80 research outputs found
Proceedings, International Taxus Symposium, October 1, 1975
- Author
- Publication venue
- Publication date
- 01/01/1975
- Field of study
History and development of Taxus in the U.S. / Ray A. Keen -- The best of the Taxus cultivars / L. C. Chadwick -- Poisonous properties of Taxus / Jack L. Beal -- Production of Taxus / Arie J. Radder -- Effective use of Taxus in the landscape / Clarence E. Lewis -- Taxus species and hybrids / Harold G. Hillier -- Japanese yew (Taxus cuspidata) / Makoto Kawase -- Fertilizing Taxus for optimum growth / Elton M. Smith -- Taxus insects: problems and research in Ohio / David G. Nielsen -- Taxus locations in the Secrest Arboretu
Hierarchies of Pain
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Trauma has become a pervasive cultural model for representing individual and collective injuries and suffering. This process has produced what may be called a trauma aesthetic, a set of recognizable tropes in widespread use in trauma narratives. This chapter examines the adoption of this aesthetic in graphic narratives, focusing on the special capacities of the form. Familiar tropes, such as dissociation and the somatic trace, are presented in complex combinations of visual and textual components, often exploiting the differential appearance of text and image to introduce a dynamic of belatedness or disarticulation. This chapter analyses five works ordered according to their diminishing reliance on ‘trauma’. The trauma aesthetic is used, though not explicitly, in Catherine Meurisse’s La Légèreté (2016) about the Charlie Hebdo attack, Jean-Philip Stassen’s Déogratias (2000/2006) about the genocide in Rwanda, and Emmanuel Lepage’s Un printemps à Tchernobyl (2012) about the aftermath of the Chernobyl nuclear disaster. By contrast, it is absent from Mazen Kerbaj’s Beirut Won’t Cry (2007/2017) about the Israel-Hezbollah conflict and Josh Neufeld’s A.D. about Hurricane Katrina (2009). These works’ reliance on formalized and sanctioned trauma tropes not only is influenced by narrative characteristics, such as temporal distance from the event or the presence of a single narrator-protagonist but may also be motivated by the prestige conferred by trauma as recognized suffering, affecting the canonization and translatability of the graphic narratives in question
Why is Liberal Peace-Building so Difficult? Some Lessons from Central America
- Author
- Alain Rouqui�
- Arnson Cynthia
- Bertine Kamphuis
- Carlos Sojo
- Carlos Vilas
- Carlos Vilas
- Chester A Crocker
- Comisi�n De
- C�rdoba Mac�as
- David Keen
- David Keen
- Donald Rothchild
- Donald Rothchild
- Gruppen
- H�vard
- H�vard Hegre
- Isacson
- Jack Child
- James Dunkerley
- Jeffrey M Paige
- Jennie K Lincoln
- Jennifer Schirmer
- Jennifer Schirmer
- Jeong
- John
- John Darby
- Kaldor
- Le Billon
- Lynn Horton
- Mark Plunkett
- Michael W Doyle
- Michael/Neil Pugh
- Paul
- Paul Pierson
- Pei
- Peter Scott
- Popkin
- Ray Jennings
- Roland Paris
- Roy
- Sabine Kurtenbach
- Sabine Kurtenbach
- Samuel H Barnes
- Stephen Stedman
- Susan C Peacock
- Susan L Woodward
- Tristan Borer
- Walter
- William
- William I Robinson
- Wolfgang
- Wolfgang Merkel
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2007
- Field of study
Optimizing CRE and PhiC31 mediated recombination in Aedes aegypti
- Author
- Publication venue
- Frontiers Media S.A.
