Zusammensetzung des Begleitinfiltrats und Koexpression von B-Zell-Transkriptionsfaktoren in follikulären Lymphomen

Follikuläre Lympome sind die zweithäufigsten Lymphome in der westlichen Welt, mit bisher nur schwer vorhersagbarem klinischen Verlauf. Da follikuläre Lymphome morphologisch Keimzentren immitieren, wurde im Rahmen dieser Arbeit der Einfluss von Regulationsfaktoren der physiologischen Keimzentrumsreaktion auf den Verlauf des follikulären Lymphoms untersucht. insbeondere wurde die Zusammensetzung des T-Zell-Begleitinfiltrats, sowie die Expression des Transkriptionsfaktors Mum1 untersucht

The Extended Star Formation History of the Andromeda Spheroid at 35 Kpc on the Minor Axis

Using the HST ACS, we have obtained deep optical images reaching well below the oldest main sequence turnoff in fields on the southeast minor-axis of the Andromeda Galaxy, 35 kpc from the nucleus. These data probe the star formation history in the extended halo of Andromeda -- that region beyond 30 kpc that appears both chemically and morphologically distinct from the metal-rich, highly-disturbed inner spheroid. The present data, together with our previous data for fields at 11 and 21 kpc, do not show a simple trend toward older ages and lower metallicities, as one might expect for populations further removed from the obvious disturbances of the inner spheroid. Specifically, the mean ages and [Fe/H] values at 11 kpc, 21 kpc, and 35 kpc are 9.7 Gyr and -0.65, 11.0 Gyr and -0.87, and 10.5 Gyr and -0.98, respectively. In the best-fit model of the 35 kpc population, one third of the stars are younger than 10 Gyr, while only ~10% of the stars are truly ancient and metal-poor. The extended halo thus exhibits clear evidence of its hierarchical assembly, and the contribution from any classical halo formed via early monolithic collapse must be small.Comment: Accepted for publication in The Astrophysical Journal Letters. 4 pages, latex, 2 color figure

Caenorhabditis elegans as Model System in Pharmacology and Toxicology: Effects of Flavonoids on Redox-Sensitive Signalling Pathways and Ageing

Flavonoids are secondary plant compounds that mediate diverse biological activities, for example, by scavenging free radicals and modulating intracellular signalling pathways. It has been shown in various studies that distinct flavonoid compounds enhance stress resistance and even prolong the life span of organisms. In the last years the model organism C. elegans has gained increasing importance in pharmacological and toxicological sciences due to the availability of various genetically modified nematode strains, the simplicity of modulating genes by RNAi, and the relatively short life span. Several studies have been performed demonstrating that secondary plant compounds influence ageing, stress resistance, and distinct signalling pathways in the nematode. Here we present an overview of the modulating effects of different flavonoids on oxidative stress, redox-sensitive signalling pathways, and life span in C. elegans introducing the usability of this model system for pharmacological and toxicological research

Adoptive Cell Transfer of Allogeneic Epstein-Barr Virus-Specific T Lymphocytes for Treatment of Refractory EBV-Associated Posttransplant Smooth Muscle Tumors: A Case Report

Posttransplant smooth muscle tumors (PTSMTs) are rare Epstein-Barr virus (EBV)-associated neoplasms, mostly occurring after solid organ transplantation. Current therapeutic strategies include surgery and reduction of immunosuppressive medication. We describe for the first time a novel treatment approach for PTSMT by adoptive cell transfer (ACT) of EBV-specific T cells to a 20-year-old patient with a medical history of cardiac transplantation, posttransplant lymphoproliferative disease, and multilocular PTSMT. During ACT, mild cytokine release syndrome occurred, while no unexpected safety signals were recorded. We observed in vivo expansion of EBV-specific T cells and reduction of EBV viremia. Best response was stable disease after 4 months with reduction of EBV viremia and normalization of lactate dehydrogenase levels. ACT with EBV-specific T cells may be a safe and efficacious therapeutic option for PTSMT that warrants further exploration

The SPLASH Survey: A Spectroscopic Analysis of the Metal-Poor, Low-Luminosity M31 dSph Satellite Andromeda X

