Portfolio Vol. VI N 1

Wyman, John. Mrs. Brannon\u27s Bathtub . Prose. 1. Holbrook, Harold R. Sonnet . Poem. 7. Hayne, Barbara. Prayer of A Youth . Poem. 7. Egger, Ellen. An Evening . Poem. 7. Cuninggim, Merrimon. Lambda Pi Beta Mu . Prose. 9. Willett, Thelma. White Rosebuds . Poem. 11. Willett, Thelma. Span of A Life in Mine . Poem. 11. Willett, Thelma. Seventeen . Poem. 11. Willett, Thelma. Ave Atque Vale . Poem. 11. Willett, Thelma. The Ashes of Letters . Poem. 11. Miller, Albert. ...To One I Have Known and Loved . Prose. 12. Wyman, John. Browning the Artist . Prose. 14. Brannon, Pat. Revolution . Poem. 18. Forsberg, Nancy. Unnamed. Poem. 18. Kearns, Carolyn. A Co-Ed\u27s Wish . Poem. 18. Goetz, Marilyn. Fate\u27s Fury . Prose. 19. Harvey, Richard. Man Who Ate the Cheesecake . Prose. 21. Spike, Robert. Mechanikos . Poem. 22. Stodghill, Patricia. Anodyne . Poem. 23. Ladd, Donald. Torch-Light . Poem. 23

Portfolio Vol. VI N 2

Wyman, John. Mrs. Brannon\u27s Bathtub . Prose. 1. Holbrook, Harold R. Sonnet . Poem. 7. Hayne, Barbara. Prayer of A Youth . Poem. 7. Egger, Ellen. An Evening . Poem. 7. Cuninggim, Merrimon. Lambda Pi Beta Mu . Prose. 9. Willett, Thelma. White Rosebuds . Poem. 11. Willett, Thelma. Span of A Life in Mine . Poem. 11. Willett, Thelma. Seventeen . Poem. 11. Willett, Thelma. Ave Atque Vale . Poem. 11. Willett, Thelma. The Ashes of Letters . Poem. 11. Miller, Albert. ...To One I Have Known and Loved . Prose. 12. Wyman, John. Browning the Artist . Prose. 14. Brannon, Pat. Revolution . Poem. 18. Forsberg, Nancy. Unnamed. Poem. 18. Kearns, Carolyn. A Co-Ed\u27s Wish . Poem. 18. Goetz, Marilyn. Fate\u27s Fury . Prose. 19. Harvey, Richard. Man Who Ate the Cheesecake . Prose. 21. Spike, Robert. Mechanikos . Poem. 22. Stodghill, Patricia. Anodyne . Poem. 23. Ladd, Donald. Torch-Light . Poem. 23

The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

Background: Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy. Methods: Consecutive women undergoing mastectomy ± IBR for breast cancer July–December, 2016 were included. Patient demographics, operative, oncological and complication data were collected. Time from last definitive cancer surgery to first adjuvant treatment for patients undergoing mastectomy ± IBR were compared and risk factors associated with delays explored. Results: A total of 2540 patients were recruited from 76 centres; 1008 (39.7%) underwent IBR (implant-only [n = 675, 26.6%]; pedicled flaps [n = 105,4.1%] and free-flaps [n = 228, 8.9%]). Complications requiring re-admission or re-operation were significantly more common in patients undergoing IBR than those receiving mastectomy. Adjuvant chemotherapy or radiotherapy was required by 1235 (48.6%) patients. No clinically significant differences were seen in time to adjuvant therapy between patient groups but major complications irrespective of surgery received were significantly associated with treatment delays. Conclusions: IBR does not result in clinically significant delays to adjuvant therapy, but post-operative complications are associated with treatment delays. Strategies to minimise complications, including careful patient selection, are required to improve outcomes for patients

