Effects of acupressure at the hugo point (LI4) on labor pain and duration of delivery in nulliparous women

Introduction: Most women have experienced child birth and its pain, which is inevitable. If this pain is not controlled it leads to prolonged labor and injury to the mother and fetus. This study was conducted to identify the effect of acupressure on sanyinjiao and hugo points on delivery pain in nulliparous women. Methods:This was a randomized controlled clinical trial on 84 nulliparous women in hospitals of Ardebil, Iran. The participants were divided by randomized blocks of 4 and 6 into two groups. The intervention was in the form of applying pressure at sanyinjiao and hugo points based on different dilatations. The intensity of the pain before and after the intervention was recorded by visual scale of pain assessment. To determine the effect of pressure on the intensity of labor pain, analytical descriptive test was conducted in SPSS (version 13). Results:There was a significant decrease in mean intensity of pain after each intervention in the experimental group with different dilatations (4, 6, 8, and 10 cm). Moreover, the Student’s independent t-test results indicated that the mean intensity of pain in the experimental group after the intervention in all four dilatations was significantly lower than the control group. Repeated measures ANOVA test indicated that in both experimental and control groups in four time periods, there was a statistically significant difference. Conclusion:Acupressure on sanyinjiao and hugo points decreases the labor pain. Therefore, this method can be used effectively in the labor process

An Energetic AGN Outburst Powered by a Rapidly Spinning Supermassive Black Hole or an Accreting Ultramassive Black Hole

Powering the 10^62 erg nuclear outburst in the MS0735.6+7421 cluster central galaxy by accretion implies that its supermassive black hole (SMBH) grew by ~6x10^8 solar masses over the past 100 Myr. We place upper limits on the amount of cold gas and star formation near the nucleus of <10^9 solar masses and <2 solar masses per year, respectively. These limits imply that an implausibly large fraction of the preexisting cold gas in the bulge must have been consumed by its SMBH at the rate of ~3-5 solar masses per year while leaving no trace of star formation. Such a high accretion rate would be difficult to maintain by stellar accretion or the Bondi mechanism, unless the black hole mass approaches 10^11 solar masses. Its feeble nuclear luminosities in the UV, I, and X-ray bands compared to its enormous mechanical power are inconsistent with rapid accretion onto a ~5x10^9 solar mass black hole. We suggest instead that the AGN outburst is powered by a rapidly-spinning black hole. A maximally-spinning, 10^9 solar mass black hole contains enough rotational energy, ~10^62 erg, to quench a cooling flow over its lifetime and to contribute significantly to the excess entropy found in the hot atmospheres of groups and clusters. Two modes of AGN feedback may be quenching star formation in elliptical galaxies centered in cooling halos at late times. An accretion mode that operates in gas-rich systems, and a spin mode operating at modest accretion rates. The spin conjecture may be avoided in MS0735 by appealing to Bondi accretion onto a central black hole whose mass greatly exceeds 10^10 solar mass. The host galaxy's unusually large, 3.8 kpc stellar core radius (light deficit) may witness the presence of an ultramassive black hole.Comment: Accepted for publication in ApJ. Modifications: adopted slightly higher black hole mass using Lauer's M_SMBH vs L_bulge relation and adjusted related quantities; considered more seriously the consequences of a ultramassive black hole, motivated by new Kormendy & Bender paper published after our submission; other modifications per referee comments by Ruszkowsk

Gender Determination Using Diagnostic Values of Foramen Magnum

Background: Foramen magnum is a big hole in the base of the skull. Its appearance can be useful in gender determination. So far, no study has been conducted in Iran that evaluates the value of foramen magnum in sex determination and calculates the cut-off points. This study aimed to evaluating of diagnostic value of the foramen magnum and to calculate the cut-off points for sex determination.Methods: In this cross sectional study 50 male and 50 female patients referring to the radiology department of Rasol Akram Hospital in Tehran were evaluated. The required information about the sagittal diameter, transverse diameter, and diameter of foramen magnum were assessed by brain CT scan. Chi-square and independent t test was used for the comparison of different shapes and diameters between the sexes. ROC curve was used to determine the optimal cut-off point for each indicator.Results: The best cut-off point to distinguish males from females along the anterior-posterior foramen magnum was calculated as 36.45 mm, at the transverse diameter of 30.4 mm. The proper cut-off points for the area of the foramen magnum were 877.477 mm2 and 870.29 mm2, based on the Teixeria formula and Routal formula respectively. Overall, the accuracy of these indicators was calculated as 85%.Conclusion: Based on the results of this study using CT scans images, the diameter of the foramen magnum and its area had a high accuracy in sex determination

