Investigation of the Relationship Between the Level of Health Literacy and Vaccine Hesitancy

Objective: The objective of the study was to investigate the relationship between the level of health literacy and vaccine hesitancy. Furthermore, the dependence of the level of health literacy and vaccine hesitancy on socio-demographic variables were analyzed. Material and Methods: The study was conducted with 403 individuals via online and the questionnaire included the socio-demographic questions and two scales. The study was designed as a cross-sectional study and carried out during February- March, 2022 in Turkey. The online survey included a brief information on the study objective, anonymity and confidentiality of the collected data and voluntary participation. Data were collected through Turkish Health Literacy Scale-32 (TSOY-32) which was developed on the basis of the HLS-EU Study Conceptual Framework for Turkey and Vaccine Hesitancy Likert Scale. Data were analyzed by using SPSS-25 ve Lisrel 8.80. Results: The study suggested that there was a positive weak association between the level of health literacy and vaccine hesitancy, meaning as health literacy of participants increased the vaccine hesitancy of participants decreased. In terms of socio-demographic factors, both health literacy average index scores and vaccine hesitancy average scores were found to be differing in relation with education and income status of participants. Discussion and Conclusion: According to the recent European Health Literacy Survey study conducted in Europe, the findings indicated that 12% of the people who participated in in survey had insufficient general health literacy, and 35% had problematic health literacy. Our findings showed that 43% of respondents fell into a problematic category, and 30% were in the insufficient category. There is a need to conduct new studies using multiple measurement tools that are specific to vaccine literacy and those used to measure general health literacy. Keywords: Health literacy, Vaccine hesitancy, Turkish health literacy scale-32 DOI: 10.7176/JHMN/104-04 Publication date: November 30th 202

Recessive osteogenesis imperfecta caused by LEPRE1 mutations: clinical documentation and identification of the splice form responsible for prolyl 3-hydroxylation

Abstract: Background: Recessive forms of osteogenesis imperfecta (OI) may be caused by mutations in LEPRE1, encoding prolyl 3-hydroxylase-1 (P3H1) or in CRTAP, encoding cartilage associated protein. These proteins constitute together with cyclophilin B (CyPB) the prolyl 3-hydroxylation complex that hydroxylates the Pro986 residue in both the type I and type II collagen alpha 1-chains. Methods: We screened LEPRE1, CRTAP and PPIB (encoding CyPB) in a European/Middle Eastern cohort of 20 lethal/severe OI patients without a type I collagen mutation. Results: Four novel homozygous and compound heterozygous mutations were identified in LEPRE1 in four probands. Two probands survived the neonatal period, including one patient who is the eldest reported patient (17(7/12) years) so far with P3H1 deficiency. At birth, clinical and radiologic features were hardly distinguishable from those in patients with autosomal dominant (AD) severe/lethal OI. Follow-up data reveal that the longer lived patients develop a severe osteochondrodysplasia that overlaps with, but has some distinctive features from, AD OI. A new splice site mutation was identified in two of the four probands, affecting only one of three LEPRE1 mRNA splice forms, detected in this study. The affected splice form encodes a 736 amino acid (AA) protein with a "KDEL'' endoplasmic reticulum retention signal. While western blotting and immunocytochemical analysis of fibroblast cultures revealed absence of this P3H1 protein, mass spectrometry and SDS-urea-PAGE data showed severe reduction of alpha 1(I) Pro986 3-hydroxylation and overmodification of type I (pro) collagen chains in skin fibroblasts of the patients. Conclusion: These findings suggest that the 3-hydroxylation function of P3H1 is restricted to the 736AA splice form

Görsel sanatlar öğretmenlerinin sanat benlik kavram düzeylerinin farklı değişkenler açısından incelenmesi