Housing stressors, social support and psychological distress

This paper explores the links between housing stressors, social supports and psychological distress. It was hypothesised that exposure to housing stressors would be significantly related to psychological distress, but that the adverse effects of housing stressors would be moderated by perceptions of social support resources. In other words, the stress/symptom relationship would be attenuated for individuals who believe that they have active and supportive social relationships. The results of a study conducted in the two New Zealand cities of Auckland and Christchurch partially confirmed this hypothesis, indicating that social support plays a role in mitigating the adverse effects of housing stressors. However, this relationship depends on the severity of the housing stressors. Among our respondents, the presence of social support was indeed associated with reduced symptom levels for those exposed to moderate housing stressors. However, among respondents subjected to high levels of housing stressors, social support was not associated with reduced psychological distress, indicating the need for a more specific policy response to the issue of seriously deficient housing.mental health housing stressors social support psychological distress New Zealand housing and health

GC-MS Determination of Amphetamine and Methamphetamine in Human Urine for 12 Hours Following Oral Administration of Dextro-Methamphetamine: Lack of Evidence Supporting the Established Forensic Guidelines for Methamphetamine Confirmation

Ten human volunteers, naive to amphetamines and divided into two groups of five each, were given an oral dose of 30 mg/70 kg D-methamphetamine in one of two different paradigms: the initial dose at 0930 h or the initial dose at 2130 h. One week later, each subject was crossed over with regard to time but given the same dose. A total of 214 urine specimens were collected either prior to dosing or at each micturition for a 12-h period post dose. Specimens were analyzed on a blind basis for methamphetamine and one of its metabolites, amphetamine, by gas chromatography-mass spectrometry (GC-MS) using coinjection of extracted sample and pentafluoropropionic anhydride and selected-ion monitoring. Approximately 20% of the D-methamphetamine was recovered unchanged from the urine specimens, and 2% was recovered as amphetamine. The mean urine methamphetamine concentration in both groups reached a maximum within 4-6 h and declined thereafter. A residual amount of methamphetamine was found in some predose specimens at the crossover evaluation, reflecting that methamphetamine may be detected in urine for up to 7 days. The amphetamine concentration reached a plateau by 4-6 h. This observation coupled with the finding that all subjects excreted approximately 2% of the methamphetamine dose as amphetamine suggested a saturable process for its biotransformation. Concentrations of both methamphetamine and amphetamine tended to be higher, but were not significantly different, for night administration. Methamphetamine concentrations were consistently greater than the 500-ng/mL cutoff in most post-dosing specimens, whereas amphetamine concentrations generally did not achieve the 200-ng/mL cutoff specified by the Substance Abuse and Mental Health Services Administration (SAMHSA) guidelines for GC-MS confirmation of methamphetamine. Some specimens containing methamphetamine had no amphetamine metabolite. The current guidelines would have resulted in 90.2% of the specimens containing methamphetamine being ruled negative by confirmation following either night or day administration, whereas one subject following the initial day administration and another following night crossover administration would have been judged positive at most time intervals. These findings suggest that the current SAMHSA guidelines select for individual metabolic variations and that GC-MS confirmation of methamphetamine will result in most occasional users being ruled negative following an oral dose of methamphetamine while some will be ruled positive

Patient care standards for primary mitochondrial disease in Australia: an Australian adaptation of the Mitochondrial Medicine Society recommendations

This document provides consensus-based recommendations for general physicians and primary care physicians who diagnose and manage patients with mitochondrial diseases (MD). It builds on previous international guidelines, with particular emphasis on clinical management in the Australian setting. This statement was prepared by a working group of medical practitioners, nurses and allied health professionals with clinical expertise and experience in managing Australian patients with MD. As new treatments and management plans emerge, these consensus-based recommendations will continue to evolve, but current standards of care are summarised in this document

Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE.

Mucin-domain glycoproteins are densely O-glycosylated and play critical roles in a host of biological functions. In particular, the T cell immunoglobulin and mucin-domain containing family of proteins (TIM-1, -3, -4) decorate immune cells and act as key regulators in cellular immunity. However, their dense O-glycosylation remains enigmatic, primarily due to the challenges associated with studying mucin domains. Here, we demonstrate that the mucinase SmE has a unique ability to cleave at residues bearing very complex glycans. SmE enables improved mass spectrometric analysis of several mucins, including the entire TIM family. With this information in-hand, we perform molecular dynamics (MD) simulations of TIM-3 and -4 to understand how glycosylation affects structural features of these proteins. Finally, we use these models to investigate the functional relevance of glycosylation for TIM-3 function and ligand binding. Overall, we present a powerful workflow to better understand the detailed molecular structures and functions of the mucinome