A review of the most important native medicinal plants of Iran effective on gastric acid

Gastrointestinal diseases such as gastric acid hypersecretion are highly prevalent. Gastrointestinal diseases manifest frequently with gastric and duodendal ulcers, gastritis, and dyspepsia which are due to impaired gastric acid secretion. Given the frequency of developing gastrointestinal diseases such as gastric acid hypersecretion and consequently gastric ulcer, the aim of this review article is to report the native medicinal plants of Iran that are used to decrease or neutralize gastric acid. Ziziphora clinopodioidesl, Achillea wilhelmsii, Allium sativum, Amirkabiria odoratissim, Heracleum persicum L. and Medicago sativa are the most native medicinal plants of Iran used to treat gastric acid hypersecretion. Certain compounds such as pulegon, cisisopulegon, cineol, thymol, alpha and betapinene, piperitenone, terpenoids, flavonoids, allicin, tannin, terpenoids, saponin, sterol, and leucoanthocyanin, 3, 4, and 7-trihydroxy flavonol, caffeic acid, and fetalid existing in these plants may be the main agents for reducing gastric acid

Guided routing on spinning microfluidic platforms

Flow directionality, valving and liquid routing in centrifugal microfluidics (Lab-on-CD) are typically controlled by applying centrifugal and Coriolis forces and have been the subject of active research interest in recent years. Determining and switching the flow direction at a T-junction is a common fluidic operation important for implementing several chemical and clinical assays for Lab-on-CDs. The present work describes a novel approach to route samples and control flow direction on a spinning disc that employs a guiding microstructure that relies on a two-stage valve comprised of an auxiliary inlet, which is a recess embedded at a T-junction, and a bent auxiliary outlet. The distinctive feature that makes this approach different from other types of passive capillary valves is the strong control of liquid movement, which is achieved by employing two adjustable sequential burst valves called a primary valve and a secondary burst valve. The guiding method can be used to route samples and reagents at given flow rates to a selection of receiving reservoirs, which are determined by the spinning frequency of the disc. The technique also allows for the switching of the flow direction instantaneously from the direction along the disc rotation to the opposite direction by increasing the rotational speed of the disc rather than relying on the Coriolis force, which would require reversing the spin direction. The flow routing by the proposed technique has been studied theoretically, and the flow behavior has been numerically investigated. These studies have been experimentally validated for a wide range of capillary sizes and for various liquids including di-water, mixtures of water and ethanol and bovine serum albumin (BSA)

Characterization of progenitor domains in the developing mouse thalamus

To understand the molecular basis of the specification of thalamic nuclei, we analyzed the expression patterns of various transcription factors and defined progenitor cell populations in the embryonic mouse thalamus. We show that the basic helix-loop-helix (bHLH) transcription factor Olig3 is expressed in the entire thalamic ventricular zone and the zona limitans intrathalamica (ZLI). Next, we define two distinct progenitor domains within the thalamus, which we name pTH-R and pTH-C, located caudal to the ZLI. pTH-R is immediately caudal to the ZLI and expresses Nkx2.2, Mash1, and Olig3. pTH-C is caudal to pTH-R and expresses Ngn1, Ngn2, and Olig3. Short-term lineage analysis of Olig3-, Mash1-, Ngn1-, and Ngn2-expressing progenitor cells as well as tracing the Pitx2 cell lineage suggests that pTH-C is the only major source of thalamic nuclei containing neurons that project to the cerebral cortex, whereas pTH-R and ZLI are likely to produce distinct postmitotic populations outside of the cortex-projecting part of the thalamus. To determine if pTH-C is composed of subdomains, we characterized expression of the homeodomain protein Dbx1 and the bHLH protein Olig2. We show that Dbx1 is expressed in caudodorsal-high to rostroventral-low gradient within pTH-C. Analysis of heterozygous Dbx1 nlslacZ knockin mice demonstrated that Dbx1-expressing progenitors preferentially give rise to caudodorsal thalamic nuclei. Olig2 is expressed in an opposite gradient within pTH-C to that of Dbx1. These results establish the molecular heterogeneity within the progenitor cells of the thalamus, and suggest that such heterogeneity contributes to the specification of thalamic nuclei. J. Comp. Neurol. 505:73–91, 2007. © 2007 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/56116/1/21467_ftp.pd

