95 research outputs found
Damage Prediction in Woven and Non-woven Fabric Composites
This chapter presents a step-by-step review on different damage prediction approaches for woven and non-woven fabric composites. First, the characteristics of woven and non-woven fabrics are distinguished one from another, suggesting more complex analyses required for non-woven fabrics. Then, the subsequent sub-sections are geared toward a comparison of different approaches utilized in predicting the mechanical behavior and damage mechanisms of these composites at various material scales including micro, meso, and macro. The merits and demerits of each approach with regard to practicality, accuracy, effectiveness, and characterization expense are discussed. Moreover, using recent experimental evidences, the chapter aims to highlight a number of inherent complexities in the interlaced architecture of woven composites, which may not be precisely taken into account by the damage models originally developed for non-woven and unidirectional composites. Finally, two illustrative examples on the effect of the aforementioned complexities on the mechanical behavior of woven composites are presented in more detail, through some recent works of the authors
Examining the Effectiveness of Mindfulness Based Cognitive Therapy (MBCT) on Increasing Resilience of War Injured Veterans
The present study aimed to investigate the impression of Mindfulness based on cognitive therapy (MBCT) on raise resilience of war injured veterans. The study is quasi-experimental study, with pre-test and post-test and control group. The sample included 30 war injured veterans in Mashhad city and they were divided into two groups as 15 in Mindfulness based cognitive therapy and 15 people in control group. The members of MBCT received 8 sessions of MBCT but there was no intervention for control group. Before and after intervention, Conner-Davidson Resilience Scale (CD-RISC) was completed by sample group. The results of covariance analysis showed that in post-test resilience scores in MBCT group had significant increase compared to control group. The study findings released that MBCT increased resilience of war injured veterans
Effects of progressive and non-progressive threads of an immediate loading dental implant
Immediate loading of dental implants are always a cause of concern in implant dentistry with no consensus regarding the prerequisites to achieve optimum results. The purpose of the present simulation study was to assess the stress/strain distribution at the surrounding marginal bone of an immediately loaded implant with two different thread designs—progressive and non-progressive threads. A three dimensional finite element model of an adult mandible was developed from computed tomography scan images, and a static vertical load of 100 N was applied to the implant. The min/max von Mises stresses and strains of cancellous bone surrounding the implants were analysed. The results showed that the implant designed with progressive thread had uniform distribution and well dissipated stress/ strain for the bone
Computer-Aided Fabrication System Structure
Contains report on one research project.Defense Advanced Research Projects Agency Contract MDA 972 88-K-000
Kavosh: a new algorithm for finding network motifs
<p>Abstract</p> <p>Background</p> <p>Complex networks are studied across many fields of science and are particularly important to understand biological processes. Motifs in networks are small connected sub-graphs that occur significantly in higher frequencies than in random networks. They have recently gathered much attention as a useful concept to uncover structural design principles of complex networks. Existing algorithms for finding network motifs are extremely costly in CPU time and memory consumption and have practically restrictions on the size of motifs.</p> <p>Results</p> <p>We present a new algorithm (Kavosh), for finding k-size network motifs with less memory and CPU time in comparison to other existing algorithms. Our algorithm is based on counting all k-size sub-graphs of a given graph (directed or undirected). We evaluated our algorithm on biological networks of <it>E. coli </it>and <it>S. cereviciae</it>, and also on non-biological networks: a social and an electronic network.</p> <p>Conclusion</p> <p>The efficiency of our algorithm is demonstrated by comparing the obtained results with three well-known motif finding tools. For comparison, the CPU time, memory usage and the similarities of obtained motifs are considered. Besides, Kavosh can be employed for finding motifs of size greater than eight, while most of the other algorithms have restriction on motifs with size greater than eight. The Kavosh source code and help files are freely available at: <url>http://Lbb.ut.ac.ir/Download/LBBsoft/Kavosh/</url>.</p
Computer-Aided Fabrication System Structure
Contains reports on one research project.Defense Advanced Research Projects Agency MDA 972 88-K-000
Cognitive Information Processing
Contains reports on two research projects.Center for Advanced Television StudiesDARPA/U.S. Navy - Office of Naval Research (Contract MDA-972-88-K-0008)DARPA/U.S. Navy - Office of Naval Research (Contract N00014-85-K-0213
Saffron (Crocus sativus) versus duloxetine for treatment of patients with fibromyalgia: A randomized double-blind clinical trial
Objective: Saffron was found efficient and safe in treatment of neuropsychiatric disorders, in particular depression. We compared the efficacy of saffron with duloxetine in treatment of patients with fibromyalgia. Materials and Methods: In this double-blind parallel-group clinical trial, outpatients with fibromyalgia were randomized to receive either saffron 15 mg or duloxetine 30 mg starting with 1 capsule per day in the first week followed by 2 capsules per day from week 2 until the end of week 8. Participants were men and women aged 18-60 years diagnosed with fibromyalgia based on the American College of Rheumatology 2010 criteria who also had a pain score ≥40 based on visual analogue scale. Participants were excluded in case they had rheumatologic diseases, inflammatory/infectious/autoimmune arthritis, comorbid neuropsychiatric disorders except depressive disorders, pain due to traumatic injuries, drug history of duloxetine or saffron use, current use of psychoactive medications, recent use of muscle relaxants, steroids, opioid analgesics, benzodiazepines, anti-epileptics, or injective analgesics. Primary outcomes included differences in mean score changes from baseline to endpoint between the treatment arms for Hamilton Rating Scale for Depression, Fibromyalgia Impact Questionnaire, and Brief Pain Inventory. Results: Socio-demographic characteristics and baseline scores were similarly distributed between the two treatment arms (2n=46). No significant difference was detected for any of the scales neither in terms of score changes from baseline to endpoint between the two treatment arms (Mean score changes: -4.26 to 2.37; p-values: 0.182-0.900) nor in terms of time´treatment interactions (p-values: 0.209-0.964). Conclusions: Saffron and duloxetine demonstrated comparable efficacy in treatment of fibromyalgia symptoms
Evaluation of overall survival and disease-free survival of adjuvant chemotherapy and hormone therapy in patients with breast cancer
Abstract :
Background: This study evaluated the effect of adjuvant chemotherapy and hormone therapy on overall survival and disease-free survival in patients with breast cancer with hormone receptor-positive, HER2-negative tumor without lymph node involvement.
