Microfossils from Middle Triassic beds near Mišji Dol, central Slovenia

Middle Triassic beds exposed along the road between Mišji Dol and Poljane pri Primskovem (Posavje Hills) comprise marlstone, tuff, volcaniclastic sandstone, and thin- to medium-bedded limestone and dolostone. The succession was logged and sampled for conodonts. A relatively rich conodont assemblage was determined, consisting of Budurovignathus gabrielae Kozur, Budurovignathus sp., Cratognathodus kochi (Huckriede), Gladigondolella malayensis Nogami, Gladigondolella tethydis Huckriede, Gladigondolella sp., Neogondolella balkanica Budurov & Stefanov, Neogondolella cf. excentrica Budurov & Stefanov, Neogondolella constricta (Mosher & Clark), Neogondolella cornuta Budurov & Stefanov, Neogondolella sp., Paragondolella excelsa Mosher, Paragondolella liebermani (Kovacs & Kozur), Paragondolella trammeri (Kozur), Paragondolella cf. alpina (Kozur & Mostler), and Paragondolella sp. The assemblage correlates with the upper Anisian and lowermost Ladinian assemblages from the Global Boundary Stratotype Section and Point (GSSP) of the Ladinian at Bagolino in the Southern Alps in northern Italy. Along with conodonts, numerous specimens of benthic foraminifera Nodobacularia? vujisici Urošević & Gaździcki were recovered from the lowermost part of the succession. Previous research on this taxon is critically evaluated

Clinical Characteristics of Inpatients with Childhood vs. Adolescent Anorexia Nervosa

We aimed to compare the clinical data at first presentation to inpatient treatment of children (<14 years) vs. adolescents (≥14 years) with anorexia nervosa (AN), focusing on duration of illness before hospital admission and body mass index (BMI) at admission and discharge, proven predictors of the outcomes of adolescent AN. Clinical data at first admission and at discharge in 289 inpatients with AN (children: n = 72; adolescents: n = 217) from a German multicenter, web-based registry for consecutively enrolled patients with childhood and adolescent AN were analyzed. Inclusion criteria were a maximum age of 18 years, first inpatient treatment due to AN, and a BMI <10th BMI percentile at admission. Compared to adolescents, children with AN had a shorter duration of illness before admission (median: 6.0 months vs. 8.0 months, p = 0.004) and higher BMI percentiles at admission (median: 0.7 vs. 0.2, p = 0.004) as well as at discharge (median: 19.3 vs. 15.1, p = 0.011). Thus, in our study, children with AN exhibited clinical characteristics that have been associated with better outcomes, including higher admission and discharge BMI percentile. Future studies should examine whether these factors are actually associated with positive long-term outcomes in children

Seasonal variation of BMI at admission in German adolescents with anorexia nervosa

Objective Recent preliminary studies indicated a seasonal association of BMI at admission to inpatient treatment for anorexia nervosa (AN), indicating lower BMI in the cold season for restrictive AN. An impaired thermoregulation was proposed as the causal factor, based on findings in animal models of AN. However, findings regarding seasonality of BMI and physical activity levels in the general population indicate lower BMI and higher physical activity in summer than in winter. Therefore, we aimed to thoroughly replicate the findings regarding seasonality of BMI at admission in patients with AN in this study. Method AN subtype, age- and gender-standardized BMI scores (BMI-SDS) at admission, mean daily sunshine duration and ambient temperature at the residency of 304 adolescent inpatients with AN of the multi-center German AN registry were analyzed. Results A main effect of DSM-5 AN subtype was found (F(2,298) = 6.630, p = .002), indicating differences in BMI-SDS at admission between restrictive, binge/purge and subclinical AN. No main effect of season on BMI-SDS at admission was found (F(1,298) = 4.723, p = .025), but an interaction effect of DSM-5 subtype and season was obtained (F(2,298) = 6.625, p = .001). Post-hoc group analyses revealed a lower BMI-SDS in the warm season for restrictive AN with a non-significant small effect size (t(203.16) = 2.140, p = .033; Hedges′g = 0.28). Small correlations of mean ambient temperature (r = −.16) and daily sunshine duration (r = −.22) with BMI-SDS in restrictive AN were found. However, the data were widely scattered. Conclusions Our findings are contrary to previous studies and question the thermoregulatory hypothesis, indicating that seasonality in AN is more complex and might be subject to other biological or psychological factors, for example physical activity or body dissatisfaction. Our results indicate only a small clinical relevance of seasonal associations of BMI-SDS merely at admission. Longitudinal studies investigating within-subject seasonal changes might be more promising to assess seasonality in AN and of higher clinical relevance

Smoking, Variation In N-acetyltransferase 1 (nat1) And 2 (nat2), And Risk Of Non-hodgkin Lymphoma: A Pooled Analysis Within The Interlymph Consortium

