez Carmen
- Myers Amanda J
- Nacmias Benedetta
- Naj Adam C
- Naranjo Maria Candida Deniz
- Nicolas Gael
- Nöthen Markus M
- O\u27Bryant Sid
- O\u27Donovan Michael C
- Olaso Robert
- Olichney John M
- Orellana Adelina
- Orfei Maria Donata
- Owen Michael J
- Panza Francesco
- Parisi Joseph E
- Pasquier Florence
- Passmore Peter
- Pastor Pau
- Patel Yogen
- Paulson Henry L
- Pericak-Vance Margaret A
- Perry William R
- Peskind Elaine
- Peters Oliver
- Petersen Ronald C
- Pickering-Brown Stuart
- Pierce Aimee
- Pilotto Alberto
- Poon Wayne W
- Potter Huntington
- Powell John F
- Proitsi Petra
- Psaty Bruce M
- Qu Liming
- Quinn Joseph F
- Quintela Inés
- Raj Ashok
- Ramirez Alfredo
- Raskind Murray
- Raybould Rachel
- Real Luis M
- Reiman Eric M
- Reisberg Barry
- Reisch Joan S
- Reitz Christiane
- Riedel-Heller Steffi
- Riemenschneider Matthias
- Ringman John M
- Ritchie Karen
- Rivadeneira Fernando
- Roberson Erik D
- Rodriguez-Rodriguez Eloy
- Rogaeva Ekaterina
- Rosen Howard J
- Rosenberg Roger N
- Roshchupkin Gennady
- Rossor Martin
- Rotter Jerome I
- Royall Donald R
- Rubinsztein David C
- Ruiz Agustin
- Russo Giancarlo
- Ryan Natalie S
- Saba Yasaman
- Sacchinelli Eleonora
- Sager Mark A
- Salani Francesca
- Sanchez-Garcia Florentino
- Sanchez-Juan Pascual
- Sano Mary
- Sarnowski Chloe
- Saykin Andrew J
- Scarpini Elio
- Schellenberg Gerard D
- Scherer Martin
- Schmidt Helena
- Schmidt Reinhold
- Schneider Julie A
- Schneider Lori S
- Schott Jonathan M
- Seeley William W
- Seshadri Sudha
- Shaw Christopher E
- Sims Rebecca
- Singleton Andrew B
- Sleegers Kristel
- Slifer Susan
- Smith A David
- Smith Albert V
- Smith Amanda G
- Soininen Hilkka
- Solfrizzi Vincenzo
- Song Yuenjoo
- Sonnen Joshua A
- Sorbi Sandro
- Sordon Sabrina
- Spalletta Gianfranco
- Spina Salvatore
- Squassina Alessio
- Stern Robert A
- Sussams Rebecca
- Swerdlow Russell H
- Tang Mitchell
- Tanzi Rudolph E
- Tarraga Lluís
- Thonberg Hakan
- Trojanowski John Q
- Troncoso Juan C
- Tschanz JoAnn
- Tsolaki Magda
- Tsuang Debby W
- Turton James
- Uitterlinden A G Andre
- Uphill James
- Valladares Otto
- Van Broeckhoven Christine
- Van Deerlin Vivianna M
- van den Bussche Hendrik
- van der Lee Sven J
- van Duijn Cornelia M
- Van Eldik Linda J
- Vance Jeffery M
- Vandenberghe Rik
- Vardarajan Badri N
- Vardy Emma
- Vellas Bruno
- Vinters Harry V
- Voijnovic Dina
- Vonsattel Jean Paul
- Vronskaya Maria
- Wallon David
- Wang Li-San
- Warden Donald
- Warner Nick
- Warren Jason D
- Weintraub Sandra
- Welsh-Bohmer Kathleen A
- White Charles C
- Whitehead Patrice
- Wichmann H-Erich
- Wilcock Gordon
- Wilhelmsen Kirk C
- Williams Julie
- Williamson Jennifer
- Wiltfang Jens
- Wingo Thomas S
- Woltjer Randall L
- Wright Clinton B
- Wu Chuang-Kuo
- Yang Qiong
- Younkin Steven G
- Yu Chang-En
- Yu Lei
- Zhao Yi
- Publication venue
- Providence St. Joseph Health Digital Commons
- Publication date
- 01/09/2019
- Field of study
An amendment to this paper has been published and can be accessed via a link at the top of the paper
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
- Author
- A Olmos-Alonso
- A Ruiz
- AC Naj
- Adam Boxer
- Adam C Naj
- Agustin Ruiz
- Aimee Pierce
- AL Richards
- Albert Hofman
- Albert V Smith