- Publication date
- 01/09/2023
- Field of study
Introduction: Genetic manipulation of Aedes aegypti is key to developing a deeper understanding of this insects’ biology, vector-virus interactions and makes future genetic control strategies possible. Despite some advances, this process remains laborious and requires highly skilled researchers and specialist equipment.Methods: Here we present two improved methods for genetic manipulation in this species. Use of transgenic lines which express Cre recombinase and a plasmid-based method for expressing PhiC31 when injected into early embryos.Results: Use of transgenic lines which express Cre recombinase allowed, by simple crossing schemes, germline or somatic recombination of transgenes, which could be utilized for numerous genetic manipulations. PhiC31 integrase based methods for site-specific integration of genetic elements was also improved, by developing a plasmid which expresses PhiC31 when injected into early embryos, eliminating the need to use costly and unstable mRNA as is the current standard.Discussion: Here we have expanded the toolbox for synthetic biology in Ae. aegypti. These methods can be easily transferred into other mosquito and even insect species by identifying appropriate promoter sequences. This advances the ability to manipulate these insects for fundamental studies, and for more applied approaches for pest control
Social learning in LEADER: Exogenous, endogenous and hybrid evaluation in rural development
- Author
- Bache I.
- Baker J.
- Bassand M.
- Beckman A.
- Blackburn J.
- Bryden J.
- Bunch R.
- Casley D.
- Chambers R.
- Checkland P.
- Cooke B.
- Davis-Case D.A.
- Estrella M.
- European Association for Information on Local Development (AEIDL)
- European Commission
- European Commission
- Farrell G.
- Finger M.
- Fraser J.
- Gibson T.
- Gosling L.
- Guijt I.
- Gupte M.
- Hickey S.
- High C.
- High C.
- Ison R.
- Jackson E.T.
- Keen M.
- Krippendorff K.
- Lave J.
- Lawrenz F.
- Leeuwis C.
- Lowe P.
- Marks G.
- Marsden T.
- Midmore P.
- Moseley M.J.
- Moseley M.J.
- Mtshali S.M.
- Murphy J.
- Nemes G.
- Nemes G.
- North D.C.
- Office of Evaluation and Strategic Planning
- Organisation for Economic Co-operation and Development
- Patton M.
- Pretty J.
- Ray C.
- Ray C.
- Ray C.
- Rengasamy S.
- Richardson K.A.
- Robson C.
- Saraceno E.
- Scheurich J.J.
- Sociologia Ruralis
- Vorley B.
- Wadsworth Y.
- Wenger E.
- Publication venue
- 'Wiley'
- Publication date
- 01/04/2007
- Field of study
This paper considers the relationship between the centralised exogenous, institutions and the embedded, endogenous institutions of rural governance in Europe through an examination the evaluation procedures of the European LEADER programme. LEADER is presented in the literature as progressive in terms of innovation and stakeholder engagement. Yet while the planning and management of LEADER embraces heterogeneity and participation, programmatic evaluation is centralised and held at arms length from delivery organisations. The paper reviews previous efforts to improve evaluation in LEADER and considers alternative strategies for evaluation, contrasting LEADER practice with participatory evaluation methodologies in the wider international context. Can evaluation in itself be valuable as a mode of social learning and hence a driver for endogenous development in rural communities in Europe? The paper concludes by examining the challenges in producing a hybrid form of evaluation which accommodates endogenous and exogenous values