Andromeda X (And X) is a newly discovered low-luminosity M31 dwarf spheroidal galaxy (dSph) found by Zucker et al. (2007) in the Sloan Digital Sky Survey (SDSS - York et al. 2000). In this paper, we present the first spectroscopic study of individual red giant branch stars in And X, as a part of the SPLASH Survey (Spectroscopic and Photometric Landscape of Andromeda's Stellar Halo). Using the Keck II telescope and multiobject DEIMOS spectrograph, we target two spectroscopic masks over the face of the galaxy and measure radial velocities for ~100 stars with a median accuracy of sigma_v ~ 3 km/s. The velocity histogram for this field confirms three populations of stars along the sight line: foreground Milky Way dwarfs at small negative velocities, M31 halo red giants over a broad range of velocities, and a very cold velocity ``spike'' consisting of 22 stars belonging to And X with v_rad = -163.8 +/- 1.2 km/s. By carefully considering both the random and systematic velocity errors of these stars (e.g., through duplicate star measurements), we derive an intrinsic velocity dispersion of just sigma_v = 3.9 +/- 1.2 km/s for And X, which for its size, implies a minimum mass-to-light ratio of M/L =37^{+26}_{-19} assuming the mass traces the light. Based on the clean sample of member stars, we measure the median metallicity of And X to be [Fe/H] = -1.93 +/- 0.11, with a slight radial metallicity gradient. The dispersion in metallicity is large, sigma([Fe/H]) = 0.48, possibly hinting that the galaxy retained much of its chemical enrichment products. We discuss the potential for better understanding the formation and evolution mechanisms for M31's system of dSphs through (current) kinematic and chemical abundance studies, especially in relation to the Milky Way sample. (abridged version)Comment: Accepted for Publication in Astrophys. J. 14 pages including 7 figures and 2 tables (journal format

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depressive episodes (MDE) were recruited into this 6-week study. They received interpersonal psychotherapy (IPT) twice weekly. Results: After 6 weeks of IPT, 17 patients responded (reduction of 6 50% of baseline HAMD); after 1 week of treatment pCREB increased significantly compared to the nonresponder group. Measurement of the BDNF plasma levels revealed no differences between the responder and nonresponder groups. Furthermore, the correlations between BDNF plasma levels and pCREB were not significant. Conclusions: The early increase in pCREB is related to treatment response and does not depend on pharmacological interventions or BDNF plasma levels. For the first time, cellular biological markers could be associated with response to psychotherapy

The SPLASH Survey: A Spectroscopic Portrait of Andromeda's Giant Southern Stream

The giant southern stream (GSS) is the most prominent tidal debris feature in M31's stellar halo. The GSS is composed of a relatively metal-rich, high surface-brightness "core" and a lower metallicity, lower surface brightness "envelope." We present Keck/DEIMOS spectroscopy of red giant stars in six fields in the vicinity of M31's GSS and one field on Stream C, an arc-like feature on M31's SE minor axis at R=60 kpc. Several GSS-related findings and measurements are presented here. We present the innermost kinematical detection of the GSS core to date (R=17 kpc). This field also contains the continuation of a second kinematically cold component originally seen in a GSS core field at R=21 kpc. The velocity gradients of the GSS and the second component in the combined data set are parallel over a radial range of 7 kpc, suggesting a possible bifurcation in the line-of-sight velocities of GSS stars. We also present the first kinematical detection of substructure in the GSS envelope. Using kinematically identified samples, we show that the envelope debris has a ~0.7 dex lower mean photometric metallicity and possibly higher intrinsic velocity dispersion than the GSS core. The GSS is also identified in the field of the M31 dSph satellite And I; the GSS in this field has a metallicity distribution identical to that of the GSS core. We confirm the presence of two kinematically cold components in Stream C, and measure intrinsic velocity dispersions of ~10 and ~4 km/s. This compilation of the kinematical (mean velocity, intrinsic velocity dispersion) and chemical properties of stars in the GSS core and envelope, coupled with published surface brightness measurements and wide-area star-count maps, will improve constraints on the orbit and internal structure of the dwarf satellite progenitor.Comment: Accepted for publication in Ap

The Panchromatic Hubble Andromeda Treasury: Triangulum Extended Region (PHATTER). V. The Structure of M33 in Resolved Stellar Populations

We present a detailed analysis of the the structure of the Local Group flocculent spiral galaxy M33, as measured using the Panchromatic Hubble Andromeda Treasury Triangulum Extended Region (PHATTER) survey. Leveraging the multiwavelength coverage of PHATTER, we find that the oldest populations are dominated by a smooth exponential disk with two distinct spiral arms and a classical central bar $-$ completely distinct from what is seen in broadband optical imaging, and the first-ever confirmation of a bar in M33. We estimate a bar extent of $\sim$1 kpc. The two spiral arms are asymmetric in orientation and strength, and likely represent the innermost impact of the recent tidal interaction responsible for M33's warp at larger scales. The flocculent multi-armed morphology for which M33 is known is only visible in the young upper main sequence population, which closely tracks the morphology of the ISM. We investigate the stability of M33's disk, finding $Q{\sim}1$ over the majority of the disk. We fit multiple components to the old stellar density distribution and find that, when considering recent stellar kinematics, M33's bulk structure favors the inclusion of an accreted halo component, modeled as a broken power-law. The best-fit halo model has an outer power-law index of $-$3 and accurately describes observational evidence of M33's stellar halo from both resolved stellar spectroscopy in the disk and its stellar populations at large radius. Integrating this profile yields a total halo stellar mass of ${\sim}5{\times}10^8\ M_{\odot}$, giving a total stellar halo mass fraction of 16%, most of which resides in the innermost 2.5 kpc.Comment: 31 pages, 17 figures, 5 tables, Accepted for publication in Ap