- Alberto Lleó
- Alberto Pilotto
- Alessio Squassina
- Alexa S Beiser
- Alexis Brice
- Alfredo Ramirez
- Alison M Goate
- Allan I Levey
- Alun Meggy
- Amalia Cecilia Bruni
- Amanda B Kuzma
- Amanda G Smith
- Amanda J Myers
- Ammar Al-Chalabi
- Amy Braddel
- Amy Gerrish
- Ana Frank-García
- Andre G Uitterlinden
- Andreas J Forstner
- Andrew J Saykin
- Andrew N McDavid
- Andrew P Lieberman
- Angela Hodges
- Anita L DeStefano
- Ann C McKee
- Anna Karydas
- Annakaisa Haapasalo
- Anne Boland
- Anne Braae
- Anne Kinhult-Stählbom
- Anne Maria Koivisto
- Annette L Fitzpatrick
- Annette M Hartmann
- Antonio Ciaramella
- Antonio Daniele
- Aoibhinn Lynch
- Ashley R Winslow
- Ashok Raj
- ASP Lim
- B Devlin
- B Howie
- Badri N Vardarajan
- Barry Reisberg
- Benedetta Nacmias
- Benjamin Grenier-Boley
- Bernadette McGuinness
- Bernardino Ghetti
- Beth Dombroski
- BN Vardarajan
- BN Vardarajan
- BP Fairfax
- Bradley F Boeve
- Bradley T Hyman
- Brian Lawlor
- Brian W Kunkle
- Bruce L Miller
- Bruce M Psaty
- Bruno Dubois
- Bruno Vellas
- C Cruchaga
- C Dirk Keene
- C Fuchsberger
- C Igartua
- C Schwab
- Carlo Caltagirone
- Carlo Masullo
- Carlos Cruchaga
- Carmen Muñoz Fernadez
- Carol A Miller
- Carol Brayne
- Carole Dufouil
- Carolina Ceballos Diaz
- Caroline Graff
- Chang-En Yu
- Charlene Thomas
- Charles C White
- Charles DeCarli
- Charlotte Forsell
- Chiara Cupidi
- Chiara Fenoglio
- Chris Corcoran
- Chris S Carlson
- Christiane Reitz
- Christine M Hulette
- Christine Van Broeckhoven
- Christophe Tzourio
- Christopher E Shaw
- Christopher J O'Donnell
- Christopher Medway
- Chuang-Kuo Wu
- Chuanhai Cao
- CJ Willer
- Claudia L Satizabal
- Claudine Berr
- Clinton B Wright
- Clinton T Baldwin
- Clive Holmes
- Constantine G Lyketsos
- Cornelia M van Duijn
- Cory C Funk
- Craig S Atwood
- Cynthia M Carlsson
- Cécile Dulary
- Céline Bellenguez
- Céline Derbois
- D Harold
- D Paris
- Dan Rujescu
- Daniel C Marson
- Daniel H Geschwind
- Daniel Levy
- Daniela Galimberti
- David A Bennett
- David C Rubinsztein
- David Carrell
- David Craig
- David G Clark
- David H Cribbs
- David Mann
- David W Fardo
- David Wallon
- Davide Seripa
- Debby W Tsuang
- Deborah Blacker
- Deborah C Mash
- Delphine Bacq
- Denis A Evans
- Denise Harold
- Dennis W Dickson
- Didier Hannequin
- Dominique Campion
- Donald R Royall
- Douglas R Galasko
- Duane Beekly
- Eden R Martin
- Eileen H Bigio
- Ekaterina Rogaeva
- Elaine Peskind
- Eleonora Sacchinelli
- Eliecer Coto
- Eliezer Masliah
- Elio Scarpini
- Elisa Majounie
- Elizabeth A Crocco
- Eric B Larson
- Eric Boerwinkle
- Eric M Reiman
- Erik D Roberson
- Erin Abner
- Fabienne Garzia
- Fernando Rivadeneira
- Feroze Golamaully
- Florence Pasquier
- Florentino Sanchez Garcia
- Francesco Panza
- Frank J Wolters
- Frank Jessen
- Frank M LaFerla
- Frank Martiniuk
- G Chan
- G Jun
- Gail P Jarvik
- Gary W Beecham
- Ge Li
- Gerard D Schellenberg
- Gianfranco Spalletta
- Gislain Septier
- Gudny Eiriksdottir
- Gyungah Jun
- H Neumann
- Hakan Thonberg
- Hakon Hakonarson
- Harald Hampel
- Harry V Vinters
- Helena C Chui
- Helena Schmidt
- Henry L Paulson
- Hieab H Adams
- Hilkka Soininen
- HM Wisniewski
- Hongdong Li
- Honghuang Lin
- Howard J Rosen
- Huntington Potter
- I Surakka
- I Tachmazidou