Current practice in methodology and reporting of the sample size calculation in randomised trials of hip and knee osteoarthritis: a protocol for a systematic review
- Author
- A Bafeta
- A Lundh
- AJ Vickers
- B Djulbegovic
- Bethan Copsey
- DF Williamson
- DG Altman
- DM Wenner
- E Losina
- E Tavernier
- EM Balk
- G Schott
- HI Keen
- J Cohen
- JA Cook
- JA Cook
- JA Cook
- Jonathan A. Cook
- KF Schulz
- L StataCorp
- LH Pengel
- P Charles
- R Mhaskar
- Ray Fitzpatrick
- RV Lenth
- S Hopewell
- S Lewin
- Sarah E. Lamb
- SD Halpern
- SJ Arnup
- Susan Dutton
- T Clark
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adhyapak S
- Agarwal H
- Aggarwal R
- Aggarwal RK
- Aguirre A
- Ahmed H
- Ahremark U
- Ahuad Guerrero RA
- Aidar Ayoub JC
- Airaksinen JK
- Aitken D
- Akatova E
- Akhter F
- Ako J
- Akright L
- Akyea-Djamson A
- Al Joundi T
- Al-Windy NYY
- Alan D
- Alcocer Gamba MA
- Alexander JH
- Alexander K
- Alexandru TM
- Alings M
- Alonso Martin JJ
- Alvarisqueta AF
- Alves De Lima AE
- Amarasekera S
- Amarasena N
- Amir O
- Amlani M
- Amosova E
- Amuchastegui M
- Andersen K
- Andersen R
- Anderson J
- Ando K
- Angel Hominal M
- Annam S
- Anscombe R
- Apostolovic SR
- Appel K-F
- Arandjelovic A
- Araneda G
- Arango Benecke JL
- Arbel Y
- Arif I
- Armaganijan L
- Arroyo JAC
- Arstall MA
- Asanin MR
- Atar S
- Athyros V
- Auguadro C
- Ayala CAC
- Aylward PE
- Azizad MM
- Bagai A
- Bagriy A
- Bahit MC
- Bai F
- Balaguer Recena J
- Baldari D
- Balinovac J
- Ball E
- Bang LE
- Banuru S
- Barakovic F
- Baranov E
- Baranova E
- Barbarash OL
- Barbato E
- Barna OM
- Barone-Rochette G
- Barr C
- Barrucco R
- Bartels GL
- Bashir R
- Basson MMDV
- Bastos JM
- Bata I
- Batushkin V
- Bayat J
- Bayram Llamas EA
- Bayron C
- Beauloye C
- Bednarski J
- Behrens S
- Belhassane A
- Benedicto A
- Bengus CM
- Benov HO
- Berger R
- Berglund S
- Berk M
- Berland J
- Berli MA
- Berlowitz M
- Berman B
- Bernan A
- Berti S
- Bhagwat A
- Bhagwat R
- Bhansali P
- Bhatt DL
- Binder R
- Birchem J
- Bittner VA
- Blicharski T
- Blok T
- Blumberg EDS
- Boccara F
- Bodanese LC
- Bodi Peris V
- Boecker D
- Bojovski S
- Bokarev I
- Bokern MJJA
- Bonfanti AJC
- Bono JOE
- Bordonava AP
- Borse R
- Bortnick A
- Bos RJ
- Botas Rodriguez J
- Botelho A
- Botelho RV
- Botia DCL
- Bottcher M
- Bourgeois R
- Brabham D
- Braganza D
- Braun-Dullaeus R
- Breedveld RW
- Brennan JM
- Brodison A
- Bronzwaer PNA
- Brueren BRG
- Bruguera Cortada J
- Budaj A
- Bugan V
- Busmane A
- Bustamante Labarta MH
- Busz-Papiez B
- Butler R
- Bystryk L
- Caccavo A
- Caime GD
- Calabro P
- Camprubi Potau M
- Camsari A
- Caraco Y
- Carey C
- Carlson E
- Carnero GS
- Carranza Madrigal J
- Carrillo Calvillo J
- Carroll PA
- Cartasegna LR
- Carter L
- Caruso OC
- Cassimjee S
- Castadot M
- Cavallini C
- Cequier Fillat AR
- Cerqueira MJAG
- Cestari HG
- Cevc M
- Cha J
- Chae I-H
- Chaitman B
- Chalavarya G
- Chaleff F
- Chambilla JMC
- Chandna H
- Chane M
- Chang M
- Chaudhary S
- Chavez V-CER
- Chen D
- Chen J
- Chen Y
- Cheng S-C
- Cheng X
- Chiang C-E
- Chiang C-E
- Chizhov P
- Chopda M
- Chopra VK
- Christenson S
- Chu A