Bu araştırmanın amacı, görsel sanatlar öğretmenlerinin sanat benlik kavram düzeyini cinsiyet, yaş, medeni durum, mesleki kıdem, görev yapılan okul türü ve mezun olunan fakülte değişkenleri açısından incelemektir. Araştırma nicel araştırma yaklaşımlarından betimsel tarama (survey) tekniği ile yürütülmüştür. Uygun örnekleme tekniği kullanılarak 275 görsel sanatlar öğretmenine ulaşılmıştır. Veriler, Duran ve Tezer (2005) tarafından geliştirilen Sanat Benlik Kavram Ölçeği kullanılarak elde edilmiştir. Veriler, Kolmogorov-Smirnov, Shapiro-Wilk, Mann- Whitney U, Kruskal-Wallis ve bağımsız gruplar t-testi ile analiz edilmiştir. Verilerin analizi sonucunda görsel sanatlar öğretmenlerinin sanat benlik kavram düzeyleri, cinsiyet, yaş, medeni durum, mesleki deneyim değişkenlerine göre farklılaşmadığı tespit edilmiştir. Buna karşılık görev yapılan okul türü değişkenine göre bilim sanat merkezleri ve güzel sanatlar liselerinde çalışan öğretmenler lehine anlamlı bir farklılık olduğu; güzel sanatlar fakültesi mezunu görsel sanatlar öğretmenlerinin sanat benlik kavram düzeyinin eğitim fakültesi mezunu görsel sanatlar öğretmenlerinin sanat benlik kavramında anlamlı olarak yüksek olduğu tespit edilmiştir. Veri analizi sonucunda ulaşılan bulgular, benlik kavramının sosyolojik ve psikolojik boyutları açısından yorumlanmış; ilgili literatür ışığında tartışılmış ve önerilerde bulunulmuştur.The present study was conducted in survey research method, which is one of the quantitative research approach. Research sample consisted of 275 fine arts teachers through convenience sampling. Data was collected through the Art SelfConcept Scale developed by Duran and Tezer (2005). Data was analyzed through Kolmogorov-Smirnov, Shapiro-Wilk, Mann Whitney U, independent ttest. As a result of the data analysis it was determined that level of fine arts teachers’ art self-concept do not vary in terms of gender, age, marital status, and professional experience variables however there is a significant difference in favor of the fine arts teachers working in science art centers, fine arts high schools in terms of type of the school, there is a significant difference in favor the fine arts teachers who graduated from fine arts faculties in terms of type of the faculty. Findings, obtained through the data analysis, were interpreted with respect to sociological and psychological aspects of the self-concept, discussed in the light of the relevant literature, suggestions were made