- Imelda S Barber
- Ina Giegling
- Isabel Henández
- Iwona Kloszewska
- J Hunkapiller
- J Wessel
- J Xing
- J-C Lambert
- J-C Lambert
- Jacques Epelbaum
- Jade Chapman
- James B Leverenz
- James D Bowen
- James J Lah
- James R Burke
- James T Becker
- James Turton
- James Uphill
- Janet Johnston
- Jayanadra J Himali
- JC Nolz
- JD Milner
- JD Ulrich
- Jean Paul Vonsattel
- Jean-Charles Lambert
- Jean-François Dartigues
- Jean-François Deleuze
- Jeffrey A Kaye
- Jeffrey M Burns
- Jennifer A Brody
- Jennifer Williamson
- Jenny Lord
- Jeremy D Burgess
- Jerome I Rotter
- JI Goldstein
- Jill R Murrell
- JK Pritchard
- Joan S Reisch
- JoAnn Tschanz
- Joel H Kramer
- Johanna Jakobsdottir
- Johannes Kornhuber
- John C Morris
- John Collinge
- John H Growdon
- John Hardy
- John Keoni Kauwe
- John M Olichney
- John M Ringman
- John Malamon
- John Morris
- John Powell
- John Q Trojanowski
- John R Gilbert
- Jonathan L Haines
- Jordi Clarimón
- Jose Bras
- Joseph D Buxbaum
- Joseph E Parisi
- Joseph F Quinn
- Joseph T Hughes
- Joshua A Sonnen
- Joshua C Bis
- Joshua W Miller
- Josée Dupuis
- JR Huyghe
- Juan C Troncoso
- Juan Fortea
- Julie A Schneider
- Julie Williams
- Kara L Hamilton-Nelson
- Karen Ritchie
- Kathleen A Welsh-Bohmer
- Kathryn L Lunetta
- Keeley Brookes
- Kelley M Faber
- Kenneth B Fallon
- Kevin Morgan
- Kirk C Wilhelmsen
- Kristel Sleegers
- Kristelle Brown
- L Adrienne Cupples
- Lars Lannfelt
- Laura B Cantwell
- Laura Fratiglioni
- Lawrence S Honig
- Lee-Way Jin
- Lei Yu
- Lena Kilander
- Lena Lilius
- Lenore J Launer
- Lesley Jones
- Letizia Concari
- Li-San Wang
- Liana G Apostolova
- Liming Qu
- Lina Keller
- Linda J Van Eldik
- Lindsay A Farrer
- Lindy E Harrell
- Lisa L Barnes
- Lluis Tarraga
- Lon S Schneider
- LS Perlmutter
- M Arfan Ikram
- M Bao
- M Gatz
- M Ilyas Kamboh
- Magda Tsolaki
- Makrina Daniilidou
- Malcolm Dick
- Manuel Mayhaus
- Margaret A Pericak-Vance
- Maria Candida Deniz Naranjo
- Maria Donata Orfei
- Maria Norton
- Maria Serpente
- Maria Urbano
- Maria Vronskaya
- Mariet Allen
- Marilyn S Albert
- Marina Arcaro
- Mark A Sager
- Markus Leber
- Markus M Nöthen
- Marla Gearing
- Marsel Mesulam
- Martin Dichgans
- Martin Ingelsson
- Martin R Farlow
- Martin Scherer
- Mary Sano
- María J Bullido
- Matt Hill
- Matthew J Huentelman
- Matthew P Frosch
- Matthias Riemenschneider
- Maura Gallo
- Megan L Grove
- Melanie Dunstan
- Melissa E Garcia
- Merce Boada
- Michael C O'Donovan
- Michael Gill
- Michael J Owen
- Michelangelo Mancuso
- Michelle K Lupton
- Mikko Hiltunen
- Mindy J Katz
- Minerva M Carrasquillo
- Miquel Aguilar
- MK Wetzel-Smith
- ML Grove
- MM Painter
- Murray Raskind
- MW Logue
- Myriam Fornage
- Mònica Díez Fairén
- N Patterson
- Najaf Amin
- Nandini Badarinarayan
- Nathalie Fievet
- Nathan D Price
- Neil W Kowall
- Neill R Graff-Radford
- Nick C Fox
- Nicola Denning
- Nigel J Cairns
- Nilufer Ertekin-Taner
- NJ Schork
- Oliver Peters
- Olivier Hanon
- Onofre Combarros
- Oscar L Lopez
- Oscar Sotolongo-Grau
- Otto Valladares
- P Hollingworth
- P Holmans
- P Yuan
- Paola Bossù
- Paolo Bosco
- Paolo Caffarra
- Paramita Chakrabarty
- Pascual Sánchez-Juan
- Patrice Whitehead
- Patrizia Mecocci
- Pau Pastor
- Paul K Crane
- Per Hoffmann