Studies of smoking and risk of non-Hodgkin lymphoma (NHL) have yielded inconsistent results, possibly due to subtype heterogeneity and/or genetic variation impacting the metabolism of tobacco-derived carcinogens, including substrates of the N-acetyltransferase enzymes NAT1 and NAT2. We conducted a pooled analysis of 5,026 NHL cases and 4,630 controls from seven case-control studies in the international lymphoma epidemiology consortium to examine associations between smoking, variation in the N-acetyltransferase genes NAT1 and NAT2, and risk of NHL subtypes. Smoking data were harmonized across studies, and genetic variants in NAT1 and NAT2 were used to infer acetylation phenotype of the NAT1 and NAT2 enzymes, respectively. Pooled odds ratios (ORs) and 95 % confidence intervals (95 % CIs) for risk of NHL and subtypes were calculated using joint fixed effects unconditional logistic regression models. Current smoking was associated with a significant 30 % increased risk of follicular lymphoma (n = 1,176) but not NHL overall or other NHL subtypes. The association was similar among NAT2 slow (OR 1.36; 95 % CI 1.07-1.75) and intermediate/rapid (OR 1.27; 95 % CI 0.95-1.69) acetylators (p (interaction) = 0.82) and also did not differ by NAT1*10 allelotype. Neither NAT2 phenotype nor NAT1*10 allelotype was associated with risk of NHL overall or NHL subtypes. The current findings provide further evidence for a modest association between current smoking and follicular lymphoma risk and suggest that this association may not be influenced by variation in the N-acetyltransferase enzymes

RECOGNISING THE SYMPTOMS OF STROKE AND FIRST AID AMONG LAY POPULATION

Teoretična izhodišča: V diplomskem delu sta predstavljena prepoznavanje simptomov možganske kapi in prva pomoč laičnega prebivalstva. Pomembno je, da laično prebivalstvo takoj prepozna simptome možganske kapi ter pomaga bolnemu ali poškodovanemu po svojih najboljših zmožnostih. Metodologija: V diplomskem delu smo v teoretičnem delu uporabili deskriptivno metodo dela, v empiričnem delu pa kvantitativno metodologijo. Uporabljena je bila strokovna in znanstvena tuja in domača literatura. Pridobljeno literaturo smo dobili preko podatkovnih baz COBISS, PubMed, Wiley in CINAHL. Razprava: Ugotovljeno je, da laično prebivalstvo pozna simptome možganske kapi, kako se pravilno odreagira pri možganski kapi ter kako se odzove na nudenje prve pomoči. Velikokrat je prav prva pomoč tista, ki se je laično prebivalstvo najbolj izogiba. Sklep: Možganska kap je bolezen, za katero ne moremo predvideti, kdo izmed nas bo zbolel. Kljub temu, da se število obolelih zmanjšuje, mora vsak posameznik biti seznanjen, na kakšen način se lahko izogne možganski kapi. Pravilna izbira prve pomoči lahko bolnemu ali poškodovanemu reši življenje. Pri tem je za vse zdravstvene delavce in laično prebivalstvo pomembno, da takoj začnejo nuditi prvo pomoč in s tem zmanjšajo škodo ponesrečencu ali bolnemu.Hintergrund: In der Diplomarbeit sind präsentieren die Symptome eines Schlaganfalls mit denen wir ein Identifizieren können und Erste Hilfe eine betroffene Person zu geben. Es ist wichtig, dass die Bevölkerung weiß über die Symptome von Schlaganfällen um sie erkennt und Erste Hilfe eine betroffene Person zu geben. Material und Methode: Im theoretischem Teil dieser Arbeit wurde die deskriptive bzw. beschreibende Methode verwendet. Der empirischer Teil bedient sich der quantitativen Methode. Herangezogen wurden fachliche und wissenschaftliche Texte der in- und ausländischen Literatur. Diese Forschungsliteratur wurde mit Hilfe von der COBISS Datenbank, sowie durch PubMed, CINAHL und Wiley erfasst. Diskussion: Unsere Forschung hat gezeigt, dass die Bevölkerung um die Symptome eines Schlaganfalls, wie man richtig reagiert auf der Straße und wie man richtig eine Erste Hilfe gibt weisen Sie Bescheid. Aber viele Personen haben angst eine Erste Hilfe zu geben, weil sie wollen kein Fehler machen. Schlussfolgerung: Der Schlaganfall ist eine Krankheit die wir nicht rechtzeitig vorhersagen können. Trotz der Tatsache, dass die Zahl der Schlaganfälle sinkt muss noch immer eine Prävention an der Bevölkerung aus üben. Damit sie besser vor beugen können. Die richtige erste Hilfe kann einem kranken oder verletztem Leben retten. Es ist für alle Gesundheit Arbeiter und die Bevölkerung wichtig, dass sie sofort eine erste Hilfe leisten und dadurch weitere schaden verhindert könne