Fine arts teaching self-effıcacy scale: validity and reliability study

Bu çalışma, görsel sanatlar öğretmenlerinin görsel sanatlar öğretimi öz-yeterliliğini ölçmede geçerli ve güvenilir sonuçlar verebilecek ölçme aracı geliştirmeyi amaçlamaktadır. Görsel sanatlar öğretmenlerinin öğretim performanslarını mesleki bilgilerinin yanı sıra duyuşsal ve motivasyonel süreçler de etkiler. Bu duyuşsal ve motivasyonel süreçlerden bir tanesi de öz-yeterliliktir. Öz-yeterlilik, bireyin gelecektik belli bir iş veya görevde ne kadar iyi performans sergileyebileceğine ilişkin öz-algılaması, öz-inancı olarak tanımlanabilir. Çalışma örneklemini uygun örneklem yolu ile ulaşılabilen 212 görsel sanatlar öğretmeni oluşturmaktadır. Görsel Sanatlar Öğretimi Öz-Yeterlilik Ölçeğinin faktör yapısı ve sayısını belirlemek amacıyla Açımlayıcı Faktör Analizi (AFA) yapılmış ve üç faktörlü bir yapı elde edilmiştir. Birinci faktör Hazırlayıcı ve Uygulamalı Süreçlere Yönelik Öz-Yeterlilik, ikinci faktör Öğretim Sürecine Yönelik Öz-Yeterlilik, üçüncü faktör ise Farklılıklara Karşı ÖzYeterlilik olarak adlandırılmıştır. Üç faktörlü yapının Cronbach Alpha iç tutarlılık katsayısı .93 olarak tespit edilmiştir.Elde edilen üç faktörlü yapının model uyumunu tespit etmek amacıyla DFA yapılmıştır. DFA sonucunda elde edilen üç faktörlü yapının kabul edilebilir düzeyde model uyumuna sahip olduğunu göstermiştir (CFI= .97, GFI= .90, TLI=.96, NNFI=.94, IFI=.97, RMSEA= .07). Güvenirlik analizi iç tutarlılık katsayısına bağlı olarak yapılmış Görsel Sanatlar Öğretimi Öz-Yeterlilik Ölçeğinin Cronbach Alpha iç tutarlılık katsayısı .93 olarak bulunmuştur. Bu sonuçlara dayalı olarak Görsel Sanatlar Öğretimi Öz-Yeterlilik Ölçeğinin görsel sanatlar öğretmenlerinin öz-yeterliliğini geçerli ve güvenilir olarak ölçebileceği sonucuna ulaşılmıştır.Purpose of the present study is to develop an instrument which will produce valid and reliable results in measuring self-efficacy of fine arts teachers. Affective and motivational processes influence performance of fine arts teachers as much as professional knowledge of the fine arts teacher. Self-efficacy is one of those processes. Self-efficacy is described as self-perceptions or self-beliefs on how well the individual will perform the specif task or work. Sample of the study consist of 212 fine arts teachers. Exploratory Factor Analysis (EFA) was conducted to determine how many factors the Fine Art Teaching Self-Efficacy Scale includes and construct with three factors was revealed. Those factors were named as Self-Efficacy for Preparatory and Practical Process, Self-Efficacy on Instructional Process, Self-Efficacy for Diversity. Overall Cronbach Alpha internal consistency coefficient of the scale was determined as .93. Confirmatory Factor Analysis (CFA) was carried out in order to examine how well the construct with three factors fit into the data. Results of the CFA indicated that the construct with three factors fits into the data moderately (CFI= .97, GFI= .90, TLI=.96, NNFI=.94, IFI=.97, RMSEA= .07). Reliability analysis was conducted through internal consistency coefficient. As a result of the reliability analysis Cronbach Alpha coefficient of the Fine Art Teaching Self-Efficacy Scale was found as .93. Based on results of the study it was concluded that Fine Art Teaching Self-Efficacy Scale can measure validly and reliably self-efficacy of fine art teachers

A homozygous CREB3L1 missense mutation expands the mutational spectrum of CREB3L1-related osteogenesis imperfecta

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A homozygous pathogenic missense variant broadens the phenotypic and mutational spectrum of CREB3L1-related osteogenesis imperfecta

The cyclic adenosine monophosphate (AMP) responsive element binding protein 3-like 1 (CREB3L1) gene codes for the endoplasmic reticulum stress transducer old astrocyte specifically induced substance (OASIS), which has an important role in osteoblast differentiation during bone development. Deficiency of OASIS is linked to a severe form of autosomal recessive osteogenesis imperfecta (OI), but only few patients have been reported. We identified the first homozygous pathogenic missense variant (p.(Ala304Val)) in a patient with lethal OI, which is located within the highly conserved basic leucine zipper domain, four amino acids upstream of the DNA binding domain. In vitro structural modeling and luciferase assays demonstrate that this missense variant affects a critical residue in this functional domain, thereby decreasing the type I collagen transcriptional binding ability. In addition, overexpression of the mutant OASIS protein leads to decreased transcription of the SEC23A and SEC24D genes, which code for components of the coat protein complex type II (COPII), and aberrant OASIS signaling also results in decreased protein levels of SEC24D. Our findings therefore provide additional proof of the potential involvement of the COPII secretory complex in the context of bone-associated disease

DOCK6 Mutations Are Responsible for a Distinct Autosomal-Recessive Variant of Adams-Oliver Syndrome Associated with Brain and Eye Anomalies

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