- Chua T
- Chumakova G
- Chumburidze V
- Civeira Murillo F
- Claeys M
- Clemmensen P
- Clerc J
- Cleveland D
- Clifford P
- Clifton S
- Coching RM
- Codutti OR
- Cohen S
- Collins N
- Colombo HR
- Colquhoun D
- Commerford PJ
- Concha YMR
- Conrad G
- Constantine G
- Constantinescu MCA
- Convens C
- Cools F
- Corbett C
- Cornel JH
- Correa Flores RM
- Cosavalente LAC
- Cosin Sales J
- Costa F
- Coste P
- Cottin Y
- Coufal Z
- Coverdale SGM
- Cristian G
- Cruz Fernandez JM
- Cuccia C
- Cui L
- Cyster HP
- Czerski T
- D'Urso M
- Daboul N
- Dagher G
- Dahl C
- Dai K
- Dalby AJ
- Dalby AJ
- Danchin N
- Dandillaya R
- Daniels C
- Das S
- Davidovic G
- Davidsen F
- Davies R
- Davis W
- De Berrazueta Fernandez JR
- De Cesare NB
- De Leo A
- De Luca G
- De Mora Martin M
- De Pellegrin A
- De Salazar DIM
- de Santos MON
- de Silva HA
- de Souza JA
- De Wolf L
- Delarche N
- Deloatch S
- Demirtas M
- Denham D
- Devarapalli SK
- DeVore AD
- Diamantis S
- Diaz Fernandez JF
- Diaz A
- Diaz R
- Dickey S
- Dilic M
- Dimkovic S
- Dimov BI
- Dincic DV
- Ding C
- Dion D
- Dodic S
- Dombrowski K
- Doncovska S
- Dong S
- Dong Y
- Dorobantu M
- Dorsel T
- Dran RD
- Drexel H
- Drzewiecka A
- Ducas J
- Ducrocq G
- Duda N
- Dujardin K
- Dukat A
- Dulak E
- Dupuis R
- Durak-Nalbantic A
- Duronto EA
- Dzupina A
- Dzyak G
- Eagerton D
- Eapen Z
- East C
- Eaton C
- Ebrahim IO
- Edelberg JM
- Edes I
- Egorova L
- Eisenberg S
- Ekanayaka R
- El Shahawy M
- El-Ahdab F
- Elias M
- Eliaschewitz FG
- Elliott J
- Endsley P
- Eppinger A
- Erglis A
- Erglis A
- Ersanli M
- Fadlallah H
- Faes D
- Faggiano P
- Fairlamb J
- Fajardo Campos P
- Falukozy J
- Fang C-Y
- Fang W
- Fanghanel Salmon G
- Farhat N
- Farrar M
- Fausto Ovando SR
- Fazekas F
- Fazlibegovic E
- Feitosa GS
- Fell D
- Feng Y
- Fernandes Manenti ERF
- Fernandez Portales J
- Fernandez AM
- Fernandez M
- Fernando N
- Ferrari E
- Ferratini M
- Ferrolino A
- Filardi PP
- Fischer S
- Fishberg R
- Fisher D
- Fisher N
- Fisher R
- Florenzano F
- Flores E
- Flores REO
- Fong P
- Forgosh L
- Foster M
- Foster R
- Francis A
- Franek E
- Fras Z
- French WJ
- Friedman D
- Frost L
- Fu G
- Fuchs S
- Fuentes Jimenez F
- Fujii K
- Fujimoto K
- Fujinaga H
- Fulop P
- Fulwani MC
- Furukawa Y
- Galski T
- Galvani M
- Gapon L
- Garcia Brasca DF
- Garcia Castillo A
- Garcia Duran RO
- Garcia Lledo JA
- Garcia-Dorado D
- Gardner G
- Garrahy PJ
- Garrido M
- Garza Ruiz JA
- Gavish D
- Ge J
- Gelormini J
- Gerber J
- Gerber R
- Ghitis A
- Ghlonti R
- Gibson P
- Gielen S
- Giesler G
- Gil-Extremera B
- Gilbert JM
- Gillespie E
- Gilmore R
- Gimple L
- Giordano JA
- Giorgeto FE
- Gislason G
- Giuliano ME
- Gniot J
- Goch A
- Goloborodko B
- Gomez Vilamajo OA
- Gonsorcik J
- Gonzales RJV
- Gonzalez Diaz B
- Gonzalez Salas LG
- Gonzalez-Juanatey C
- Gonzalez-Juanatey JR
- Goodman SG
- Goodman SG
- Gordeev I
- Gordienko A
- Gorny J
- Gosselin G
- Gosselink ATM
- Gotcheva NN
- Gotcheva NN
- Govinda RA
- Goyal NK
- Gremmler U
- Grewal JS
- Griffiths H
- Gring C
- Groenemeijer BE
- Groutars RGEJ
- Guardigli G
- Guerrero De Leon M
- Guha S
- Gullestad L
- Guneri S
- Guneri S
- Guo Y
- Gurevich V
- Gusi Tragant G
- Guzman PN
- Haddad T
- Hagstrom E
- Hagstrom E
- Hahalis PIG
- Halabi M
- Halcox J
- Hald F
- Haldis T
- Hall J
- Halvorsen S
- Hameed A
- Haniffa R
- Hanotin C
- Hansen O