- Perrie M Adams
- Peter A Holmans
- Peter P De Deyn
- Peter Passmore
- Peter St George-Hyslop
- Petra Proitsi
- Philip L De Jager
- Philippe Amouyel
- PL De Jager
- Qiong Yang
- R Guerreiro
- R Rademakers
- R Talluri
- Rachel Marshall
- Rachel Raybould
- Rachelle S Doody
- Rafael Blesa
- Raffaele Giovanni Maletta
- Randall L Woltjer
- Ranjan Duara
- Rebecca Sims
- Rebecca Sussams
- Regina M Carney
- Reinhard Heun
- Reinhold Schmidt
- Rhodri Thomas
- Richard B Lipton
- Richard Mayeux
- Rik Vandenberghe
- Rita Guerreiro
- Robert A Stern
- Robert C Barber
- Robert C Green
- Robert Olaso
- Robert R Graham
- Roberta Cecchetti
- Roger L Albin
- Roger N Rosenberg
- Ron Munger
- Ronald C Petersen
- Ronald Kim
- Ronald L Hamilton
- RoseMarie Brundin
- Rudolph E Tanzi
- Russell H Swerdlow
- Ryan M Huebinger
- S Das
- S Hong
- S McCarthy
- S Sekino
- S Seshadri
- S Steinberg
- Sabrina Pichler
- Salvatore Spina
- Sandra Barral
- Sandra Weintraub
- Sandro Sorbi
- Sanjay Asthana
- Sara Ortega-Cubero
- Sarah Taylor
- SC Jin
- Sebastien Engelborghs
- Seppo Helisalmi
- Seung-Hoan Choi
- Shahzad Ahmad
- Shubhabrata Mukherjee
- Shuo Li
- Sid O'Bryant
- Simon Lovestone
- Simon Mead
- Sonia Moreno-Grau
- Stefan Herms
- Stefanie Heilmann-Heimbach
- Steffi Riedel-Heller
- Stephen Todd
- Steven E Arnold
- Steven Ferris
- Steven G Younkin
- Steven L Carroll
- Sudha Seshadri
- Susan M McCurry
- Susanne Moebus
- Sven J van der Lee
- T Jonsson
- T Jonsson
- T Kurosaki
- Taniesha Morgan
- Tatiana M Foroud
- Thomas D Bird
- Thomas G Beach
- Thomas H Mosley
- Thomas J Fairchild
- Thomas J Montine
- Thomas S Wingo
- Thor Aspelund
- Timothy W Behrens
- Todd E Golde
- Tricia A Thornton-Wells
- Ubaldo Bonuccelli
- V Escott-Price
- V Escott-Price
- Valentina Escott-Price
- Valur Emilsson
- Vernon S Pankratz
- Victoria Alvarez
- Vilmantas Giedraitis
- Vilmundur Gudnason
- Vincent Chouraki
- Vincent Dermecourt
- Vincenzo Solfrizzi
- Virginia Boccardi
- Vivianna M Van Deerlin
- W Bodmer
- W T Longstreth Jr
- Walter A Kukull
- Wayne C McCormick
- Wayne W Poon
- Wei Gu
- William Perry
- William W Seeley
- Wolfgang Maier
- Xue Wang
- Xueqiu Jian
- Y Lu
- Y Wang
- Y Wang
- Y Zhang
- Yi Zhao
- Yogen Patel
- Yoland Aladro Benito
- Yuning Chen
- Publication venue
- Nat Genet
- Publication date
- 01/01/2017
- Field of study
We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, we used an additional 14,997 samples to test the most significant stage 2 associations (P < 5 × 10-8) using imputed genotypes. We observed three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease: a protective variant in PLCG2 (rs72824905: p.Pro522Arg, P = 5.38 × 10-10, odds ratio (OR) = 0.68, minor allele frequency (MAF)cases = 0.0059, MAFcontrols = 0.0093), a risk variant in ABI3 (rs616338: p.Ser209Phe, P = 4.56 × 10-10, OR = 1.43, MAFcases = 0.011, MAFcontrols = 0.008), and a new genome-wide significant variant in TREM2 (rs143332484: p.Arg62His, P = 1.55 × 10-14, OR = 1.67, MAFcases = 0.0143, MAFcontrols = 0.0089), a known susceptibility gene for Alzheimer's disease. These protein-altering changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified risk genes in Alzheimer's disease. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's disease