A Chandra X-ray Analysis of Abell 1664: Cooling, Feedback and Star Formation in the Central Cluster Galaxy

The brightest cluster galaxy (BCG) in the Abell 1664 cluster is unusually blue and is forming stars at a rate of ~ 23 M_{\sun} yr^{-1}. The BCG is located within 5 kpc of the X-ray peak, where the cooling time of 3.5x10^8 yr and entropy of 10.4 keV cm^2 are consistent with other star-forming BCGs in cooling flow clusters. The center of A1664 has an elongated, "bar-like" X-ray structure whose mass is comparable to the mass of molecular hydrogen, ~ 10^{10} M_{\sun} in the BCG. We show that this gas is unlikely to have been stripped from interloping galaxies. The cooling rate in this region is roughly consistent with the star formation rate, suggesting that the hot gas is condensing onto the BCG. We use the scaling relations of Birzan et al. 2008 to show that the AGN is underpowered compared to the central X-ray cooling luminosity by roughly a factor of three. We suggest that A1664 is experiencing rapid cooling and star formation during a low-state of an AGN feedback cycle that regulates the rates of cooling and star formation. Modeling the emission as a single temperature plasma, we find that the metallicity peaks 100 kpc from the X-ray center, resulting in a central metallicity dip. However, a multi-temperature cooling flow model improves the fit to the X-ray emission and is able to recover the expected, centrally-peaked metallicity profile.Comment: 15 pages, 13 figure

Large-scale unit commitment under uncertainty: an updated literature survey

The Unit Commitment problem in energy management aims at finding the optimal production schedule of a set of generation units, while meeting various system-wide constraints. It has always been a large-scale, non-convex, difficult problem, especially in view of the fact that, due to operational requirements, it has to be solved in an unreasonably small time for its size. Recently, growing renewable energy shares have strongly increased the level of uncertainty in the system, making the (ideal) Unit Commitment model a large-scale, non-convex and uncertain (stochastic, robust, chance-constrained) program. We provide a survey of the literature on methods for the Uncertain Unit Commitment problem, in all its variants. We start with a review of the main contributions on solution methods for the deterministic versions of the problem, focussing on those based on mathematical programming techniques that are more relevant for the uncertain versions of the problem. We then present and categorize the approaches to the latter, while providing entry points to the relevant literature on optimization under uncertainty. This is an updated version of the paper "Large-scale Unit Commitment under uncertainty: a literature survey" that appeared in 4OR 13(2), 115--171 (2015); this version has over 170 more citations, most of which appeared in the last three years, proving how fast the literature on uncertain Unit Commitment evolves, and therefore the interest in this subject

Effect of local papaverine on arteriovenous fistula maturation in patients with end-stage renal disease

BACKGROUND: Arteriovenous fistula (AVF) maturation is one of the main concerns in patients with end-stage renal disease (ESRD) and finding a strategy for increasing success rate and accelerating fistula maturation is valuable. The aim of this study was to evaluate the effects of papaverine injection on AVF maturation and success rate. METHOD: This study was a randomized clinical trial that involved 110 patients with ESRD that were referred for AVF construction. Patients were allocated in papaverine group and control group with block randomization according to age and sex. In the case group, papaverine (0.1 or 0.2 cc) was injected locally within the subadventitia of artery and vein after proximal and distal control during AVF construction and in the control group, AVF construction was done routinely without papaverine injection. RESULTS: Maturation time in case and control groups was 37.94 +/- 11.49 and 44.23 +/- 9.57 days, respectively (p=0.004). Hematoma was not seen in the case group but occurred in one patient in the control group. One patient of the case group developed venous hypertension. Four functional fistulas, 1 (1.8) in the case group and 3 (5.5) in the control group, failed to mature (p=0.618). Maturation rate did not differ between the two groups statistically (p=0.101). CONCLUSION: Local papaverine injection increased vessel diameter and blood flow, increasing shearing stress in both arterial and venous segment of recently created AVF. In this way, papaverine probably can decrease AVF maturation time without an increase in complications