- Haraguchi T
- Harding S
- Harkut P
- Harrington RA
- Harris B
- Harris B
- Hart H
- Hata Y
- Hattler B
- Hedman A
- Heidenreich L
- Heinc P
- Heitzer T
- Hemetsberger R
- Henderson D
- Henkin Y
- Herath JI
- Herazo AS
- Hermans K
- Hermans WRM
- Hernandez HAA
- Herrman JPR
- Hersbach FMRJ
- Hess CN
- Higashikata T
- Higuera JD
- Hii CLS
- Hirayama A
- Hirooka K
- Hlatky MA
- Hoag G
- Hodes Z
- Hoffer E
- Hoffman D
- Hong T
- Hoogslag PAM
- Hoppe U
- Horak D
- Horowitz J
- Horvath I
- Horwitz P
- Hove JD
- Hrabar AD
- Hranai M
- Hsieh I-C
- Huang L
- Huang S
- Huang T-Y
- Huang W
- Huber K
- Huidobro L
- Huikuri H
- Hunter J
- Hurtig U
- Hussein O
- Huynh T
- Hwang J-J
- II TC
- III DG
- III KG
- Ilic S
- Ilieva-Pandeva KA
- Ince C
- Iniguez A
- Investigators ODYSSEYOUTCOMES
- Iqbal SMR
- Irimpen A
- Istratoaie O
- Ito K
- Ivanov IG
- Ivanova R
- Ivanovic N
- Iyengar SS
- Izzo M
- Jacoby D
- Jafar Z
- Jaffrani N
- Jain D
- Janik M
- Janosik D
- Jaramillo N
- Jatin FGM
- Jaworska K
- Jayawardena J
- Jensen SA
- Jensen SA
- Jeong MH
- Jeppesen J
- Jeserich M
- Jiang W
- Jintapakorn W
- Johansen PB
- Jonas M
- Jones WS
- Jordan JD
- Jortveit J
- Joshi AB
- Joshi P
- Jovin I
- Jr CE
- Jr HW
- Jr LC
- Jr MJ
- Jr PW
- Jr RW
- Jr SJ
- Jr SJF
- Jr WD
- Jujjuru S
- Jukema JW
- Juonala M
- Jure HO
- Jurgaitiene R
- Kadr H
- Kaewsuwanna P
- Kahali D
- Kaikkonen K
- Kaiser S
- Kalashetti S
- Kalil R
- Kamensky G
- Kamiya H
- Kandasamy B
- Kapin T
- Kaplan R
- Kapp IE
- Karalis I
- Karlsberg R
- Karna S
- Karpenko O
- Karpenko Y
- Karpov Y
- Karpov Y
- Kartalis A
- Kasim S
- Katona A
- Katsuda Y
- Katz A
- Kaucak V
- Kavaliauskiene R
- Kawasaki T
- Ke Y
- Keating F
- Kedev S
- Keen W
- Kehasukcharoen W
- Kelsey SF
- Kerkar P
- Khabeishvili G
- Khaira AS
- Khaisheva L
- Khan A
- Khan A
- Khan M
- Khasanov N
- Khintibidze I
- Khurana S
- Kibarskis A
- Kichukov KN
- Killat H
- Kim C
- Kim HS
- Kim MH
- Kim S-H
- Kimmelstiel C
- Kimura K
- Kimura T
- King M
- Kirma C
- Kishi K
- Kiss RG
- Kiss RG
- Kiviniemi T
- Kjovkaroski A
- Klancke K
- Klantsa A
- Klausen IC
- Kline G
- Klutstein M
- Knickelbine T
- Knowles JW
- Knutson T
- Koba S
- Kobalava Z
- Kobayashi J
- Koike A
- Koldas L
- Kolls BJ
- Kondo NI
- Kong DF
- Kopytsya M
- Koren M
- Kormann A
- Kornder J
- Kornowski R
- Korol M
- Kosinski E
- Kosmachova E
- Kostarska-Srokosz E
- Kostis J
- Kotha P
- Kouz S
- Kovalskyi I
- Kozuma K
- Krasowski W
- Krawczyk J
- Krichmar P
- Kristensen KS
- Kubica J
- Kubilius R
- Kuchar J
- Kuhlman P
- Kultursay H
- Kumar A
- Kumar P
- Kumbla M
- Kumkumian G
- Kuo J-Y
- Kurian J
- Kushnir M
- Kutniy O
- Kyiak Y
- Labroo A
- Lai C
- Lai W-T
- Landzberg J
- Larry J
- Larsen J
- Laucevicius A
- Laufs U
- Laxson D
- Lazov PV
- Leaes PE
- Leclercq F
- Lee K
- Lee K
- Lefevre T
- Leggewie S
- Lehman SJ
- Leimbach W
- Lekakis J
- Leon RPC
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- Leone A
- Lepage S
- Lepor N
- Leshchuk O
- Lester FM
- Leung R
- Levy T
- Li H
- Li J
- Li X
- Li Y
- Lianopoulos E
- Liberman A
- Liberopoulos E
- Liberopoulos E
- Libov I
- Licciardello G
- Lieber I
- Liem AAH
- Liew HB
- Lillis L
- Lin J
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- Lin WH
- Lin X
- Lindsey J
- Linhart A
- Link C
- Lip GYH
- Lipar L
- Lipko JA
- Liu M-E
- Liu S
- Llamas Esperon GA
