KTU-GEOD IVS Analysis Center Annual Report 2012

This report summarizes the activities of the KTU-GEOD IVS Analysis Center (AC) in 2012 and outlines planned activities for 2013. The analysis of the EUROPE sessions is one of our specific interests, and the combination of different AC solutions for continuous VLBI campaigns, e.g. CONT11, will be investigated

Kendzia, Victoria Bishop (2017), Visitors tot he House of Memory. Identity and the Political Education at the Jewish Museum Berlin. Col. “Museum and Collections”, 9. New York-Oxford: Berghahn, 174 pp. ISBN: 978-1-78533-639-3.

Kendzia, Victoria Bishop (2017), Visitors tot he House of Memory. Identity and the Political Education at the Jewish Museum Berlin. Col. “Museum and Collections”, 9. New York-Oxford: Berghahn, 174 pp. ISBN: 978-1-78533-639-3. 978-1-78533-640-9 (eBook)

Nuclear matrix protein Matrin3 regulates alternative splicing and forms overlapping regulatory networks with PTB.

Matrin3 is an RNA- and DNA-binding nuclear matrix protein found to be associated with neural and muscular degenerative diseases. A number of possible functions of Matrin3 have been suggested, but no widespread role in RNA metabolism has yet been clearly demonstrated. We identified Matrin3 by its interaction with the second RRM domain of the splicing regulator PTB. Using a combination of RNAi knockdown, transcriptome profiling and iCLIP, we find that Matrin3 is a regulator of hundreds of alternative splicing events, principally acting as a splicing repressor with only a small proportion of targeted events being co-regulated by PTB. In contrast to other splicing regulators, Matrin3 binds to an extended region within repressed exons and flanking introns with no sharply defined peaks. The identification of this clear molecular function of Matrin3 should help to clarify the molecular pathology of ALS and other diseases caused by mutations of Matrin3.We thank Nejc Haberman (UCL) for assisting in the generation of the splicing maps and preparation of the iCLIP data. This work was supported by Wellcome Trust programme grants to CWJS (077877 and 092900), and by grants to EE and NB BIO2011-23920 and RNAREG (CSD2009-00080) from the Spanish Government and by the Sandra Ibarra Foundation for Cancer (FSI2013). JA was supported by a Boehringer Ingelheim Fonds studentship.This is the final version of the article. It first appeared from EMBO Press/Wiley via http://dx.doi.org/10.15252/embj.20148985

Relational Ethics: Volunteering and the Responsibilities of the Good Muslim

This article explores the ways in which female Belgian Muslim volunteers experience responsibility. It argues that responsibility consists of multiple dynamics for the volunteers, for example, the duties that are embedded in the Islamic tradition and the duties that arise from being a good citizen in a liberal/secular context. While these are often emphasized as being contentious binaries—especially for Muslims living in the West—this paper suggests that volunteering allows the Muslim women to bring these worlds together. The ways in which volunteering enables this is by introducing a relational reading of ethics and ethical self-formation. Relationality is highly significant for the female Muslim volunteer. It signifies being in touch with both (non-liberal) Islamic ethics and liberal public norms, even when pursuing a pious lifestyle. Hence, the article explores the ways in which responsibility is actualized in this framework. Finally, the last section interrogates how this idea of responsibility and relationality re-articulates binaries of the good-Muslim and the bad-Muslim

Single-cell analysis of CD4+ T-cell differentiation reveals three major cell states and progressive acceleration of proliferation