Methods: Breast cancer patients with hormone receptor-positive, HER2-negative, and no lymph node involvement were included in this retrospective cohort study. Patient records were used to collect data on sex, age, time of disease onset, tumor subtype, tumor size, grade, lymphovascular and perineural involvement, ki67, and treatment protocols. Patients were divided into 2 groups: Patients who received both adjuvant chemotherapy and hormonal therapy and patients who received hormonal therapy only. Disease-free survival index (DFS) and overall survival index (OS) were evaluated.
Results: Sixty-seven female patients were enrolled in this study. Of them, 68.2% received both adjuvant chemotherapy and hormonal therapy and 31.6% received hormonal therapy only. During follow-up, recurrences occurred in 8 patients. The 3-year and 5-year DFS were 93.4% and 90%, respectively. The 3-year and 5-year DFS were 94% and 92%, respectively, in patients who received both adjuvant chemotherapy and hormonal therapy, and 91% and 85%, respectively, in patients who received hormonal therapy. None of the factors studied affected the 3-year and 5-year DFS. The 3-year and 5-year DFS OS were 98.6% and 96.9%, respectively
CONCLUSION: Adjuvant chemotherapy in patients with breast cancer with hormone receptor-positive, HER2-negative, and no lymph node involvement compared with similar patients receiving hormone therapy alone had no significant difference in disease-free survival index and overall survival index.
Keywords: breast cancer; disease-free survival index; overall survival inde
The global, regional, and national burden of adult lip, oral, and pharyngeal cancer in 204 countries and territories:A systematic analysis for the Global Burden of Disease Study 2019
Importance Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy planning.Objective To analyze the total and risk-attributable burden of lip and oral cavity cancer (LOC) and other pharyngeal cancer (OPC) for 204 countries and territories and by Socio-demographic Index (SDI) using 2019 Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study estimates.Evidence Review The incidence, mortality, and disability-adjusted life years (DALYs) due to LOC and OPC from 1990 to 2019 were estimated using GBD 2019 methods. The GBD 2019 comparative risk assessment framework was used to estimate the proportion of deaths and DALYs for LOC and OPC attributable to smoking, tobacco, and alcohol consumption in 2019.Findings In 2019, 370 000 (95% uncertainty interval [UI], 338 000-401 000) cases and 199 000 (95% UI, 181 000-217 000) deaths for LOC and 167 000 (95% UI, 153 000-180 000) cases and 114 000 (95% UI, 103 000-126 000) deaths for OPC were estimated to occur globally, contributing 5.5 million (95% UI, 5.0-6.0 million) and 3.2 million (95% UI, 2.9-3.6 million) DALYs, respectively. From 1990 to 2019, low-middle and low SDI regions consistently showed the highest age-standardized mortality rates due to LOC and OPC, while the high SDI strata exhibited age-standardized incidence rates decreasing for LOC and increasing for OPC. Globally in 2019, smoking had the greatest contribution to risk-attributable OPC deaths for both sexes (55.8% [95% UI, 49.2%-62.0%] of all OPC deaths in male individuals and 17.4% [95% UI, 13.8%-21.2%] of all OPC deaths in female individuals). Smoking and alcohol both contributed to substantial LOC deaths globally among male individuals (42.3% [95% UI, 35.2%-48.6%] and 40.2% [95% UI, 33.3%-46.8%] of all risk-attributable cancer deaths, respectively), while chewing tobacco contributed to the greatest attributable LOC deaths among female individuals (27.6% [95% UI, 21.5%-33.8%]), driven by high risk-attributable burden in South and Southeast Asia.Conclusions and Relevance In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use. These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts
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