- Loma-Osorio Rincon P
- Lomakin NV
- Lomholdt JD
- Lominadze Z
- Lopes RD
- Lopes RD
- Lopes RD
- Lopes RD
- Lopez Rosas E
- Lopez RB
- Lopez-Jaramillo P
- Lorenzatti AJ
- Lotan C
- Lottering H
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- Loussararian A
- Love M
- Lozada HJG
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- Lubinski A
- Luciardi HL
- Lui H
- Luis Zamorano J
- Luo Z
- Lupkovics G
- Lupovitch S
- Luquez HA
- Lyamina N
- Lysek R
- M Escudier J
- MacDonald P
- Macdonell A
- Mach F
- Machado L
- Machova V
- Mackinnon IJ
- Mahaffey KW
- Mahajan A
- Mahal S
- Maia LN
- Majercak I
- Makotoko EM
- Malhotra V
- Malik A
- Malozzi C
- Malynovsky Y
- Manakshe GV
- Mannucci JEB
- Mano T
- Manolis A
- Mansourati J
- Marais HJ
- Marcus J
- Marin Neto JA
- Marin F
- Markov DT
- Markov V
- Maron DJ
- Martinez Sanchez CR
- Martins D
- Martsin K
- Marusincova I
- Marx N
- Marx N
- Marx R
- Maskon O
- Matas Pericas L
- Matei AV
- Mathews R
- Mathur A
- Mathur R
- Matiga G
- May O
- May W
- Mayurathan G
- Mazur J
- Mcclure S
- Mcgough M
- Mclaurin B
- Medrano Allende JC
- Mehta RH
- Mehta S
- Meloni C
- Mendis S
- Mendonca C
- Mendoza JLA
- Mentz RJ
- Merkely B
- Michalaros YL
- Michaud N
- Michishita I
- Micko K
- Midzic Z
- Miguel SAN
- Miklaszewicz B
- Militaru C
- Mincheva VM
- Minescu B
- Mintale I
- Mirek-Bryniarska E
- Misonis N
- Moccetti T
- Mody F
- Mohamed WMIW
- Mohart AE
- Molchanova O
- Mollov MN
- Montalescot G
- Montana OR
- Monteiro MR
- Monteiro P
- Montenegro Valdovinos PC
- Montenegro Valdovinos PC
- Moodley R
- Morais J
- Morales DD
- Moran J
- Moreira HG
- Morel O
- Moriarty A
- Moriarty PM
- Moriarty PM
- Morino Y
- Moris De La Tassa C
- Morisset A
- Moryusef A
- Mosseri M
- Mostovoy Y
- Motovska Z
- Moura Jorge JC
- Mourtzinis G
- Mudawi T
- Mueller C
- Muenzel T
- Mulkay A
- Muller C
- Muller G
- Munk PS
- Munusamy V
- Murin J
- Muslibegovic A
- Musumeci G
- Muthusamy R
- Mutlu B
- Mynhardt JH
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- Zainea M
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- Zong W
- Zrazhevsky K
- Zuniga JDH
- Zurakowski A
- Zuran I
- Zweiker R
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
Aims The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisin–kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (≥1.8 mmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and results Median follow-up was 2.8 years. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (n = 2) or Type 5 (n = 5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77–0.95; P = 0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77–0.99; P = 0.032) and Type 2 (0.77, 0.61–0.97; P = 0.025), but not Type 4 MI. Conclusion After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.For complete list of authors see http://dx.doi.org/10.1093/eurheartj/ehz299</p
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
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- Babbage Anne
- Babbage Sarah
- Bach Phil
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- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
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- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
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- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