Background: Differentiation of lymphocytes is frequently accompanied by cell cycle changes, interplay that is of central importance for immunity but is still incompletely understood. Here, we interrogate and quantitatively model how proliferation is linked to differentiation in CD4+ T cells. Results: We perform ex vivo single-cell RNA-sequencing of CD4+ T cells during a mouse model of infection that elicits a type 2 immune response and infer that the differentiated, cytokine-producing cells cycle faster than early activated precursor cells. To dissect this phenomenon quantitatively, we determine expression profiles across consecutive generations of differentiated and undifferentiated cells during Th2 polarization in vitro. We predict three discrete cell states, which we verify by single-cell quantitative PCR. Based on these three states, we extract rates of death, division and differentiation with a branching state Markov model to describe the cell population dynamics. From this multi-scale modelling, we infer a significant acceleration in proliferation from the intermediate activated cell state to the mature cytokine-secreting effector state. We confirm this acceleration both by live imaging of single Th2 cells and in an ex vivo Th1 malaria model by single-cell RNA-sequencing. Conclusion: The link between cytokine secretion and proliferation rate holds both in Th1 and Th2 cells in vivo and in vitro, indicating that this is likely a general phenomenon in adaptive immunity

On the contribution of wind farms in automatic generation control: Review and new control approach

© 2018 by the authors. Wind farms can contribute to ancillary services to the power system, by advancing and adopting new control techniques in existing, and also in new, wind turbine generator systems. One of the most important aspects of ancillary service related to wind farms is frequency regulation, which is partitioned into inertial response, primary control, and supplementary control or automatic generation control (AGC). The contribution of wind farms for the first two is well addressed in literature; however, the AGC and its associated controls require more attention. In this paper, in the first step, the contribution of wind farms in supplementary/load frequency control of AGC is overviewed. As second step, a fractional order proportional-integral-differential (FOPID) controller is proposed to control the governor speed of wind turbine to contribute to the AGC. The performance of FOPID controller is compared with classic proportional-integral-differential (PID) controller, to demonstrate the efficacy of the proposed control method in the frequency regulation of a two-area power system. Furthermore, the effect of penetration level of wind farms on the load frequency control is analyzed

The Views of Educational Supervisors on Clinical Supervision

Contemporary educational supervision expresses democratic and leadership focused supervisory approach which consists of collaboration, trust, sharing and improving. The aims of the study are to investigate the answer of how current teacher supervision in Turkey is conducted according to the views of educational supervisors, and to unearth what the general attitudes and evaluations of educational supervisors regarding clinical supervision. A phenemological research design was used in the study. The study group consists of 53 educational supervisors working in the province of Antalya. A structured form consists of both open and close ended questions was delivered to the supervisors participated in the study. Data was gathered oral and written via interviews. A conference lasting six hours on clinical supervision’s aim, processes, techniques, observation and data collecting tools was held for the supervisors within the study. According to the results of the study, current supervision may be categorized under four stages; the stage before reaching the school setting, pre-observation, observation, and post-observation. That the views of educational supervisors are positive regarding the applicability of clinical supervision. The participants, mostly, stressed that the supervisory duties must be divided from the duties of investigation, and that the supervisors must be trained on clinical supervision. Keywords: clinical supervision, educational supervisors, evaluation, school

Klinische und immunologische Aspekte von CVID-Patienten

Der variable Immundefekt oder common variable immunodeficiency syndrome (CVID) ist ein primärer Immundefekt mit einer Häufigkeit von ca. 1:25.000 - 50.000 in der westlichen Bevölkerung und ist somit der häufigste symptomatische primäre Immundefekt. CVID wird nach internationalem Konsens definiert als ein signifikanter Mangel an IgG, sowie mindestens einer weiteren Immunglobulinklasse (IgA oder IgM), verbunden mit einer defizienten Bildung spezifischer Antikörper nach Antigenexposition. Das klinische Krankheitsbild ist dominiert von wiederkehrenden bakteriellen Infektionen, Autoimmunerkrankungen, lymphoproliferativen Erkrankungen und Neoplasien. Ziel dieser Studie war die Überprüfung der Diagnosestellung, Einteilung der Patienten in verschiedene Gruppen (primäre CVID-Patienten: early-onset und late-onset, sekundäre CVID- und Agammaglubulinämie-Patientinnen) und der Vergleich dieser Gruppen in Bezug auf klinische Manifestationen, Familienanamnese, Laborparameter und Therapien