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- Bashman David
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- Batzer Mark
- Baumgart Cornelia
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- Beall Keith
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- Beaudet Arthur
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- Bergmann Anne
- Berkowicz Nicolas
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- Bird Christine
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- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
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- Blomstrom David B.
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- Chen Jianlong
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- Chen Lihong
- Chen Lixia
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- Chen Tong
- Chen Xiaoyun
- Chen Xinyi
- Chen Yanjiong
- Chen Yiyu
- Chen Zhu
- Chen Zhu
- Chen Zhu
- Cheng Jan-Fang
- Cheng Zhihua
- Chertkov Olga
- Cheshatsang Yama
- Chi Cheng
- Chi Han C.
- Chillingworth Neil
- Chin Sylvia
- Chinn Corey
- Chinwalla Asif
- Chissoe Stephanie
- Chiu Sally
- Chothia Tom
- Christensen Mari
- Christopoulos Constantine
- Chu Joseph
- Chui Connie
- Chung A
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- Clarke Betty
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- Clarke Kay
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- Clee Chris
- Clegg Shelia
- Clerc Blankenburg Kerstin Petra
- Cleveland David
- Clifford Karen
- Clifton Sandra W.
- Coates Julia
- Cobley Victoria
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- Coffey Alison
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- Coggill Penelope
- Cohn Judith D.
- Colayco Rick
- Cole Lotte
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- Collings Simon
- Collins Francis S.
- Collins John
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- Collymore Al
- Colman Louise
- Combs Jessie
- Comstock Robin
- Cong Bin
- Conner Richard
- Connolly Anthony
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- Considine Tony
- Constance Doug
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- Cummings Paul
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- Czubayko Martin
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- David Robert
- Davidson Lucy
- Davidson Stuart
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- Davis Cheryl
- Davis Clay
- Davis Jayne
- Davis John
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- Dawoe Tenzin
- Dawson Elisabeth
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- Deadman Rebecca
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- Dhami Pawandeep
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- Diekhans Mark
- Dietz-Band Jeanne
- Digennaro Richard
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- Dockree Catherine
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- Edionwe Susan Omwanghe Osayanro
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- Elkin Chris
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- Elliot Jeffrey
- Ellwood Matthew
- Emberson Becky
- Emelianenko Natalia
- Emery-Cohen Alexandra J.
- Endrizzi Matthew
- Engh Ger van den
- Engle David
- Erickson Jeffery
- Erler Anne Marie
- Errington Helen
- Escobar Julio
- Escotto Michael
- Eugene Craig S.
- Evans Gareth
- Evans John
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- Eveleth Gerald
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- Footman Simon
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- Fujiyama Asao
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- Fuller Liam
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- Fullerton Kathryn
- Fulton Lucinda A.
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- Furey Terrence S.
- Furuhashi Mie
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- Garcia-Martinez Antonio
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- Garnes Jeffrey A.
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- Griffiths Coline
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- Hitchens Matthew Edward
- Ho Issac
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- Pennacchio Len A.
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- Perez Lesette M.
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- Zhang Guohua
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- Zhang Haiqing
- Zhang Haiqing
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- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
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- Zhang Jiuchun
- Zhang Jiuchun
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- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
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- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
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- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Effect of alirocumab on mortality after acute coronary syndromes. An analysis of the ODYSSEY OUTCOMES randomized clinical trial
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- Abhyanakar AD
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- Varleta P
- Vatutin M
- Vedere A
- Vejar M
- Velcheva ES
- Verdel GJE
- Vered Z
- Verrier M
- Vervoort G
- Vico ML
- Vida M
- Videbaek L
- Vidotti MH
- Vidovich M
- Viergever EP
- Viigimaa M
- Vijay N
- Vijayaraghavan R
- Vikman S
- Viktorova I
- Vincendet M
- Violini R
- Vishnevsky AY
- Vizel S
- Vo A
- Voeller H
- Voevoda MI
- Vogel R
- Vohra R
- Vora K
- Voyce S
- Vrolix MCM
- Vulic D
- Vuurmans T
- Wada A
- Waider W
- Waisman GD
- Waites JH
- Wali A
- Walichiewicz PM
- Waltenberger J
- Waltman J
- Wang J
- Wang J
- Wang J
- Wattanakit K
- Wei M
- Weidinger F
- Weil J
- Weintraub H
- Weissbrodt M
- Welka S
- Welker J
- Wells T
- Werner N
- Westbrook M
- Westerhausen D
- Whitaker J
- White HD
- White L
- White M
- Wiersma JJ
- Wilkins G
- Wilkinson P
- Willems FF
- Wilson MD
- Winkelmann B
- Wiseman A
- Witt N
- Wlodarczak A
- Wojewod P
- Wollaert B
- Wong Y-K
- Wongpraparut N
- Wozniak J
- Wright S
- Wu C
- Xavier D
- Xenakis M
- Xu B
- Xu D
- Xu X
- Xu Y
- Yagensky A
- Yakushin S
- Yan AT-K
- Yan BPY
- Yanez M
- Yang E
- Yang X
- Yang X
- Yao Z
- Yazdani S
- Yerra SK
- Yin W-H
- Yong H
- Yoon JH
- Younis L
- Yu Y
- Yuan Z
- Yusoff K
- Yusoff K
- Zahger D
- Zaidman CJ
- Zainea M
- Zaman A
- Zapata G
- Zdravko B
- Zea Nunez CA
- Zeiher AM
- Zeiher AM
- Zhang R
- Zhang W
- Zhang X
- Zhang Z
- Zhao X
- Zheleznyy V
- Zheng Y
- Zheng Z
- Zhou Y
- Zhu C
- Zhu H
- Zhu J
- Zirlik A
- Zizka J
- Zobouyan I
- Zong W
- Zrazhevsky K
- Zurakowski A
- Zuran I
- Zweiker R
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 04/01/2019
- Field of study
Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. In a prespecified analysis of 8242 patients eligible for ≥3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P<0.0001 for the associations). Alirocumab reduced total nonfatal cardiovascular events (P<0.001) and thereby may have attenuated the number of cardiovascular and noncardiovascular deaths. A post hoc analysis found that, compared to patients with lower LDL-C, patients with baseline LDL-C ≥100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; Pinteraction=0.007). In the alirocumab group, all-cause death declined wit h achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). Conclusions: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for ≥3 years, if baseline LDL-C is ≥100 mg/dL, or if achieved LDL-C is low. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01663402
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